Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting β-cells under in vitro conditions of glucolipotoxicity

Molecular and Cellular Biochemistry

Volumn 329, Issue 1-2, 2009, Pages 121-129

  Veluthakal, Rajakrishnan ^a   Suresh, Madathilparambil V ^a   Kowluru, Anjaneyulu ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

Gluco lipotoxicity; GTP binding proteins; Insulin secretion; Islet cell; Nucleoside diphosphate kinase; Oxidative stress

Indexed keywords

CERAMIDE; NUCLEOSIDE DIPHOSPHATE KINASE; NUCLEOSIDE DIPHOSPHATE KINASE A; NUCLEOSIDE DIPHOSPHATE KINASE B; PALMITIC ACID; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; ENZYME INHIBITOR; GLUCOSE; INSULIN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GLUCOLIPOTOXICITY; IN VITRO STUDY; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DOSE RESPONSE; GENETICS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TIME;

ANIMALIA; RATTUS;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; NUCLEOSIDE-DIPHOSPHATE KINASE; PALMITIC ACID; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 70449730103     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0113-6     Document Type: Article

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