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1
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0004947365
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Division of Microbiology and Infectious Diseases: Bethesda, MD: National Institute of Allergy and Infectious Diseases
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Division of Microbiology and Infectious Diseases: The Jordan Report: Accelerated Development of Vaccines. Bethesda, MD: National Institute of Allergy and Infectious Diseases; 1998.
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(1998)
The Jordan Report: Accelerated Development of Vaccines
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2
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0031863854
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Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato
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This landmark paper describes the first human clinical trial of a plant-derived, edible vaccine. Oral delivery of the plant-derived vaccinogen enabled recognition of the vaccinogen by the human immune system and induction of a mucosal immune response
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Tacket C.O., Mason H.S., Losonsky G., Clements J.D., Levine M.M., Arntzen C.J. Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nat Med. 4:1998;607-609. This landmark paper describes the first human clinical trial of a plant-derived, edible vaccine. Oral delivery of the plant-derived vaccinogen enabled recognition of the vaccinogen by the human immune system and induction of a mucosal immune response.
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Nat Med
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Tacket, C.O.1
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3
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Expression of hepatitis B surface antigen in transgenic plants
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Ehsani, P.1
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0028863460
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Expression of the rabies virus glycoprotein in transgenic tomatoes
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McGarvey P.B., Hammond J., Dienelt M.M., Hooper D.C., Fu Z.F., Dietzschold B., Kiprowski H., Michaels F.H. Expression of the rabies virus glycoprotein in transgenic tomatoes. Bio/Technology. 13:1995;1484-1487.
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7
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0031281621
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Expression of cholera toxin B subunit oligomers in transgenic potato plants
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Arakawa T., Chong D.K.X., Merritt J.L., Langridge W.H.R. Expression of cholera toxin B subunit oligomers in transgenic potato plants. Trans Res. 6:1997;403-413.
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8
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0033529588
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Development of biopharmaceuticals in plant expression systems: Cloning, expression and immunological reactivity of human cytomegalovirus glycoprotein B (UL55) in seeds of transgenic tobacco
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The first report of tissue specific expression of a vaccinogen is given by this paper. It was demonstrated that the rice glutelin promoter can direct expression of a vaccinogen from the human cytomegalovirus specifically to the seeds of tobacco
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Tackaberry E.S., Dudani A.K., Prior F., Tocchi M., Sardana R., Altosaar I., Ganz P.R. Development of biopharmaceuticals in plant expression systems: cloning, expression and immunological reactivity of human cytomegalovirus glycoprotein B (UL55) in seeds of transgenic tobacco. Vaccine. 17:1999;3020-3029. The first report of tissue specific expression of a vaccinogen is given by this paper. It was demonstrated that the rice glutelin promoter can direct expression of a vaccinogen from the human cytomegalovirus specifically to the seeds of tobacco.
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Vaccine
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9
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Haq T.A., Mason H.S., Clements J.D., Arntzen C.J. Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science. 268:1995;714-716.
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Haq, T.A.1
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12
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0029891823
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Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice
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Mason H.S., Ball J.M., Shi J-J., Jiang X., Estes M.K., Arntzen C.J. Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci USA. 93:1996;5340-5353.
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13
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Carillo C., Wigdorovitz A., Oliveros J.C., Zamorano P.I., Sadir A.M., Gomez N., Salinas J., Escribano J.M., Borca M.V. Protective immune response to foot-and-mouth disease virus with VP1 expressed in transgenic plants. J Virol. 72:1998;1688-1690.
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14
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16
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Clarke B.E., Brown A.L., Grace K.G., Hastings G.Z., Brown F., Rowlands D.J., Francis M.J. Presentation and immunogenicity of viral epitopes on the surface of hybrid hepatits B virus core particles produced in bacteria. J Gen Virol. 71:1990;1109-1117.
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Usha R., Rohll J.B., Spall V.E., Shanks M., Maule A.J., Johnson J.E., Lomonossoff G.P. Expression of an animal virus antigenic site on the surface of a plant virus particle. Virology. 197:1993;366-374.
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Development of cowpea mosaic virus as a high-yielding system for the presentation of foreign peptides
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Porta C., Spall V.E., Loveland J., Johnson J.E., Barker P.J., Lomonossoff G.P. Development of cowpea mosaic virus as a high-yielding system for the presentation of foreign peptides. Virology. 202:1994;949-955.
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22
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Stimulation of neutralizing antibodies to human immunodeficiency virus type 1 in three strains of mice immunized with a 22 amino acid peptide of gp41 expressed on the surface of a plant virus
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McLain L., Durrani Z., Wisniewski L.A., Porta C., Lomonossoff G.P., Dimmock N.J. Stimulation of neutralizing antibodies to human immunodeficiency virus type 1 in three strains of mice immunized with a 22 amino acid peptide of gp41 expressed on the surface of a plant virus. Vaccine. 14:1996;799-810.
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McLain, L.1
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23
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Presentation of a foreign peptide on the surface of tomato bushy stunt virus
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Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1
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Yusibov V., Modelska A., Steplewski K., Agadjanyan M., Weiner D., Hooper D.G., Koprowski H. Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1. Proc Natl Acad Sci USA. 94:1997;5784-5788.
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Dalsgaard K., Uttenthal A., Jones T.D., Xu F., Merryweather A., Hamilton W.D.O., Langeveld J.P.M., Boshuizen R.S., Kamstrup S., Lomonossoff G.P.et al. Plant-derived vaccine protects target animals against a viral disease. Nat Biotechnol. 15:1997;248-252.
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Intranasal immunization with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and systemic HIV-1-specific IgA and IgG than oral immunization
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Durrani Z., McInerney T.L., McLain L., Jones T., Bellaby T., Brennan F.R., Dimmock N.J. Intranasal immunization with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and systemic HIV-1-specific IgA and IgG than oral immunization. J Immunol Methods. 220:1998;93-103.
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Pseudomonas aeroginosa outer-membrane protein F epitopes are highly immunogenic in mice when expressed on a plant virus
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Protective immunity against murine hepatitis virus (MHV) induced by intranasal or subcutaneous administration of hybrids of tobacco mosaic virus that carries an MHV epitope
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Koo M., Bendahmane M., Lettieri G.A., Paoletti A.D., Lane T.E., Fitchen J.H., Buchmeier M.J., Beachy R.N. Protective immunity against murine hepatitis virus (MHV) induced by intranasal or subcutaneous administration of hybrids of tobacco mosaic virus that carries an MHV epitope. Proc Natl Acad Sci USA. 96:1999;7774-7779.
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Induction of a protective antibody response to foot and mouth disease virus in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viral structural protein VP1
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Wigdorovitz A.W., Carrillo C. Dus, Santos, M.J., Trono, K., Peralta, A., Gomez, M.C., Rios, R.D., Franzone, P.M., Sadir, A.M., Escribano, J.M., Borca, M.V. Induction of a protective antibody response to foot and mouth disease virus in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viral structural protein VP1 Virology. 255:1999;347-353.
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Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): Potatoes expressing a synthetic LT-B gene
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The ability of a synthetic gene to increase the stability of mRNA and hence gene expression is demonstrated in this report. After constructing a plant-optimized synthetic gene, transgene expression levels were increased 3-14-fold when compared to wild-type transgene expression
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Mason H.S., Haq T.A., Clements J.D. Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene. Vaccine. 16:1998;1336-1343. The ability of a synthetic gene to increase the stability of mRNA and hence gene expression is demonstrated in this report. After constructing a plant-optimized synthetic gene, transgene expression levels were increased 3-14-fold when compared to wild-type transgene expression.
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Chimeric plant virus particles administered nasally or orally induce systemic and mucosal immune responses in mice
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This paper extensively researches the immune response elicited after mucosal delivery of a plant-derived vaccine. It demonstrates the ability of a nasally administered vaccinogen to induce a mucosal immune response in multiple distant sites without the requirement of an adjuvant
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Brennan F.R., Bellaby T., Helliwell S.M., Jones T.D., Kamstrup S., Dalsgaard K., Flock J-I., Hamilton W.D.O. Chimeric plant virus particles administered nasally or orally induce systemic and mucosal immune responses in mice. J Virol. 73:1999;930-938. This paper extensively researches the immune response elicited after mucosal delivery of a plant-derived vaccine. It demonstrates the ability of a nasally administered vaccinogen to induce a mucosal immune response in multiple distant sites without the requirement of an adjuvant.
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35
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Immunization against rabies with a plant-derived antigen
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Induction of a significant mucosal immune response after oral immunization with a chimeric plant virus is described for the first time in this paper. Mice fed chimeric virus-infected spinach leaves displayed significant local and systemic immune responses. The immune responses were approximately two times higher than the responses induced by 10 times as much purified chimeric virus delivered through gastric intubation
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Modelska A., Dietzschold B., Sleysh N., Fu Z.F., Steplewski K., Hooper D.C., Kiprowski H., Yusibov V. Immunization against rabies with a plant-derived antigen. Proc Natl Acad Sci USA. 95:1998;2481-2485. Induction of a significant mucosal immune response after oral immunization with a chimeric plant virus is described for the first time in this paper. Mice fed chimeric virus-infected spinach leaves displayed significant local and systemic immune responses. The immune responses were approximately two times higher than the responses induced by 10 times as much purified chimeric virus delivered through gastric intubation.
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