Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

Molecular Cell

Volumn 7, Issue 5, 2001, Pages 927-936

  Liu, Jun ^a   Stevens, Jeffery ^a   Rote, Cynthia A ^b   Yost, H Joseph ^b   Hu, Yaoxiong ^a   Neufeld, Kristi L ^a   White, Raymond L ^a   Matsunami, Nori ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEASOME; PROTEIN; PROTEIN P53; PROTEIN SIAH 1; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; DOWN REGULATION; MAMMAL CELL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; XENOPUS;

EID: 0035947083     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00241-6     Document Type: Article

References (39)

1. Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: Activation of the vertebrate homologue of the drosophila seven in absentia gene
2. Linking colorectal cancer to Wnt signaling
3. SIAH-1 inhibits cell growth by altering the mitotic process
4. Seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye
5. The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of β-catenin-lymphocyte enhancer-binding factor signaling
6. A targeted chain-termination mutationin the mouse Apc gene results in multiple intestinal tumors
7. The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell
8. Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins
9. Characterization of human homologs of the Drosophila seven in absentia (sina) gene
10. Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway
11. The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos
12. An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
13. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma
14. Photoreceptor cell differentiation requires regulated proteolysis of transcriptional repressor Tramtrack
15. p21WAF-1 reorganizes the nucleus in tumor suppression
16. Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses
17. p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: Suppression by BAG-1
18. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
19. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
20. Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression
21. APC-mediated downregulation of β-catenin activity involves nuclear sequestration and nuclear export
22. Exogenous expression of β-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest
23. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
24. Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
25. APC mutations occur early during colorectal tumorigenesis
26. SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: Identification of common effectors with p53 and p21(Waf1)
27. β-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas
28. Axin1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of axin1
29. Cytoskeletal reorganization by soluble Wnt-3a protein signalling
30. The APC gene product in normal and tumor cells
31. Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center
32. Apc1638T: A mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
33. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
34. PHYL acts to downregulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism
35. p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3
36. Germline mutations in the 3′ part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli
37. Tumor suppressing pathways
38. The SCFβ-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro
39. Proteasomal regulation of nuclear receptor corepressor-mediated repression