Synthesis and assembly of a cholera toxin B subunit-rotavirus VP7 fusion protein in transgenic potato

Molecular Biotechnology

Volumn 31, Issue 3, 2005, Pages 193-202

  Choi, Nak Won ^a   Estes, Mary K ^b   Langridge, William H R ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Adjuvant; Cholera toxin; Edible vaccine; Rotavirus; Solanum tuberosum

Indexed keywords

ADJUVANT; EDIBLE VACCINE; ROTAVIRUS; SOLANUM TUBEROSUM;

ANTIGENS; BIOASSAY; BIOSYNTHESIS; ENZYMES; GENES; IMMUNOLOGY; PLANTS (BOTANY); VIRUSES;

PROTEINS;

CHOLERA TOXIN;

ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE IDENTIFICATION; GENOMICS; NONHUMAN; PLANT GENETICS; POLYMERASE CHAIN REACTION; POTATO; PROTEIN ANALYSIS; ROTAVIRUS;

ANTIGENS, VIRAL; BIOTECHNOLOGY; CAPSID PROTEINS; CHOLERA TOXIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; PLANT LEAVES; PLANTS, GENETICALLY MODIFIED; RECOMBINANT FUSION PROTEINS; SOLANUM TUBEROSUM; TRANSFORMATION, GENETIC;

AGROBACTERIUM TUMEFACIENS; MIRIDAE; ROTAVIRUS; SIMIAN ROTAVIRUS; SOLANUM TUBEROSUM;

EID: 26844433882     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:31:3:193     Document Type: Article

References (39)

1. Mason, H. S., Ball, J. M., Shi, J. J., Jiang, X., Estes, M. K., and Arntzen C. A. (1996) Expression of Norwalk capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc. Natl. Acad. Sci. USA 93, 5335-5340.
2. Arakawa, T., Yu, J., and Langridge, W.H.R. (2001) Synthesis of a cholera toxin B subunit-rotavirus NSP4 fusion protein in potato. Plant Cell Reports 20, 343-348.
3. Thanavala, Y., Yang, Y. F., Lyons, P., and Mason, H. S. (1995) Immunogenicity of transgenic plant-derived hepatitis B surface antigen. Proc. Natl. Acad. Sci. USA 92, 3358-3361.
4. Yu, J. and Langridge, W. H. R. (2001) A plant-based multicomponent vaccine protects mice from enteric diseases. Nat. Biotechnol. 19, 548-552.
5. Zhang, R. G., Scott, D. L., Westrook, M. L., et al. (1995) The three-dimensional crystal structure of cholera toxin. J. Mol. Biol. 251, 563-573.
6. Holmgren, J., Lonnroth, I., Mansson, J-E., and Svennerholm, L. (1975) Interaction of cholera toxin and membrane GM1 ganglioside of small intestine. Proc. Nat. Acad. Sci. USA 72, 2520-2524.
7. Arakawa, T., Yu, J., Chong, D. K., Hough, J., Engen, P. C., and Langridge, W. H. R. (1998) A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes. Nat. Biotechnol. 16, 934-938.
8. Kuziemko, G. M., Stroh, M., and Stevens, R. C. (1996) Cholera toxin binding affinity and specificity for gangliosides determined by surface plasmon resonance. Biochemistry. 35, 6375-6384.
9. Arakawa, T., Chong, D. K., Merritt, J. L., and Langridge, W. H. R. (1997) Expression of cholera toxin B subunit oligomers in transgenic potato plants. Transgenic Res. 16, 403-413.
10. Dertzbaugh, M. T. and Elson, C. O. (1993) Reduction in oral immunogenicity of cholera toxin B subunits by N-terminal peptide addition. Infect. Immunol. 61, 384-390.
11. Sun, J. B., Holmgren, J., and Czerkinsky, C. (1994) Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc. Nat. Acad. Sci. USA 93, 7196-7201.
12. Weiner, H. L. (1994) Oral tolerance. Proc. Nat. Acad. Sci. USA 91, 10762-10765.
13. Dodet, B., Heseltine, E., Mary, C., and Saliou, P. (1997) Rotaviruses in human and veterinary medicine. Sante. 7, 195-199.
14. Glass, R. I., Gentsch, J., and Smith, J. C. (1994) Rotavirus vaccine: success by reassortment? Science 265, 1389-1392.
15. Petrie, B. L., Estes, M. K., and Graham, D. Y. (1983) Effects of tunicamycin on rotavirus morphogenesis and infectivity. J. Virol. 46, 270-274.
16. Greenberg, H. B., Valdesuso, J., Wyke, K. V., et al. (1983) Production and preliminary characterization of monoclonal antibodies directed at two surface proteins of rhesus rotavirus. J. Virol. 47, 267-275.
17. Sahara, M., Gilchrist, J. E., Hudson, G. R., and Babiuk, L. A. (1985) Preliminary characterization of an epitope involved in neutralization and cell attachment that is located on the major bovine rotavirus glycoprotein. J. Virol. 53, 58-66.
18. Hoshino, Y. and Kapikian, A. Z. (1996) Classification of rotavirus VP4 and VP7 serotypes. Arch. Virol. Suppl. 12, 99-111.
19. Mattion, N., Cohen, J., and Estes, M. K. (1994) The rotavirus proteins. In Viral Infections of the Gastroenteritis Tract (Kapikian AZ, ed. Marcel Dekker, New York; pp. 169-249.
20. Greenberg, H. B., Flores, J., Kalica, A. R., et al. (1983) Gene coding assignments for growth restriction, neutralization and subgroup specificities of the W and DS-1 strains of human rotavirus. J. Gen. Virol. 64, 313-320.
21. Dyall-Smith, M. L., Lazdins, I., Tregear, G. W., and Holmes, I. H. (1986) Location of the major antigenic sites involved in rotavirus serotype-specific neutralization. Proc. Natl. Acad. Sci. USA 83, 3465-3468.
22. Offit, P. A., Coupar, B. E., Svoboda, Y. M., et al. (1994) Induction of rotavirus-specific cytotoxic T lymphocytes by vaccinia virus recombinant expressing individual rotavirus genes. Virology 98, 10-16.
23. Wu, Y-Z., Li, J-T., Mou, Z-R., et al. (2003) Oral immunization with rotavirus VP7 expressed in transgenic potatoes induced high titers of mucosal neutralizing IgA. Virology 313, 337-342.
24. + T lymphocytes that mediate clearance of chronic rotavirus infection in SCID mice. J. Virol. 65, 5928-5932.
25. Clements, J. D. (1990) Construction of a nontoxic fusion peptide for immunization against Escherichia coli strains that produce heat-labile enterotoxins. Infect. Immun. 58, 1159-1166.
26. Velten, J., Velton, L., Hain, R., and Schell, J. (1984) Isolation of a dual plant promoter fragment from the Ti plasmid of Agrobacterium tumefaciens. EMBO J. 3, 2723-2730.
27. McGarvey, P. B., Hammond, L., Dienelt, M. M., et al. (1995) Expression of the rabies virus glycoprotein in transgenic tomatoes. Biotechnology 13, 1484-1487.
28. Mason, H. S., Lam, D. M. K., and Arntzen, C. J. (1992) Expression of hepatitis B surface antigen in transgenic plants. Proc. Natl. Acad. Sci. USA 89, 11745-11749.
29. Mead, P. S., Slutsker, L., Dietz, V., et al. (1999) Food-related illness and death in the United States. Emerg. Infect. Dis. 5, 607-625.
30. Bernstein, D. I., Glass, R. I., Rogers, G., Davidson, B. L., and Sack, D. A. (1996) Evaluation of rhesus rotavirus monovalent and tetravalent reassortant vaccines in U.S. children. JAMA 273, 1191-1196.
31. George-Chandy, A., Eriksson, K., Lebens, M., Nordstrom, I., Schon, E., and Holmgren, J. (2001) Cholera toxin B subunit as a carrier molecule promotes antigen presentation and increases CD40 and CD86 expression on antigen-presenting cells. Infect. Immun. 69, 5716-5725.
32. Kim, T. G. and Langridge, W. H. R. (2003) Assembly of cholera toxin B subunit full-length rotavirus NSP4 fusion protein oligomers in transgenic potato. Plant Cell Rep. 21, 884-890.
33. Hoshino, Y. and Kapikian, A. Z. (1996) Classification of rotavirus VP4 and VP7 serotypes. Arch. Virol. Suppl. 12, 179-227.
34. Caust, J., Dyall-Smith, M. L., Lazdins, I., and Holmes, I. H. (1987) Glycosylation, an important modifier of rotavirus antigenicity. Arch. Virol. 96, 123-134.
35. McCrae, M. A. and McCorquodale, J. G. (1987) Expression of a major bovine rotavirus neutralization antigen (VP7c) in Escherichia coli. Gene 55, 9-18.
36. Kabcenell, A. K., Poruchynsky, M. S., Bellamy, A. R., Greenberg, H. B., and Atkinson, P. H. (1988) Two forms of VP7 are involved in assembly of SA11 rotavirus in endoplasmic reticulum. J. Virol. 62, 2929-2941.
37. Clements, J. D., Sack, D. A., Harris, J. R., et al. (1990) Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up. Lancet 335, 270-273.
38. Tacket, C. O., Mason, H. S., Losonsky, G., Estes, M. K., Levine, M. M., and Arntzen, C. J. (2000) Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J. Infect. Dis. 182, 302-305.
39. Tacket, C. O., Mason, H. S., Losonsky, G., Clements, J. D., Levine, M. M., and Arntzen, C. J. (1998) Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nat. Med. 4, 607-609.