Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: Potential mechanisms underlying ceramide-mediated metabolic dysfunction of the β cell

Apoptosis

Volumn 10, Issue 4, 2005, Pages 841-850

  Veluthakal, R ^a   Palanivel, R ^a,c   Zhao, Y ^a   McDonald, P ^c   Gruber, S ^b   Kowluru, A ^a,b  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Ceramide; Mitochondria; Pancreatic cell; Protein phosphatase

Indexed keywords

CERAMIDE; CYTOCHROME C; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MATRIX METALLOPROTEINASE; NITRIC OXIDE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSOL; GENE EXPRESSION; INSULIN RELEASE; MEMBRANE POTENTIAL; METABOLIC DISORDER; MITOCHONDRIAL MEMBRANE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN TARGETING; PURIFICATION; RAT;

ANIMALS; CATALYTIC DOMAIN; CELL LINE; CELL SURVIVAL; CERAMIDES; CYTOCHROMES C; ENZYME ACTIVATION; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; MEMBRANE POTENTIAL, MITOCHONDRIAL; METHYLATION; MITOCHONDRIA; NITRIC OXIDE; PHOSPHOPROTEIN PHOSPHATASES; RATS;

EID: 23944484541     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10495-005-0431-4     Document Type: Article

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