Functional rafts in cell membranes

Nature

Volumn 387, Issue 6633, 1997, Pages 569-572

  Simons, Kai ^a   Ikonen, Elina ^b  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; SPHINGOLIPID;

BILAYER MEMBRANE; CELL MEMBRANE; EPITHELIUM CELL; LIPID METABOLISM; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CHOLESTEROL; DETERGENTS; GOLGI APPARATUS; HUMANS; MEMBRANE LIPIDS; MEMBRANE PROTEINS; SIGNAL TRANSDUCTION; SOLUBILITY; SPHINGOLIPIDS;

EID: 0030949124     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/42408     Document Type: Review

References (67)

1. Singer, S. J. & Nicolson, G. L. The fluid mosaic model of the structure of cell membranes. Science 175, 720-731 (1972).
2. van Meer, G. Lipid traffic in animal cells. Annu. Rev. Cell Biol. 5, 247-275 (1989).
3. Kusumi, A. & Sako, Y. Cell surface organization by the membrane skeleton. Curr. Opin. Cell Biol. 8, 566-574 (1996).
4. Rodriguez-Boulan, E. & Nelson, W. J. Morphogenesis of the polarized epithelial cell phenotype. Science 245, 718-725 (1989).
5. Simons, K. & van Meer, G. Lipid sorting in epithelial cells. Biochemistry 27, 6197-6202 (1988).
6. van Helvoort, A. et al. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while M P-glycoprotein specifically translocates phosphatidylcholine. Cell 87, 507-518 (1996).
7. Brown, D. & Rose, J. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68, 533-544 (1992).
8. Parton, R. G. Caveolae and caveolins. Curr. Opin. Cell Biol. 8, 542-548 (1996).
9. Tran, D. J., Carpentier, J. L., Sawano, F., Gorden, P. & Orci, L. Ligands internalized through coated or non-coated invaginations follow a common intracellular pathway. Proc. Natl Acad. Sci. USA 84, 7957-7961 (1987).
10. Rothberg, K. G., Ying, Y. S., Kamen, B. A. & Anderson, R. G. W. Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate. J. Cell Biol. 111, 2931-2938 (1990).
11. Ghitescu, L., Fixman, A., Simionescu, M. & Simionescu, N. Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium; receptor-mediated transcytosis. J. Cell Biol. 102, 1304-1311 (1986).
12. Dupree, P., Parton, R. G., Raposo, G., Kurzchalia, T. V. & Simons, K. Caveolae and sorting in the Trans-Golgi network of epithelial cells. EMBO J. 12, 1597-1605 (1993).
13. Morrow, M. R., Singh, D., Lu, D. & Grant, C. W. M. Glycosphingolipid fatty acid arrangement in phospholipid bilayers: cholesterol effects. Biophysical J. 68, 179-186 (1995).
14. Boggs, J. M. & Koshy, K. M. Do the long fatty acid chains of sphingolipids interdigitate across the center of bilayer of shorter chain symmetric phospholipids? Biochim. Biophys. Acta 1189, 233-241 (1994).
15. Parton, R. G. & Simons, K. Digging into caveolae. Science 269, 1398-1399 (1995).
16. Schroeder, R., London, E. & Brown, D. Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol(GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior. Proc. Natl Acad. Sci. USA 91, 12130-12134 (1994).
17. Skibbens, J. E., Roth, M. G. & Matlin, K. S. Differential extractibility of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and nonpolar fibroblasts. J. Cell Biol. 108, 821-832 (1989).
18. Sargiacomo, M., Sudol, M., Tang, Z. & Lisanti, M. P. Signal transducing molecules and GPI-linked proteins from a caveolin-rich insoluble complex in MDCK cells. J. Cell Biol. 122, 789-807 (1993).
19. Fra, A. M., Williamson, E., Simons, K. & Parton, R. G. Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae. J. Biol. Chem. 269, 30745-30748 (1994).
20. Danielsen, E. M. A transferrin-like GPI-linked iron-binding protein in detergent-insoluble non-caveolar microdomains at the apical surface of fetal intestinal epithelial cells. Biochemistry 34, 1596-1605 (1995).
21. Casey, P. J. Protein lipidation in cell signalling. Science 268, 221-225 (1995).
22. Cerneus, D. P., Ueffing, E., Posthuma, G., Strous, G. J. & van der Ende, A. Detergent insolubility of alkaline phosphatase during biosynthetic transport and endocytosis. Role of cholesterol. J. Biol. Chem. 268, 3150-3155 (1993).
23. Hanada, K., Nishijima, M., Akamatsu, Y. & Pagano, R. E. Both sphingolipids and cholesterol participate in the detergent-insolubility of alkaline phosphatase, a glycosyl-phosphatidylinositol anchored protein in mammalian cells. J. Biol. Chem. 270, 6254-6260 (1995).
24. Hannan, L. A. & Edidin, M. Glycosylphosphatidytinositol-anchored protein after LDL-deprivation of MDCK cells. J. Cell Biol. 133, 1265-1276 (1996).
25. Kundu, A., Avalos, R. T., Sanderson, C. M. & Nayak, D. P. Transmembrane domain of influenza virus neuraminidase, a type II protein, possesses an apical sorting signal in polarized MDCK cells. J. Virol. 70, 6508-6515 (1996).
26. Murata, M. et al. VIP21-caveolin is a cholesterol-binding protein. Proc. Natl Acad. Sci. USA 92, 10339-10343 (1995).
27. Lisanti, M. P., Sargiacomo, M., Graeve, L., Saltiel, A. & Rodriguez-Boulan, E. Polarized apical distribution of glycosyl-phosphatidylinositol-anchored proteins in a renal epithelial cell line. Proc. Natl Acad. Sci. USA 85, 9557-9561 (1989).
28. Scheiffele, P., Peränen, J. & Simons, K. N-glycans as apical sorting signals in epithelial cells. Nature 378, 96-98 (1995).
29. Fiedler, K., Parton, R. G., Kellner, R., Etzold, T. & Simons, K. VIP36, a novel component of glycolipid rafts and exocytic carrier vesicles in epithelial cells. EMBO J. 13, 1729-1740 (1994).
30. Matter, K. & Mellman, I. Mechanisms of cell polarity: Sorting and transport in epithelial cells. Curr. Opin. Cell. Biol. 6, 545-554 (1994).
31. Ikonen, E., Tagaya, M., Ullrich, O., Montecucco, C. & Simons, K. Different requirements for NSF, SNAP, and Rab proteins in apical and basolateral transport in MDCK cells. Cell 81, 1-20 (1995).
32. Rothman, J. E. & Wieland, F. T. Protein sorting by transport vesicles. Science 272, 227-234 (1996).
33. Müsch, A., Xu, H., Shield, D. & Rodriguez-Boulan, E. Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells. J. Cell Biol. 133, 543-558 (1996).
34. Yoshimori, T., Keller, P., Roth, M. G. & Simons, K. Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells. J. Cell Biol. 133, 247-256 (1996).
35. Danielsen, E. M. & van Deurs, B. Involvement of detergent-insoluble complexes in the intracellular transport of intestinal brush border enzymes. J. Cell Biol. 131, 939-950 (1995).
36. Schnitzer, J. E., Oh, P., Pinney, E. & Allard, J. Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules. J. Cell Biol. 127, 1217-1232 (1994).
37. Anderson, R. G. W., Kamen, B. A., Rothberg, K. G. & Lacey, S. W. Potocytosis: sequestration and transport of small molecules by caveolae. Science 255, 410-411 (1992).
38. Anderson, H. A., Chen, Y. & Norkin, L. C. Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae, Mol. Biol. Cell 7, 1825-1834 (1996).
39. Deckert, M. et al. Endocytosis of GPI-anchored proteins in human lymphocytes: role of glycolipid-based domains, actin cytoskeleton, and protein kinases. J. Cell Biol. 133, 791-799 (1996).
40. Mostov, K. E., Apodaca, G., Aroeti, B. & Okamoto, C. Plasma membrane protein sorting in polarized epithelial cells. J. Cell Biol. 116, 577-583 (1992).
41. Simons, K, et al. The biogenesis of cell surface polarity in epithelial cells and neurons. Cold Spring Harbor Symp. Quant. Biol. LVII, 611-619 (1992).
42. Pfeiffer, S. E., Warrington, A. E. & Bansal, R. The oligodendrocyte and its many cellular processes. Trends Cell Biol. 3, 191-197 (1993).
43. Peranen, J., Auvinen, P., Virta, H., Wepf, R. & Simons, K. Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts. J. Cell Biol. 135, 153-167 (1996).
44. Anderson, R. G. W. Caveolae: where incoming and outgoing messengers meet. Proc. Natl Acad. Sci. USA 90, 10909-10913 (1993).
45. Lisanti, M. P., Scherer, P. E., Tang, Z. L. & Sargiacomo, M. Caveolaer, caveolin and caveolin-rich membrane domains: a signalling hypothesis. Trends Cell Biol. 4, 231-235 (1994).
46. Parpal, S., Gustavsson, J. & Strålfors, P. Isolation of phosphooligosaccharide/phosphoinositol glycan from caveolae and cytosol of insulin-stimulated cells. J. Cell Biol. 131, 125-135 (1995).
47. Li, S. et al. Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J. Biol. Chem. 270, 15693-15701 (1995).
48. Song, K. S. et al. Co-purification and direct interaciton of Ras with caveolin, an integral membrane protein of caveolae microdomains. J. Biol. Chem. 271, 9690-9697 (1996).
49. Mineo, C., James, G. L., Smart, E. J. & Anderson, R. G. Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane. J. Biol. Chem. 217, 11930-11935 (1996).
50. Hope, H. R. & Pike, L. J. Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains. Mol. Biol. Cell 7, 843-851 (1996).
51. Linardic, C. M. & Hannun, Y. A. Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. J. Biol. Chem. 269, 23530-23537 (1994).
52. Liu, P. & Anderson, R. G. W. Compartmentalized production of ceramide at the cell surface. J. Biol. Chem. 270, 27179-27185 (1995).
53. Mayor, S., Rothberg, K. G. & Maxfield, F. R. Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking. Science 264, 1948-1951 (1994).
54. 2-macroglobulin receptor/low density lipoprotein receptor-related protein. J. Biol. Chem. 269, 25668-25676 (1994).
55. Field, K. A., Holowka, D. & Baird, B. FcεRI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling. Proc. Natl Acad. Sci. USA 92, 9201-9205 (1995).
56. Klein, U., Gimpl, G. & Fahrenholz, F. Alteration of myometrial plasma membrane cholesterol content with β-cyclodextrin modulates the binding affinity of the oxytocin receptor. Biochemistry 34, 13784-13793 (1995).
57. Mutoh, T., Tokuda, A., Miyadai, T., Hamaguchi, M. & Fujiki, N. Ganglioside GM1 binds to the Trk protein and regulates receptor function. Proc. Natl Acad. Sci. USA 92, 5087-5091 (1995).
58. Bretscher, M. S. & Munro, S. Cholesterol and the Golgi apparatus. Science 261, 1280-1281 (1993).
59. Rock, P., Allietta, M., Young, W. W. Jr, Thompson, T. E. & Tillack, T. W. Organization of glycosphingolipids in phosphatidylcholine bilayers: use of antibody molecules and Fab fragments as morphologic markers. Biochemistry 29, 8484-8490 (1990).
60. Spiegel, S., Kassis, S., Wilchek, M. & Fishman, P. H. Direct visualization of redistribution and cappiang of fluorescent gangliosides on lymphocytes. J. Cell Biol. 99, 1575-1581 (1984).
61. Boggs, J. M. Lipid intermolecular hydrogen bonding: influence on structural organization and membrane function. Biochim. Biophys. Acta 906, 353-404 (1987).
62. Smaby, J. M., Momsen, M., Kulkarni, V. S. & Brown, R. E. Cholesterol-induced interfacial area condensations of galactosylceramides and sphingomyelins with identical acyl chains. Biochemistry 35, 5696-5704 (1996).
63. Silvius, J. R. Cholesterol modulation of lipid intermixing in phospholipid and glycosphingolipid mixtures. Evaluation using fluorescent lipid probes and brominated lipid quenchers. Biochemistry 31, 3398-3408 (1992).
64. Sankaram, M. B. & Thompson, T. E. Interaction of cholesterol with various glycerophospholipids and sphingomyelin. Biochemistry 29, 10670-10675 (1990).
65. Neuringer, L. J., Sears, B. & Jungalwala, F. B. Deuterium NMR studies of cerebroside-phospholipid bilayers. Biochim. Biophys. Acta 558, 325-329 (1979).
66. Chong, P.-L. Evidence for regular distribution of sterols in liquid crystalline phosphatidylcholine bilayers. Proc. Natl Acad. Sci. USA 91, 10069-10073 (1994).
67. Fiedler, K., Lafont, F., Parton, R. G. & Simons, K. Annexin XIIIb: A novel epithelial specific annexin is implicated in vesicular traffic to the apical plasma membrane. J. Cell Biol. 128, 1043-1053 (1995).