Production of human α-1-antitrypsin from transgenic rice cell culture in a membrane bioreactor

Biotechnology Progress

Volumn 21, Issue 3, 2005, Pages 728-734

  McDonald, Karen A ^a   Lo, Ming Hong ^a   Trombly, David M ^a   Xie, Qing ^a   Jackman, Alan P ^a  

^a University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOREACTORS; CELLS; PLANT CELL CULTURE; SUGARS;

EXTRACELLULAR PROTEINS; MEMBRANE BIOREACTORS; PRODUCT CONCENTRATION; TRANSGENIC PLANT CELL CULTURES;

BIOTECHNOLOGY;

ALPHA 1 ANTITRYPSIN; RECOMBINANT PROTEIN; SERPINA1 PROTEIN, HUMAN;

ARTICLE; ARTIFICIAL MEMBRANE; BIOREACTOR; BIOSYNTHESIS; CELL LINE; CULTURE TECHNIQUE; EQUIPMENT; EQUIPMENT DESIGN; EVALUATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; INSTRUMENTATION; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROTEIN ENGINEERING; RICE; TRANSGENIC PLANT;

ALPHA 1-ANTITRYPSIN; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL LINE; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HUMANS; MEMBRANES, ARTIFICIAL; ORYZA SATIVA; PLANTS, GENETICALLY MODIFIED; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

EID: 20144367975     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp0496676     Document Type: Article

References (44)

1. Fischer, R.; Emans, N.; Schuster, F.; Hellwig, S.; Drossard, J. Towards molecular farming in the future: Using plant-cell-suspension cultures as bioreactors. Biotechnol. Appl. Biochem. 1999, 30, 109-112.
2. Doran, P. M. Foreign protein production in plant tissue cultures. Curr. Opin. Biotechnol. 2000, 11, 199-204.
3. Magnuson, N. S.; Linzmaier, P. M.; Reeves, R.; An, G.; Hayglass, K.; Lee, J. M. Secretion of biologically active human interleukin-2 and interleukin-4 from genetically modified tobacco cells in suspension culture. Protein Expression Purif. 1998, 13, 45-52.
4. Wongsamuth, R.; Doran, P. M. Production of monoclonal antibodies by tobacco hairy roots. Biotechnol. Bioeng. 1997, 54, 401-415.
5. Fischer, R.; Liao, Y.-C.; Drossard, J. Affinity-purification of a TMV-specific recombinant full-size antibody from a transgenic tobacco suspension culture. J. Immunol. Methods 1999, 226, 1-10.
6. James, E. A.; Wang, C.; Wang, Z.; Reeves, R.; Shin, J. H.; Magnuson, N. S.; Lee, J. M. Production and characterization of biologically active human GM-CSF secreted by genetically modified plant cells. Protein Expression Purif. 2000, 19, 131-138.
7. Kwon, T.-H.; Shin, Y.-M.; Kim, Y.-S.; Jang, Y.-S.; Yang, M.-S. Secretory production of hGM-CSF with a high specific biological activity by transgenic plant cell suspension culture. SO - Biotechnol. Bioprocess Eng. 2003, 8, 135-141.
8. Shin, Y.-J.; Hong, S.-Y.; Kwon, T.-H.; Jang, Y.-S.; Yang, M.-S. High level of expression of recombinant human granulocyte-macrophage colony stimulating factor in transgenic rice cell suspension culture. Biotechnol. Bioeng. 2003, 82, 778-783.
9. Hong, S.-Y.; Kwon, T.-H.; Lee, J.-H.; Jang, Y.-S.; Yang, M.-S. Production of biologically active hG-CSF by transgenic plant cell suspension culture. Enzyme Microb. Technol. 2002, 30, 763-767.
10. Terashima, M.; Murai, Y.; Kawamura, M.; Nakanishi, S.; Stoltz, T.; Chen, L.; Drohan, W.; Rodriguez, R. L.; Katoh, S. Production of functional human alpha1-antitrypsin by plant cell culture. Appl. Microbiol. Biotechnol. 1999, 52, 516-523.
11. Huang, J.; Sutliff, T. D.; Wu, L.; Nandi, S.; Benge, K.; Terashima, M.; Ralston, A. H.; Drohan, W.; Huang, N.; Rodriguez, R. L. Expression and purification of functional human α-1-antitrypsin from cultured plant cells. Biotechnol. Prog. 2001, 17, 126-133.
12. Trexler, M. M.; McDonald, K. A.; Jackman, A. P. Bioreactor production of human α1-antitrypsin using metabolically regulated plant cell cultures. Biotechnol. Prog. 2002, 18, 501-508.
13. Sijmons, P. C.; Hoekema, A.; Dekker, B. M. M.; Schrammeijer, B.; Verwoerd, T. C.; Van, D. E. P. J. M. Production of heterologous proteins in plants and plant cells. Off. Gaz. U.S. Pat. Trademark Off. Pat. 1998, 1207, 1305.
14. Sharp, J. M.; Doran, P. M. Effect of bacitracin on growth and monoclonal antibody production by tobacco hairy roots and cell suspensions. Biotechnol. Bioprocess Eng. 1999, 253-258.
15. Hellwig, S.; Drossard, J.; Twyman, R.; Fischer, R. Plant cell cultures for the production of recombinant proteins. Nat. Biotechnol. 2004, 22, 1415-1422.
16. Su, W. W.; Caram, H. S.; Humphrey, A. E. Optimal Design of the Tubular Microporous Membrane Aerator for Shear Sensitive Cell Culture. Biotechnol. Prog. 1992, 8, 19-24.
17. Qi, H. N.; Goudar, C. T.; Michaels, J. D.; Henzler, H.-J.; Jovanovic, G. N.; Konstantinov, K. B. Experimental and theoretical analysis of tubular membrane aeration for mammalian cell bioreactors. Biotechnol. Prog. 2003, 19, 1183-1189.
18. Ben Aim, R. M.; Semmens, M. J. Membrane bioreactors for wastewater treatment and reuse: A success story. Water Sci. Technol. 2003, 47, 1-5.
19. Jager, V.; Kobold, A. Propagation of Spodoptera frugiperda cells (Sf9) and production of recombinant proteins with the baculovirus expression system using improved spinner flasks with membrane aeration. Biotechnol. Tech. 1995, 9, 435-440.
20. Payne, G. F.; Payne, N. N.; Shuler, M. L. Bioreactor considerations for secondary metabolite production from plant cell tissue culture indole alkaloids from Catharanthus roseus. Biotechnol. Bioeng. 1988, 31, 905-912.
21. Blank, C.; Brantly, M. Clinical features and molecular characteristics of α-1-antitrypsin deficiency. Ann. Allergy 1994, 72, 105-121.
22. Huang, J.; Wu, L.; Yalda, D.; Adkins, Y.; Kelleher, S. L.; Crane, M.; Lonnerdal, B.; Rodriguez, R. L.; Huang, N. Expression of functional recombinant human lysozyme in transgenic rice cell culture. Transgenic Res. 2002, 11, 229-239.
23. McDonald, K. A.; Jackman, A. P.; Hurst, S. Characterization of plant suspension cultures using the focused beam reflectance technique. Biotechnol. Lett. 2001, 23, 317-324.
24. Stoger, E.; Sack, M.; Perrin, Y.; Vaquero, C.; Torres, E.; Twyman, R. M.; Christou, P.; Fischer, R. Practical considerations for pharmaceutical antibody production in different crop systems. Mol. Breeding 2002, 9, 149-158.
25. Scott, L. E.; Aggett, H.; Glencross, D. K. Manufacture of pure monoclonal antibodies by heterogeneous culture without downstream purification. Biotechniques 2001, 31, 666-668.
26. Trebak, M.; Chong, J. M.; Herlyn, D.; Speicher, D. W. Efficient laboratory-scale production of monoclonal antibodies using membrane-based high-density cell culture technology. J. Immunol. Methods 1999, 230, 59-70.
27. Bruce, M. P.; Boyd, V.; Duch, C.; White, J. R. Dialysis-based bioreactor systems for the production of monoclonal antibodies: Alternatives to ascites production in mice. J. Immunol. Methods 2002, 264, 59-68.
28. Nagel, A.; Koch, S.; Valley, U.; Emmrich, F.; Marx, U. Membrane-Based Cell Culture Systems - An Alternative to in Vivo Production of Monoclonal Antibodies. In Developments in Biological Standardization. Alternatives to Animals in the Development and Control of Biological Products for Human and Veterinary Use; S. Karger Publishing: Basel, Switzerland, 1999; pp 57-64.
29. Docagne, F.; Colloc'h, N.; Bougueret, V.; Page, M.; Paput, J.; Tripier, M.; Dutartre, P.; MacKenzie, E. T.; Buisson, A.; Komesli, S.; Vivien, D. A soluble transforming growth factor-beta (TGF-beta) type I receptor mimics TGF-beta responses. J. Biol. Chem. 2001, 276, 46243-46250.
30. Huang, N.; Chandler, J.; Thomas, B. R.; Koizumi, N.; Rodriguez, R. L. Metabolic regulation of alpha-amylase gene expression in transgenic cell cultures of rice (Oryza sativa L.). Plant Mol. Biol. 1993, 23, 737-747.
31. Thompson, J. A.; Abdullah, R.; Cocking, E. C. Protoplast culture of rice (Oryza sativa L.) using media solidified with agarose. Plant Sci. 1986, 47, 123-133.
32. Terashima, M.; Ejiri, Y.; Hashikawa, N.; Yoshida, H. Effect of osmotic pressure on human alpha(1)-antitrypsin production by plant cell culture. Biochem. Eng. J. 1999, 4, 31-36.
33. Beatty, K.; Bieth, J.; Travis, J. Kinetics of association of serine proteinases with native and oxidized α-1-proteinase inhibitor and α-1-antichymotrypsin. J. Biol. Chem. 1980, 255, 3931-3934.
34. Wilczynska, M.; Fa, M.; Karolin, J.; Ohlsson, P.; Johansson, L.; Ny, T. Structural Insights into Serpin-Protease Complexes Reveal the Inhibitory Mechanism of Serpins. Nat. Struct. Biol. 1997, 4, 354-357.
35. Doran, P. M. Design of mixing systems for plant cell suspensions in stirred reactors. Biotechnol. Prog. 1999, 15, 319-335.
36. Sijmons, P. C.; Dekker, B. M. M.; Schrammeijer, B.; Verwoerd, T. C.; Van, D. E. P. J. M.; Hoekema, A. Production of Correctly Processed Human Serum Albumin in Transgenic Plants. Biotechnology 1990, 8, 217-221.
37. Kwon, T.-H.; Kim, Y.-S.; Lee, J.-H.; Yang, M.-S. Production and secretion of biologically active human granulocyte-macrophage colony stimulating factor in transgenic tomato suspension cultures. Biotechnol. Lett. 2003, 25, 1571-1574.
38. Firek, S.; Draper, J.; Owen, M. R. L.; Gandecha, A.; Cockburn, B.; Whitelam, G. C. Secretion of a functional single-chain Fv protein in transgenic tobacco plants and cell suspension cultures. Plant Mol. Biol. 1993, 23, 861-870.
39. 1-antitrypsin using metabolically induced plant cell suspension cultures. Biotechnol. Prog. 2005, 21, 321-328.
40. Wolf, M. CELLine Technical Report I: CELLine Overview. Application: Introduction. http://www.integra-biosciences.com/ pdf/cell_culture/ IBS_Tech_Sheet1.pdf. Accessed December 26, 2004.
41. Fischer, R.; Schillberg, S.; Emans, N. Molecular farming of medicines: A field of growing promise. Outlook Agric. 2001, 30, 31-36.
42. Ramakrishnan, D.; Luyk, D.; Curtis, W. R. Monitoring biomass in root culture systems. Biotechnol. Bioeng. 1999, 62, 711-721.
43. Steward, N.; Martin, R.; Engasser, J. M.; Goergen, J. L. Determination of growth and lysis kinetics in plant cell suspension cultures from the measurement of esterase release. Biotechnol. Bioeng. 1999, 66, 114-121.
44. Weston, A. D.; Hood, L. Systems biology, proteomics, and the future of health care: Toward predictive, preventative, and personalized medicine. J. Proteome Res. 2004, 3, 179-196.