Enhanced Self-Renewal Capability in Hepatic Stem/Progenitor Cells Drives Cancer Initiation

Gastroenterology

Volumn 133, Issue 3, 2007, Pages 937-950

  Chiba, Tetsuhiro ^a,b   Zheng, Yun Wen ^b   Kita, Kaoru ^b   Yokosuka, Osamu ^c   Saisho, Hiromitsu ^c   Onodera, Masafumi ^d   Miyoshi, Hiroyuki ^e   Nakano, Masayuki ^f   Zen, Yoh ^g   Nakanuma, Yasuni ^g   Nakauchi, Hiromitsu ^h   Iwama, Atsushi ^a   Taniguchi, Hideki ^b,i,j  

^a CHIBA UNIVERSITY   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c CHIBA UNIVERSITY   (Japan)

^d Graduate School of Comprehensive Human Sciences   (Japan)

^e RIKEN TSUKUBA INSTITUTE   (Japan)

^f NATIONAL HOSPITAL ORGANIZATION CHIBA MEDICAL CENTER   (Japan)

^g KANAZAWA UNIVERSITY   (Japan)

^h The Universtiry of Tokyo   (Japan)

ⁱ INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^j NATIONAL INSTITUTE FOR MATERIALS SCIENCE   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA6 INTEGRIN; BETA CATENIN; BETA1 INTEGRIN; CD45 ANTIGEN; EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; LENTIVIRUS VECTOR; STEM CELL FACTOR; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT CARCINOMA; CANCER GROWTH; CANCER STEM CELL; CARCINOGENICITY; CELL RENEWAL; CLONAL VARIATION; CONTROLLED STUDY; GENE TRANSFER; HEMATOPOIETIC STEM CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER TRANSPLANTATION; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCID MOUSE; TISSUE SECTION;

EID: 34548471937     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.06.016     Document Type: Article

References (52)

1. Shiojiri N., Lemire J.M., and Fausto N. Cell lineages and oval cell progenitors in rat liver development. Cancer Res 51 (1991) 2611-2620
2. Zheng Y.W., and Taniguchi H. Diversity of hepatic stem cells in the fetal and adult liver. Semin Liver Dis 23 (2003) 337-348
3. Suzuki A., Zheng Y.W., Kaneko S., et al. Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver. J Cell Biol 156 (2002) 173-184
4. Suzuki A., Zheng Y., Kondo R., et al. Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver. Hepatology 32 (2000) 1230-1239
5. Weissman I.L. Stem cells: units of development, units of regeneration, and units in evolution. Cell 100 (2000) 157-168
6. Reya T., Morrison S.J., Clarke M.F., and Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 414 (2001) 105-111
7. Valk-Lingbeek M.E., Bruggeman S.W., and van Lohuizen M. Stem cells and cancer; the polycomb connection. Cell 118 (2004) 409-418
8. Iwama A., Oguro H., Negishi M., et al. Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity 21 (2004) 843-851
9. Park I.K., Qian D., Kiel M., et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423 (2003) 302-305
10. Molofsky A.V., Pardal R., Iwashita T., Park I.K., Clarke M.F., and Morrison S.J. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425 (2003) 962-967
11. Leung C., Lingbeek M., Shakhova O., et al. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 428 (2004) 337-341
12. Pardal R., Clarke M.F., and Morrison S.J. Applying the principles of stem-cell biology to cancer. Nature Rev Cancer 3 (2003) 895-902
13. Hussain S.Z., Sneddon T., Tan X., Micsenyi A., Michalopoulos G.K., and Monga S.P. Wnt impacts growth and differentiation in ex vivo liver development. Exp Cell Res 292 (2004) 157-169
14. Tan X., Behari J., Cieply B., Michalopoulos G.K., and Monga S.P. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology 131 (2006) 1561-1572
15. Monga S.P., Pediaditakis P., Mule K., Stolz D.B., and Michalopoulos G.K. Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Hepatology 33 (2001) 1098-1109
16. Zucman-Rossi J., Jeannot E., Nhieu J.T., et al. Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology 43 (2006) 515-524
17. Reya T., and Clevers H. Wnt signaling in stem cells and cancer. Nature 434 (2004) 843-850
18. Giles R.H., van Es J.H., and Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653 (2001) 1-24
19. Neo SY, Leow CK, Vega VB, et al. Identification of discriminators of hepatoma by gene expression profiling using a minimal dataset approach. Hepatology 39:944-953.
20. Taniguchi K., Roberts L.R., Aderca I.N., et al. Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 21 (2002) 4863-4871
21. Dean M., Fojo T., and Bates S. Tumour stem cells and drug resistance. Nature Rev Cancer 5 (2005) 275-284
22. Xin L., Lawson D.A., and Witte O.N. The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Proc Natl Acad Sci U S A 102 (2005) 6942-6947
23. Shackleton M., Vaillant F., Simpson K.J., et al. Generation of a functional mammary gland from a single stem cell. Nature 439 (2006) 84-88
24. Zender L., Spector M.S., Xue W., et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125 (2006) 1253-1267
25. Lee J.S., Heo J., Libbrecht L., et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 12 (2006) 410-416
26. Harada N., Tamai Y., Ishikawa T., et al. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J 18 (1999) 5931-5942
27. Katayama K., Wada K., Miyoshi H., et al. RNA interfering approach for clarifying the PPARgamma pathway using lentiviral vector expressing short hairpin RNA. FEBS Lett 560 (2004) 178-182
28. Chinzei R., Tanaka Y., Shimizu-Saito K., et al. Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology 36 (2002) 22-29
29. Kakinuma S., Tanaka Y., Chinzei R., et al. Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells 21 (2003) 217-227
30. Park I.K., Morrison S.J., and Clarke M.F. Bmi1, stem cells, and senescence regulation. J Clin Invest 113 (2004) 175-179
31. Shtutman M., Zhurinsky J., Simcha I., et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A 96 (1999) 5522-5527
32. He T.C., Sparks A.B., Rago C., et al. Identification of c-MYC as a target of the APC pathway. Science 281 (1998) 1509-1512
33. Monga S.P., Monga H.K., Tan X., Mule K., Pediaditakis P., and Michalopoulos G.K. Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Gastroenterology 124 (2003) 202-216
34. Wicha M.S., Liu S., and Dontu G. Cancer stem cells: an old idea-a paradigm shift. Cancer Res 66 (2006) 1883-1890
35. Jamieson C.H., Weissman I.L., and Passegue E. Chronic versus acute myelogenous leukemia: a question of self-renewal. Cancer Cell 6 (2004) 531-533
36. Kato Y., Iwama A., Tadokoro Y., et al. Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis. J Exp Med 202 (2005) 169-179
37. Bruix J., Boix L., Sala M., and Llovet J.M. Focus on hepatocellular carcinoma. Cancer Cell 5 (2004) 215-219
38. Roberts L.R., and Gores G.J. Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin Liver Dis 25 (2005) 212-225
39. Al-Hajj M., and Clarke M.F. Self-renewal and solid tumor stem cells. Oncogene 23 (2004) 7274-7282
40. Theise N.D., Yao J.L., Harada K., et al. Hepatic 'stem cell' malignancies in adults: four cases. Histopathology 43 (2003) 263-271
41. Beachy P.A., Karhadkar S.S., and Berman D.M. Tissue repair and stem cell renewal in carcinogenesis. Nature 432 (2004) 324-331
42. Sherr C.J. Cancer cell cycles. Science 274 (1996) 1672-1677
43. Jacobs J.J., Kieboom K., Marino S., DePinho R.A., and van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397 (1999) 164-168
44. Oguro H., Iwama A., Morita Y., Kamijo T., van Lohuizen M., and Nakauchi H. Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med 203 (2006) 2247-2253
45. Valk-Lingbeek M.E., Bruggeman S.W., and van Lohuizen M. Stem cells and cancer; the polycomb connection. Cell 118 (2004) 409-418
46. Molofsky A.V., He S., Bydon M., Morrison S.J., and Pardal R. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev 19 (2005) 1432-1437
47. Sekhon S.S., Tan X., Micsenyi A., Bowen W.C., and Monga S.P. Fibroblast growth factor enriches the embryonic liver cultures for hepatic progenitors. Am J Pathol 164 (2004) 2229-2240
48. Cadoret A., Ovejero C., Saadi-Kheddouci S., et al. Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin. Cancer Res 61 (2001) 3245-3249
49. Bellusci S., Moens G., Gaudino G., et al. Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity. Oncogene 9 (1994) 1091-1099
50. Huang C., Ma W.Y., and Dong Z. Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells. Mol Cell Biol 16 (1996) 6427-6435
51. Goyette M., Faris R., Braun L., Hixson D., and Fausto N. Expression of hepatocyte and oval cell antigens in hepatocellular carcinomas produced by oncogene-transfected liver epithelial cells. Cancer Res 50 (1990) 4809-4817
52. Dumble M.L., Croager E.J., Yeoh G.C., and Quail E.A. Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma. Carcinogenesis 23 (2002) 435-445