An aging pathway controls the TrkA to p75NTR receptor switch and amyloid β-peptide generation

EMBO Journal

Volumn 25, Issue 9, 2006, Pages 1997-2006

  Costantini, Claudio ^a   Scrable, Heidi ^b   Puglielli, Luigi ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Alzheimer's disease; Amyloid peptide; Ceramide; IGF1 R; p75 NTR

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE; BETA SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1; CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; INSULIN RECEPTOR SUBSTRATE 2; NEUROTROPHIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P44; PROTEIN P53; PROTEIN P75; PROTEIN TYROSINE KINASE A; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

AGING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; HUMAN; HUMAN CELL; LIFESPAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RECEPTOR UPREGULATION; SECOND MESSENGER; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AGING, PREMATURE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; CELL LINE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; NEURONS; PHOSPHOPROTEINS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTOR, IGF TYPE 1; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MUS MUSCULUS;

EID: 33646591261     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601062     Document Type: Article

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