메뉴 건너뛰기




Volumn 3, Issue 6, 2011, Pages 649-665

Postgenomic technologies targeting the Wnt signaling network

Author keywords

[No Author keywords available]

Indexed keywords

CATENIN; WNT PROTEIN;

EID: 80053535558     PISSN: 19395094     EISSN: 1939005X     Source Type: Journal    
DOI: 10.1002/wsbm.140     Document Type: Review
Times cited : (2)

References (130)
  • 1
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in development and disease.
    • Clevers H. Wnt/β-catenin signaling in development and disease. Cell 2006, 127:469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 2
    • 19644373254 scopus 로고    scopus 로고
    • Wnt signaling in disease and in development.
    • Nusse R. Wnt signaling in disease and in development. Cell Res 2005, 15:28-32.
    • (2005) Cell Res , vol.15 , pp. 28-32
    • Nusse, R.1
  • 3
    • 4344584730 scopus 로고    scopus 로고
    • WNT and β-catenin signalling: diseases and therapies.
    • De
    • Moon RT, Kohn AD, De Ferrari GV, Kaykas A. WNT and β-catenin signalling: diseases and therapies. Nat Rev Genet 2004, 5:691-701.
    • (2004) Nat Rev Genet , vol.5 , pp. 691-701
    • Moon, R.T.1    Kohn, A.D.2    Ferrari, G.V.3    Kaykas, A.4
  • 4
    • 0032916351 scopus 로고    scopus 로고
    • WNT targets. Repression and activation.
    • Nusse R. WNT targets. Repression and activation. Trends Genet 1999, 15:1-3.
    • (1999) Trends Genet , vol.15 , pp. 1-3
    • Nusse, R.1
  • 5
    • 0032406715 scopus 로고    scopus 로고
    • Mechanisms of Wnt signaling in development.
    • Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 1998, 14: 59-88.
    • (1998) Annu Rev Cell Dev Biol , vol.14 , pp. 59-88
    • Wodarz, A.1    Nusse, R.2
  • 6
    • 48449105489 scopus 로고    scopus 로고
    • Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal.
    • Yi F, Pereira L, Merrill BJ. Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Stem Cells 2008, 26:1951-1960.
    • (2008) Stem Cells , vol.26 , pp. 1951-1960
    • Yi, F.1    Pereira, L.2    Merrill, B.J.3
  • 7
    • 52449116723 scopus 로고    scopus 로고
    • WNT signaling in stem cell biology and regenerative medicine.
    • Katoh M. WNT signaling in stem cell biology and regenerative medicine. Curr Drug Targets 2008, 9:565-570.
    • (2008) Curr Drug Targets , vol.9 , pp. 565-570
    • Katoh, M.1
  • 8
    • 34748837360 scopus 로고    scopus 로고
    • Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
    • Katoh M. Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis. Stem Cell Rev 2007, 3:30-38.
    • (2007) Stem Cell Rev , vol.3 , pp. 30-38
    • Katoh, M.1
  • 9
    • 34748853361 scopus 로고    scopus 로고
    • The Wnt signal transduction pathway in stem cells and cancer cells: influence on cellular invasion.
    • Neth P, Ries C, Karow M, Egea V, Ilmer M, Jochum M. The Wnt signal transduction pathway in stem cells and cancer cells: influence on cellular invasion. Stem Cell Rev 2007, 3:18-29.
    • (2007) Stem Cell Rev , vol.3 , pp. 18-29
    • Neth, P.1    Ries, C.2    Karow, M.3    Egea, V.4    Ilmer, M.5    Jochum, M.6
  • 10
    • 0033590172 scopus 로고    scopus 로고
    • Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways.
    • Miller JR, Hocking AM, Brown JD, Moon RT. Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways. Oncogene 1999, 18:7860-7872.
    • (1999) Oncogene , vol.18 , pp. 7860-7872
    • Miller, J.R.1    Hocking, A.M.2    Brown, J.D.3    Moon, R.T.4
  • 11
    • 37349025355 scopus 로고    scopus 로고
    • SnapShot: noncanonical Wnt signaling pathways.
    • Semenov MV, Habas R, Macdonald BT, He X. SnapShot: noncanonical Wnt signaling pathways. Cell 2007, 131:1378.
    • (2007) Cell , vol.131 , pp. 1378
    • Semenov, M.V.1    Habas, R.2    Macdonald, B.T.3    He, X.4
  • 12
    • 0345343608 scopus 로고    scopus 로고
    • Nuclear localization of β-catenin by interaction with transcription factor LEF-1.
    • Huber O, Korn R, McLaughlin J, Ohsugi M, Herrmann BG, Kemler R. Nuclear localization of β-catenin by interaction with transcription factor LEF-1. Mech Dev 1996, 59:3-10.
    • (1996) Mech Dev , vol.59 , pp. 3-10
    • Huber, O.1    Korn, R.2    McLaughlin, J.3    Ohsugi, M.4    Herrmann, B.G.5    Kemler, R.6
  • 13
    • 0028572556 scopus 로고
    • E-cadherin and APC compete for the interaction with β-catenin and the cytoskeleton.
    • Hulsken J, Birchmeier W, Behrens J. E-cadherin and APC compete for the interaction with β-catenin and the cytoskeleton. J Cell Biol 1994, 127(6 Pt 2): 2061-2069.
    • (1994) J Cell Biol , vol.127 , Issue.6 PART 2 , pp. 2061-2069
    • Hulsken, J.1    Birchmeier, W.2    Behrens, J.3
  • 14
    • 0037007231 scopus 로고    scopus 로고
    • Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila.
    • Yanagawa S, Matsuda Y, Lee JS, Matsubayashi H, Sese S, Kadowaki T, Ishimoto A. Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. Embo J 2002, 21:1733-1742.
    • (2002) Embo J , vol.21 , pp. 1733-1742
    • Yanagawa, S.1    Matsuda, Y.2    Lee, J.S.3    Matsubayashi, H.4    Sese, S.5    Kadowaki, T.6    Ishimoto, A.7
  • 15
    • 0032473355 scopus 로고    scopus 로고
    • Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin.
    • Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin. EMBO J 1998, 17:1371-1384.
    • (1998) EMBO J , vol.17 , pp. 1371-1384
    • Ikeda, S.1    Kishida, S.2    Yamamoto, H.3    Murai, H.4    Koyama, S.5    Kikuchi, A.6
  • 17
    • 0032841989 scopus 로고    scopus 로고
    • A Drosophila Axin homolog, Daxin, inhibits Wnt signaling.
    • Willert K, Logan CY, Arora A, Fish M, Nusse R. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. Development 1999, 126:4165-4173.
    • (1999) Development , vol.126 , pp. 4165-4173
    • Willert, K.1    Logan, C.Y.2    Arora, A.3    Fish, M.4    Nusse, R.5
  • 18
    • 0034576628 scopus 로고    scopus 로고
    • APC-mediated downregulation of β-catenin activity involves nuclear sequestration and nuclear export.
    • Neufeld KL, Zhang F, Cullen BR, White RL. APC-mediated downregulation of β-catenin activity involves nuclear sequestration and nuclear export. EMBO Rep 2000, 1:519-523.
    • (2000) EMBO Rep , vol.1 , pp. 519-523
    • Neufeld, K.L.1    Zhang, F.2    Cullen, B.R.3    White, R.L.4
  • 19
    • 0034282097 scopus 로고    scopus 로고
    • Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover.
    • Henderson BR. Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover. Nat Cell Biol 2000, 2:653-660.
    • (2000) Nat Cell Biol , vol.2 , pp. 653-660
    • Henderson, B.R.1
  • 20
    • 0034739023 scopus 로고    scopus 로고
    • The APC tumour suppressor has a nuclear export function.
    • Rosin-Arbesfeld R, Townsley F, Bienz M. The APC tumour suppressor has a nuclear export function. Nature 2000, 406:1009-1012.
    • (2000) Nature , vol.406 , pp. 1009-1012
    • Rosin-Arbesfeld, R.1    Townsley, F.2    Bienz, M.3
  • 21
    • 0032170327 scopus 로고    scopus 로고
    • β-TrCP is a negative regulator of Wnt/β-catenin signaling pathway and dorsal axis formation in Xenopus embryos.
    • Marikawa Y, Elinson RP. β-TrCP is a negative regulator of Wnt/β-catenin signaling pathway and dorsal axis formation in Xenopus embryos. Mech Dev 1998, 77:75-80.
    • (1998) Mech Dev , vol.77 , pp. 75-80
    • Marikawa, Y.1    Elinson, R.P.2
  • 23
    • 0033034120 scopus 로고    scopus 로고
    • β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation.
    • Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X. β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A 1999, 96:6273-6278.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 6273-6278
    • Liu, C.1    Kato, Y.2    Zhang, Z.3    Do, V.M.4    Yankner, B.A.5    He, X.6
  • 24
    • 0033068154 scopus 로고    scopus 로고
    • The SCFβ-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and β-catenin and stimulates IkappaBalpha ubiquitination in vitro.
    • Beer
    • Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW. The SCFβ-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and β-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev 1999, 13:270-283.
    • (1999) Genes Dev , vol.13 , pp. 270-283
    • Winston, J.T.1    Strack, P.2    Romero, P.3    Chu, C.Y.4    Elledge, S.J.5    Harper, J.W.6
  • 25
    • 0036830126 scopus 로고    scopus 로고
    • Ligand receptor interactions in the Wnt signaling pathway in Drosophila.
    • Wu CH, Nusse R. Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem 2002, 277:41762-41769.
    • (2002) J Biol Chem , vol.277 , pp. 41762-41769
    • Wu, C.H.1    Nusse, R.2
  • 26
    • 0242704649 scopus 로고    scopus 로고
    • Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors.
    • Schweizer L, Varmus H. Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. BMC Cell Biol 2003, 4:4.
    • (2003) BMC Cell Biol , vol.4 , pp. 4
    • Schweizer, L.1    Varmus, H.2
  • 27
    • 0037513408 scopus 로고    scopus 로고
    • A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling.
    • Cliffe A, Hamada F, Bienz M. A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling. Curr Biol 2003, 13:960-966.
    • (2003) Curr Biol , vol.13 , pp. 960-966
    • Cliffe, A.1    Hamada, F.2    Bienz, M.3
  • 28
    • 0035802116 scopus 로고    scopus 로고
    • Physiological regulation of [β]-catenin stability by Tcf3 and CK1epsilon.
    • Lee E, Salic A, Kirschner MW. Physiological regulation of [β]-catenin stability by Tcf3 and CK1epsilon. J Cell Biol 2001, 154:983-993.
    • (2001) J Cell Biol , vol.154 , pp. 983-993
    • Lee, E.1    Salic, A.2    Kirschner, M.W.3
  • 30
    • 0033517102 scopus 로고    scopus 로고
    • Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.
    • Farr GH 3rd
    • Li L, Yuan H, Weaver CD, Mao J, Farr GH 3rd, Sussman DJ, Jonkers J, Kimelman D, Wu D. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J 1999, 18:4233-4240.
    • (1999) EMBO J , vol.18 , pp. 4233-4240
    • Li, L.1    Yuan, H.2    Weaver, C.D.3    Mao, J.4    Sussman, D.J.5    Jonkers, J.6    Kimelman, D.7    Wu, D.8
  • 31
    • 0032511194 scopus 로고    scopus 로고
    • GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.
    • Farr GH 3rd
    • Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell 1998, 93:1031-1041.
    • (1998) Cell , vol.93 , pp. 1031-1041
    • Yost, C.1    Pierce, S.B.2    Ferkey, D.M.3    Chen, M.M.4    Kimelman, D.5
  • 33
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.
    • Farr GH 3rd
    • Mao J, Wang J, Liu B, Pan W, Farr GH 3rd, Flynn C, Yuan H, Takada S, Kimelman D, Li L, et al. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell 2001, 7:801-809.
    • (2001) Mol Cell , vol.7 , pp. 801-809
    • Mao, J.1    Wang, J.2    Liu, B.3    Pan, W.4    Flynn, C.5    Yuan, H.6    Takada, S.7    Kimelman, D.8    Li, L.9
  • 35
    • 28644444440 scopus 로고    scopus 로고
    • Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.
    • Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature 2005, 438:867-872.
    • (2005) Nature , vol.438 , pp. 867-872
    • Davidson, G.1    Wu, W.2    Shen, J.3    Bilic, J.4    Fenger, U.5    Stannek, P.6    Glinka, A.7    Niehrs, C.8
  • 36
    • 47049121052 scopus 로고    scopus 로고
    • Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.
    • MacDonald BT, Yokota C, Tamai K, Zeng X, He X. Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6. J Biol Chem 2008, 283:16115-16123.
    • (2008) J Biol Chem , vol.283 , pp. 16115-16123
    • MacDonald, B.T.1    Yokota, C.2    Tamai, K.3    Zeng, X.4    He, X.5
  • 37
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling: components, mechanisms, and diseases.
    • MacDonald BT, Tamai K, He X. Wnt/β-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009, 17:9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 38
    • 0034585939 scopus 로고    scopus 로고
    • Tcf/Lef transcription factors during T-cell development: unique and overlapping functions.
    • Staal FJ, Clevers H. Tcf/Lef transcription factors during T-cell development: unique and overlapping functions. Hematol J 2000, 1:3-6.
    • (2000) Hematol J , vol.1 , pp. 3-6
    • Staal, F.J.1    Clevers, H.2
  • 39
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease.
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004, 20:781-810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 40
    • 1542346154 scopus 로고    scopus 로고
    • Wnt signalling via the epidermal growth factor receptor: a role in breast cancer?
    • Musgrove EA. Wnt signalling via the epidermal growth factor receptor: a role in breast cancer? Breast Cancer Res 2004, 6:65-68.
    • (2004) Breast Cancer Res , vol.6 , pp. 65-68
    • Musgrove, E.A.1
  • 41
    • 0344464720 scopus 로고    scopus 로고
    • Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
    • Nusse R. Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development 2003, 130:5297-5305.
    • (2003) Development , vol.130 , pp. 5297-5305
    • Nusse, R.1
  • 42
    • 0037470952 scopus 로고    scopus 로고
    • Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.
    • Von
    • Lum L, Yao S, Mozer B, Rovescalli A, Von Kessler D, Nirenberg M, Beachy PA. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 2003, 299:2039-2045.
    • (2003) Science , vol.299 , pp. 2039-2045
    • Lum, L.1    Yao, S.2    Mozer, B.3    Rovescalli, A.4    Kessler, D.5    Nirenberg, M.6    Beachy, P.A.7
  • 43
    • 0034126988 scopus 로고    scopus 로고
    • Cross-regulation of the Wnt signalling pathway: a role of MAP kinases.
    • Behrens J. Cross-regulation of the Wnt signalling pathway: a role of MAP kinases. J Cell Sci 2000, 113(Pt 6):911-919.
    • (2000) J Cell Sci , vol.113 , Issue.PART 6 , pp. 911-919
    • Behrens, J.1
  • 44
    • 0037214344 scopus 로고    scopus 로고
    • The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/β-catenin signaling.
    • Hyodo-, Ninomiya-Tsuji J
    • Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/β-catenin signaling. Mol Cell Biol 2003, 23:131-139.
    • (2003) Mol Cell Biol , vol.23 , pp. 131-139
    • Ishitani, T.1    Kishida, S.2    Miura, J.3    Ueno, N.4    Yasuda, J.5    Waterman, M.6    Shibuya, H.7    Moon, R.T.8    Matsumoto, K.9
  • 45
    • 0033600239 scopus 로고    scopus 로고
    • The TAK1-NLK-MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF.
    • Ninomiya-, Clevers H
    • Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H, et al. The TAK1-NLK-MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF. Nature 1999, 399:798-802.
    • (1999) Nature , vol.399 , pp. 798-802
    • Ishitani, T.1    Tsuji, J.2    Nagai, S.3    Nishita, M.4    Meneghini, M.5    Barker, N.6    Waterman, M.7    Bowerman, B.8    Shibuya, H.9
  • 48
    • 0037461958 scopus 로고    scopus 로고
    • Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation.
    • Arsura M, Panta GR, Bilyeu JD, Cavin LG, Sovak MA, Oliver AA, Factor V, Heuchel R, Mercurio F, Thorgeirsson SS, et al. Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation. Oncogene 2003, 22:412-425.
    • (2003) Oncogene , vol.22 , pp. 412-425
    • Arsura, M.1    Panta, G.R.2    Bilyeu, J.D.3    Cavin, L.G.4    Sovak, M.A.5    Oliver, A.A.6    Factor, V.7    Heuchel, R.8    Mercurio, F.9    Thorgeirsson, S.S.10
  • 50
    • 31444444985 scopus 로고    scopus 로고
    • Activation of TGF-β1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats.
    • Matsumoto-Ida M, Takimoto Y, Aoyama T, Akao M, Takeda T, Kita T. Activation of TGF-β1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats. Am J Physiol Heart Circ Physiol 2006, 290:H709-H715.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Matsumoto-Ida, M.1    Takimoto, Y.2    Aoyama, T.3    Akao, M.4    Takeda, T.5    Kita, T.6
  • 51
    • 18844393670 scopus 로고    scopus 로고
    • Notch modulates Wnt signalling by associating with Armadillo/β-catenin and regulating its transcriptional activity.
    • Martinez
    • Hayward P, Brennan K, Sanders P, Balayo T, DasGupta R, Perrimon N, Martinez Arias A. Notch modulates Wnt signalling by associating with Armadillo/β-catenin and regulating its transcriptional activity. Development 2005, 132:1819-1830.
    • (2005) Development , vol.132 , pp. 1819-1830
    • Hayward, P.1    Brennan, K.2    Sanders, P.3    Balayo, T.4    DasGupta, R.5    Perrimon, N.6    Arias, A.7
  • 52
    • 0033571390 scopus 로고    scopus 로고
    • Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function.
    • Helms W, Lee H, Ammerman M, Parks AL, Muskavitch MA, Yedvobnick B. Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function. Dev Biol 1999, 215:358-374.
    • (1999) Dev Biol , vol.215 , pp. 358-374
    • Helms, W.1    Lee, H.2    Ammerman, M.3    Parks, A.L.4    Muskavitch, M.A.5    Yedvobnick, B.6
  • 53
    • 0034867110 scopus 로고    scopus 로고
    • Identification of chromosomal deficiencies that modify Drosophila mastermind mutant phenotypes.
    • Yedvobnick B, Helms W, Barrett B. Identification of chromosomal deficiencies that modify Drosophila mastermind mutant phenotypes. Genesis 2001, 30:250-258.
    • (2001) Genesis , vol.30 , pp. 250-258
    • Yedvobnick, B.1    Helms, W.2    Barrett, B.3
  • 54
    • 34548708035 scopus 로고    scopus 로고
    • Mastermind-like 1 is a specific coactivator of β-catenin transcription activation and is essential for colon carcinoma cell survival.
    • Alves-Guerra MC, Ronchini C, Capobianco AJ. Mastermind-like 1 is a specific coactivator of β-catenin transcription activation and is essential for colon carcinoma cell survival. Cancer Res 2007, 67:8690-8698.
    • (2007) Cancer Res , vol.67 , pp. 8690-8698
    • Alves-Guerra, M.C.1    Ronchini, C.2    Capobianco, A.J.3
  • 56
    • 33749067198 scopus 로고    scopus 로고
    • Unwinding a path to nuclear β-catenin.
    • He X. Unwinding a path to nuclear β-catenin. Cell 2006, 127:40-42.
    • (2006) Cell , vol.127 , pp. 40-42
    • He, X.1
  • 57
    • 33749078750 scopus 로고    scopus 로고
    • P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing axin from β-catenin.
    • Yang L, Lin C, Liu ZR. P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing axin from β-catenin. Cell 2006, 127:139-155.
    • (2006) Cell , vol.127 , pp. 139-155
    • Yang, L.1    Lin, C.2    Liu, Z.R.3
  • 58
    • 30544439006 scopus 로고    scopus 로고
    • Planar cell polarity signalling couples cell division and morphogenesis during neurulation.
    • Ciruna B, Jenny A, Lee D, Mlodzik M, Schier AF. Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature 2006, 439:220-224.
    • (2006) Nature , vol.439 , pp. 220-224
    • Ciruna, B.1    Jenny, A.2    Lee, D.3    Mlodzik, M.4    Schier, A.F.5
  • 59
    • 0031869926 scopus 로고    scopus 로고
    • The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice.
    • Grove EA, Tole S, Limon J, Yip L, Ragsdale CW. The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development 1998, 125:2315-2325.
    • (1998) Development , vol.125 , pp. 2315-2325
    • Grove, E.A.1    Tole, S.2    Limon, J.3    Yip, L.4    Ragsdale, C.W.5
  • 60
    • 33744919790 scopus 로고    scopus 로고
    • Development of the upper lip: morphogenetic and molecular mechanisms.
    • Jiang R, Bush JO, Lidral AC. Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn 2006, 235:1152-1166.
    • (2006) Dev Dyn , vol.235 , pp. 1152-1166
    • Jiang, R.1    Bush, J.O.2    Lidral, A.C.3
  • 62
    • 0036802645 scopus 로고    scopus 로고
    • Wnt7b regulates mesenchymal proliferation and vascular development in the lung.
    • Shu W, Jiang YQ, Lu MM, Morrisey EE. Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development 2002, 129:4831-4842.
    • (2002) Development , vol.129 , pp. 4831-4842
    • Shu, W.1    Jiang, Y.Q.2    Lu, M.M.3    Morrisey, E.E.4
  • 63
    • 1342332090 scopus 로고    scopus 로고
    • Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization.
    • Yang
    • Kaykas A, Yang-Snyder J, Heroux M, Shah KV, Bouvier M, Moon RT. Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization. Nat Cell Biol 2004, 6:52-58.
    • (2004) Nat Cell Biol , vol.6 , pp. 52-58
    • Kaykas, A.1    Snyder, J.2    Heroux, M.3    Shah, K.V.4    Bouvier, M.5    Moon, R.T.6
  • 65
    • 0037233138 scopus 로고    scopus 로고
    • B-catenin: a transforming actor on many stages.
    • Miyoshi K, Hennighausen L. B-catenin: a transforming actor on many stages. Breast Cancer Res 2003, 5:63-68.
    • (2003) Breast Cancer Res , vol.5 , pp. 63-68
    • Miyoshi, K.1    Hennighausen, L.2
  • 66
    • 0037103985 scopus 로고    scopus 로고
    • Activation of different Wnt/β-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors.
    • Landesman
    • Miyoshi K, Rosner A, Nozawa M, Byrd C, Morgan F, Landesman-Bollag E, Xu X, Seldin DC, Schmidt EV, Taketo MM, et al. Activation of different Wnt/β-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors. Oncogene 2002, 21:5548-5556.
    • (2002) Oncogene , vol.21 , pp. 5548-5556
    • Miyoshi, K.1    Rosner, A.2    Nozawa, M.3    Byrd, C.4    Morgan, F.5    Bollag, E.6    Xu, X.7    Seldin, D.C.8    Schmidt, E.V.9    Taketo, M.M.10
  • 67
    • 3142590865 scopus 로고    scopus 로고
    • Wnt signaling and breast cancer.
    • Howe LR, Brown AM. Wnt signaling and breast cancer. Cancer Biol Ther 2004, 3:36-41.
    • (2004) Cancer Biol Ther , vol.3 , pp. 36-41
    • Howe, L.R.1    Brown, A.M.2
  • 69
    • 0033867475 scopus 로고    scopus 로고
    • Genetics of hepatocellular carcinoma.
    • Buendia MA. Genetics of hepatocellular carcinoma. Semin Cancer Biol 2000, 10:185-200.
    • (2000) Semin Cancer Biol , vol.10 , pp. 185-200
    • Buendia, M.A.1
  • 73
    • 14544270262 scopus 로고    scopus 로고
    • Mutations of β-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis.
    • Park JY, Park WS, Nam SW, Kim SY, Lee SH, Yoo NJ, Lee JY, Park CK. Mutations of β-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis. Liver Int 2005, 25:70-76.
    • (2005) Liver Int , vol.25 , pp. 70-76
    • Park, J.Y.1    Park, W.S.2    Nam, S.W.3    Kim, S.Y.4    Lee, S.H.5    Yoo, N.J.6    Lee, J.Y.7    Park, C.K.8
  • 74
    • 0034953664 scopus 로고    scopus 로고
    • CTNNB1 mutations and β-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1.
    • Devereux TR, Stern MC, Flake GP, Yu MC, Zhang ZQ, London ZQ, Taylor JA. CTNNB1 mutations and β-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1. Mol Carcinog 2001, 31:68-73.
    • (2001) Mol Carcinog , vol.31 , pp. 68-73
    • Devereux, T.R.1    Stern, M.C.2    Flake, G.P.3    Yu, M.C.4    Zhang, Z.Q.5    London, Z.Q.6    Taylor, J.A.7
  • 75
    • 0033772553 scopus 로고    scopus 로고
    • Pilomatricomas contain activating mutations in β-catenin.
    • Chan EF. Pilomatricomas contain activating mutations in β-catenin. J Am Acad Dermatol 2000, 43: 701-702.
    • (2000) J Am Acad Dermatol , vol.43 , pp. 701-702
    • Chan, E.F.1
  • 76
    • 0032953231 scopus 로고    scopus 로고
    • A common human skin tumour is caused by activating mutations in β-catenin.
    • Chan EF, Gat U, McNiff JM, Fuchs E. A common human skin tumour is caused by activating mutations in β-catenin. Nat Genet 1999, 21:410-413.
    • (1999) Nat Genet , vol.21 , pp. 410-413
    • Chan, E.F.1    Gat, U.2    McNiff, J.M.3    Fuchs, E.4
  • 78
    • 0034760407 scopus 로고    scopus 로고
    • B-catenin antisense treatment decreases β-catenin expression and tumor growth rate in colon carcinoma xenografts.
    • Green DW, Roh H, Pippin JA, Drebin JA. B-catenin antisense treatment decreases β-catenin expression and tumor growth rate in colon carcinoma xenografts. J Surg Res 2001, 101:16-20.
    • (2001) J Surg Res , vol.101 , pp. 16-20
    • Green, D.W.1    Roh, H.2    Pippin, J.A.3    Drebin, J.A.4
  • 79
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5.
    • Green DW, Roh H, Pippin JA, Drebin JA. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007, 449:1003-1007.
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Green, D.W.1    Roh, H.2    Pippin, J.A.3    Drebin, J.A.4
  • 83
    • 33847740988 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in cancer stemness and malignant behavior.
    • Fodde R, Brabletz T. Wnt/β-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol 2007, 19:150-158.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 150-158
    • Fodde, R.1    Brabletz, T.2
  • 84
    • 34347235843 scopus 로고    scopus 로고
    • Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma.
    • Kang S, Bennett CN, Gerin I, Rapp LA, Hankenson KD, Macdougald OA. Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma. J Biol Chem 2007, 282:14515-14524.
    • (2007) J Biol Chem , vol.282 , pp. 14515-14524
    • Kang, S.1    Bennett, C.N.2    Gerin, I.3    Rapp, L.A.4    Hankenson, K.D.5    Macdougald, O.A.6
  • 87
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics.
    • Barker N, Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov 2006, 5:997-1014.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 88
    • 18244400410 scopus 로고    scopus 로고
    • Functional genomic analysis of the Wnt-wingless signaling pathway.
    • DasGupta R, Kaykas A, Moon RT, Perrimon N. Functional genomic analysis of the Wnt-wingless signaling pathway. Science 2005, 308:826-833.
    • (2005) Science , vol.308 , pp. 826-833
    • DasGupta, R.1    Kaykas, A.2    Moon, R.T.3    Perrimon, N.4
  • 89
    • 23944468103 scopus 로고    scopus 로고
    • Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila.
    • Baeg GH, Zhou R, Perrimon N. Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev 2005, 19:1861-1870.
    • (2005) Genes Dev , vol.19 , pp. 1861-1870
    • Baeg, G.H.1    Zhou, R.2    Perrimon, N.3
  • 90
    • 28444451148 scopus 로고    scopus 로고
    • A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway.
    • Nybakken K, Vokes SA, Lin TY, McMahon AP, Perrimon N. A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet 2005, 37:1323-1332.
    • (2005) Nat Genet , vol.37 , pp. 1323-1332
    • Nybakken, K.1    Vokes, S.A.2    Lin, T.Y.3    McMahon, A.P.4    Perrimon, N.5
  • 91
    • 33750887331 scopus 로고    scopus 로고
    • A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling.
    • Friedman A, Perrimon N. A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature 2006, 444:230-234.
    • (2006) Nature , vol.444 , pp. 230-234
    • Friedman, A.1    Perrimon, N.2
  • 95
    • 33748939584 scopus 로고    scopus 로고
    • Prevalence of off-target effects in Drosophila RNA interference screens.
    • Ma Y, Creanga A, Lum L, Beachy PA. Prevalence of off-target effects in Drosophila RNA interference screens. Nature 2006, 443:359-363.
    • (2006) Nature , vol.443 , pp. 359-363
    • Ma, Y.1    Creanga, A.2    Lum, L.3    Beachy, P.A.4
  • 97
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application.
    • Jackson AL, Linsley PS. Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov 2010, 9:57-67.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 102
    • 73349124764 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant {β}-catenin activation in colon cancer.
    • Piwnica
    • Naik S, Dothager RS, Marasa J, Lewis CL, Piwnica-Worms D. Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant {β}-catenin activation in colon cancer. Clin Cancer Res 2009, 15: 7529-7537.
    • (2009) Clin Cancer Res , vol.15 , pp. 7529-7537
    • Naik, S.1    Dothager, R.S.2    Marasa, J.3    Lewis, C.L.4    Worms, D.5
  • 104
    • 33646555522 scopus 로고    scopus 로고
    • Parafibromin/ Hyrax activates Wnt/Wg target gene transcription by direct association with β-catenin/Armadillo.
    • Mosimann C, Hausmann G, Basler K. Parafibromin/ Hyrax activates Wnt/Wg target gene transcription by direct association with β-catenin/Armadillo. Cell 2006, 125:327-341.
    • (2006) Cell , vol.125 , pp. 327-341
    • Mosimann, C.1    Hausmann, G.2    Basler, K.3
  • 105
    • 61449249121 scopus 로고    scopus 로고
    • Selective activation mechanisms of Wnt signaling pathways.
    • Kikuchi A, Yamamoto H, Sato A. Selective activation mechanisms of Wnt signaling pathways. Trends Cell Biol 2009, 19:119-129.
    • (2009) Trends Cell Biol , vol.19 , pp. 119-129
    • Kikuchi, A.1    Yamamoto, H.2    Sato, A.3
  • 106
    • 33644763022 scopus 로고    scopus 로고
    • The APC tumor suppressor counteracts β-catenin activation and H3K4 methylation at Wnt target genes.
    • Sierra J, Yoshida T, Joazeiro CA, Jones KA. The APC tumor suppressor counteracts β-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev 2006, 20:586-600.
    • (2006) Genes Dev , vol.20 , pp. 586-600
    • Sierra, J.1    Yoshida, T.2    Joazeiro, C.A.3    Jones, K.A.4
  • 107
    • 33646580781 scopus 로고    scopus 로고
    • Mediator is a transducer of Wnt/β-catenin signaling.
    • Kim S, Xu X, Hecht A, Boyer TG. Mediator is a transducer of Wnt/β-catenin signaling. J Biol Chem 2006, 281:14066-14075.
    • (2006) J Biol Chem , vol.281 , pp. 14066-14075
    • Kim, S.1    Xu, X.2    Hecht, A.3    Boyer, T.G.4
  • 113
    • 33747597785 scopus 로고    scopus 로고
    • Hexachlorophene inhibits Wnt/β-catenin pathway by promoting Siah-mediated β-catenin degradation.
    • Park S, Gwak J, Cho M, Song T, Won J, Kim DE, Shin JG, Oh S. Hexachlorophene inhibits Wnt/β-catenin pathway by promoting Siah-mediated β-catenin degradation. Mol Pharmacol 2006, 70:960-966.
    • (2006) Mol Pharmacol , vol.70 , pp. 960-966
    • Park, S.1    Gwak, J.2    Cho, M.3    Song, T.4    Won, J.5    Kim, D.E.6    Shin, J.G.7    Oh, S.8
  • 114
    • 0035947083 scopus 로고    scopus 로고
    • Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.
    • Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, Matsunami N. Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 2001, 7:927-936.
    • (2001) Mol Cell , vol.7 , pp. 927-936
    • Liu, J.1    Stevens, J.2    Rote, C.A.3    Yost, H.J.4    Hu, Y.5    Neufeld, K.L.6    White, R.L.7    Matsunami, N.8
  • 116
    • 28244496603 scopus 로고    scopus 로고
    • Identification of a specific inhibitor of the dishevelled PDZ domain.
    • Shan J, Shi DL, Wang J, Zheng J. Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 2005, 44:15495-15503.
    • (2005) Biochemistry , vol.44 , pp. 15495-15503
    • Shan, J.1    Shi, D.L.2    Wang, J.3    Zheng, J.4
  • 117
    • 59449102727 scopus 로고    scopus 로고
    • Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.
    • Moore WJ, Kern JC, Bhat R, Commons TJ, Fukayama S, Goljer I, Krishnamurthy G, .Magolda RL, Nogle L, Pitts K, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem 2009, 52:105-116.
    • (2009) J Med Chem , vol.52 , pp. 105-116
    • Moore, W.J.1    Kern, J.C.2    Bhat, R.3    Commons, T.J.4    Fukayama, S.5    Goljer, I.6    Krishnamurthy, G.7    Magolda, R.L.8    Nogle, L.9    Pitts, K.10
  • 120
    • 49549092476 scopus 로고    scopus 로고
    • Mapping multiprotein complexes by affinity purification and mass spectrometry.
    • Collins MO, Choudhary JS. Mapping multiprotein complexes by affinity purification and mass spectrometry. Curr Opin Biotechnol 2008, 19:324-330.
    • (2008) Curr Opin Biotechnol , vol.19 , pp. 324-330
    • Collins, M.O.1    Choudhary, J.S.2
  • 121
    • 33645714061 scopus 로고    scopus 로고
    • The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-β-catenin pathway by targeting dishevelled for degradation.
    • Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon RT. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-β-catenin pathway by targeting dishevelled for degradation. Nat Cell Biol 2006, 8:348-357.
    • (2006) Nat Cell Biol , vol.8 , pp. 348-357
    • Angers, S.1    Thorpe, C.J.2    Biechele, T.L.3    Goldenberg, S.J.4    Zheng, N.5    MacCoss, M.J.6    Moon, R.T.7
  • 123
    • 36749036712 scopus 로고    scopus 로고
    • Functional screening identifies miR-315 as a potent activator of Wingless signaling.
    • Silver SJ, Hagen JW, Okamura K, Perrimon N, Lai EC. Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc Natl Acad Sci U S A 2007, 104:18151-18156.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18151-18156
    • Silver, S.J.1    Hagen, J.W.2    Okamura, K.3    Perrimon, N.4    Lai, E.C.5
  • 124
    • 48649099908 scopus 로고    scopus 로고
    • Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer.
    • le, van der, Oude
    • Nagel R, le Sage C, Diosdado B, van der Waal M, Oude Vrielink JA, Bolijn A, Meijer GA, Agami R. Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res 2008, 68:5795-5802.
    • (2008) Cancer Res , vol.68 , pp. 5795-5802
    • Nagel, R.1    Sage, C.2    Diosdado, B.3    Waal, M.4    Vrielink, J.A.5    Bolijn, A.6    Meijer, G.A.7    Agami, R.8
  • 125
    • 77954112841 scopus 로고    scopus 로고
    • Epigenetic disruption of the WNT/β-catenin signaling pathway in human cancers.
    • Ying Y, Tao Q. Epigenetic disruption of the WNT/β-catenin signaling pathway in human cancers. Epigenetics 2009, 4:307-312.
    • (2009) Epigenetics , vol.4 , pp. 307-312
    • Ying, Y.1    Tao, Q.2
  • 127
    • 44449134715 scopus 로고    scopus 로고
    • DACT3 is an epigenetic regulator of Wnt/β-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.
    • Jiang X, Tan J, Li J, Kivimae S, Yang X, Zhuang L, Lee PL, Chan MT, Stanton LW, Liu ET, et al. DACT3 is an epigenetic regulator of Wnt/β-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell 2008, 13:529-541.
    • (2008) Cancer Cell , vol.13 , pp. 529-541
    • Jiang, X.1    Tan, J.2    Li, J.3    Kivimae, S.4    Yang, X.5    Zhuang, L.6    Lee, P.L.7    Chan, M.T.8    Stanton, L.W.9    Liu, E.T.10
  • 129
    • 33845769956 scopus 로고    scopus 로고
    • Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens.
    • Mathey
    • Perrimon N, Friedman A, Mathey-Prevot B, Eggert US. Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. Drug Discov Today 2007, 12:28-33.
    • (2007) Drug Discov Today , vol.12 , pp. 28-33
    • Perrimon, N.1    Friedman, A.2    Prevot, B.3    Eggert, U.S.4
  • 130
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control.
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004, 10:789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.