Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors

BMC Cell Biology

Volumn 4, Issue , 2003, Pages

  Schweizer, Liang ^a   Varmus, Harold ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BETA CATENIN; CYSTEINE; DOUBLE STRANDED RNA; FRIZZLED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LUCIFERASE; UNCLASSIFIED DRUG; WNT1 PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; DROSOPHILA; GENE ACTIVATION; GENE TARGETING; NONHUMAN; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; BLOTTING, NORTHERN; CELL LINE; CYTOSKELETAL PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; FRIZZLED RECEPTORS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1; LUCIFERASES; MUTATION; PROTO-ONCOGENE PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROTRANSMITTER; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; WNT1 PROTEIN;

ARMADILLO; MAMMALIA;

EID: 0242704649     PISSN: 14712121     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2121-4-4     Document Type: Article

References (28)

1. Cadigan KM and Nusse R Wnt signaling: a common theme in animal development Genes & Development 1997, 11:3286-305
2. Wodarz A and Nusse R Mechanisms of Wnt signaling in development Annual Review of Cell & Developmental Biology 1998, 14:59-88
3. Nusse R and Varmus HE Wnt genes Cell 1992, 69:1073-87
4. Polakis P Wnt signaling and cancer Genes Dev 2000, 14:1837-51
5. Yang-Snyder J, Miller JR, Brown JD, Lai CJ and Moon RT A frizzled homolog functions in a vertebrate Wnt signaling pathway Curr Biol 1996, 6:1302-6
6. Bhanot P, Brink M, Samos CH, Hsieh JC, Wang Y, Macke JP, Andrew D, Nathans J and Nusse R A new member of the frizzled family from Drosophila functions as a Wingless receptor Nature 1996, 382:225-30
7. Pinson KI, Brennan J, Monkley S, Avery BJ and Skarnes WC An LDLreceptor-related protein mediates Wnt signaling in mice Nature 2000, 407:535-8
8. Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP and He X LDL-receptor-related proteins in Wnt signal transduction Nature 2000, 407:530-5
9. Wehrli M, Dougan ST, Caldwell K, O'Keefe L, Schwartz S, Vaizel-Ohayon D, Schejter E, Tomlinson A and DiNardo S arrow encodes an LDL-receptor-related protein essential for Wingless signaling Nature 2000, 407:527-30
10. Bafico A, Liu G, Yaniv A, Gazit A and Aaronson SA Novel mechanism of Wnt signaling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow Nat Cell Biol 2001, 3:683-6
11. Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A and Niehrs C LDL-receptor-related protein 6 is a receptor for Dickkopf proteins Nature 2001, 411:321-5
12. Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S and He X Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6 Curr Biol 2001, 11:951-61
13. Mao J, Wang J, Liu B, Pan W, Farr GH 3rd, Flynn C, Yuan H, Takada S, Kimelman D and Li L Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway Mol Cell 2001, 7:801-9
14. Li L, Mao J, Sun L, Liu W and Wu D Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled J Biol Chem 2002, 277:5977-81
15. Caplen NJ, Fleenor J, Fire A and Morgan RA dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference Gene 2000, 252:95-105
16. Worby CA, Simonson-Leff N and Dixon JE RNA interference of gene expression (RNAi) in cultured Drosophila cells Sci STKE 2001, 2001:L1
17. Sato A, Kojima T, Ui-Tei K, Miyata Y and Saigo K Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants Development 1999, 126:4421-30
18. Yanagawa S, Lee JS and Ishimoto A Identification and characterization of a novel line of Drosophila Schneider S2 cells that respond to wingless signaling J Biol Chem 1998, 273:32353-9
19. Hsu SC, Galceran J and Grosschedl R Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin Mol Cell Biol 1998, 18:4807-18
20. Umbhauer M, Djiane A, Goisset C, Penzo-Mendez A, Riou JF, Boucaut JC and Shi DL The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signaling Embo J 2000, 19:4944-54
21. Boutros M, Mihaly J, Bouwmeester T and Mlodzik M Signaling specificity by Frizzled receptors in Drosophila Science 2000, 288:1825-8
22. Wu CH and Nusse R Ligand receptore interactions in the WNT signaling pathway in Drosophila J Biol Chem 2002, 29:29
23. Siegfried E, Wilder EL and Perrimon N Components of wingless signaling in Drosophila Nature 1994, 367:76-80
24. Noordermeer J, Klingensmith J, Perrimon N and Nusse R dishevelled and armadillo act in the wingless signaling pathway in Drosophila Nature 1994, 367:80-3
25. Klingensmith J, Nusse R and Perrimon N The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal Genes Dev 1994, 8:118-30
26. Rothbacher U, Laurent MN, Deardorff MA, Klein PS, Cho KW and Fraser SE Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis Embo J 2000, 19:1010-22
27. Koelle M and Hogness D Technical Notes: Plasmid vectors for expressing proteins in tissue culture cells or studying enhancer function DIN 1992, 8:
28. Koelle M and Hogness D Technical Notes: Plasmid vectors for expressing proteins in tissue culture cells or studying enhancer function DIS 1993, 72:197