Physiological regulation of β-catenin stability by Tcf3 and CK1ε

Journal of Cell Biology

Volumn 154, Issue 5, 2001, Pages 983-993

  Lee, Ethan ^a   Salic, Adrian ^a   Kirschner, Marc W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

catenin; Casein kinase; Tcf; wnt; Xenopus

Indexed keywords

AXIN; BETA CATENIN; CASEIN KINASE; CASEIN KINASE I; DNA BINDING PROTEIN; ENZYME INHIBITOR; PROTEIN TFC3; UNCLASSIFIED DRUG;

ADENOMATOUS POLYP; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN STABILITY; XENOPUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BETA CATENIN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CASEIN KINASES; CELL FRACTIONATION; CYTOSKELETAL PROTEINS; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; HMGB PROTEINS; IMMUNOBLOTTING; OOCYTES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; TCF TRANSCRIPTION FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; XENOPUS LAEVIS; XENOPUS PROTEINS;

ANIMALIA;

EID: 0035802116     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200102074     Document Type: Article

References (40)

1. Beta-catenin is a target for the ubiquitin-proteasome pathway
2. The Yin-Yang of TCF/beta-catenin signaling
3. Functional interaction of beta catenin with the transcriptional factor LEF-1
4. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
5. A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus
6. Drosophila Tcf and Groucho interact to repress Wingless signalling activity
7. A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis
8. Effects of rat axin domains on axis formation in Xenopus embryos
9. Crystal structure of a beta-catenin/Tcf complex
10. Downregulation of beta-catenin by human axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
11. Nuclear DNA sythesis in vitro is mediated via stable replication forks assembled in a temporally specific fashion in vivo
12. Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover
13. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1
14. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
15. Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin
16. Domains of axin and disheveled required for interaction and function in wnt signaling
17. Inhibition of Wnt signaling pathway by a novel axin-binding protein
18. Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
19. A molecular mechanism for the effect of lithium on development
20. A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways
21. LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter
22. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
23. Beta-carenin signaling and cancer
24. Cyclin synthesis drives the early embryonic cell cycle
25. Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer
26. Casein kinase I transduces Wnt signals
27. Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin
28. WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans
29. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
30. Casein kinase iepsilon in the wnt pathway: Regulation of beta-catenin function
31. Control of beta-catenin stability: Reconstitution of the cytoplasmic steps of the wnt signaling pathway
32. Analysis of dishevelled signalling pathways during Xenopus development
33. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein
34. The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression
35. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
36. Hot spots in beta-catenin for interactions with LEF-1, conductin and APC
37. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
38. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
39. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis
40. Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin