Fibrillogenic Amylin Evokes Islet β-Cell Apoptosis through Linked Activation of a Caspase Cascade and JNK1

Journal of Biological Chemistry

Volumn 278, Issue 52, 2003, Pages 52810-52819

  Zhang, Shaoping ^a   Liu, Junxi ^a   Dragunow, Michael ^b   Cooper, Garth J S ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL ACTIVATION; DISEASES; ENZYME INHIBITION;

APOPTOSIS; BIOCHEMICAL PATHWAYS;

BIOCHEMISTRY;

AMYLIN; ANTISENSE OLIGONUCLEOTIDE; CASPASE; CASPASE 3; CASPASE 8; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; JANUS KINASE; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; BETA SHEET; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; IMMUNOHISTOCHEMISTRY; INSULINOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; WESTERN BLOTTING;

AMYLOID; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 1; CASPASE 3; CASPASE 8; CASPASES; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRIN; HUMANS; IMMUNOHISTOCHEMISTRY; INSULINOMA; ISLETS OF LANGERHANS; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; TIME FACTORS;

ANIMALIA; JANUS;

EID: 0346101742     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308244200     Document Type: Article

References (60)

1. Cooper, G. J. S. (1994) Endocrine Rev. 15, 163-201
2. Hoppener, J. W. M., Ahren, B., and Lips, C. J. M. (2000) N. Engl. J. Med. 343, 411-419
3. Clark, A., Cooper, G. J. S., Lewis, C. E., Morris, J. F., Willis, A. C., Reid, K. B. M., and Turner, R. C. (1987) Lancet 2, 231-234
4. Cooper, G. J. S., Willis, A. C., Clark, A., Turner, R. C., Sim, R. B., and Reid, K. B. M. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 8628-8632
5. Moore, C. X., and Cooper, G. J. S. (1991) Biochem. Biophys. Res. Commun. 179, 1-9
6. Ogawa, A., Harris, V., McCorkle, S. K., Unger, R. H., and Luskey, K. L. (1990) J. Clin. Invest. 85, 973-976
7. Lorenzo, A., Razzaboni, B., Weir, G. C., and Yankner, B. A. (1994) Nature 368, 756-760
8. Janson, J., Soeller, W. C., Roche, P. C., Nelson, R. T., Torchia, A. J., Kreutter, D. K., and Butler, P. C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 7283-7288
9. Zhang, S. P., Liu, J. X., MacGibbon, G., Dragunow, M., and Cooper, G. J. S. (2002) J. Mol. Biol. 324, 271-285
10. Zhang, S. P., Liu, J. X., Saafi, E. L., and Cooper, G. J. S. (1999) FEBS Lett. 455, 315-320
11. Saafi, E. L., Konarkowska, B., Zhang, S., Kistler, J., and Cooper, G. J. S. (2001) Cell Biol. Int. 25, 339-350
12. Kahn, S. E., Andrikopoulos, S., and Verchere, C. B. (1999) Diabetes 48, 241-253
13. Kapurniotu, A. (2001) Biopolymers 60, 438-459
14. Tenidis, K., Waldner, M., Bernhagen, J., Fischle, W., Bergmann, M., Weber, M., Merkle, M. L., Voelter, W., Brunner, H., and Kapurniotu, A. (2000) J. Mol. Biol. 295, 1055-1071
15. Green, J., Goldsbury, C., Min, T., Sunderji, S., Frey, P., Kistler, J., Cooper, G., and Aebi, U. (2003) J. Mol. Biol. 326, 1147-1156
16. Goldsbury, C., Goldie, K., Pellaud, J., Seelig, J., Frey, P., Muller, S. A., Kistler, J., Cooper, G. J. S., and Aebi, U. (2000) J. Struct. Biol. 130, 352-362
17. Goldsbury, C., Kistler, J., Aebi, U., Arvinte, T., and Cooper, G. J. S. (1999) J. Mol. Biol. 285, 33-39
18. Goldsbury, C. S., Cooper, G. J. S., Goldie, K. N., Müller, S. A., Saafi, E. L., Gruijters, W. T. M., Misur, M. P., Engel, A., Aebi, U., and Kistler, J. (1997) J. Struct. Biol. 119, 17-27
19. Cooper, G. J. S., Day, A. J., Willis, A. C., Roberts, A. N., Reid, K. B. M., and Leighton, B. (1989) Biochim. Biophys. Acta 1014, 247-258
20. Westermark, P., Engström, U., Johnson, K. H., Westermark, G. T., and Betsholtz, C. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 5036-5040
21. Janes, S., Gaeta, L., Beaumont, K., Beely, N., and Rink, T. (1996) Diabetes 45, abstract 865
22. Nilsson, M. R., and Raleigh, D. P. (1999) J. Mol. Biol. 294, 1375-1385
23. Jaikaran, E., Higham, C. E., Serpell, L. C., Zurdo, J., Gross, M., Clark, A., and Fraser, P. E. (2001) J. Mol. Biol. 308, 515-525
24. Mazor, Y., Gilead, S., Benhar, I., and Gazit, E. (2002) J. Mol. Biol. 322, 1013-1024
25. van Hulst, K. L., Oosterwijk, C., Born, W., Vroom, T. M., Nieuwenhuis, M. G., Blankenstein, M. A., Lips, C. J. M., Fischer, J. A., and Hoppener, J. W. M. (1999) Eur. J. Endocrinol. 140, 69-78
26. Verchere, C. B., D'Alessio, D. A., Palmiter, R. D., Weir, G. C., Bonner-Weir, S., Baskin, D. G., and Kahn, S. E. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 3492-3496
27. Janciauskiene, S., and Ahren, B. (2000) Biochem. Biophys. Res. Commun. 267, 619-625
28. Mirzabekov, T. A., Lin, M. C., and Kagan, B. L. (1996) J. Biol. Chem. 271, 1988-1992
29. Bai, J. Z., Saafi, E. L., Zhang, S., and Cooper, G. J. S. (1999) Biochem. J. 343, 53-61
30. Janson, J., Ashley, R. H., Harrison, D., McIntyre, S., and Butler, P. C. (1999) Diabetes 48, 491-498
31. Soeller, W. C., Janson, J., Hart, S. E., Parker, J. C., Carty, M. D., Stevenson, R. W., Kreutter, D. K., and Butler, P. C. (1998) Diabetes 47, 743-750
32. Vaux, D. L. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 786-789
33. Strasser, A., Harris, A. W., Bath, M. L., and Cory, S. (1990) Nature 22, 331-333
34. Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A., and Nagata, S. (1992) Nature 356, 314-317
35. Strasser, A., O'Connor, L., and Dixit, V. M. (2000) Annu. Rev. Biochem. 69, 217-245
36. Thompson, C. B. (1995) Science 267, 1455-1462
37. Thornberry, N. A., and Lazebnik, Y. (1998) Science 281, 1312-1316
38. Earnshaw, W. C., Martins, L. M., and Kaufmann, S. H. (1999) Annu. Rev. Biochem. 68, 383-424
39. Budihardjo, I., Oliver, H., Lutter, M., Luo, X., and Wang, X. (1999) Annu. Rev. Cell Dev. Biol. 15, 269-290
40. Yamada, K., Ichikawa, F., Ishiyama-Shigemoto, S., Yuan, X., and Nonaka, K. (1999) Diabetes 48, 478-483
41. Schulzeosthoff, K., Ferrari, D., Los, M., Wesselborg, S., and Peter, M. E. (1998) Eur. J. Biochem. 254, 439-459
42. Ohtsuka, T., and Zhou, T. (2002) J. Biol. Chem. 277, 29294-29303
43. Juo, P., Kuo, C. J., Yuan, J., and Blenis, J. (1998) Curr. Biol. 8, 1001-1008
44. Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K., and Gotoh, Y. (1997) Science 275, 90-94
45. Gueli, N., Toto, A., Palmieri, G., Carmenini, G., Delpino, A., and Ferrini, U. (1987) J. Exp. Clin. Cancer Res. 6, 281-285
46. Bonny, C., Oberson, A., Negri, S., Sauser, C., and Schorderet, D. F. (2001) Diabetes 50, 77-82
47. Poyner, D. (1995) Trends Pharmacol. Sci. 16, 424-428
48. Roberts, A. N., Leighton, B., Todd, J. A., Cockburn, D., Schofield, P. N., Sutton, R., Holi, S., Boyd, Y., Day, A. J., and Foot, E. A. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 9662-9666
49. Hettiarachchi, M., Chalkley, S., Furler, S. M., Choong, Y. S., Heller, M., Cooper, G., and Kraegen, E. W. (1997) Am. J. Physiol. 273, E859-E863
50. Enari, M., Talanian, R. V., Wong, W. W., and Nagata, S. (1996) Nature 380, 723-726
51. Ip, Y. T., and Davis, R. J. (1998) Curr. Opin. Cell Biol. 10, 205-219
52. Kumagae, Y., Zhang, Y., Kim, O. J., and Miller, C. A. (1999) Brain Res. 67, 10-17
53. Longthorne, V. L., and Williams, G. T. (1997) EMBO J. 16, 3805-3812
54. Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., and Woodgett, J. R. (1994) Nature 369, 156-160
55. Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Derijard, B., and Davis, R. J. (1996) EMBO J. 15, 2760-2770
56. Villunger, A., Huang, D. C. S., Holler, N., Tschopp, J., and Strasser, A. (2000) J. Immunol. 165, 1337-1343
57. Weyer, C., Maggs, D. G., Young, A. A., and Kolterman, O. G. (2001) Curr. Pharm. Des. 7, 1353-1373
58. Thompson, R. G., Gottlieb, A., Organ, K., Koda, J., Kisicki, J., and Kolterman, O. G. (1997) Diabetic Med. 14, 547-555
59. Fineman, M., Gottlieb, A., Skare, S., and Kolterman, O. (2000) Diabetes 49, pA106
60. Fineman, M. S., Koda, J. E., Shen, L. Z., Strobel, S. A., Maggs, D. G., Weyer, C., and Kolterman, O. G. (2002) Metabol. Clin. Exp. 51, 636-641