Production of recombinant proteins by microbes and higher organisms

Biotechnology Advances

Volumn 27, Issue 3, 2009, Pages 297-306

  Demain, Arnold L ^a   Vaishnav, Preeti ^b  

^a DREW UNIVERSITY   (United States)

^b GIDC   (India)

Author keywords

bacteria; enzymes; filamentous fungi; insect cells; mammalian cells; recombinant proteins; transgenic animals; transgenic plants; yeasts

Indexed keywords

FILAMENTOUS FUNGI; INSECT CELLS; MAMMALIAN CELLS; RECOMBINANT PROTEINS; TRANSGENIC ANIMALS; TRANSGENIC PLANTS;

BACTERIA; BACTERIOLOGY; CATALYSTS; ENZYMES; ESCHERICHIA COLI; ESTERIFICATION; GLYCOSYLATION; MAMMALS; YEAST;

PLANTS (BOTANY);

RECOMBINANT PROTEIN;

BACTERIUM; GENE EXPRESSION; GENETICALLY MODIFIED ORGANISM; PROTEIN; RECOMBINATION; YEAST;

ANIMAL; BACTERIUM; BIOREACTOR; BIOSYNTHESIS; EUKARYOTIC CELL; METABOLISM; METHODOLOGY; PROTEIN ENGINEERING; REVIEW; YEAST;

ANIMALS; BACTERIA; BIOREACTORS; EUKARYOTIC CELLS; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; YEASTS;

ANIMALIA; ARABIDOPSIS; ARABIDOPSIS THALIANA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; FUNGI; HEXAPODA; MAMMALIA; PICHIA PASTORIS; PROKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 61349178501     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2009.01.008     Document Type: Review

References (115)

1. Agathos S.N. Production scale insect cell culture. Biotechnol Adv 9 (1991) 51-68
2. Aldridge S. Downstream processing needs a boost. Gen Eng News 26 1 (2006) 1-51
3. Andersen D.C., and Krummen L. Recombinant protein expression for therapeutic applications. Curr Opin Biotechnol 13 (2002) 117-123
4. Arnold F.H. Design by directed evolution. Acc Chem Res 31 (1998) 125-131
5. Barnard G.C., Henderson G.E., Srinivasan, and Gerngross T.U. High level recombinant protein expression in Ralstonia eutropha using T7 RNA polymerase based amplification. Protein Expr Purif 38 (2004) 264-271
6. Bisbee C.A. Current perspectives on manufacturing and scaleup of biopharmaceuticals. Gen Eng News 13 (1993) 8-10 Aug (Dec)
7. Brem G., Besenfelder U., and Hartl P. Production of foreign proteins in the mammary gland of transgenic mammals. Chim Oggi 11 21 (1993) 25
8. Cantell K., Hirvonen S., Sareneva T., Pirhonen J., and Julkunen I. Differential inactivation of interferons by a protease from human granulocytes. J Interfer Res 12 (1992) 177-183
9. Chew N.J. Emerging technologies: transgenic therapeutics. Biopharm 6 3 (1993) 24-26
10. Choi J.H., and Lee S.Y. Secretory and extracellular production of recombinant proteins using Escherichia coli. Appl Microbiol Biotechnol 64 (2004) 625-635
11. Choi B.K., Bobrowicz P., Davidson R.C., Hamilton S.R., Kung D.H., et al. Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris. Proc Natl Acad Sci U S A 100 (2003) 5022-5027
12. Chou C.P. Engineering cell physiology to enhance recombinant protein production in Escherichia coli. Appl Microbiol Biotechnol 76 (2007) 521-532
13. Christensen T., Woeldike H., Boel E., Mortensen S.B., Hjortshoej K., Thim L., et al. High level expression of recombinant genes in Aspergillus oryzae. Bio/Technology 6 (1988) 1419-1422
14. Clare J.J., Rayment F.B., Ballantine S.P., Sreekrishna K., and Romanos M.A. High level expression of tetanus toxin fragment C in Pichia pastoris strains containing multiple tandem integrations of the gene. Bio/Technology 9 (1991) 455-460
15. CocoMartin J.M., and Harmsen M.M. A review of therapeutic protein expression by mammalian cells. Bioprocess Int 6 Suppl 4 (2008) 28-33
16. Cowan D. Industrial enzyme technology. Trends Biotechnol 14 (1996) 177-178
17. Cregg J.M., Vedvick T.S., and Raschke W.C. Recent advances in the expression of foreign genes in Pichia pastoris. Bio/Technology 11 (1993) 905-910
18. Dale C., Allen A., and Fogarty S. Pichia pastoris: a eukaryotic system for the large-scale production of biopharmaceuticals. Biopharm 12 11 (1999) 36-42
19. Dartar R.V., Cartwright T., and Rosen C.-G. Process economics of animal cell and bacterial fermentations: a case study analysis of tissue plasminogen activator. Bio/Technology 11 (1993) 349-357
20. Demain A.L. The biopharmaceutical revolution. Chem Today (Chim Oggi) 22 (2004) 11-12
21. Dixon B. Enzyme expression. Glycosylation enhances stability. Bio/Technology 9 (1991) 418
22. Dunn-Coleman N.S., Bloebaum P., Berka R., Bodie E., Robinson N., Armstrong G., et al. Commercial levels of chymosin production by Aspergillus. Bio/Technology 9 (1991) 976-981
23. Dunn-Coleman N.S., Bodie E., Carter G.L., and Armstrong G. Stability of recombinant strains under fermentation conditions. In: Kinghorn J.R., and Turner G. (Eds). Applied Molecular Genetics of Fungi (1993), Bluchi and Son, Scotland 152-174
24. Durand H., and Clanet M. Genetic improvement of Trichoderma reesei for large scale cellulase production. Enzyme Microb Technol 10 (1988) 341-346
25. Dutton G. Transgenic animal-based protein products move toward clinical trial. Gen Eng News 16 9 (1996) 37
26. Ebisu S., Takagi H., Kadowaki K., Yamagata H., and Udaka S. Production of human epidermal growth factor by Bacillus brevis increased with a stable plasmid from Bacillus brevis. Biosci Biotechnol Biochem 56 (1992) 812-813
27. Elbein A.D., and Molyneux R.J. Effect of castanospermine on the structure and secretion of glycoprotein enzymes in Aspergillus fumigatus. J Bacteriol 160 (1985) 67-75
28. Falch E. Industrial enzymes-developments in production and application. Biotechnol Adv 9 (1991) 643-658
29. Fieshko J.C. In: Rehm H.J., and Reed G. (Eds). Fermentation technology using recombinant organisms. Biotechnology vol. 7b (1989), VCH Veerlagsgesellschaft, Weinheim 117-140
30. Fischer B., Summer I., and Goodenough P. Isolation, renaturation and formation of disulfide bonds of eukaryotic proteins expressed in Escherichia coli as inclusion bodies. Biotechnol Bioeng 41 (1993) 3-13
31. Fitzgerald D.A. Revving up the green express. Scientist 17 14 (2003) 45-47
32. Gellison G., Janowicz Z.A., Weydemann U., Melber K., Strasser A.W.M., and Hollenberg C.P. High-level expression of foreign genes in Hansenula polymorpha. Biotech Adv 10 (1992) 179-189
33. Gerngross T.U. Advances in the production of human therapeutic proteins in yeasts and filamentous fungi. Nat Biotechnol 22 (2004) 1409-1414
34. Glanz J. Herman: the pharmaceutical industry's next star?. R and D Magazine (1992) 36-42 June
35. Goldwasser E., Kung C.K.-H., and Ellason J. On the mechanism of erythropoietin-induced differentiation. 13. The role of sialic acid in erythropoietin action. J Biol Chem 249 (1974) 4202-4206
36. Goodrick J.C., Xu M., Finnegan R., Schilling B.M., Schiavi S., Hoppe H., and Wan N.C. High-level expression and stabilization of recombinant human chitinase produced in a continuous constitutive Pichia pastoris expression system. Biotech Bioeng 74 (2001) 492-497
37. Griffin T.J., Seth G., Xie H., Bandhakavi S., and Hu W.-S. Advancing mammalian cell culture engineering using genome-scale technologies. Trends Biotechnol 25 (2007) 401-408
38. Hamilton S.R., Bobrowicz P., Bobrowicz B., Davidson T.C., Li H., et al. Production of complex human glycoproteins in yeast. Science 301 (2006) 1244-1246
39. Hansson M., Samuelson P., Nguyen T.N., and Stahl S. General expression vectors for Staphylococcus carnosus enabled efficient production of the outer membrane protein A of Klebsiella pneumoniae. FEMS Microbiol Lett 210 (2002) 263-270
40. He X.S., Bruekner R., and Doi R.H. The protease genes of Bacillus subtilis. Res Microbiol 142 (1991) 797-803
41. Hodgson J. The changing bulk biocatalyst market. Bio/Technology 12 (1994) 789-790
42. Hood E.E. From green plants to industrial enzymes. Enzyme Microb Technol 30 (2002) 279-283
43. Jaeger K.E., Reetz M.T., and Dijkstra B.W. Directed evolution to create enantioselective biocatalysts. ASM News 68 (2002) 556-562
44. Jarvis L.M. A technology bet. DSM's pharma product unit leverages its biotech strength to survive in a tough environment. Chem Eng News 86 29 (2008) 30-31
45. Jenkins N., and Curling E.M. Glycosylation of recombinant proteins: problems and prospects. Enzyme Microb Technol 16 (1994) 354-364
46. Johannes T.W., and Zhao H. Directed evolution of enzymes and biosynthetic pathways. Curr Opin Microbiol 9 (2006) 261-267
47. Kerr D.E., Liang F., Bondiopli K.R., Zhao H., Kreibich G., Wall R.J., and Sun T.-T. The bladder as a bioreactor: urothelium production and secretion of growth hormone into urine. Nat Biotechnol 16 (1998) 75-79
48. Knight P. Baculovirus vectors for making proteins in insect cells. ASM News 57 (1991) 567-570
49. Kuchner O., and Arnold F.H. Directed evolution of enzyme catalysis. Trends Biotechnol 15 (1997) 523-530
50. Kusnadi A.R., Nikolovv Z.L., and Howard J.A. Production of recombinant proteins in transgenic plants: practical considerations. Biotechnol Bioeng 56 (1997) 473-484
51. Lamsa M., and Bloebaum P. Mutation and screening to increase chymosin yield in a genetically-engineered strain of Aspergillus awamori. J Ind Microbiol 5 (1990) 229-238
52. Langer L.J. U.S. biotech symposium focuses on bioprocessing; economic strategies to increase production yields. Gen Eng News 19 1 (1999) 1-14
53. LaVallie E.R., DiBlasio E.A., Kovacic S., Grant K.L., Schendel P.F., and McCoy J.M. A thioredoxin gene fusion expression system that circumvents inclusion body formation in the E. coli cytoplasm. Bio/Technology 11 (1993) 187-193
54. Lee S.Y. High cell density culture of Escherichia coli. Trends Biotechnol 14 (1996) 98-105
55. Luckow V.A., and Summers M.D. Trends in the development of baculovirus expression vectors. Bio/Technology 6 (1988) 47-55
56. Lunn C.A., Kathju S., Wallace B.J., Kushner S.R., and Pigiet V. Amplification and purification of plasmid-encoded thioredoxin from Escherichia coli K12. J Biol Chem 259 (1984) 10469-10474
57. Macauly-Patrick S., Fazenda M.L., McNeil B., and Harvey L.M. Heterologous protein production using the Pichia pastoris expression system. Yeast 22 (2005) 249-270
58. Machida M. Progress of Aspergillus oryzae genomics. Adv Appl Microbiol 51 (2002) 81-106
59. Maiorella B., and Harano D. Large scale insect cell culture for recombinant protein production. Bio/Technology 6 (1988) 1406-1409
60. Maldonado L.M.T.P., et al. Optimization of culture conditions for a synthetic gene expression in Escherichia coli using response surface methodology: the case of human interferon beta. Biomol Eng 24 (2007) 217-222
61. McKown, R.L., Teutonico, R.A., Transgenic animals for production of proteins. Gen Eng News 1999; 19(9): 1,14,29,46,55,60.
62. Mergulhao F.J.M., Summers D.K., and Monteiro G.A. Recombinant protein secretion in Escherichia coli. Biotechnol. Adv. 23 (2005) 177-202
63. Meyer H.P., and Fiechter A. Production of cloned human leukocyte interferon by Bacillus subtilis: optimal production is connected with restrained growth. Appl Environ Microbiol 50 (1985) 503-507
64. Miller L.K. Baculoviruses as gene expression vectors. Annu Rev Microbiol 42 (1988) 177-199
65. Morrow Jr. K.J. Improving protein production processes. Gen Eng News 27 5 (2007) 50-54 1
66. Murashima K., Chen C.-L., Kosugi A., Tamaru Y., Doi R.H., and Wong S.-L. Heterologous production of Clostridium cellulovorans engB, using protease-deficient Bacillus subtilis, and preparation of active recombinant cellulosomes. J Bacteriol 184 (2002) 76-81
67. Nevalainen K.M.H., Te'o V.S.J., and Bergquist P.L. Heterologous protein expression in filamentous fungi. Trends Biotech 23 (2005) 468-474
68. Nunberg J.H., Meade J.H., Cole G., Lawyer F.C., MacCabe P., Schweickart V., et al. Molecular cloning and characterization of the glucoamylase gene of Aspergillus niger. Molec Cell Biol 2 (1984) 2306-2315
69. Parekh R. Polypeptide glycosylation and biotechnology. Biotech Eur 6 1 (1989) 18-21
70. Qiu J. Protein expression systems. Gen Eng News 18 Aug (1998) 17-40
71. Rader R.A. Expression systems for process and product improvement. BioProcess Int 6 Suppl 4 (2008) 4-9
72. Rinderknecht E., O'Connor B.H., and Rodriguez H. Natural human interferon-γ: complete amino acid sequencing and determination of site of glycosylation. J Biol Chem 259 (1984) 6790-6797
73. Rudolph N. Technologies and economics for protein production in transgenic animal milk. Gen Eng News 17 16 (1997) 36-37
74. Ryll T. Antibody production using mammalian cell culture-how high can we push productivity?. Abstr. S146, SIM Ann Mtg Prog and Abstr, San Diego, CA, Aug (2008) 101
75. Salovouri I., Makarow M., Rauvala H., Knowles J., and Kääriäinen L. Low molecular weight high-mannose type glycans in a secreted protein of the filamentous fungus Trichoderma reesei. Bio/Technology 5 (1987) 152-156
76. Sarmientos P., Duchesne M., Denefle P., Boiziau J., Fromage N., Delporte N., et al. Synthesis and purification of active human tissue plasminogen activator from Escherichia coli. Bio/Technology 127 (1989) 495-501
77. Schein C.H. Production of soluble recombinant proteins in bacteria. Bio/Technology 7 (1989) 1141-1149
78. Shiloach J., and Fass R. Growing E. coli to a high cell density - a historical perspective on method development. Biotechnol Adv 23 (2005) 345-357
79. Sohn J.H., Kang H.A., Rao K.J., Kim C.H., Choi E.S., Chung B.H., et al. Current status of the anticoagulant hirudin: its biotechnological production and clinical practice. Appl Microbiol Biotechnol 57 (2001) 606-613
80. Squires C.H., and Lucy P. Vendor voice: a new paradigm for bacterial strain engineering. BioProcess Int 6 Suppl 4 (2008) 22-27
81. Sreekrishana K., Nelles L., Potenz R., Cruze J., Mazzaferro P., et al. High level expression, purification, and characterization of recombinant human tumor necrosis factor synthesized in the methylotrophic yeast Pichia pastoris. Biochemistry 28 (1989) 4117-4125
82. Sterling J. Plant Genetic Systems creates plants that produce peptides. Gen Eng News 9 3 (1989) 1-39
83. Stroh W.H. Trends in the use of industrial bioprocessing enzymes for the 21st century. Gen Eng News 14 16 (1994) 10-12
84. Stroh W.H. Industrial enzymes. Gen Eng News 19 3 (1999) 13-35
85. Swartz J.R. Escherichia coli recombinant DNA technology. In: Neidhardt F.C. (Ed). Escherichia coli and Salmonella: Cellular and Molecular Biology. 2nd ed. (1996), American Society of Microbiology Press, Washington DC 1693-1711
86. Swartz J.R. Advances in Escherichia coli production of therapeutic proteins. Curr Opin Biotechnol 12 (2001) 195-201
87. Terpe K. Overview of bacterial expression systems for heterologous protein production: from molecular and biochemical fundamentals to commercial systems. Appl Microbiol Biotechnol 72 (2006) 211-223
88. Thayer A. Transgenics. Dolly's maker to close its doors. C and E News 86 38 (2003) 9
89. Tobin M.B., Gustafsson C., and Huisman G.W. Directed evolution: the 'rational' basis for 'irrational' design. Curr Opin Struct Biol 10 (2000) 421-427
90. Udaka S., and Yamagata H. Extremely efficient protein secretion system in Bacillus brevis. In: Murooka Y., and Imanaka T. (Eds). Recombinant Microbes for Industrial and Agricultural Applications (1994), Marcel Dekker, New York 71-79
91. Van Hartingsveldt W., van Zeijl C.M., Harteeld G.M., Gouka R.J., Suykerbuyk M.E., et al. Cloning, characterization and overexpression of the phytase-encoding gene (phyA) of Aspergillus niger. Gene 127 (1993) 87-94
92. van Leen R.W., Bakhuis J.G., van Beckhoven R.F.W.C., Burger H., Dorssers L.C.J., et al. Production of human interleukin-3 using industrial microorganisms. Bio/Technology 9 (1991) 47-52
93. Velander W.H., Johnson J.L., Subramanian A., Degener A.W., Morcol T., et al. Expression of human protein in ttransgenic swine. Abstr. 15, 9th Internat Biotechnol Symp., Crystal City, VA, Aug. (1992)
94. Verdoes J.C., Punty P.J., and van den Hondel C.A.M.J.J. Molecular genetic strain improvement for the overproduction of fungal proteins by filamentous fungi. Appl Microbiol Biotechnol 43 (1995) 195-205
95. Verdoes J.C., Punt P.J., Burlingame R., Bartels J., van Dijk R., Slump E., Meens M., Joosten R., and Emalfarb M. A dedicated vector for efficient library construction and high throughput screening in the hyphal fungus Chrysosporium lucknowense. Ind Biotechnol 3 (2007) 48-57
96. Walsh G. Biopharmaceutical benchmarks - 2003. Nat Biotechnol 21 (2003) 865-870
97. Wang Y., Liang Z.-H., Zhang Y.-S., Yao S.-Y., Xu Y.-G., et al. Human insulin from a precursor overexpressed in the methylotrophic yeast Pichia pastoris and a simple procedure for purifying the expression product. Biotech Bioeng 73 (2001) 74-79
98. Ward M., Lin C., Victoria D.C., Fox B.P., Fox J.A., et al. Characterization of humanized antibodies secreted by Aspergillus niger. Appl Environ Microbiol 70 (2004) 2567-2576
99. Ward P.P., Piddlington C.S., Cunningham G.A., Zhou X., Wyatt R.D., and Conneely O.M. A system for production of commercial quantities of human lactoferrin: a broad spectrum natural antibiotic. Bio/technology 13 (1995) 498-503
100. Ward O.P., Qin W.M., Hanjoon J.D., and Singh E.J.Y.A. Physiology and biotechnology of Aspergillus. Adv Appl Microbiol 58 (2006) 1-75
101. Warren C.E. Glycosylation-considerations for protein engineering. Biofutur Eur 7 (1990) 392-394
102. Weikert C., Sauer U., and Bailey J.E. Use of a glycerol-limited, long term chemostat for isolation of Escherichia coli mutants with improved physiological properties. Microbiology 143 (1997) 1567-1574
103. Weikert C., Sauer U., and Bailey J.E. An Escherichia coli host strain useful for efficient overproduction of secreted recombinant protein. Biotechnol Bioeng 59 (1998) 386-391
104. Werten M.W.T., van den Bosch T.J., Wind R.D., Mooibroek H., and De Wolf F.A. High-yield secretion of recombinant gelatins by Pichia pastoris. Yeast 15 (1999) 1087-1096
105. Wilkinson B.E., and Cox M. Baculovirus expression system: the production of proteins for diagnostic, human therapeutic or vaccine use. Gen Eng News 18 (1998) 35 (Nov)
106. Wittwer A.J., and Howard S.C. Glcosylation at Asn-184 inhibits the conversion of single-chain to two-chain tissue-type plasminogen activator by plasmin. Biochemistry 29 (1990) 4175-4180
107. Wong M.S., Wu S., Causey T.B., Bennett G.N., and San K.-Y. Reduction of acetate accumulation in Escherichia coli cultures for increased recombinant protein production. Metab Eng 10 (2008) 97-108
108. Wright G., Carver A., Cottom D., Reeves D., Scott A., et al. High level expression of active human alpha-1-antitrypsin in the milk of transgenic sheep. Bio/Technology 9 (1991) 830-834
109. Wrotnowski C. Animal cell culture; novel systems for research and production. Gen Eng News 18 3 (1998) 13-37
110. Wu X.-C., Lee W., Tran L., and Wong S.-L. Engineering a Bacillus subtilis expression-secretion system with a strain deficient in six extracellular proteases. J Bacteriol 173 (1991) 4952-4958
111. Wurm F., and Bernard A. Large scale transient expression in mammalian cells for recombinant protein production. Curr Opin Biotechnol 10 (1999) 156-159
112. Yamaguchi K., Akai K., Kawanishi G., Ueda M., and Masuda S. Effects of site-directed removal of N-glycosylation sites in human erythropoietin on its production. J Biol Chem 266 (1991) 20434-20439
113. Yu E.Y. High-yield mAb expression: ACE system testing and process development. Abstract, BIOT 239. 232nd ACS Natl Mtg, San Francisco (2006) 114
114. Zhang J., and Robinson D. Development of animal-free, protein-free and chemically-defined media for NS0 cell culture. Cytotechnology 48 (2005) 59-74
115. Zhang J., Robinson D., and Salmon P. Selenite as a novel and highly effective iron carrier for Chinese Hamster Ovary cell growth and biopharmaceutical production. Soc Indust Microbiol (SIM) abstract S-8 (2006) 67 SIM Ann Mtg Prog and Abstr