Contrasting in Vivo and in Vitro Fates of Glioblastoma Cell Subpopulations with Amplified EGFR

Genes Chromosomes and Cancer

Volumn 39, Issue 1, 2004, Pages 29-36

  Pandita, Ajay ^a,c   Aldape, Kenneth D ^b   Zadeh, Gelareh ^a   Guha, Abhijit ^a   James, C David ^c  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

ARTICLE; CELL SUBPOPULATION; CONTROLLED STUDY; GENE AMPLIFICATION; GENE MUTATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; MUTATION; NUDE MOUSE; PRIORITY JOURNAL; TUMOR GROWTH; WILD TYPE; XENOGRAFT;

ANIMALS; CELL DIVISION; GENE AMPLIFICATION; GLIOBLASTOMA; HUMANS; MICE; MICE, NUDE; MUTATION; NEOPLASM TRANSPLANTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

MUS MUSCULUS;

EID: 0344420263     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10300     Document Type: Article

References (34)

1. Bigner SH, Friedman HS, Vogelstein B, Oakes WJ, Bigner DD. 1990. Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. Cancer Res 50:2347-2350.
2. Burton EC, Lamborn KR, Forsvth P, Scott J, O'Campo J, Uyehara-Lock J, Prados M, Berger M, Passe S, Uhm J, O'Neill BP, Jenkins RB, Aldape KD. 2002. Aberrant p53, mdm2, and proliferation differ in glioblastomas from long-term compared with typical survivors. Clin Cancer Res 8:180-187.
3. Ekstrand AJ, James CD, Cavenee WK, Seliger B, Pettersson RF, Collins VP. 1991. Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res 51:2164-2172.
4. El-Obeid A, Hesselager G, Westermark B, Nister M. 2002. TGF-alpha-driven tumor growth is inhibited by an EGF receptor tyrosine kinase inhibitor. Biochem Biophys Res Commun 290:349-358.
5. Filmus J, Pollak MN, Cairncross JG, Buick RN. 1985. Amplified, overexpressed and rearranged epidermal growth factor receptor gene in a human astrocytoma cell line. Biochem Biophys Res Commun 131:207-215.
6. Frederick L, Wang XY, Eley G, James CD. 2000. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Research 60:1383-1387, 2000.
7. Galanis E, Buckner J, Kimmel D, Jenkins R, Alderete B, O'Fallon J, Wang CH, Scheithauer BW, James CD. 1998. Gene amplification as a prognostic factor in primary and secondary high-grade malignant gliomas. Int J Oncol 13:717-724.
8. Goike HM, Asplund AC, Pettersson EH, Liu L, Sanoudou D, Collins VP. 1999. Acquired rearrangement of an amplified epidermal growth factor receptor (EGFR) gene in a human glioblastoma xenograft. J Neuropath Exp Neurol 58:697-701.
9. He J, Reifenberger G, Liu L, Collins VP, James CD. 1994a. Analysis of glioma cell lines for amplification and overexpression of MDM2. Genes Chromosomes Cancer 11:91-96.
10. He J, Allen JR, Collins VP, Allalunis-Turner MJ, Godbout R, Day RS 3rd, James CD. 1994b. CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines. Cancer Res 54:5804-5807.
11. Humphrey PA, Wong AJ, Vogelstein B, Friedman HS, Werner MH, Bigner DD, Bigner SH. 1988. Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. Cancer Res 48:223-2238.
12. Humphrey PA, Wong AJ, Vogelstein B, Zalutsky MR, Fuller GN, Archer GE, Friedman HS, Kwatra MM, Bigner SH, Bigner DD. 1990. Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. Proc Natl Acad Sci USA 87:4207-4211.
13. James CD, Carlbom E, Dumanski JP, Hansen M, Nordenskjold M, Collins VP, Cavenee WK. 1988. Clonal genomic alterations in glioma malignancy stages. Cancer Res 48:5546-5551.
14. James CD, Galanis E, Frederick L, Kimmel DW, Cunningham JM, Atherton-Skaff PJ, O'Fallon JR, Jenkins RB, Buckner JC, Hunter SB, Olson JJ, Scheithauer BW. 1999. Tumor suppressor gene alterations in malignant gliomas: histopathological associations and prognostic evaluation. Int J Oncol 15:547-553.
15. Johns TG, Stockert E, Ritter G, Jungbluth AA, Huang HJ, Cavenee WK, Smyth FE, Hall CM, Watson N, Nice EC, Gullick WJ, Old LJ, Burgess AW, Scott AM. 2002. Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene. Int J Cancer 98:398-408.
16. Kleihues P, Cavenee WK, editors. 2000. Pathology and genetics of tumours of the nervous system. Lyon: International Agency for Research on Cancer.
17. Klingler-Hoffmann M, Fodero-Tavolerti MT, Mishima K, Narita Y, Cavenee WK, Furnari FB, Huang HJ, Tiganis T. 2001. The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor. J Biol Chem 276:46313-46318.
18. Lammering G, Valerie K, Lin PS, Mikkelsen RB, Contessa JN, Feden JP, Farnsworth J, Dent P, Schmidt-Ullrich RK. 2001. Radiosensitization of malignant glioma cells through over-expression of dominant-negative epidermal growth factor receptor. Clin Cancer Res 7:682-690.
19. Leenstra S, Oskam NT, Bijleveld EH, Bosch DA, Troost D, Hulsebos TJ. 1998. Related genetic sub-types of human malignant astrocytoma correlate with survival. Int J Cancer 79:159-165.
20. Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J. 1985. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 313:144-147.
21. Liu W, James CD, Frederick L, Alderete BE, Jenkins RB. 1997. PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. Cancer Res 57:5254-5257.
22. Malden LT, Novak U, Kaye AH, Burgess AW. 1988. Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme. Cancer Res 48: 2711-2714.
23. Mills GB, Lu Y, Kohn EC. 2001. Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc Natl Acad Sci USA 98:10031-10033.
24. Nister M, Libermann TA, Betsholtz C, Pettersson M, Claesson-Welsh L, Heldin CH, Schlessinger J, Westermark B. 1988. Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines. Cancer Res 48:3910-3918.
25. Okada Y, Hurwitz EE, Esposito JM, Brower MA, Nutt CL, Louis DN. 2003. Selection pressures of TP53 mutation and microenvironmental location influence epidermal growth factor receptor gene amplification in human glioblastomas. Cancer Res 63:413-416.
26. Rubenstein M, Glick R, Lichtor T, Mirochnik Y, Chou P, Guinan P. 2001. Treatment of the T98G glioblastoma cell line with antisense oligonucleotides directed toward mRNA encoding transforming growth factor-alpha and the epidermal growth factor receptor. Med Oncol 18:121-130
27. Smith JS, Wang XY, Qian J, Hosek SM, Scheithauer BW, Jenkins RB, James CD. 2000. Amplification of the platelet-derived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features. J Neuropath Exp Neurol 59: 495-503.
28. Steinbach JP, Supra P, Huang HJ, Cavenee WK, Weller M. 2002. CD95-mediated apoptosis of human glioma cells: modulation by epidermal growth factor receptor activity. Brain Pathol 12:12-20.
29. Sugawa N, Ekstrand AJ, James CD, Collins VP. 1990. Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci USA 87:8602-8606.
30. Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen KL, Vinson VL, Gumpper KL, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford LA, Lee J, Mills GB, Pershouse MA, Pollack RE, Tornos C, Troncoso P, Yung WK, Fujii G, Berson A, Steck PA. 1997. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res 57:5221-5225.
31. Thomas C, Ely G, James CD, Jenkins R, Kastan M, Jedlicka A, Burger P, Wharen R. 2001. Glioblasroma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells. Acta Neuropath 101:105-115.
32. Watanabe K, Tachibana O, Sata K, Yonekawa Y, Kleihues P, Ohgaki H. 1996. Over-expression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 6:217-223.
33. Wong AJ, Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B. 1987. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA 84: 6899-6903.
34. Yamazaki H, Fukui Y, Ueyama Y, Tamaoki N, Kawamoto T, Taniguchi S, Shibuya M. 1988. Amplification of the structurally and functionally altered epidermal growth factor receptor gene (cerbB) in human brain tumors. Mol Cell Biol 8:1816-1820.