A biologically active rhIGF-1 fusion accumulated in transgenic rice seeds can reduce blood glucose in diabetic mice via oral delivery

Peptides

Volumn 29, Issue 11, 2008, Pages 1862-1870

  Xie, Tingting ^a   Qiu, Qingchuan ^a   Zhang, Wei ^b   Ning, Tingting ^a   Yang, Wei ^a   Zheng, Congyi ^a   Wang, Chuan ^a   Zhu, Yingguo ^a   Yang, Daichang ^a  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Blood glucose; Diabetes mellitus; Human insulin like growth factor 1; Hyperglycemia; Transgenic rice seeds

Indexed keywords

RECOMBINANT SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULIN SENSITIVITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET CELL; PLANT SEED; PRIORITY JOURNAL; RICE; TRANSGENE;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; BREAST NEOPLASMS; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MICE; ORYZA SATIVA; PLANTS, GENETICALLY MODIFIED; RECOMBINANT FUSION PROTEINS; SEEDS; TUMOR CELLS, CULTURED;

MUS;

EID: 54149119320     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2008.07.014     Document Type: Article

References (37)

1. Arakawa T., Yu J., Chong D.K., Hough J., Engen P.C., and Langridge W.H. A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes. Nat Biotechnol 16 (1998) 934-938
2. Bouwens L., and Rooman I. Regulation of pancreatic beta-cell mass. Physiol Rev 85 (2005) 1255-1270
3. Breier B.H., Gallaher B.W., and Gluckman P.D. Radioimmunoassay for insulin-like growth factor-I: solutions to some potential problems and pitfalls. J Endocrinol 128 (1991) 347-357
4. Brem G., Hartl P., Besenfelder U., Wolf E., Zinovieva N., and Pfaller R. Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-1) in the mammary gland of transgenic rabbits. Gene 149 (1994) 351-355
5. Clemmons D.R. Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer. Nat Rev Drug Discov 6 (2007) 821-833
6. Dellaporta S.L., Wood J., and Hicks J.B. A plant DNA minipreparation: Version II. Plant Mol Biol Rep 1 (1983) 19-21
7. George M., Ayuso E., Casellas A., Costa C., Devedjian J.C., and Bosch F. Beta cell expression of IGF-I leads to recovery from type 1 diabetes. J Clin Invest 109 (2002) 1153-1163
8. Guo Y., Lu Y., Houle D., Robertson K., Tang Z., Kopchick J.J., et al. Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice. Endocrinology 146 (2005) 2602-2609
9. Hamman J.H., Enslin G.M., and Kotze A.F. Oral delivery of peptide drugs: barriers and developments. BioDrugs 19 (2005) 165-177
10. Hugl S.R., White M.F., and Rhodes C.J. Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells. J Biol Chem 273 (1998) 17771-17779
11. Joly J.C., Leung W.S., and Swartz J.R. Overexpression of Escherichia coli oxidoreductases increases recombinant insulin-like growth factor-I accumulation. Proc Natl Acad Sci USA 95 (1998) 2773-2777
12. Le Roith D. Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. N Engl J Med 336 (1997) 633-640
13. Mahato R.I., Narang A.S., Thoma L., and Miller D.D. Emerging trends in oral delivery of peptide and protein drugs. Crit Rev Ther Drug Carrier Syst 20 (2003) 153-214
14. Morishita M., and Peppas N.A. Is the oral route possible for peptide and protein drug delivery?. Drug Discov Today 11 (2006) 905-910
15. Ning T., Xie T., Qiu Q., Yang W., Zhou S., Zhou L., et al. Oral administration of recombinant human granulocyte-macrophage colony stimulating factor expressed in rice endosperm can increase leukocytes in mice. Biotechnol Lett (2008)
16. Panahi M., Alli Z., Cheng X., Belbaraka L., Belgoudi J., Sardana R., et al. Recombinant protein expression plasmids optimized for industrial E. coli fermentation and plant systems produce biologically active human insulin-like growth factor-1 in transgenic rice and tobacco plants. Transgenic Res 13 (2004) 245-259
17. Pimpl P., Taylor J.P., Snowden C., Hillmer S., Robinson D.G., and Denecke J. Golgi-mediated vacuolar sorting of the endoplasmic reticulum chaperone BiP may play an active role in quality control within the secretory pathway. Plant Cell 18 (2006) 198-211
18. Saukkonen T., Amin R., Williams R.M., Fox C., Yuen K.C., White M.A., et al. Dose-dependent effects of recombinant human insulin-like growth factor (IGF)-I/IGF binding protein-3 complex on overnight growth hormone secretion and insulin sensitivity in type 1 diabetes. J Clin Endocrinol Metab 89 (2004) 4634-4641
19. Savage M.O., Camacho-Hubner C., and Dunger D.B. Therapeutic applications of the insulin-like growth factors. Growth Horm IGF Res 14 (2004) 301-308
20. Wirth S., Calamante G., Mentaberry A., Bussmann L., Lattanzi M., Barañao L., et al. Expression of active human epidermal growth factor (hEGF) in tobacco plants by integrative and non-integrative systems. Mol Breed 13 (2004) 23-35
21. Stoger E., Ma J.K., Fischer R., and Christou P. Sowing the seeds of success: pharmaceutical proteins from plants. Curr Opin Biotechnol 16 (2005) 167-173
22. Sugita K., Endo-Kasahara S., Tada Y., Lijun Y., Yasuda H., Hayashi Y., et al. Genetically modified rice seeds accumulating GLP-1 analogue stimulate insulin secretion from a mouse pancreatic beta-cell line. FEBS Lett 579 (2005) 1085-1088
23. Takagi H., Hiroi T., Yang L., Tada Y., Yuki Y., Takamura K., et al. A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. Proc Natl Acad Sci USA 102 (2005) 17525-17530
24. Takagi H., Saito S., Yang L., Nagasaka S., Nishizawa N., and Takaiwa F. Oral immunotherapy against a pollen allergy using a seed-based peptide vaccine. Plant Biotechnol J 3 (2005) 521-533
25. Takaiwa F. A rice-based edible vaccine expressing multiple T-cell epitopes to induce oral tolerance and inhibit allergy. Immunol Allergy Clin North Am 27 (2007) 129-139
26. Vai M., Brambilla L., Orlandi I., Rota N., Ranzi B.M., Alberghina L., et al. Improved secretion of native human insulin-like growth factor 1 from gas1 mutant Saccharomyces cerevisiae cells. Appl Environ Microbiol 66 (2000) 5477-5479
27. Walmsley A.M., and Arntzen C.J. Plants for delivery of edible vaccines. Curr Opin Biotechnol 11 (2000) 126-129
28. Wu J., Yu L., Li L., Hu J., Zhou J., and Zhou X. Oral immunization with transgenic rice seeds expressing VP2 protein of infectious bursal disease virus induces protective immune responses in chickens. Plant Biotechnol J 5 (2007) 570-578
29. Xia Y., Jin L., Zhang B., Xue H., Li Q., and Xu Y. The potentiation of curcumin on insulin-like growth factor-1 action in MCF-7 human breast carcinoma cells. Life Sci 80 (2007) 2161-2169
30. Xiong X.Y., Li Y.P., Li Z.L., Zhou C.L., Tam K.C., Liu Z.Y., et al. Vesicles from Pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery. J Control Release 120 (2007) 11-17
31. Yakar S., Setser J., Zhao H., Stannard B., Haluzik M., Glatt V., et al. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest 113 (2004) 96-105
32. Yamada Y., Nishizawa K., Yokoo M., Zhao H., Onishi K., Teraishi M., et al. Anti-hypertensive activity of genetically modified soybean seeds accumulating novokinin. Peptides 29 (2008) 331-337
33. Yang D., Guo F., Liu B., Huang N., and Watkins S.C. Expression and localization of human lysozyme in the endosperm of transgenic rice. Planta 216 (2003) 597-603
34. Yang D., Wu L., Hwang Y.S., Chen L., and Huang N. Expression of the REB transcriptional activator in rice grains improves the yield of recombinant proteins whose genes are controlled by a Reb-responsive promoter. Proc Natl Acad Sci USA 98 (2001) 11438-11443
35. Yang L., Tada Y., Yamamoto M.P., Zhao H., Yoshikawa M., and Takaiwa F. A transgenic rice seed accumulating an anti-hypertensive peptide reduces the blood pressure of spontaneously hypertensive rats. FEBS Lett 580 (2006) 3315-3320
36. Yasuda H., Tada Y., Hayashi Y., Jomori T., and Takaiwa F. Expression of the small peptide GLP-1 in transgenic plants. Transgenic Res 14 (2005) 677-684
37. Zinovieva N., Lassnig C., Schams D., Besenfelder U., Wolf E., Muller S., et al. Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations. Transgenic Res 7 (1998) 437-447