Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

Nature Cell Biology

Volumn 6, Issue 1, 2004, Pages 52-58

  Kaykas, Ajamete ^a   Yang Snyder, Julia ^a   Héroux, Madeleine ^b   Shah, Kavita V ^a   Bouvier, Michel ^b   Moon, Randall T ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FRIZZLED PROTEIN; G PROTEIN COUPLED RECEPTOR; MUTANT PROTEIN; WNT PROTEIN; CELL SURFACE RECEPTOR; FZD1 PROTEIN, HUMAN; FZD4 PROTEIN, HUMAN; NEUROTRANSMITTER RECEPTOR; ONCOPROTEIN; PEPTIDE FRAGMENT; PROTEIN; ZEBRAFISH PROTEIN;

ANIMAL CELL; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL FATE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; HYPOTHESIS; MORPHOGENESIS; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VITREORETINOPATHY; WILD TYPE; ALLELE; ANIMAL; CELL STRAIN COS1; DOMINANT GENE; GENETICS; METABOLISM; MUTATION;

ANIMALIA; HOMO;

ALLELES; ANIMALS; COS CELLS; ENDOPLASMIC RETICULUM; FRIZZLED RECEPTORS; GENES, DOMINANT; HUMANS; MUTATION; PEPTIDE FRAGMENTS; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROTRANSMITTER; SIGNAL TRANSDUCTION; VITREORETINOPATHY, PROLIFERATIVE; WNT PROTEINS; ZEBRAFISH PROTEINS;

EID: 1342332090     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1081     Document Type: Article

References (23)

1. Slusarski, D. C., Corces, V. G. & Moon, R. T. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 390, 410-413 (1997).
2. Sumanas, S. & Ekker, S. C. Xenopus frizzled-7 morphant displays defects in dorsoventral patterning and convergent extension movements during gastrulation, Genesis 30, 119-122 (2001).
3. Winklbauer, R., Medina, A., Swain, R. K. & Steinbeisser, H. Frizzled-7 signalling controls tissue separation during Xenopus gastrulation. Nature 413, 856-860 (2001).
4. Kuhl, M., Sheldahl, L. C., Park, M., Miller, J. R. & Moon, R. T. The Wnt/Ca2+ pathway: A new vertebrate Wnt signaling pathway takes shape. Trends Genet. 16, 279-283 (2000).
5. Salahpour, A., Angers, S. & Bouvier, M. Functional significance of oligomerization of G-protein-coupled receptors. Trends Endocrinol. Metab. 11, 163-168 (2000).
6. Angers, S., Salahpour, A. & Bouvier, M. Dimerization: An emerging concept for G protein-coupled receptor ontogeny and function. Annu. Rev. Pharmacol. Toxicol. 42, 409-435 (2002).
7. Rios, C. D., Jordan, B. A., Gomes, I. & Devi, L. A. G-protein-coupled receptor dimerization: Modulation of receptor function. Pharmacol. Ther. 92, 71-87 (2001).
8. Robitaille, J. et al. Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nature Genet. 32, 326-330 (2002).
9. Rossi, F. M., Blakely, B. T., Charlton, C. A. & Blau, H. M. Monitoring protein-protein interactions in live mammalian cells by beta-galactosidase complementation. Methods Enzymol. 328, 231-251 (2000).
10. Rossi, F., Charlton, C. A. & Blau, H. M. Monitoring protein-protein interactions in intact eukaryotic cells by β-galactosidase complementation. Proc. Natl Acad. Sci. USA 94, 8405-8410 (1997).
11. Mercier, J. F., Salahpour, A., Angers, S., Breit, A. & Bouvier, M. Quantitative assessment of β1-and β2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer. J. Biol. Chem. 277, 44925-44931 (2002).
12. Schlessinger, J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110, 669-672 (2002).
13. Dann, C. E. et al. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 412, 86-90 (2001).
14. Bafico, A. et al. Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J. Biol. Chem. 274, 16180-16187 (1999).
15. Carron, C. et al. Frizzled receptor dimerization is sufficient to activate the Wnt/β-catenin pathway. J. Cell Sci. 116, 2541-2550 (2003).
16. Zhang, Z., Sun, S., Quinn, S. J., Brown, E. M. & Bai, M. The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions. J. Biol. Chem. 276, 5316-5322 (2001).
17. Rivera, V. M. et al. Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science 287, 826-830 (2000).
18. Ou, W. & Silver, J. Role of a conserved amino-terminal sequence in the ecotropic MLV receptor mCAT1. Virology 308, 101-113 (2003).
19. Sheldahl, L. C., Park, M., Malbon, C. C. & Moon, R. T. Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr. Biol. 9, 695-698 (1999).
20. Kuhl, M., Sheldahl, L. C., Malbon, C. C. & Moon, R. T. Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J. Biol. Chem. 275, 12701-12711 (2000).
21. Gomes, I. et al. G protein coupled receptor dimerization: implications in modulating receptor function. J. Mol. Med. 79, 226-242 (2001).
22. Goodwin, A. M. & D'Amore, P. A. Wnt signaling in the vasculature. Angiogenesis 5, 1-9 (2002).
23. Veeman, M. T., Slusarski, D. C., Kaykas, A., Louie, S. H. & Moon, R. T. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr. Biol. 13, 680-685 (2003).