Mechanisms of pancreatic β-cell apoptosis in diabetes and its therapies

Advances in Experimental Medicine and Biology

Volumn 654, Issue , 2010, Pages 447-462

  Johnson, James D ^a   Luciani, Dan S ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NONE

Author keywords

Autoimmune diabetes; Clinical islet transplantation; Endoplasmic reticulum stress; Gene environment interactions; Glucotoxicity and lipotoxicity; Mitochondrial death pathway

Indexed keywords

CALPAIN 10; DEATH RECEPTOR; EXENDIN 4; FAS ANTIGEN; FAS LIGAND; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HYPOXIA INDUCIBLE FACTOR 1BETA; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; RAF PROTEIN; RAPAMYCIN; SOMATOMEDIN C RECEPTOR; STAT1 PROTEIN; TACROLIMUS; TRANSCRIPTION FACTOR 7 LIKE 2; TRANSCRIPTION FACTOR PDX 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; LIGAND;

APOPTOSIS; CELL FUNCTION; CELL SURVIVAL; DIABETES MELLITUS; DISEASE COURSE; DISEASE PREDISPOSITION; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; GLUCOSE HOMEOSTASIS; GRAFT REJECTION; HUMAN; IMMUNE SYSTEM; INSULIN DEPENDENT DIABETES MELLITUS; LIPOTOXICITY; MATURITY ONSET DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; ENDOPLASMIC RETICULUM; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; MITOCHONDRION;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM; HUMANS; INSULIN-SECRETING CELLS; LIGANDS; MITOCHONDRIA; MODELS, BIOLOGICAL; MODELS, GENETIC;

EID: 77953936771     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-90-481-3271-3_19     Document Type: Review

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