Downregulation of the HERG (KCNH2) K+ channel by ceramide: Evidence for ubiquitin-mediated lysosomal degradation

Journal of Cell Science

Volumn 118, Issue 22, 2005, Pages 5325-5334

  Chapman, Hugh ^a   Ramström, Cia ^a,b   Korhonen, Laura ^c   Laine, Mika ^a,d   Wann, Kenneth T ^e   Lindholm, Dan ^a,c   Pasternack, Michael ^a   Törnquist, Kid ^a,b  

^a MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c UPPSALA UNIVERSITY   (Sweden)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Ceramide; Channels; HERG; Internalisation; Sphingolipids; Ubiquitin

Indexed keywords

CELL SURFACE PROTEIN; CERAMIDE; POTASSIUM CHANNEL HERG; POTASSIUM ION; UBIQUITIN;

ARTICLE; BIOTINYLATION; CELL STIMULATION; CHANNEL GATING; CONTROLLED STUDY; DEGRADATION; DOWN REGULATION; EMBRYO; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LYSOSOME; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REDUCTION; REGULATORY MECHANISM; UBIQUITINATION; WESTERN BLOTTING;

CELLS, CULTURED; CERAMIDES; DOWN-REGULATION; GENE EXPRESSION; HUMANS; ION CHANNEL GATING; LYSOSOMES; MEMBRANE POTENTIALS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN PROCESSING, POST-TRANSLATIONAL; TIME FACTORS; UBIQUITIN;

EID: 29244467945     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.02635     Document Type: Article

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