Role of transgenic plants in agriculture and biopharming

Biotechnology Advances

Volumn 30, Issue 3, 2012, Pages 524-540

  Ahmad, Parvaiz ^a   Ashraf, Muhammad ^b,e   Younis, Muhammad ^c   Hu, Xiangyang ^d   Kumar, Ashwani ^c   Akram, Nudrat Aisha ^b   Al Qurainy, F ^e  

^a UNIVERSITY OF KASHMIR   (India)

^b UNIVERSITY OF AGRICULTURE   (Pakistan)

^c INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

^d KUNMING INSTITUTE OF BOTANY   (China)

^e KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Antibodies; Biopharming; Stress tolerance; Transgenics; Vaccines

Indexed keywords

ABIOTIC STRESS; ARABLE LAND; BIOFUEL PRODUCTION; BIOPHARMING; COST-INTENSIVE; DOWN-REGULATION; EDIBLE VACCINES; FOOD PLANTS; HEPATITIS B; HUMAN LIVES; PLANET EARTH; PLANT BREEDING; RECOMBINANT PROTEIN; SAFETY MEASURES; STRESS TOLERANCE; TRANSGENIC LINES; TRANSGENIC PLANTS; TRANSGENICS;

ANIMALS; ANTIBODIES; CROPS; DEVELOPING COUNTRIES; EARTH (PLANET); FRUITS; GENES; GENETIC ENGINEERING; HERBICIDES; VACCINES; VIRUSES; WEED CONTROL;

DISEASES;

EDIBLE VACCINE;

ANTIBODY; ARABLE FARMING; BIOFUEL; BIOTECHNOLOGY; COMMERCIALIZATION; CULTIVAR; DISEASE RESISTANCE; ENVIRONMENTAL DEGRADATION; GENETIC ENGINEERING; HEPATITIS; HERBICIDE; HUMAN IMMUNODEFICIENCY VIRUS; MAIZE; PLANT BREEDING; POPULATION GROWTH; POTATO; RICE; TRANSGENIC PLANT; VACCINE;

AGRICULTURE; CLASSIFICATION; CROP; GENETICS; HERBICIDE RESISTANCE; HUMAN; IMMUNOLOGY; INSECT CONTROL; METHODOLOGY; PHARMACEUTICS; PHYSIOLOGICAL STRESS; PLANT DISEASE; REVIEW; TRANSGENIC PLANT;

AGRICULTURE; CROPS, AGRICULTURAL; HERBICIDE RESISTANCE; HUMANS; INSECT CONTROL; PLANT DISEASES; PLANTS, GENETICALLY MODIFIED; STRESS, PHYSIOLOGICAL; TECHNOLOGY, PHARMACEUTICAL; VACCINES, EDIBLE;

ANIMALIA; BACTERIA (MICROORGANISMS); DAUCUS CAROTA; HEXAPODA; HUMAN IMMUNODEFICIENCY VIRUS; LYCOPERSICON ESCULENTUM; SOLANUM TUBEROSUM; ZEA MAYS;

EID: 84857499706     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2011.09.006     Document Type: Review

References (383)

1. Abe H., Urao T., Ito T., Seki M., Shinozaki K., Yamaguchi-Shinozaki K. Arabidopsis AtMYC2 (b-HLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signalling. Plant Cell 2003, 15:63-78.
2. Abede T., Guenzi A.C., Martin B., Cushman J.C. Tolerance of mannitol-accumulating transgenic wheat to water stress and salinity. Plant Physiol 2003, 131:1748-1755.
3. Agarwal S., Kapoor A., Lakshmi O.S., Grover A. Production and phenotypic analysis of rice transgenics with altered levels of pyruvate decarboxylase and alcohol dehydrogenase proteins. Plant Physiol Biochem 2007, 45:637-646.
4. Ahmad P., Jaleel C.A., Nabi G., Sharma S. Roles of enzymatic and non-enzymatic antioxidants in plants during abiotic stress. Crit Rev Biotechnol 2010, 30:161-175.
5. Ahmad P., Jaleel C.A., Sharma S. Antioxidative defence system, lipid peroxidation, proline metabolizing enzymes and biochemical activity in two genotypes of Morus alba L. subjected to NaCl stress. Russ J Plant Physiol 2010, 57:509-517.
6. Alcantara E.P., Aguda R.M., Curtiss A., Dean D.H., Cohen M.B. Bacillus thuringiensis δ-endotoxin binding to brush border membrane vesicles of rice stem borers. Arch Insect Biochem Physiol 2004, 55:169-177.
7. Alfonso-Rubi J., Ortego F., Castanera P., Carbonero P., Diaz I. Transgenic expression of trypsin inhibitor CMe from barley in indica and japonica rice, confers resistance to the rice weevil Sitophilus oryzae. Transgenic Res 2003, 12:23-31.
8. Alia, Kondo Y., Sakamoto A., Nonaka H., Hayashi H., Saradhi P.P., Chen T.H., Murata N. Enhanced tolerance to light stress of transgenic Arabidopsis plants that express the coda gene for a bacterial choline oxidase. Plant Mol Biol 1999, 40:279-288.
9. Altabella T., Chrispeels M.J. Tobacco plants transformed with the bean aai gene expressing an inhibitor of insect a-amylase in their seeds. Plant Physiol 1990, 93:805-810.
10. Al-Taweel K., Iwaki T., Yabuta Y., Shigeoka S., Murata N., Wadan A.A. Bacterial transgene for catalase protects translation of D protein during exposure of salt-stressed tobacco leaves to strong light. Plant Physiol 2007, 145:258-265.
11. Altman, A. Plant biotechnology in the 21st century: the challenges ahead. Electronic J Biotechnol, 1999. http://www.ejb.org.
12. Alvarez M.L., Pinyerd H.L., Crisantes J.D., Rigano M.M., Pinkhasov J., Walmsley A.M., Mason H.S., Cardineau G.A. Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice. Vaccine 2006, 24:2477-2490.
13. Andrews R.W., Fausr R., Wabiko M.H., Roymond K.C., Bulla L.A. Biotechnology of Bt: a critical review. Bio/Technol 1987, 6:163-232.
14. Appaiahgari M.B., Abdin M.Z., Bansal K.C., Vrati S. Expression of Japanese encephalitis virus envelope protein in transgenic tobacco plants. J Virolo Method 2009, 162:22-29.
15. Arakawa T., Chong D.K.X., Langridge W.H.R. Efficacy of a food plant based oral cholera toxin B subunit vaccine. Nature Biotechnol 1998, 16:292-297.
16. Ashraf M., Akram N.A., Arteca R.N., Foolad M.R. The physiological, biochemical and molecular roles of brassinosteroids and salicylic acid in plant processes and salt tolerance. Crit Rev Plant Sci 2010, 29:162-190.
17. Ashraf M., Akram N.A. Improving salinity tolerance of plants through conventional breeding and genetic engineering: an analytical comparison. Biotechnol Adv 2009, 27:744-752.
18. Ashraf M. Inducing drought tolerance in plants: recent advances. Biotechnol Adv 2010, 28:169-183.
19. Ashraf M. Some important physiological selection criteria for salt tolerance in plants. Flora 2004, 199:361-376.
20. Austin S., Bingham E.T., Mathews D.E., Shahan M.N., Will J., Burgess R.R. Production and field performance of transgenic alfalfa (Medicago sativa L.) expressing alpha-amylase and manganese-dependent lignin peroxidise. Euphytica 1995, 85:381-393.
21. Aziz M.A., Sikriwal D., Singh S., Jarugula S., Kumar P.A., Bhatnagar R. Transformation of an edible crop with the pagA gene of Bacillus anthracis. FASEB J 2005, 19:1501-1503.
22. Aziz M.A., Singh S., Anand K.P., Bhatnagar R. Expression of protective antigen in transgenic plants: a step towards edible vaccine against anthrax. Biochem Biophys Res Commun 2002, 299:345-351.
23. Badawi G.H., Kawano N., Yamauchi Y., Shimada E., Sasaki R., Kubo A., Tanaka K. Overexpression of ascorbate peroxidase in tobacco chloroplasts enhances the tolerance to salt stress and water deficit. Physiol Plant 2004, 121:231-237.
24. Bagni N., Ruiz-Carrasco K., Franceschetti M., Fornalè S., Fornasiero R.B., Tassoni A. Polyamine metabolism and biosynthetic gene expression in Arabidopsis thaliana under salt stress. Plant Physiol Biochem 2006, 44:776-786.
25. BANR (Board on Agriculture and Natural Resources) Genetically modified pest protected plant: science and regulation 2000, 292.
26. Bashir K., Husnain T., Fatima T., Riaz N., Makhdoom R., Riazuddin S. Novel indica basmati line (B-370) expressing two unrelated genes of Bacillus thuringiensis is highly resistant to two lepidopteran insects in the field. Crop Protection 2005, 24:870-879.
27. Beachy R.N. Transgenic resistance to plant viruses. Semin Virol 1993, 4:327-416.
28. Bell H.A., Fitches E.C., Marris G.C., Bell J., Edwards J.P., Gatehouse J.A., Gatehouse A.M.R. Transgenic GNA expressing potato plants augment the beneficial biocontrol of Lacanobia oleracea (Lepidoptera; Noctuidae) by the parasitoid Eulophus pennicornis (Hymenoptera; Eulophidae). Transgenic Res 2001, 10:35-42.
29. Benekos K., Kissoudis C., Nianiou-Obeidat I., Labrou N., Madesis P., Kalamaki M., Makris A., Tsaftaris A. Overexpression of a specific soybean GmGSTU4 isoenzyme improves diphenyl ether and chloroacetanilide herbicide tolerance of transgenic tobacco plants. J Biotechnol 2010, 150:195-201.
30. Bhatnagar-Mathur P., Rao J.S., Vadez V., Sharma K.K. Transgenic strategies for improved drought tolerance in legumes of semi-arid tropics. J Crop Improvement 2010, 24:92-111.
31. Bhutani S., Kumar R., Chauhan R., Singh R., Choudhury V.K., Choudhury J.B. Development of transgenic indica rice plants containing potato proteinase inhibitor 2 gene with improved defense against yellow stem borer. Physiol Mol Biol Plant 2006, 12:43-52.
32. Biemelt S., Tschiersch H., Sonnewald U. Impact of altered gibberellin metabolism on biomass accumulation, lignin biosynthesis and photosynthesis in transgenic tobacco plants. Plant Physiol 2004, 135:254-265.
33. Black R. Micronutrient deficiency-an underlying cause of morbidity and mortality. Bull World Health Organ 2003, 81:79.
34. Bogers W.M., Bergmeier L.A., Ma J., Oostermeijer H., Wang Y., Kelly C.G., Ten Haaft P., Singh M., Heeney J.L., Lehner T. A novel HIV-CCR5 receptor vaccine strategy in the control of mucosal SIV/HIV infection. AIDS 2004, 18:25-36.
35. Boulter D., Edwards G.A., Gatehouse A.M.R., Gatehouse J.A., Hilder V.A. Additive protective effects of incorporating two different higher plant derived insect resistance genes in transgenic tobacco plants. Crop Protect 1990, 9:351-354.
36. Brar D.S., Khush G.S. Breeding rice for resistance to biotic stresses: conventional and molecular approaches. Sabrao J 2007, 45:225-234.
37. Brar D.S., Ohtani T., Uchimiya H. Genetically engineered plants for quality improvement. Biotechnol Genet Engineer Rev 1995, 13:167-169.
38. Brar D.S., Virk P.S., Jena K.K., Khush G.S. Breeding for resistance to planthoppers in rice. Int Rice Res Inst 2009, 401-408. K.L. Heong, B. Hardy (Eds.).
39. Brodzik R., Spitsin S., Pogrebnyak N., Bandurska K., Portocarrero C., Andryszak K., Koprowski H., Golovkin M. Generation of plant-derived recombinant DTP subunit vaccine. Vaccine 2009, 27:3730-3734.
40. Brookes G., Barfoot P. Global impact of biotech crops: environmental effects 1996-2009. Lands Biosci 2011, 2:34-49.
41. Cao H., Li X., Dong X. Generation of broad-spectrum disease resistance by overexpression of an essential regulatory gene in systemic acquired resistance. PNAS 1998, 95:6531-6536.
42. Cao J., Shelton A.M., Earle E.D. Sequential transformation to pyramid two Bt genes in vegetable Indian mustard (Brassica juncea L.) and its potential for control of diamondback moth larvae. Plant Cell Rep 2008, 27:479-487.
43. Capell T., Bassie L., Christou P. Modulation of the polyamine biosynthetic pathway in transgenic rice confers tolerance to drought stress. PNAS 2004, 101:9909-9914.
44. Carpenter J.E. Peer-reviewed surveys indicate positive impact of commercialized GM crops 2010.
45. Carter J.E., Langridge W.H.R. Plant-based vaccines for protection against infectious and autoimmune diseases. Crit Rev Plant Sci 2002, 21:93-109.
46. Cerdeira A.L., Duke S.O. Effects of glyphosate-resistant crop cultivation on soil and water quality. 2010, 1:16-24.
47. Chassy B.C. Food safety risks and consumer health. New Biotechnol 2010, 27:535-543.
48. Chen D.X., Chen X.W., Ma B.T., Wang Y.P., Zhu L.H., Li S.G. Genetic transformation of rice with Pi-d2 gene enhances resistance to rice blast fungus Magnaporthe oryzae. Rice Sci 2010, 17:19-27.
49. Chen H., Zhang G., Zhang Q., Lin Y. Effect of transgenic Bacillus thuringiensis rice lines on mortality and feeding behavior of rice stem borers (Lepidoptera: Crambidae). J Econ Entomol 2008, 101:182-189.
50. Chen H., Tang W., Xu C., Li X., Lin Y., Zhang Q. Transgenic indica rice plants harboring a synthetic cry2A gene of Bacillus thuringiensis exhibit enhanced resistance against lepidopteran rice pests. Theor Appl Genet 2005, 111:1330-1337.
51. Chen H.J., Su C.T., Lin C.H., Huang G.J., Lin Y.H. Expression of sweet potato cysteine protease SPCP2 altered developmental characteristics and stress responses in transgenic Arabidopsis plants. J Plant Physiol 2010, 167:838-847.
52. Chen J.B., Wang S.M., Jing R.L., Mao X.G. Cloning the PvP5CS gene from common bean (Phaseolus vulgaris) and its expression patterns under abiotic stresses. J Plant Physiol 2009, 166:12-19.
53. Chida H., Nakazawa A., Akazaki H., Hirano T., Suruga K., Ogawa M., Satoh T., Kadokura K., Yamada S., Hakamata W., Isobe K., Ito T., Ishii R., Nishio T., Sonoike K., Oku T. Expression of the algal cytochrome c6 gene in Arabidopsis enhances photosynthesis and growth. Plant Cell Physiol 2007, 48:948-957.
54. Chikwamba R.K., Scott M.P., Mejia L.B., Mason H.S., Wang K. Localization of a bacterial protein in starch granules of transgenic maize kernels. PNAS 2003, 100:11127-11132.
55. Cho S.K., Kim J.E., Park J.A., Eom T.J., Kim W.T. Constitutive expression of abiotic stress-inducible hot pepper CaXTH3, which encodes a xyloglucan endotransglucosylase/hydrolase homolog, improves drought and salt tolerance in transgenic Arabidopsis plants. FEBS Lett 2006, 580:3136-3144.
56. Choi N.W., Estes M.K., Langridge W.H. Synthesis and assembly of a cholera toxin B subunit-rotavirus VP7 fusion protein in transgenic potato. Mol Biotechnol 2005, 31:193-202.
57. Chory J, Wang Z. Das5, a P450 protein involved in the brassinosteroid biosynthesis pathway of plants. 09/995, 917; 2004, USA Patent No. 6, 768, 043.
58. Chrispeels M.J., Raikhel N.V. Lectins, lectin genes, and their role in plant defense. Plant Cell 1991, 3:1-9.
59. Christine F., Henri C., Lionel M., Jos K., Michel R., Henno H., Germain P., Jean-Pierre S., Pierre R. Characterization and sugar-binding properties of arcelin-1, an insecticidal lectin-like protein isolated from kidney bean (Phaseolus vulgaris l. Cv. Raz-2) seeds. Biochem J 1998, 329:551-560.
60. Chuck G., Cigan A.M., Saeteurn K., Hake S. The heterochronic maize mutant Corngrass1 results from overexpression of a tandem microRNA. Nat Genet 2007, 39:544-549.
61. Cockcroft C.E., den Boer B.G.W., Healy J.M.S., Murray J.A.H. Cyclin D control of growth rate in plants. Nature 2000, 405:575-579.
62. Cohen B.M., Gould F., Bentur J.C. Bt rice: practical steps to sustainable use. Int Rice Res 2000, 25:4-10.
63. Cong L., Zheng H.C., Zhang Y.X., Chai T.Y. Arabidopsis DREB1A confers high salinity tolerance and regulates the expression of GA dioxygenases in tobacco. Plant Sci 2008, 174:156-164.
64. Conklin P.L., Gatzek S., Wheeler G.L., Dowdle J., Raymond M.J., Rolinski S., Isupov M., Littlechild J.A., Smirnoff N. Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme. J Biol Chem 2006, 281:15662-15670.
65. Cotter J. Genetically engineered (GE) Bt eggplant (talong): health risks, environmental impacts and contamination from field trials. Greenpeace Breifing, GRL-TN-02-2011.
66. Cramer C.L., Weissenborn D.L., Oishi K.K., Grabau E.A., Bennett S., Ponce E., Grabowski G.A., Radin D.N. Bioproduction of human enzymes in transgenic tobacco. Ann Acad Sci 1996, 792:62-71.
67. Curtiss RI, Cardineau CA. 1990; World patent app WO 90/02484.
68. DaMatta F.M. Exploring drought tolerance in coffee: a physiological approach with some insights for plant breeding. Braz J Plant Physiol 2004, 16:1-6.
69. Daniell H., Kumar S., Dufourmantel N. Breakthrough in chloroplast genetic engineering of agronomically important crops. Trends Biotechnol 2005, 23:238-245.
70. Daniell H., Streatfield J., Wycoff K. Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci 2001, 6:219-226.
71. De Block M. Factors influencing the tissue culture and the Agrobacterium tumefaciens-mediated transformation of hybrid aspen and poplar clones. Plant Physiol 1990, 93:1110-1116.
72. Delessert C., Kazan K., Wilson I.W., Straeten D.V.D., Manners J., Dennis E.S., Dolferus R. The transcription factor ATAF2 represses the expression of pathogenesis related genes in Arabidopsis. Plant J 2005, 43:745-757.
73. Demain A.L., Vaishnav P. Production of recombinant proteins by microbes and higher organisms. Biotechnol Adv 2009, 27:297-306.
74. Dempsey D.A., Silva H., Klessig D.E. Engineering disease and pest resistance in plants. Trends Microbiol 1998, 6:54-61.
75. Dewitte W., Riou-Khamlichi C., Scofield S., Healy J.M.S., Jacqmard A., Kilby N.J., Murray J.A.H. Altered cell cycle distribution, hyperplasia and inhibited differentiation in Arabidopsis caused by the D-type cyclin CYCD3. Plant Cell 2003, 15:79-92.
76. D'Halluin K., Botterman J., De Greef W. Engineering of herbicide resistant alfalfa and evaluation under field conditions. Crop Sci 1990, 30:866-871.
77. Di R., Blechl A., Dill-Macky R., Tortora A., Tumer N.E. Expression of a truncated form of yeast ribosomal protein L3 in transgenic wheat improves resistance to Fusarium head blight. Plant Sci 2010, 178:374-380.
78. Dias S.C., da Silva M.C.M., Teixeira F.R., Figueira E.L.Z., de Oliveira-Neto O.B., de Lima L.A., Franco O.L., Grossi-de-Sa M.F. Investigation of insecticidal activity of rye α-amylase inhibitor gene expressed in transgenic tobacco (Nicotiana tabacum) toward cotton boll weevil (Anthonomus grandis). Pesticide Biochem Physiol 2010, 98:39-44.
79. Dinan L. Phytoecdysteroids: biological aspects. Phytochemistry 2001, 57:325-339.
80. Dreesen I.A.J., El Hamri G.C., Fussenegger M. Heat-stable oral alga-based vaccine protects mice from Staphylococcus aureus infection. J Biotechnol 2010, 145:273-280.
81. Dubouzet J.G., Sakuma Y., Ito Y., Kasuga M., Dubouzet E.G., Miura S., Seki M., Shinozaki K., Yamaguchi-Shinozaki K. OsDREB genes in rice, (Oryza sativa L.) encode transcription activators that function in drought, high salt and cold responsive gene expression. Plant J 2003, 33:751-763.
82. Dus-Santos M.J., Wigdorovitz A., Trono K., Rios R.D., Franzone P.M., Gil F., Moreno J., Carrillo C., Escribano J.M., Borca M.V. A novel methodology to develop a foot and mouth disease virus (FMDV) peptide-based vaccine in transgenic plants. Vaccine 2002, 20:1141-1147.
83. Elkholy S.F., Ismail R.M., Bahieldin A., Sadik A.S., Madkour M.A. Expression of hepatitis B surface antigen (HBsAg) gene in transgenic banana (Musa Sp.). Arab J Biotechnol 2009, 12:291-302.
84. Ellul P., Rios G., Atares A., Roig L.A., Serrano R., Moreno V. The expression of the Saccharomyces cerevisiae HAL1 gene increases salt tolerance in transgenic watermelon. Theor Appl Genet 2003, 107:462-469.
85. Espinosa-Ruiz A., Belles J.M., Serrano R., Culianez-Macia F.A. Arabidopsis thaliana AtHAL3: a flavoprotein related to salt and osmotic tolerance and plant growth. Plant J 1999, 20:529-539.
86. Estruch J.J., Carozzi N.B., Desai N., Duck N.B., Warren G.W., Koziel M.G. Transgenic plants: an emerging approach to pest control. Nat Biotechnol 1997, 15:137-141.
87. Ffrench-Constant R., Bowen D. Photorhabdus toxins: novel biological insecticides. Curr Opin Microbiol 1999, 2:284-288.
88. Fischer R., Stoger E., Schillberg S. Plant-based production of biopharmaceuticals. Curr Opin Plant Biol 2004, 7:152-158.
89. Fitches E.C., Bell H.A., Powell M.E., Back E., Sargiotti C., Weaver R.J., Gatehouse J.A. Insecticidal activity of scorpion toxin (ButaIT) and snowdrop lectin (GNA) containing fusion proteins towards pest species of different orders. Pest Manag Sci 2010, 66:74-83.
90. Fukuzawa N., Tabayashi N., Okinaka Y., Furusawa R., Furuta K., Kagaya U. Matsumura T production of biologically active Atlantic salmon interferon in transgenic potato and rice plants. J Biosci Bioeng 2010, 110:201-207.
91. Gaines T.A., Zhang W., Wang D., Bukun B., Chisholm S.T., Shaner D.L., Nissen S.J., Patzoldt W.L., Tranel P.J., Culpepper A.S., Grey T.L., Webster T.M., Vencill W.K., Sammons R.D., Jiang J., Preston, Leach J.E., Westra P. Gene amplification confers glyphosate resistance in Amaranthus palmeri. PNAS 2010, 107:1029-1034.
92. Gao Y., Ma Y., Li M., Cheng T., Li S.W., Zhang J., Xia N.S. Oral immunization of animals with transgenic cherry tomatillo expressing HBsAg. World J Gastroenterol 2003, 9:996-1002.
93. Garg A.K., Kim J.K., Owens T.G., Ranwala A.P., Choi Y.D., Kochian L.V., Wu R.J. Trehalose accumulation in rice plants confers high tolerance levels to different abiotic stresses. PNAS 2002, 99:15898-15903.
94. + pump. Proc Natl Acad Sci USA 2001, 98:11444-11449.
95. Ge L.F., Chao D.Y., Shi M., Zhu M.Z., Gao J.P., Lin H.X. Overexpression of the trehalose-6-phosphate phosphatase gene OsTPP1 confers stress tolerance in rice and results in the activation of stress responsive genes. Planta 2008, 228:191-201.
96. Godge M., Kumar D., Kumar P. Arabidopsis HOG1 gene and its petunia homolog PETCBP act as key regulators of yield parameters. Plant Cell Rep 2008, 27:1497-1507.
97. Gomez E., Jespersen D.J., Harring J.A., Binnicker M.J. Evaluation of the bio-rad bioplex 2200 syphilis multiplex flow immunoassay for the detection of IgM- and IgG-class antitreponemal antibodies. Clin Vaccine Immunol 2010, 17:966-968.
98. Gómez E., Zoth S.C., Carrillo E., Roux M.E., Berinstein A. Mucosal immunity induced by orally administered transgenic plants. Immunobiology 2008, 213:671-675.
99. Grant P.G., Schindler D., Davies J.E. Mapping of trichodermin resistance in Saccharomyces cerevisiue: a genetic locus for a component of the 60s ribosomal subunit. Genetics 1976, 83:667-673.
100. Grison R., Grezes-Besset B., Schneider M., Lucante N., Olsen L., Leguay J.J., Toppan A. Field tolerance to fungal pathogens of Brassica napus constitutively expressing a chimeric chitinase gene. Nat Biotechnol 1996, 14:643-646.
101. Gu D., Liu X., Wang M., Zheng J., Hou W., Wang G., Wang J. Overexpression of ZmOPR1 in Arabidopsis enhanced the tolerance to osmotic and salt stress during seed germination. Plant Sci 2008, 174:124-130.
102. Guzman C.A., Feuerstein G.Z. Pharmaceutical biotechnology. Curr Opin Biotechnol 2004, 15:503-505.
103. Haake V., Riechmann J.L.C.D., Pineda O., Thomashow M.F., Zhang J.Z. Transcription factor CBF4 is a regulator of drought adaptation in Arabidopsis. Plant Physiol 2002, 130:639-648.
104. Harris L.J., Gleddie S.C. A modified Rpl3 gene from rice confers tolerance of the Fusarium graminearum mycotoxin deoxynivalenol to transgenic tobacco. Physiol Mol Plant Pathol 2001, 58:173-181.
105. Hasegawa M., Bressan R., Pardo J.M. The dawn of plant salt tolerance genetics. Trends Plant Sci 2000, 5:317-319.
106. Haumann B.E. Bioengineered oilseed acreage escalating. Inform 1997, 8:804-811.
107. Hayashi H., Alia, Mustardy L., Deshnium P., Ida M., Murata N. Transformation of Arabidopsis thaliana with the codA gene for choline oxidase; accumulation of glycinebetaine and enhanced tolerance to salt and cold stress. Plant J 1997, 12:133-142.
108. Hemavathi, Upadhyaya C.P., Young K.E., Akula N., Kim H., Heung J.J., Oh O.M., Aswath C.R., Chun S.C., Kim D.H., Park S.W. Over-expression of strawberry D-galacturonic acid reductase in potato leads to accumulation of vitamin C with enhanced abiotic stress tolerance. Plant Sci 2009, 177:659-667.
109. Herbette S., Taconnat L., Hugouvieux H., Piette L., Magniette M.L.M., Cuine S., Auroy P., Richaud P., Forestier C., Bourguignon J., Renou J.P., Vavas-seur A., Leonhardt N. Genome wide transcriptome profiling of the early cadmium response of Arabidopsis roots and shoots. Biochimie 2006, 88:1751-1765.
110. Hernández-Campuzano B., Suárez R., Lina L., Hernández V., Villegas E., Corzo G., Iturriaga G. Expression of a spider venom peptide in transgenic tobacco confers insect resistance. Toxicon 2009, 53:122-128.
111. Herrnstadt C., George G.S., Edward W.R., David L. A new strain of Bacillus thuringiensis with activity against coleopteran insects. Nat Biotechnol 1986, 4:305-308.
112. Hiatt A.H., Cafferkey R., Bowdish K. Production of antibodies in transgenic plants. Nature 1989, 342:76-78.
113. Hiei Y., Ohta S., Komari T., Kumashiro T. Efficient transformation of rice (Oryza sativa L.) mediated by Agrobacterium and sequence analysis of the boundaries of the T-DNA. Plant J 1994, 6:271-282.
114. 1-pyrroline-5-carboxylate synthetase increases proline production and confers salt tolerance in transgenic potato plants. Plant Sci 2005, 169:746-752.
115. Ho N.H., Baisakh N., Oliva N., Datta K., Frutos R., Datta S.K. Translational fusion hybrid Bt genes confer resistance against yellow stem borer in transgenic elite vietnamese rice (Oryza sativa L.) cultivars. Crop Sci 2006, 46:781-789.
116. Hoekstra F.A., Golovina E.A., Buitink J. Mechanisms of plant desiccation tolerance. Trends Plant Sci 2001, 6:431-438.
117. Holmstrom K.O., Somersalo S., Manda A., Palva T.E., Welin B. Improved tolerance to salinity and low temperature in transgenic tobacco producing glycine betaine. J Exp Bot 2000, 51:177-185.
118. Hood E.E., Woodard S.L., Horn M.E. Monoclonal antibody manufacturing in transgenic plants-myths and realities. Curr Opin Biotechnol 2002, 13:630-635.
119. Hood E.E. From green plants to industrial enzymes. Enzyme Microb Technol 2002, 30:279-283.
120. Horiguchi G., Kim G.T., Tsukaya H. The transcription factor AtGRF5 and the transcription coactivator AN3 regulate cell proliferation in leaf primordia of Arabidopsis thaliana. Plant J 2005, 43:68-78.
121. Horsch R.B., Fry J.E., Hoffman N.L., Wallroth M., Eichholtz D., Rogers S.G., Frailey R.T. A simple and general method for transferring genes into plants. Science 1985, 227:1229-1231.
122. Hossain M.A., Maiti M.K., Basu A., Sen S., Ghose A.K., Sen S.K. Transgenic expression of onion leaf lectin gene in Indian mustard offers protection against aphid colonization. Crop Sci 2006, 46:2022-2032.
123. Hsieh T.H., Lee J.T., Charng Y.Y., Chan M.T. Tomato plants ectopically expressing Arabidopsis CBF1 show enhanced resistance to water deficit stress. Plant Physiol 2002, 130:618-626.
124. Hu Y., Xie Q., Chua N.H. The Arabidopsis auxin inducible gene ARGOS controls lateral organ size. Plant Cell 2003, 15:1951-1961.
125. Huang J., Hirji R., Adam L., Rozwadowski K.L., Hammerlindl J.K., Keller W.A., Selvaraj G. Genetic engineering of glycinebetaine production toward enhancing stress tolerance in plants: metabolic limitations. Plant Physiol 2000, 122:747-756.
126. Huang J., Wang Q. Agricultural biotechnology development and policy in China. AgBioForum 2002, 5:122-135.
127. Huang Z., Dry I., Webster D., Strugnell R., Wesselingh S. Plant-derived measles virus hemagglutinin protein induces neutralizing antibodies in mice. Vaccine 2001, 19:2163-2171.
128. Husaini A.M., Abdin M.Z. Overexpression of tobacco osmotin gene leads to salt stress tolerance in strawberry (Fragaria x ananassa Duch.) plants. Indian J Biotechnol 2008, 7:465-472.
129. Icoz I., Stotzky G. Fate and effects of insect-resistant Bt crops in soil ecosystems. Soil Biol Biochem 2008, 40:559-586.
130. Ishimoto M., Sato T., Chrispeels M.J., Kitamura K. Bruchid resistance of transgenic azuki bean expressing seed alpha-amylase inhibitor of common bean. Entomol Exp Appl 1996, 79:309-315.
131. Ismond K.P., Dolferus R., Pauw M.D., Dennis E.S., Good A.G. Enhanced low oxygen survival in Arabidopsis through increased metabolic flux in the fermentative pathway. Plant Physiol 2003, 132:1292-1302.
132. Jain K. Genetic engineering panel to enforce Bt brinjal ban 2010, New Delhi February 18,.
133. Jain M., Chengalrayan K., Abouzid A., Gallo M. Prospecting the utility of a/MI/mannose selection system for the recovery of transgenic sugarcane (Saccharum spp. hybrid) plants. Plant Cell Rep 2007, 26:581-590.
134. James C. A global overview of biotech (GM) crops, adoption, impact and future prospects. GM Crops 2010, 1:8-12.
135. James C. Global review of commercialized transgenic crops in 1999. Int Service Acquisition Agric Biotechnol Appl 1999, 12:1-7.
136. James C. Global status of commercialized biotech/GM crops 2008, 39. ISAAA Ithaca New York.
137. James C. Global status of commercialized biotech/GM crops 2006, ISAAA publication, Brief No. 35-2006.
138. James C. Global status of commercialized transgenic crops 2000, 15. ISAAA Ithaca New York.
139. James C. Global status of transgenic crops in 1997. Int Service Acquisition Agric Biotechnol Appl 1997, 5:1-30.
140. James V.A., Neibaur I., Altpeter F. Stress inducible expression of the DREB1A transcription factor from xeric, Hordeum spontaneum L. in turf and forage grass (Paspalum notatum Flugge) enhances abiotic stress tolerance. Transgenic Res 2008, 17:93-104.
141. Jang I.C., Oh S.J., Seo J.S., Choi W.B., Song S.I., Kim C.H., Kim Y.S., Seo H.S., Choi Y.D., Nahm B.H., Kim J.K. Expression of a bifunctional fusion of the Escherichia coli genes for trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase in transgenic rice plants increases trehalose accumulation and abiotic stress tolerance without stunting growth. Plant Physiol 2003, 131:516-524.
142. Jaworski J., Cahoon E.B. Industrial oils from transgenic plants. Curr Opin Plant Biol 2003, 6:178-184.
143. Jeffrey M.S., Garcia B., Graves J., Hajdukiewicz P.T.J., Hunter P., Nehra N., Paradkar V., Schlittler M., Carroll J.A., Spatola L., Ward D., Ye G., Russell D.A. High-yield production of a human therapeutic protein in tobacco chloroplasts. Nat Biotechnol 2000, 18:333-338.
144. Jeong J.S., Kim Y.S., Baek K.H., Jung H., Ha S.W., Choi Y.D., Kim M., Reuzeau C., Kim J.K. Root specific expression of OsNAC10 improves drought tolerance and grain yield in rice under field drought conditions. Plant Physiol 2010, 153:185-197.
145. Jia G.X., Zhu Z.Q., Chang F.Q., Li Y.X. Transformation of tomato with the BADH gene from Atriplex improves salt tolerance. Plant Cell Rep 2002, 21:141-146.
146. Jie Y.U., Langridge W.H.R. A plant-based multi-component vaccine protects mice from enteric diseases. Nat Biotechnol 2001, 19:548-552.
147. Johnson R.J., Gaucher E.A., Sautin Y.Y., Henderson G.N., Angerhofer A.J., Benner S.A. The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease. Med Hypotheses 2008, 71:22-31.
148. Jongsma M.A., Bolter C. The adaptation of insects to plant protease inhibitors. J Insect Physiol 1997, 43:885-895.
149. Joshi A., Dang H.Q., Vaid N., Tuteja N. Pea lectin receptor-like kinase promotes high salinity stress tolerance in bacteria and expresses in response to stress in plants. Glycoconjugate J 2010, 27:133-150.
150. Kane M.A., Sherris J., Coursaget P., Aguadod T., Cutts F. HPV vaccine use in the developing world. Vaccine 2006, 24:132-139.
151. Kang J., Choi H., Im M., Kim S.Y. Arabidopsis basic leucine zipper proteins that mediate stress-responsive abscisic acid signaling. Plant Cell 2002, 14:343-357.
152. Kapusta J., Modelska A., Figlerowicz M., Pniewski T., Letellier M., Lisowa O., Yusibow V., Koprowski H., Plucienniczak A., Legocki A.B. A plant-derived edible vaccine against hepatitis B virus. FASEB J 1999, 13:1796-1799.
153. Karasev A.V., Foulke S., Wellens C., Rich A., Shon K.J., Zwierzynski I., Hone D., Koprowsi H., Reitz M. Plant based HIV-1 vaccine candidate: Tat protein produced in spinach. Vaccine 2005, 23:1875-1880.
154. Kasuga M., Liu Q., Miura S., Yamaguchi-Shinozaki K., Shinozaki K. Improving plant drought, salt, and freezing tolerance by gene transfer of a single stress-inducible transcription factor. Nat Biotechnol 1999, 17:287-291.
155. Kebeish R., Niessen M., Thiruveedhi K., Bari R., Hirsch H.J., Rosenkranz R., Stäbler N., Schönfeld B., Kreuzaler F., Peterhänsel C. Chloroplastic photorespiratory bypass increases photosynthesis and biomass production in Arabidopsis thaliana. Nat Biotechnol 2007, 25:593-599.
156. Khush G.S., Brar D.S. The application of biotechnology in rice. Agricultural biotechnology in international development 1998, 97-121. CAB International, Wallingford, UK. C.L. Ives, B.M. Bedford (Eds.).
157. Kim J.Y., Park S.C., Hwang I., Cheong H., Nah J.W., Hahm K.S., Park Y. Protease inhibitors from plants with antimicrobial activity. Int J Mol Sci 2009, 10:2860-2872.
158. Kim S., Kim C., Li W., Kim T., Li Y., Zaidi M.A., Altosaar I. Inheritance and field performance of transgenic Korean Bt rice lines resistant to rice yellow stem borer. Euphytica 2008, 164:829-839.
159. Kim T., Galloway D., Langridge W. Synthesis and assembly of anthrax lethal factor-cholera toxin B-subunit fusion protein in transgenic potato. Mol Biotechnol 2004, 28:175-183.
160. 1-pyrroline-5-carboxylate synthetase increases proline production and confers osmotolerance in transgenic plants. Plant Physiol 1995, 108:1387-1394.
161. Ko K., Koprowski H. Plant biopharming of monoclonal antibodies. Virus Res 2005, 111:93-100.
162. Kong Q., Richter L., Yang Y.F., Arntzen C.J., Mason H.S., Thanavala Y. Oral immunization with hepatitis B surface antigen expressed in transgenic plants. Proc Natl Acad Sci USA 2001, 98:11539-11544.
163. Kónya C., Ferdinandy P. Vitamin C new role of the old vitamin in the cardiovascular system?. Br J Pharmacol 2006, 147:125-127.
164. Koo J.C., Asurmendi S., Bick J., Woodford-Thomas T., Beachy R.N. Ecdysone agonist-inducible expression of a coat protein gene from tobacco mosaic virus confers viral resistance in transgenic Arabidopsis. Plant J 2004, 37:439-448.
165. Koprowski H. Vaccines and sera through plant biotechnology. Vaccine 2005, 23:1757-1763.
166. Kostrzak A., Gonzalez M.C., Guetard D., Nagaraju D.B., Hobson S.W., Tepfer D., Pniewski T., Sala M. Oral administration of low doses of plant based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells. Vaccine 2009, 27:4798-4807.
167. Kota M., Daniell H., Varma S., Garczynski S.F., Gould F., Moar W.J. Overexpression of the Bacillus thuringiensis (Bt) Cry2Aa2 protein in chloroplasts confers resistance to plants against susceptible and Bt-resistant insects. Proc Natl Acad Sci USA 1999, 96:1840-1850.
168. Koussevitzky S., Suzuki N., Huntington S., Armijo L., Sha W., Cortes D., Shulaev V., Mittler R. Ascorbate peroxidase 1 plays a key role in the response of Arabidopsis thaliana to stress combination. J Biol Chem 2008, 283:34197-34203.
169. Kozlov G., Maattanen P., Schrag J.D., Pollock S., Cygler M., Nagar B., Thomas D.Y., Gehring K. Crystal structure of the bb domains of the protein disulfide isomerase ERp57. Structure 2006, 14:1331-1339.
170. Krattiger A. Intellectual property, commercial needs and humanitarian benefits: must there be a conflict?. New Biotechnol 2010, 27:573-577.
171. Krizek B.A. Making bigger plants: key regulators of final organ size. Curr Opin Plant Biol 2009, 12:17-22.
172. Ku M.S.B., Cho D., Li X., Jiao D.M., Pinto M., Miyao M., Matsuoka M. Introduction of genes encoding C4 photosynthesis enzymes into rice plants: physiological consequences. Novartis Foundation Symposium 236-rice biotechnology: improving yield 2007, 100-116. Stress Tolerance and Grain Quality. A. Jamie, D.C. Goode (Eds.).
173. Kumar G.B., Ganapathi T.R., Revathi C.J., Srinivas L., Bapat V.A. Expression of hepatitis B surface antigen in transgenic banana plants. Planta 2005, 222:484-493.
174. Kumar M., Chimote V., Singh R., Mishra G.P., Naik P.S., Pandey Sk, Chakrabarti S.K. Development of Bt transgenic potatoes for effective control of potato tuber moth by using cry1Ab gene regulated by GBSS promoter. Crop Prot 2010, 29:121-127.
175. Kurek I., Chang T.K., Bertain S.M., Madrigal A., Liu L., Lassner M.W., Zhu G. Enhanced thermostability of Arabidopsis rubisco activase improves photosynthesis and growth rates under moderate heat stress. Plant Cell 2007, 19:3230-3241.
176. Lal S., Gulyani V., Khurana P. Overexpression of HVA1 gene from barley generates tolerance to salinity and water stress in transgenic mulberry (Morus indica). Transgenic Res 2008, 17:651-663.
177. Lamphear B.J., Jilka J.M., Kesl L., Welter M., Howard J.A., Streatfield S.J. A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine. Vaccine 2004, 22:2420-2424.
178. Larry L.M., Richard E.S. Lectins and protease inhibitors as plant defenses against insects. J Agric Food Chem 2002, 50:6605-6611.
179. Lau J.M., Korban S.S. Transgenic apple expressing an antigenic protein of the human respiratory syncytial virus. J Plant Physiol 2010, 167:920-927.
180. Lawrence P.K., Koundal K.R. Plant protease inhibitors in control of phytophagous insects. Electron J Biotechnol 2002, 5:93-109.
181. Lee R.W.H., Cornelisse M., Ziauddin A., Slack P.J., Hodgins D.C., Strommer J.N., Shewen P.E., Lo R.Y.C. Expression of a modified Mannheimia haemolytica GS60 outer membrane lipoprotein in transgenic alfalfa for the development of an edible vaccine against bovine pneumonic pasteurellosis. J Biotechnol 2008, 135:224-231.
182. Lei H., Qi J., Song J., Yang D., Wang Y., Zhang Y., Yang J. Biosynthesis and bioactivity of trichosanthin in cultured crown gall Maximowicz. Plant Cell Rep 2006, 25:1205-1212.
183. Lermontova I., Grimm B. Overexpression of plastidic protoporphyrinogen IX oxidase leads to resistance to the diphenyl-ether herbicide acifluorfen. Plant Physiol 2000, 122:75-84.
184. + sbtitransgenes. Pest Manag Sci 2005, 61:390-396.
185. Li Y., Romeis J. Impact of snowdrop lectin (Galanthus nivalis agglutinin; GNA) on adults of the green lacewing, Chrysoperla carnea. J Insect Physiol 2009, 55:135-142.
186. Li Y.U., Sun M., Liu J., Yang Z., Zhang Z., Shen G. High expression of foot-and-mouth disease virus structural protein VP1 in tobacco chloroplasts. Plant Cell Rep 2006, 25:329-333.
187. Lin Y.H., Huang H.E., Wu F.S., Ger M.J., Liao P.L., Chen Y.R., Tzeng K.C., Feng T.Y. Plant ferredoxin-like protein (PFLP) outside chloroplast in Arabidopsis enhances disease resistance against bacterial pathogens. Plant Sci 2010, 179:450-458.
188. Lindh I., Wallin A., Kalbina I., Sävenstrand H., Engström P., Andersson S., Strid A. Production of the p24 capsid protein from HIV-1 subtype C in Arabidopsis thaliana and Daucus carota using an endoplasmic reticulum directing SEKDEL sequence in protein expression constructs. Prot Express Purifi 2009, 66:46-51.
189. Liu K. Biotech crops: products, properties, and prospects. Food Technol 1999, 53:42-48.
190. Liu Q., Kasuga M., Sakuma Y., Abe H., Miura S., Yamaguchi-Shinozaki K., Shinozaki K. Two transcription factors, DREB1 and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought- and low-temperature-responsive gene expression, respectively, in Arabidopsis. Plant Cell 1998, 10:1391-1406.
191. Liu X., Wang Z., Wang L., Wu R., Phillips J., Deng X. LEA4 group genes from the resurrection plant Boea hygrometrica confer dehydration tolerance in transgenic tobacco. Plant Sci 2009, 176:90-98.
192. Loc N.H., Bach N.H., Kim T.G., Yang M.S. Tissue culture and expression of Escherichia coli heat labile enterotoxin B subunit intransgenic Peperomia pellucid. Prot Express Purif 2010, 72:82-86.
193. Lu X.K., Mo J.M., Dong S.F. Effects of nitrogen deposition on forest biodiversity. Acta Ecol Sin 2008, 28:5532-5548.
194. Ma J.K., Drake P.M., Christou P. The production of recombinant pharmaceutical proteins in plants. Nat Rev Genet 2003, 4:794-805.
195. Ma J.K.C., Drake P.M.W., Chargelegue D., Obregon P., Prada A. Antibody processing and engineering in plants, and new strategies for vaccine production. Vaccine 2005, 23:1814-1818.
196. Ma L., Huo R., Gao Xw, He D., Shao M., Wang Q. Transgenic rape with hrf2 gene encoding harpinxooc resistant to Sclerotinia sclerotinorium. Agric Sci China 2008, 7:455-461.
197. Marusic C., Rizza P., Lattanzi L., Mancini C., Spada M., Belardelli F., Benvenuto E., Capone I. Chimeric plant virus particles as immunogens for inducing murine and human immune responses against human immunodeficiency virus type 1. J Virol 2001, 75:8434-8439.
198. Maruyama K., Takeda M., Kidokoro S., Yamada S., Sakuma Y., Urano K., Fujita M., Yoshiwara K., Matsukura S., Morishita Y., Sasaki R., Suzuki H., Saito K., Shibata D., Shinozaki K., Yamaguchi-Shinozaki K. Metabolic pathways involved in cold acclimation identified by integrated analysis of metabolites and transcripts regulated by DREB1A and DREB2A. Plant Physiol 2009, 150:1972-1980.
199. Mascia P.N., Flavell R.B. Safe and acceptable strategies for producing foreign molecules in plants. Curr Opin Plant Biol 2004, 7:189-195.
200. Mason H.S., Arntzen C.J. Transgenic plants as vaccine production systems. Trends Biotechnol 1995, 13:388-392.
201. Mason H.S., Lam D.M., Arntzen C.J. Expression of hepatitis B surface antigen in transgenic plants. Proc Natl Acad Sci USA 1992, 89:11745-11749.
202. Mason H.S., Warzecha H., Mor T., Arntzen C.J. Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. Trends Mol Med 2002, 8:324-329.
203. Masuda H.P., Cabral L.M., De Veylder L., Tanurdzic M., de Almeida Engler J., Geelen D., Inzé D., Martienssen R.A., Ferreira P.C., Hemerly A.S. ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription. EMBO J 2008, 27:2746-2756.
204. Matsumoto Y., Suzuki S., Nozoye T., Yamakawa T., Takashima Y., Arakawa T., Tsuji N., Takaiwa F., Hayashi Y. Oral immunogenicity and protective efficacy in mice of transgenic rice plants producing a vaccine candidate antigen (As16) of Ascaris suum fused with cholera toxin B subunit. Transgenic Res 2009, 18:185-192.
205. McDonald K.A., Hong L.M., Trombly D.M., Xie Q., Jackman A.P. Production of human alpha-1-antitrypsin from transgenic rice cell culture in a membrane bioreactor. Biotechnol Prog 2005, 21:728-734.
206. McGarvey P.B., Hammond J., Dienelt M.M., Hooper D.C., Fu Z.F., Dietzschold B., Koprowski H., Michaels F.H. Expression of the rabies virus glycoprotein in transgenic tomatoes. Nat Biotechnol 1995, 13:1484-1487.
207. McLaughlin J.E., Bin-Umer M.A., Tortora A., Mendez N., McCormick S., Tumera N.E. A genome-wide screen in Saccharomyces cerevisiae reveals a critical role for the mitochondria in the toxicity of a trichothecene mycotoxin. Proc Natl Acad Sci 2009, 106:21883-21888.
208. Meeusen R.L. Commercialization of transgenic seed products: Two case studies. Engineering plants for commercial products and applications 1996, 172-176. New York Academy of Sciences. G.B. Collins, R.J. Shepherd (Eds.).
209. Mehrabadi M., Bandani A.R., Saadati F. Inhibition of sunn pest, Eurygaster integriceps, α-amylases by α-amylase inhibitors (T-αAI) from Triticale. J Insect Sci 2010, 10:1-13.
210. Menkir A., Chikoye D., Lum F. Incorporating an herbicide resistance gene into tropical maize with inherent polygenic resistance to control Striga hermonthica (Del.) Benth. Plant Breed 2010, 129:385-392.
211. Meyers A., Chakauya E., Shephard E., Tanzer F.L., Maclean J., Lynch A., Williamson A.L., Rybicki E.P. Expression of HIV-1 antigens in plants as potential subunit vaccines. BMC Biotechnol 2008, 8:1-15.
212. Mikschofsky H., Schirrmeier H., Keil G.M., Lange B., Polowick P.L., Keller W., Broer I. Pea-derived vaccines demonstrate high immunogenicity and protection in rabbits against rabbit haemorrhagic disease virus. Plant Biotechnol J 2009, 7:537-549.
213. Millis N. Genetically modified organisms' paper prepared for the 2006 Australian State of the Environment Committee 2006, Department of the Environment and Heritage, Canberra.
214. Minhas D., Grover A. Transcript levels of genes encoding various glycolytic and fermentation enzymes change in response to abiotic stresses. Plant Sci 1999, 146:41-51.
215. Miranda J.A., Avonce N., Suárez R., Thevelein J.M., Dijck P.V., Iturriaga G. A bifunctional TPS-TPP enzyme from yeast confers tolerance to multiple and extreme abiotic-stress conditions in transgenic Arabidopsis. Planta 2007, 226:1411-1421.
216. Mochizuki A., Nishizawa Y., Onodera H., Tabei Y., Toki S., Habu Y., Ugaki M., Ohashi Y. Transgenic rice plants expressing a trypsin inhibitor are resistant against rice stem borers, Chilo suppressalis. Entomol Exp Appl 1999, 93:173-178.
217. Moon H., Baek D., Lee B., Prasad D.T., Lee S.Y., Cho M.J., Lim C.O., Choi M.S., Bahk J., Kim M.O., Hong J.C., Yun D.J. Soybean ascorbate peroxidase suppresses Bax-induced apoptosis in yeast by inhibiting oxygen radical generation. Biochem Biophys Res Commun 2002, 290:457-462.
218. Muller C.P., Fack F., Damien B., Bouche F.B. Immunogenic measles antigens expressed in plants: role as an edible vaccine for adults. Vaccine 2003, 23:816-819.
219. Mundembe R., Matibiri A., Sithole-Niang I. Transgenic plants expressing the coat protein gene of cowpea aphid-borne mosaic potyvirus predominantly convey the delayed symptom development phenotype. Afr J Biotechnol 2009, 8:2682-2690.
220. Munis M.F.H., Tu L., Deng F., Tan J., Xu L., Xu S., Long L., Zhang X. A thaumatin-like protein gene involved in cotton fiber secondary cell wall development enhances resistance against Verticillium dahliae and other stresses in transgenic tobacco. Biochem Biophys Res Commun 2010, 393:38-44.
221. Nagadhara D., Ramesh S., Pasalu I.C., Rao Y.K., Sarma N.P., Reddy V.D., Rao K.V. Transgenic rice plants expressing the snowdrop lectin gene (gna) exhibit high-level resistance to the white backed plant hopper (Sogatella furcifera). Theor Appl Genet 2004, 109:1399-1405.
222. Nagadhara D., Ramesh S., Pasalu I.E., Rao Y.K., Krishnaiah N.V., Sarma N.P., Bown D.P., Gatehouse J.A., Reddy V.D., Rao K.V. Transgenic indica rice resistant to sap sucking insects. Plant Biotechnol 2003, 1:231-240.
223. Nakayama H., Yoshida K., Ono H., Murooka Y., Shinmyo A. Ectoine, the compatible solute of Halomonas elongata, confers hyperosmotic tolerance in cultured tobacco cells. Plant Physiol 2000, 122:1239-1247.
224. Nanjo T., Kobayashi M., Yoshiba Y., Kakubari Y., Yamaguchi-Shinozaki K., Shinozaki K. Antisense suppression of proline degradation improves tolerance to freezing and salinity in Arabidopsis thaliana. FEBS Lett 1999, 461:205-210.
225. Ni X., Tian Z., Liu J., Song B., Li J., Shi X., Xie C. StPUB17, a novel potato UND/PUB/ARM repeat type gene, is associated with late blight resistance and NaCl stress. Plant Sci 2010, 178:158-169.
226. Nicholson L., Gonzalez-Melendi P., van Dolleweerd C., Tuck H., Pemn Y., Ma J.K.C., Fischer R., Christou P., Stoger E. A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells. Plant Biotechnol J 2003, 3:115-127.
227. Oberschall A., Deak M., Torok K., Saa L., Vass I., Kovacs I., Feher A., Dudits D., Horvath G.V. A novel aldose/aldehyde reductase protects transgenic plants against lipid peroxidation under chemical and drought stresses. Plant J 2000, 24:437-446.
228. Oh S.J., Kim Y.C., Park H.K., Jeong J.S., Kim J.K. Overexpression of the transcription factor AP37 in rice improves grain yield under drought conditions. Plant Physiol 2009, 150:1368-1379.
229. + antiporter gene from Atriplex gmelini confers salt tolerance to rice. FEBS Lett 2002, 532:279-282.
230. Okushima Y., Overvoorde P.J., Arima K., Alonso J.M., Chan A., Chang C., Ecker J.R., Hughes B., Lui A., Nguyen D., Onodera C., Quach H., Smith A., Yu G., Theologis A. Functional genomic analysis of the auxin response factor gene family members in Arabidopsis thaliana: unique and overlapping functions of ARF7 and ARF19. Plant Cell 2005, 17:444-462.
231. Oliver H.F., Orsi R.H., Wiedmann M., Boor K.J. Listeria monocytogenes ∂B has a small core regulon and a conserved role in virulence but makes differential contributions to stress tolerance across a diverse collection of strains. Appl Environ Microb 2010, 76:4216-4232.
232. Paine J.A., Shipton C.A., Chaggar S., Howells R.M., Kennedy M.J., Vernon G., Wright S.Y., Hinchliffe E., Adams J.L., Silverstone A.L., Drake R. Improving the nutritional value of golden rice through increased pro-vitamin A content. Nat Biotechnol 2005, 23:482-487.
233. Palatnik J.F., Allen E., Wu X., Schommer C., Schwab R., Carrington J.C., Weigel D. Control of leaf morphogenesis by microRNAs. Nature 2003, 425:257-263.
234. Panos Greed or need? Genetically modified crops. Panos media briefing no. 30, Oct 1998.
235. 2+/calmodulin dependent protein phosphatase calcineurin mediates salt adaptation in plants. Proc Natl Acad Sci USA 1998, 95:9681-9686.
236. Park B.J., Liu Z., Kanno A., Kameya T. Increased tolerance to salt- and water-deficit stress in transgenic lettuce (Lactuca sativa L.) by constitutive expression of LEA. Plant Growth Regul 2005, 45:165-171.
237. Park J.M., Park C.J., Lee S.B., Ham B.K., Shin R., Paek K.H. Overexpression of the tobacco Tsi1 gene encoding an EREBP/AP2-type transcription factor enhances resistance against pathogen attack and osmotic stress in tobacco. Plant Cell 2001, 13:1035-1046.
238. Pascual D.W. Vaccines are for dinner. PNAS 2007, 104:10757-10758.
239. Pasquali G., Biricolti S., Locatelli F., Baldoni E., Mattana M. Osmyb4 expression improves adaptive responses to drought and cold stress in transgenic apples. Plant Cell Rep 2008, 27:1677-1686.
240. Pasquali G., Biricolti S., Locatelli F., Baldoni E., Mattana M. Osmyb4 expression improves adaptive responses to drought and cold stress in transgenic apples. Plant Cell Rep 2008, 27:1677-1686.
241. Peter R.E., Yu K.L., Marchant T.A., Rosenblum P.M. Direct neural regulation of the teleost adenohypophysis. J Exp Zool 1990, 4:84-89.
242. Piao H.L., Lim J.H., Kim S.J., Cheong G.W., Hwang I. Constitutive over-expression of AtGSK1 induces NaCl stress responses in the absence of NaCl stress and results in enhanced NaCl tolerance in Arabidopsis. Plant J 2001, 27:305-314.
243. Polkinghorne I., Hamerli D., Cowan P., Duckworth J. Plant based immune contraceptive control of wild life-potentials, limitations, and possums. Vaccine 2005, 23:1847-1850.
244. Potrykus I. Golden rice and beyond. Plant Physiol 2001, 125:1157-1161.
245. Powell-Abel P., Nelson R.S., De B., Hoffman H., Rogers S.G., Fraley R.T., Beachy R.N. Delay of disease development in transgenic plants that express the tobacco mosaic virus coat protein gene. Science 1986, 232:738-743.
246. Prasad K.V., Sharmila P., Saradhi P. Enhanced tolerance of transgenic Brassica juncea to choline confirms successful expression of the bacterial codA gene. Plant Sci 2000, 159:233-242.
247. Qadri F., Svennerholm A.M., Faruque A.S.G., Sack R.B. Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and prevention. Clin Microbiol Rev 2005, 18:465-483.
248. Qi Y.B., Ye S.H., Lu Y.T., Jin Q.S., Zhang X.M. Development of marker-free transgenic Cry1Ab rice with lepidopteran pest resistance by agrobacterium mixture-mediated Co-transformation. Rice Sci 2009, 16:181-186.
249. Qiu Y., Yu D. Over-expression of the stress-induced OsWRKY45 enhances disease resistance and drought tolerance in Arabidopsis. Environ Exp Bot 2009, 65:35-47.
250. Quan R., Hu S., Zhang Z., Zhang H., Zhang Z., Huang R. Overexpression of an ERF transcription factor TSRF1 improves rice drought tolerance. Plant Biotech J 2010, 8:476-488.
251. Rahman M., Rashid H., Shahid A.A., Bashir K., Husnain T., Riazuddin S. Insect resistance and risk assessment studies of advanced generations of basmati rice expressing two genes of Bacillus thuringiensis. Elect J Biotech 2007, 10(2). April 15.
252. Ramesh S., Nagadhara D., Reddy V.D., Rao K.V. Production of transgenic indica rice resistant to yellow stem borer and sap-sucking insects, using super-binary vectors of Agrobacterium tumefaciens. Plant Sci 2004, 166:1077-1085.
253. Rao K.V., Rathore K.S., Hodges T.K., Fu X.D., Stoger E., Sudhakar D., Williams S., Christou P., Bown D.P., Powell K.S., Spense J., Bharathi M., Gatehouse A.M.R., Gatehouse J.A. Expression of snowdrop lectin (GNA) in the phloem of transgenic rice plants confers resistance to rice brown plant hopper. Plant J 1998, 14:469-477.
254. Raskin I., Ribnicky D.M., Komarnytsky S., Ilk N., Poulev A., Borisjuk N., Brinker A., Moreno D.A., Ripoll C., Yakoby N., O'Neal J.M., Cornwell T., Fridlender P.I. Plants and human health in the twenty-first century. Trends Biotechnol 2002, 20:522-531.
255. Rawool D.B., Bitsaktsis C., Li Y., Gosselin D.R., Lin Y., Kurkure N.V., Metzger D.W., Gosselin E.J. Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis. J Immunol 2008, 180:5548-5557.
256. REN21 Renewables 2011: global status report 2001, 13-14. http://www.ren21.net/Portals/97/documents/GSR/GSR2011_Master18.pdf.
257. Riaz N., Husnain T., Fatima T., Makhdoom R., Bashir K., Masson L., Altosaar I., Riazuddin S. Development of indica basmati rice harboring two insecticidal genes for sustainable resistance against lepidopteran insects. South Afr J Bot 2006, 72:217-223.
258. Richter L.J., Thanavala Y., Arntzen C.J., Mason H.S. Production of hepatitis surface antigen in transgenic plants for oral immunization. Nat Biotechnol 2000, 18:1167-1171.
259. Rigano M.M., Mannab C., Giulin A., Vitale A., Cardi T. Plants as biofactories for the production of subunit vaccines against bio-security-related bacteria and viruses. Vaccine 2009, 27:3463-3466.
260. Rigaud NOECD International Futures Project on "The bioeconomy to 2030: designing a policy agenda" Biotechnology: ethical and social debates. Multi-disciplinary issues international futures programme; 2008.
261. Rivoal J., Thind S., Ricard B. Differential induction of pyruvate decarboxylase subunits and transcripts in anoxic rice seedlings. Plant Physiol 1997, 114:1021-1029.
262. Rodriguez R.E., Mecchia M.A., Debernardi J.M., Schommer C., Weigel D., Palatnik J.F. Control of cell proliferation in Arabidopsis thaliana by microRNA miR396. Development 2010, 137:103-112.
263. Rojas C.A., Eloy N., de Freitas Lima M., Rodrigues R., Franco L., Himanen K., Beemster G.T.S., Hemerly A.S., Ferreira P.C.G. Overexpression of the Arabidopsis anaphase promoting complex subunit CDC27a increases growth rate and organ size. Plant Mol Biol 2009, 71:307-318.
264. Rojas C.A., Hemerly A.S., Ferreira P.C.G. Genetically modified crops for biomass increase, genes and strategies. GM Crops 2010, 1:1-6.
265. Roosens N., Hal Bitar F., Loenders K., Angenon G., Jacobs M. Overexpression of ornithine-δ-aminotransferase increases proline biosynthesis and confers osmotolerance in transgenic plants. Mol Breed 2002, 9:73-80.
266. Rosegrant, MW, Cavalieri AJ. Bioenergy and agro-biotechnology commissioned paper submitted to the German Council on global change. International Food Policy Research Institute (IFPRI) 2033 K St NW, Washington DC 20006, USA; 2008.
267. Roxas V.P., Lodhi S.A., Garrett D.K., Mahan J.R., Allen R.D. Stress tolerance in transgenic tobacco seedlings that overexpress glutathione S-transferase/glutathione peroxidase. Plant Cell Physiol 2000, 41:1229-1234.
268. Roy S., Tyagi A., Tiwari S., Singh A., Sawant S.V., Singh P.K., Tuli R. Rabies glycoprotein fused with B subunit of cholera toxin expressed in tobacco plants folds into biologically active pentameric protein. Prot Expres Purifi 2010, 70:184-190.
269. Ruhlman T., Ahangari R., Devine A., Samsam M., Daniel H. Expression of cholera toxin B-proinsulin fusion protein in lettuce and tobacco chloroplasts-oral administration protects against development of insulitis in non-obese diabetic mice. Plant Biotechnol J 2007, 5:495-510.
270. Runge C.F., Ryan M.S.B. The global diffusion of plant biotechnology: international adoption and research in 2004 2004, A report prepared for the Council on Biotechnology Information, Washingtion, DC.
271. Rupp H.M., Frank M., Werner T., Strnad M., Schmülling T. Increased steady state mRNA levels of the STM and KNAT1 homeobox genes in cytokinin overproducing Arabidopsis thaliana indicate a role for cytokinins in the shoot apical meristem. Plant J 1999, 18:557-563.
272. Saha P., Majumder P., Dutta I., Ray T., Roy S.C., Das S. Transgenic rice expressing Allium sativum leaf lectin with enhanced resistance against sap-sucking insect pests. Planta 2006, 23:1329-1343.
273. Saibo N.J.M., Lourenço T., Oliveira M.M. Transcription factors and regulation of photosynthetic and related metabolism under environmental stresses. Ann Bot 2009, 103:609-623.
274. 2+ dependent protein kinase confers both cold and salt/drought tolerance on rice plants. Plant J 2000, 23:319-327.
275. Sainsbury F., Cañizares M.C., Lomonossoff G.P. Cowpea mosaic virus: the plant virus-based biotechnology workhorse. Annu Rev Phytopathol 2010, 48:437-455.
276. Sakamoto A., Alia, Murata N. Metabolic engineering of rice leading to biosynthesis of glycinebetaine and tolerance to salt and cold. Plant Mol Biol 1998, 38:1011-1019.
277. Sala F., Rigano M.M., Barbante A., Basso B., Walmsley A.M., Castiglione S. Vaccine antigen production in transgenic plants: strategies, gene constructs and perspectives. Vaccine 2003, 21:803-808.
278. Sala F., Rigano M.M., Barbante A., Basso B., Walmsley A.M., Castiglione S. Vaccine antigen production in transgenic plants: strategies, gene constructs and perspectives. Vaccine 2003, 21:803-808.
279. Sandhu J.S., Krasnyanski S.F., Domier L.L., Korban S.S., Osadjan M.D., Buetow D.E. Oral immunization of mice with transgenic tomato fruit expressing respiratory syncytial virus-F protein induces a systemic immune response. Transgenic Res 2000, 9:127-135.
280. Santi L., Batchelor L., Huang Z., Hjelm B., Kilbourne J., Arntzen C.J., Chen Q., Mason H.S. An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine 2008, 26:1846-1854.
281. Santia L., Huanga Z., Mason H. Virus-like particles production in green plants. Particle Based Vaccines Methods 2006, 40:66-76.
282. Schnepf H.E., Whiteley H.R. Cloning and expression of the Bacillus thuringiensis crystal protein gene in Escherichia coli. Proc Natl Acad Sci USA 1981, 78:2893-2897.
283. Schruff M.C., Spielman M., Tiwari S., Adams S., Fenby N., Scott R.J. The auxin response factor 2 gene of Arabidopsis links auxin signalling, cell division and the size of seeds and other organs. Development 2006, 133:251-261.
284. Sciutto E., Fragoso G., Manoutcharian K., Gevorkian G., Rosas-Salgad G., Hernández-Gonzalez M., Herrera-Estrella L., Cabrera-Ponce J.L., Lapez-Casillas F., Gonzalez-Bonilla C., Santigago-Machuca A., Sanchez R.J., Goldbaum F., Alujac A., Larraldea C. New approaches to improve peptide vaccine against porcine Taenia solium Cysticercosis. Arch Med Res 2002, 33:371-378.
285. Sekhar K., Priyanka B., Reddy V.D., Rao K.V. Metallothionein 1 (CcMT1) of pigeon pea (Cajanus cajan L.) confers enhanced tolerance to copper and cadmium in Escherichia coli and Arabidopsis thaliana. Environ Exp Bot 2011, 72:131-139.
286. Sexton S., Zilberman D. How agricultural biotechnology boosts food supply and accomodates biofuels. Working Paper 16699 2011, http://www.nber.org/papers/w16699.
287. Shade R.E., Schroeder H.E., Pueyo J.J., Tabe L.M., Murdock L.L., Higgins T.J.V., Chrispeels M.J. Transgenic pea seeds, expressing the a-amylase inhibitor of the common bean are resistant to bruchid beetles. Nat Biotechnol 1999, 12:793-797.
288. Shantharam S. Biosafety review and environmental assessment for the field release of genetically engineered crop plants and microbes in the United States. Afr Crop Sci J 1995, 3:331-339.
289. Sharma H.C., Sharma K.K., Crouch J.H. Genetic transformation of crops for insect resistance: potential and limitations. Crit Rev Plant Sci 2004, 23:47-72.
290. Sharma H.C., Sharma K.K., Seetharama N., Ortiz R. Prospects for using transgenic resistance to insects in crop improvement. Mol Biol Genet 2000, 3:76-95.
291. Sharma M.K., Jani D., Thungapathra M., Gautam J.K., Meena L.S., Singh Y., Ghosh A., Tyagi A.K., Sharma A.K. Expression of accessory colonization factor subunit A (ACFA) of Vibrio cholerae and ACFA fused to cholera toxin B subunit in transgenic tomato (Solanum lycopersicum). J Biotechnol 2008, 135:22-27.
292. Sheveleva E., Chmara W., Bohnert H.J., Jensen R.G. Increased salt and drought tolerance by D-ononitol production in transgenic Nicotiana tabacum L. Plant Physiol 1997, 115:1211-1219.
293. + antiporter gene improves salt tolerance in Arabidopsis thaliana. Nat Biotechnol 2003, 21:81-85.
294. Shimamura C., Ohno R., Nakamura C., Takumi S. Improvement of freezing tolerance in tobacco plants expressing a cold-responsive and chloroplast-targeting protein WCOR15 of wheat. J Plant Physiol 2006, 163:213-219.
295. Simoens C., Van Montagu M. Genetic engineering in plants. Hum Reprod Update 1995, 1:523-542.
296. Sirko A., Blaszczyk A., Liszewska F. Overproduction of SAT and/or OASTL in transgenic plants: a survey of effects. J Exp Bot 2004, 55:1881-1888.
297. Sivakumar S., Mohan M., Franco O.L., Thayumanavan B. Inhibition of insect pest α-amylases by little and finger millet inhibitors. Pesticide Biochem Physiol 2006, 85:155-160.
298. Sommer A. Golden rice. Unpublished manuscript, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA; 2001.
299. Sridevi G., Parameswari C., Sabapathi N., Raghupathy V., Veluthambi K. Combined expression of chitinase and β-1,3-glucanase genes in indica rice (Oryza sativa L.) enhances resistance against Rhizoctonia solani. Plant Sci 2008, 175:283-290.
300. Stoger E., Ma J.K.C., Fischer R., Christou P. Sowing the seeds of success: pharmaceutical proteins from plants. Curr Opin Biotechnol 2005, 16:167-173.
301. Streafield S.J., Lane J.R., Brooks C.A., Barker D.K., Poage M.L., Mayor J.M., Lamphear B.J., Drees C.F., Jilka J.M., Hood E.E., Howard J.A. Corn as a production system for human and animal vaccines. Vaccine 2003, 21:812-815.
302. Streatfield S.J., Howard J.A. Plant-based vaccines. Int J Parasitol 2003, 33:479-493.
303. Streatfield S.J. Approaches to achieve high-level heterologous protein production in plants. Plant Biotechnol J 2007, 5:2-15.
304. Streatfield S.J. Engineered chloroplasts as vaccine factories to combat bioterrorism. Trends Biotechnol 2006, 24:339-342.
305. Suarez R., Calderon C., Iturriaga G. Enhanced tolerance to multiple abiotic stresses in transgenic alfalfa accumulating trehalose. Crop Sci 2009, 49:1791-1799.
306. Sugano S., Kaminaka H., Rybka Z., Catala R., Salinas J., Matsui K., Ohme-Tkagi M., Takatsuji H. Stress-responsive zinc finger gene ZPT2-3 plays a role in drought tolerance in petunia. Plant J 2003, 36:830-841.
307. Sugino M., Hibino T., Tanaka Y., Nii N., Takabe T., Takabe T. Overexpression of DnaK from a halotolerant cyanobacterium Aphanotece halophytica acquires resistance to salt stress in transgenic tobacco plants. Plant Sci 1999, 146:81-88.
308. Sun S.S. Methionine enhancement in plants. Plant amino acids 1999, 509-521. Biochemistry and Biotechnology, Marcel Dekker. B.K. Sigh (Ed.).
309. Sun W., Bernard C., van de Cotte B., Van Montagu M., Verbruggen N. At-HSP17. 6A, encoding a small heat-shock protein in Arabidopsis, can enhance osmotolerance upon overexpression. Plant J 2001, 27:407-415.
310. Sun S.S.M. Application of agricultural biotechnology to improve food nutrition and healthcare products. Asia Pac J Clin Nutr 2008, 17:87-90.
311. Sunkar R., Bartels D., Kirch H.H. Overexpression of a stress inducible aldehyde dehydrogenase gene from Arabidopsis thaliana in transgenic plants improves stress tolerance. Plant J 2003, 35:452-464.
312. Svennerholm A. From cholera to enterotoxigenic Escherichia coli (ETEC) vaccine development. Indian J Med Res 2011, 133:188-194.
313. Tacket C., Mason H.S., Losonsky G., Clements J.D., Levine M.M., Arntzen C.J. Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nat Med 1998, 4:607-609.
314. Tacket C.O., Mason H.S., Losonsky G., Estes M.K., Levine M.M., Arntzen C.J. Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J Infect Dis 2000, 182:302-305.
315. Tacket C.O., Pasetti M.F., Edelman R., Howard J.A., Streatfield S. Immunogenicity of recombinant LT-B delivered orally to humans in transgenic corn. Vaccine 2004, 22:4385-4389.
316. Takagi H., Hiroi T., Yang L., Tada Y., Yuki Y., Takamura K., Ishimitsu R., Kawauchi H., Kiyono H., Takaiwa F. A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. Proc Natl Acad Sci USA 2005, 102:17525-17530.
317. Tanaka K., Hibino T., Hayashi Y., Tanaka A., Kishitani S., Takabe T., Yokota S., Takabe T. Salt tolerance of transgenic rice overexpressing yeast mitochondrial Mn-SOD in chloroplasts. Plant Sci 1999, 148:131-138.
318. Tang K., Zhao E., Sun X., Wan B., Qi H., Lu X. Production of transgenic rice homozygous lines with enhanced resistance to the rice brown plant hopper. Acta Biotechnol 2001, 21:117-128.
319. Taniai K., Inceoglu A.B., Hammock B.D. Expression efficiency of scorpion neurotoxin, AaHIT using in baculovirus insect cells. Appl Entomol Zool 2002, 37:225-232.
320. Teisl M.F., Garner L., Rose B., Vayda M.D. Labeling genetically modified foods: how do U.S. consumers want to see it done? AgBioForum. J Agrobiotechnol Manage Econ 2003, 6:48-54.
321. Thanavala Y., Lugade A.A. Oral transgenic plant-based vaccine for hepatitis B. Immunol Res 2010, 46:4-11.
322. Thanavala Y., Mahoney M., Pal S., Scott A., Richter L., Natarajan N., Goodwin P., Arntzen C.J., Mason H.S. Immunogenicity in humans of an edible vaccine for hepatitis B. Proc Natl Acad Sci USA 2005, 102:3378-3382.
323. Thanavala Y., Yang Y.F., Lyons P., Mason H.S., Arntzen C. Immunogenicity of transgenic plant derived hepatitis B surface antigen. Proc Natl Acad Sci USA 1995, 92:3358-3361.
324. The Biology Refugia Blogging about ecology, evolution, taxonomy and biodiversity from Singapore 2011.
325. Thipyapong P., Melkonian J., Wolfe D.W., Steffens J.C. Suppression of polyphenol oxidase increases stress tolerance in tomato. Plant Sci 2004, 167:693-703.
326. Tiwari S., Verma P.C., Singh P.K., Tuli R. Plants as bioreactors for the production of vaccine antigens. Biotechnol Adv 2009, 27:449-467.
327. Tregoning J., Maliga P., Dougan G., Nixon P.J. New advances in the production of edible plant vaccines: chloroplast expression of a tetanus vaccine antigen, TetC. Phytochemistry 2004, 65:989-994.
328. Trivedi P.K., Nath P. MaExpl, an ethylene-induced expansin from ripening banana fruit. Plant Sci 2004, 167:1351-1358.
329. Twyman R.M., Stoger E., Schillberg S., Christou P., Fischer R. Molecular farming in plants: host systems and expression technology. Trends Biotechnol 2003, 21:570-578.
330. Ushimaru T., Nakagawa T., Fujioka Y., Daicho K., Naito M., Yamauchi Y., Nonaka H., Amako K., Yamawaki K., Murata N. Transgenic Arabidopsis plants expressing the rice dehydroascorbate reductase gene are resistant to salt stress. J Plant Physiol 2006, 163:1179-1184.
331. Valdes R., Gomez L., Padilla S., Brito J., Reyes B., Alvarez T., Mendoza O., Herrera O., Ferro W., Pujol M., Leal V., Linares M., Hevia Y., Garcia C., Mila L., Garcia 0., Sanchez R., Acosta A., Geada D., Paez R., Vega J.L., Borroto C. Large scale purification of an antibody directed against hepatitis B surface antigen from transgenic tobacco plants. Biochem Biophys Res Commun 2003, 308:94-100.
332. Van Camp W., Capiau K., Van Montagu M., Inze D., Slooten L. Enhancement of oxidative stress tolerance in transgenic tobacco plants overproducing Fe-superoxide dismutase in chloroplasts. Plant Physiol 1996, 112:1703-1714.
333. Van Camp W., Van Montagu M., Inze D. Superoxide dismutases. Causes of photooxidative stress and amelioration of defense systems in plants 1994, 317-341. CRC Press, Inc, Boca Raton, FL, USA. C.H. Foyer, P.M. Mullineaux (Eds.).
334. Van Damme E.J.M. Plant lectins as part of the plant defense system against insects. Induced plant resistance to herbivory 2008, 285-307. Springer, Dordrecht. The Netherlands. A. Schaller (Ed.).
335. Vannini C., Iriti M., Bracale M., Locatelli F., Faoro F., Croce P., Pirona R., Marof A.D., Coraggioc I., Geng A. The ectopic expression of the rice Osmyb4 gene in Arabidopsis increases tolerance to abiotic, environmental and biotic stresses. Physiol Mol Plant Pathol 2006, 69:26-42.
336. Vendruscolo E.C., Schuster I., Pileggi M., Scapim C.A., Molinari H.B., Marur C.J., Vieira L.G. Stress-induced synthesis of proline confers tolerance to water deficit in transgenic wheat. J Plant Physiol 2007, 164:1367-1376.
337. Villalobos M.A., Bartels D., Iturriaga G. Stress tolerance and glucose insensitive phenotypes in Arabidopsis overexpressing the CpMYB10 transcription factor gene. Plant Physiol 2004, 135:309-324.
338. Waie B., Rajam M.V. Effect of increased polyamine biosynthesis on stress responses in transgenic tobacco by introduction of human S-denosylmethionine gene. Plant Sci 2003, 164:727-734.
339. Walmsley A.M., Arntzen C.J. Plant cell factories and mucosal vaccines. Curr Opin Biotechnol 2003, 14:145-150.
340. Walmsley A.M., Arntzen C.J. Plants for delivery of edible vaccines. Curr Opin Biotechnol 2000, 11:126-129.
341. Wang L., Webster D.E., Campbell A.E., Dry L.B., Wesselingh S.L., Coppel R.L. Immunogenicity of Plasmodium yoelii merozoite surface protein 4/5 produced intransgenic plants. Int J Parasitol 2008, 38:103-110.
342. Wang W., Vinocur B., Shoseyov O., Altman A. Role of plant heat shock proteins and molecular chaperones in the abiotic stress response. Trends Plant Sci 2004, 9:244-252.
343. Wang Y., Deng H., Zhang X., Xiao H., Jiang Y., Song Y., Fang L., Xiao S., Zhen Y., Chen H. Generation and immunogenicity of Japanese encephalitis virus envelope protein expressed in transgenic rice. Biochem Biophys Res Commu 2009, 380:292-297.
344. Wang Y., Gao C., Liang Y., Wang C., Yang C., Liu G. A novel bZIP gene from Tamarix hispida mediates physiological responses to salt stress in tobacco plants. J Plant Physiol 2010, 167:222-230.
345. Watson J., Koya V., Leppla S.H., Daniell H. Expression of Bacillus anthracis protective antigen in transgenic chloroplasts of tobacco, a non-food/feed crop. Vaccine 2004, 22:4374-4384.
346. Webster D.E., Cooney M.L., Huang Z., Drew D.R., Ramshaw I.A., Dry I.B., Strugnell R.A., Martin J.L., Wesselingh S.L. Successful boosting of a DNA measles immunization with an oral plant derived measles virus vaccine. J Virol 2002, 76:7910-7912.
347. Webster D.E., Thomas M.C., Huang Z., Wesselingh S.L. The development of a plant based vaccine for measles. Vaccine 2005, 23:1859-1865.
348. Whetstone P.A., Hammock B.D. Delivery methods for peptide and protein toxins in insect control. Toxicon 2007, 49:576-596.
349. White D.W.R. PEAPOD regulates lamina size and curvature in Arabidopsis. Proc Natl Acad Sci USA 2006, 103:13238-13243.
350. WHO Global prevalence of vitamin A deficiency in populations at risk 1995-2005. WHO global database on vitamin A deficiency 2009, World Health Organization, Geneva.
351. Winicov I. Alfin1 transcription factor overexpression enhances plant root growth under normal and saline conditions and improves salt tolerance in alfalfa. Planta 2000, 210:416-422.
352. Wojas S., Clemens S., Sklodowska A., Antosiewicz D.M. Arsenic response of AtPCS1- and CePCS-expressing plants: Effects of external As(V) concentration on As-accumulation pattern and NPT metabolism. J Plant Physiol 2010, 167:169-175.
353. Wolt J.D. Advancing environmental risk assessment for transgenic biofeedstock crops. Biotechnol Biofuels 2009, 2:27.
354. Woodard S.L., Mayor J.M., Bailey M.R., Barker D.K., Love R.T., Lane J.R., Delaney D.E., McComas-Wagner J.M., Mallubhotla H.D., Hood E.E., Dangott L.J., Tichy S.E., Howard J.A. Maize (Zea mays) derived bovine trypsin: characterization of the first large scale, commercial protein product from transgenic plants. Biotechnol Appl Biochem 2003, 38:123-130.
355. World Health Organization. The world health report 2007-A safer future: global public health security in the 21st century.
356. Xia H., Chen L., Wang F., Lu B.R. Yield benefit and underlying cost of insect-resistance transgenic rice: Implication in breeding and deploying transgenic crops. Field Crops Res 2010, 118:215-220.
357. Xiang C., Werner B.L., Christensen E.M., Oliver D.J. The biological function of glutathione revisited in Arabidopsis transgenic plants with altered glutathione levels. Plant Physiol 2001, 126:564-574.
358. Xiao B., Huang Y., Tang N., Xiong L. Over-expression of a LEA gene in rice improves drought resistance under the field conditions. Theor Appl Genet 2007, 115:35-46.
359. Xie Q., Frugis G., Colgan D., Chua N.H. Arabidopsis NAC1 transduces auxin signal downstream of TIR1 to promote lateral root development. Genes Dev 2000, 14:3024-3036.
360. Xie T., Qiu Q., Zhang W., Ning T., Yang W., Zheng C., Wang C., Zhu Y., Yang D. A biologically active rhIGF-1 fusion accumulated in transgenic rice seeds can reduce blood glucose in diabetic mice via oral delivery. Peptides 2008, 29:1862-1870.
361. Xing L.P., Wang H.Z., Jiang Z.N., Ni J.L., Cao A.Z., Yu L., Chen P.D. Transformation of wheat thaumatin-like protein gene and analysis of reactions to powdery mildew and fusarium head blight in transgenic plants. Acta Agron Sin 2008, 34:349-354.
362. Xu D., Duan X., Wang B., Hong B., Ho T.H.D., Wu R. Expression of a late embryogenesis abundant protein gene, HVA1, from barley confers tolerance to water deficit and salt stress in transgenic rice. Plant Physiol 1996, 110:249-257.
363. Xu W.Z., Wang X., Feng Q., Zhang N., Liu Y.G., Han B., Chong K., Xu Z.H., Tan K.H. Vernalization was essential for the function of VER2 promoter in immature leaves of winter wheat. Chin Sci Bull 2004, 49:151-158.
364. Yadav S.K., Singla-Pareek S.L., Reddy M.K., Sopory S.K. Transgenic tobacco plants overexpressing glyoxalase enzymes resist an increase in methylglyoxal and maintain higher reduced glutathione levels under salinity stress. FEBS Lett 2005, 579:6265-6271.
365. Yamaguchi T., Blumwald E. Developing salt-tolerant crop plants: challenges and opportunities. Trends Plant Sci 2005, 10:615-620.
366. Yan H., Yan H., Li G., Gong W., Jiao H., Chen H., Ji M. Expression of human cytomegalovirus pp 150 gene in transgenic Vicia faba L. and immunogenicity of pp150 protein in mice. Biologicals 2010, 38:265-272.
367. Yang S.X., Zhao Y.X., Zhang Q., He Y.K., Zhang H., Luo HAL1 mediate salt adaptation in Arabidopsis thaliana. Cell Res 2001, 11:142-148.
368. Yang Z., Wu Y., Li Y., Ling H.Q., Chu C. OsMT1a, a type 1 metallothionein, plays the pivotal role in zinc homeostasis and drought tolerance in rice. Plant Mol Biol 2009, 70:219-229.
369. Ye X., Al-Babili S., Klöti A., Zhang J., Lucca P., Beyer P. Engineering the pro-Vitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 2000, 287:303-305.
370. Yokotani N., Ichikawa T., Kondou Y., Maeda S., Iwabuchi M., Mori M., Hirochika H., Matsui M., Oda K. Overexpression of a rice gene encoding a small C2 domain protein OsSMCP1 increases tolerance to abiotic and biotic stresses in transgenic Arabidopsis. Plant Mol Biol 2009, 71:391-402.
371. Yusibov V., Modelska A., Steplewski K., Agadjanyan M., Weiner D., Hooper D.C., Koprowski H. Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1. Proc Natl Acad Sci USA 1997, 94:5784-5788.
372. Yu-Zhang W., Jin-Tao L., Zhi-Rong M., Lei F., Bing N., Miao G., Zheng-Cai J., Wei Z., Li-Yun Z., Yan T. Oral immunization with rotavirus VPI expressed in transgenic potatoes induced high titers of mucosal neutralizing IgA. Virology 2003, 313:337-342.
373. Zang N., Zhai H., Gao S., Chen W., He S., Liu Q. Efficient production of transgenic plants using the bar gene for herbicide resistance in sweet potato. Sci Hort 2009, 122:649-653.
374. Zhang G.G., Rodrigues L., Rovinski B., White K.A. Production of HIV-1 p24 protein in transgenic tobacco plants. Mol Biotechnol 2002, 20:131-136.
375. Zhang H., Liu M., Li Y., Zhao Y., He H., Yang G., Zheng C. Oral immunogenicity and protective efficacy in mice of a carrot-derived vaccinecandidate expressing UreB subunit against Helicobacter pylori. Prot Expres Purifi 2010, 69:127-131.
376. Zhang H.X., Blumwald E. Transgenic salt tolerant tomato plants accumulate salt in foliage but not in fruit. Nat Biotechnol 2001, 19:765-768.
377. Zhang H.X., Hodson J.N., Williams J.P., Blumwald E. Engineering salt-tolerant brassica plants: characterization of yield and seed oil quality in transgenic plants with increased vacuolar sodium accumulation. Proc Natl Acad Sci USA 2001, 98:12832-12836.
378. Zhang X., Yuan Z., Duan Q., Zhu H., Yu H., Wang Q. Mucosal immunity in mice induced by orally administered transgenic rice. Vaccine 2009, 27:1596-1600.
379. Zhang Z., Huang R. Enhanced tolerance to freezing in tobacco and tomato overexpressing transcription factor TERF2/LeERF2 is modulated by ethylene biosynthesis. Plant Mol Biol 2010, 73:241-249.
380. Zhong R., Pena M.J., Zhou G.K., Nairn C.J., Wood-Jones A., Richardson E.A., Morrison W.H., Darvill A.G., York W.S., Ye Z.H. The FRA8 gene, which encodes a putative glucuronyltransferase, is essential for normal secondary wall synthesis. Plant Cell 2005, 17:3390-3408.
381. Zhou J., Li F., Wang J.L., Ma Y., Chong K., Xu Y.Y. Basic helix-loop-helix transcription factor from wild rice (OrbHLH2) improves tolerance to salt- and osmotic stress in Arabidopsis. J Plant Physiol 2009, 166:1296-1306.
382. Zhu B., Su J., Chang M., Verma D.P.S., Fan Y.L., Wu R. Overexpression of delta1-pyrroline-5-carboxylate synthase gene and analysis of tolerance to water and salt stress in transgenic rice. Plant Sci 1998, 199:41-48.
383. Zimmermann M.B., Hurrell R. Improving iron, zinc and vitamin A nutrition through plant biotechnology. Curr Opin Biotechnol 2002, 13:142-145.