Activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine

Science

Volumn 329, Issue 5993, 2010, Pages 849-853

  Manicassamy, Santhakumar ^a   Reizis, Boris ^b   Ravindran, Rajesh ^a   Nakaya, Helder ^a   Salazar Gonzalez, Rosa Maria ^a,c   Wang, Yi Chong ^a   Pulendran, Bali ^a,d  

^a EMORY UNIVERSITY   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

ANTIGEN; CELL ORGANELLE; DIGESTIVE SYSTEM DISORDER; DISEASE PREVALENCE; ENZYME ACTIVITY; FUNCTIONAL MORPHOLOGY; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNITY; METABOLISM; NUMERICAL MODEL; PATHOGENICITY; PHYSIOLOGICAL RESPONSE; PROTEIN; RODENT; TOLERANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CECUM; CONTROLLED STUDY; DENDRITIC CELL; EFFECTOR CELL; ENTERITIS; IMMUNITY; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; INTESTINE; LAMINA PROPRIA; LYMPHOCYTE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SPLEEN;

ANIMALS; BETA CATENIN; CYTOKINES; DENDRITIC CELLS; GENE EXPRESSION PROFILING; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SELF TOLERANCE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; TRETINOIN; WNT PROTEINS;

EID: 77955634800     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1188510     Document Type: Article

References (36)

1. R. M. Steinman, J. Banchereau, Nature 449, 419 (2007).
2. B. Pulendran, Immunol. Rev. 199, 227 (2004).
3. R. M. Steinman, D. Hawiger, M. C. Nussenzweig, Annu. Rev. Immunol. 21, 685 (2003).
4. T. Kawai, S. Akira, Nat. Immunol. 11, 373 (2010).
5. G. Chen, M. H. Shaw, Y. G. Kim, G. Nuñez, Annu. Rev. Pathol. 4, 365 (2009).
6. T. B. Geijtenbeek, S. I. Gringhuis, Nat. Rev. Immunol. 9, 465 (2009).
7. S. Manicassamy, B. Pulendran, Semin. Immunol. 21, 185 (2009).
8. A. Izcue, J. L. Coombes, F. Powrie, Annu. Rev. Immunol. 27, 313 (2009).
9. Y. Belkaid, K. Tarbell, Annu. Rev. Immunol. 27, 551 (2009).
10. C. M. Sun et al., J. Exp. Med. 204, 1775 (2007).
11. T. L. Denning, Y. C. Wang, S. R. Patel, I. R. Williams, B. Pulendran, Nat. Immunol. 8, 1086 (2007).
12. J. L. Coombes et al., J. Exp. Med. 204, 1757 (2007).
13. Materials and methods are available as supporting material on Science Online.
14. F. J. Staal, T. C. Luis, M. M. Tiemessen, Nat. Rev. Immunol. 8, 581 (2008).
15. A. Lehtonen et al., J. Leukoc. Biol. 82, 710 (2007).
16. J. Zhou, P. Cheng, J. I. Youn, M. J. Cotter, D. I. Gabrilovich, Immunity 30, 845 (2009).
17. H. Clevers, Cell 127, 469 (2006).
18. S. Maretto et al., Proc. Natl. Acad. Sci. U.S.A. 100, 3299 (2003).
19. A. Jiang et al., Immunity 27, 610 (2007).
20. V. Brault et al., Development 128, 1253 (2001).
21. M. L. Caton, M. R. Smith-Raska, B. Reizis, J. Exp. Med. 204, 1653 (2007).
22. S. Uematsu et al., Nat. Immunol. 9, 769 (2008).
23. I. I. Ivanov et al., Cell 126, 1121 (2006).
24. T. Korn, E. Bettelli, M. Oukka, V. K. Kuchroo, Annu. Rev. Immunol. 27, 485 (2009).
25. K. Atarashi et al., Nature 455, 808 (2008).
26. S. Manicassamy, B. Pulendran, Semin. Immunol. 21, 22 (2009).
27. S. Manicassamy et al., Nat. Med. 15, 401 (2009).
28. I. I. Ivanov et al., Cell Host Microbe 4, 337 (2008).
29. C. Zaph et al., J. Exp. Med. 205, 2191 (2008).
30. J. A. Hall et al., Immunity 29, 637 (2008).
31. P. Clément-Lacroix et al., Proc. Natl. Acad. Sci. U.S.A. 102, 17406 (2005).
32. J. H. Cho, C. T. Weaver, Gastroenterology 133, 1327 (2007).
33. M. Rescigno, U. Lopatin, M. Chieppa, Curr. Opin. Immunol. 20, 669 (2008).
34. G. Matteoli et al., Gut 59, 595 (2010).
35. K. R. Siddiqui, S. Laffont, F. Powrie, Immunity 32, 557 (2010).
36. We thank S.A. Mertens and L. Bronner for assistance with cell sorting and D. Levesque (Emory Vaccine Center) and D. Bonenberger for assistance with maintenance of mice strains at the Emory Vaccine Center vivarium. The work in the laboratory of BP was supported by grants U54AI057157, R37AI48638, R01DK057665, U19AI057266, HHSN266 200700006C, NO1 AI50019, and NO1 AI50025 from the National Institutes of Health and a grant from the Bill & Melinda Gates Foundation. Microarray accession number is GSE2213 (http://www. ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22136).