Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 β-cells

Endocrinology

Volumn 151, Issue 7, 2010, Pages 3061-3073

  El Assaad, Wissal ^a   Joly, Erik ^a   Barbeau, Annie ^a   Sladek, Robert ^c   Buteau, Jean ^a,e   Maestre, Isabel ^d   Pepin, Emilie ^a   Zhao, Shangang ^a   Iglesias, José ^a   Roche, Enrique ^d   Prentki, Marc ^a,b  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^e LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; CERAMIDE; CHOLESTEROL; FATTY ACID; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; INSULIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRIACYLGLYCEROL; ACYLTRANSFERASE; AMINOGLYCOSIDE N1 ACETYLTRANSFERASE; AMINOGLYCOSIDE N1-ACETYLTRANSFERASE; GLUCOSE; GLYCEROL 3 PHOSPHATE CYTIDYLYLTRANSFERASE; GLYCEROL-3-PHOSPHATE CYTIDYLYLTRANSFERASE; NUCLEOTIDYLTRANSFERASE; PALMITIC ACID DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENERGY METABOLISM; ESTERIFICATION; FATTY ACID SYNTHESIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCOSE METABOLISM; INSULIN RELEASE; LIPID METABOLISM; LIPID OXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ANIMAL; BIOLOGICAL MODEL; DNA MICROARRAY; DRUG EFFECT; GENETICS; METABOLISM; MITOCHONDRION; PHYSIOLOGY; RAT; RNA INTERFERENCE;

ACETYLTRANSFERASES; ANIMALS; APOPTOSIS; CERAMIDES; CHOLESTEROL; GLUCOSE; INSULIN-SECRETING CELLS; LIPID METABOLISM; MITOCHONDRIA; MODELS, BIOLOGICAL; NUCLEOTIDYLTRANSFERASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PALMITATES; RATS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE;

EID: 77954595108     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-1238     Document Type: Article

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