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Volumn 136, Issue 4, 2006, Pages 873-876

Regulation of the insulin gene by glucose and fatty acids

Author keywords

B cell; Diabetes; Insulin

Indexed keywords

CERAMIDE; FATTY ACID DERIVATIVE; GLUCOSE; INSULIN; TRANSCRIPTION FACTOR PDX 1;

EID: 33645530700     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.4.873     Document Type: Article
Times cited : (195)

References (52)
  • 1
    • 33645533536 scopus 로고    scopus 로고
    • Insulin gene expression and biosynthesis
    • DeFronzo RA, Ferrannini, E, Keen H, Zimmet P, eds. Chichester: John Wiley & Sons
    • Poitout V, Stein R, Rhodes CJ. Insulin gene expression and biosynthesis. In: International textbook of diabetes mellitus. 3rd ed. DeFronzo RA, Ferrannini, E, Keen H, Zimmet P, eds. Chichester: John Wiley & Sons; 2004. p. 98-123.
    • (2004) International Textbook of Diabetes Mellitus. 3rd Ed. , pp. 98-123
    • Poitout, V.1    Stein, R.2    Rhodes, C.J.3
  • 2
    • 0027154077 scopus 로고
    • Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters
    • U S A
    • Melloul D, Ben-Neriah Y, Cerasi E. Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc Natl Acad Sci U S A. 1993;90:3865-9.
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 3865-3869
    • Melloul, D.1    Ben-Neriah, Y.2    Cerasi, E.3
  • 3
    • 0028149890 scopus 로고
    • Insulin-promoter factor 1 is required for pancreatic development in mice
    • Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-promoter factor 1 is required for pancreatic development in mice. Nature. 1994;371:606-9.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 4
    • 0028567837 scopus 로고
    • Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
    • Peers B, Leonard J, Sharma S, Teitelman G, Montminy MR. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol Endocrinol. 1994; 8:1798-806.
    • (1994) Mol Endocrinol , vol.8 , pp. 1798-1806
    • Peers, B.1    Leonard, J.2    Sharma, S.3    Teitelman, G.4    Montminy, M.R.5
  • 5
    • 0025822963 scopus 로고
    • Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic β cells and lymphocytes
    • Aronheim A, Ohlsson H, Park CW, Edlund T, Walker MD. Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic β cells and lymphocytes. Nucleic Acids Res. 1991;19:3893-9.
    • (1991) Nucleic Acids Res , vol.19 , pp. 3893-3899
    • Aronheim, A.1    Ohlsson, H.2    Park, C.W.3    Edlund, T.4    Walker, M.D.5
  • 6
    • 0033962883 scopus 로고    scopus 로고
    • The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter
    • Ohneda K, Mirmira RG, Wang J, Johnson JD, German MS. The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Mol Cell Biol. 2000;20:900-11.
    • (2000) Mol Cell Biol , vol.20 , pp. 900-911
    • Ohneda, K.1    Mirmira, R.G.2    Wang, J.3    Johnson, J.D.4    German, M.S.5
  • 7
    • 0036134978 scopus 로고    scopus 로고
    • Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, B2, and E47
    • Qiu Y, Guo M, Huang S, Stein R. Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, B2, and E47. Mol Cell Biol. 2002;22:412-20.
    • (2002) Mol Cell Biol , vol.22 , pp. 412-420
    • Qiu, Y.1    Guo, M.2    Huang, S.3    Stein, R.4
  • 8
    • 0037076351 scopus 로고    scopus 로고
    • Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA
    • U S A
    • Olbrot M, Rud J, Moss LG, Sharma A. Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci U S A. 2002;99:6737-42.
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 6737-6742
    • Olbrot, M.1    Rud, J.2    Moss, L.G.3    Sharma, A.4
  • 9
    • 0032578540 scopus 로고    scopus 로고
    • A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets
    • U S A
    • Sander M, Griffen SC, Huang J, German MS. A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets. Proc Natl Acad Sci U S A. 1998;95:11572-7.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 11572-11577
    • Sander, M.1    Griffen, S.C.2    Huang, J.3    German, M.S.4
  • 10
    • 0027944249 scopus 로고
    • Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes
    • U S A
    • Petersen HV, Serup P, Leonard J, Michelsen BK, Madsen OD. Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Proc Natl Acad Sci U S A. 1994;91:10465-9.
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 10465-10469
    • Petersen, H.V.1    Serup, P.2    Leonard, J.3    Michelsen, B.K.4    Madsen, O.D.5
  • 11
    • 20444482821 scopus 로고    scopus 로고
    • Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: Application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes
    • Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG. Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem. 2005;280:16798-807.
    • (2005) J Biol Chem , vol.280 , pp. 16798-16807
    • Iype, T.1    Francis, J.2    Garmey, J.C.3    Schisler, J.C.4    Nesher, R.5    Weir, G.C.6    Becker, T.C.7    Newgard, C.B.8    Griffen, S.C.9    Mirmira, R.G.10
  • 12
    • 27744606538 scopus 로고    scopus 로고
    • Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription
    • Francis J, Chakrabarti SK, Garmey JC, Mirmira RG. Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription. J Biol Chem. 2005;280:36244-53.
    • (2005) J Biol Chem , vol.280 , pp. 36244-36253
    • Francis, J.1    Chakrabarti, S.K.2    Garmey, J.C.3    Mirmira, R.G.4
  • 13
    • 11144237178 scopus 로고    scopus 로고
    • The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose
    • Mosley AL, Ozcan S. The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose. J Biol Chem. 2004;279:54241-7.
    • (2004) J Biol Chem , vol.279 , pp. 54241-54247
    • Mosley, A.L.1    Ozcan, S.2
  • 14
    • 0032483368 scopus 로고    scopus 로고
    • Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 β-cells
    • Rafiq I, Kennedy HJ, Rutter GA. Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 β-cells. J Biol Chem. 1998;273:23241-7.
    • (1998) J Biol Chem , vol.273 , pp. 23241-23247
    • Rafiq, I.1    Kennedy, H.J.2    Rutter, G.A.3
  • 15
    • 0037709390 scopus 로고    scopus 로고
    • The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 β-cells
    • Gao Y, Miyazaki J, Hart GW. The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 β-cells. Arch Biochem Biophys. 2003;415:155-63.
    • (2003) Arch Biochem Biophys , vol.415 , pp. 155-163
    • Gao, Y.1    Miyazaki, J.2    Hart, G.W.3
  • 17
    • 0033534620 scopus 로고    scopus 로고
    • Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic β-cells
    • Macfarlane WM, McKinnon CM, Felton-Edkins ZA, Cragg H, James RF, Docherty K. Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic β-cells. J Biol Chem. 1999;274:1011-6.
    • (1999) J Biol Chem , vol.274 , pp. 1011-1016
    • Macfarlane, W.M.1    McKinnon, C.M.2    Felton-Edkins, Z.A.3    Cragg, H.4    James, R.F.5    Docherty, K.6
  • 18
    • 0034680877 scopus 로고    scopus 로고
    • Regulation of gene expression by glucose in pancreatic β-cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3′-kinase
    • da Silva Xavier G, Varadi A, Ainscow EK, Rutter GA. Regulation of gene expression by glucose in pancreatic β-cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3′-kinase. J Biol Chem. 2000;275:36269-77.
    • (2000) J Biol Chem , vol.275 , pp. 36269-36277
    • Da Silva Xavier, G.1    Varadi, A.2    Ainscow, E.K.3    Rutter, G.A.4
  • 19
    • 0041856361 scopus 로고    scopus 로고
    • Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic β cells
    • Khoo S, Griffen SC, Xia Y, Baer RJ, German MS, Cobb MH. Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic β cells. J Biol Chem. 2003;278:32969-77.
    • (2003) J Biol Chem , vol.278 , pp. 32969-32977
    • Khoo, S.1    Griffen, S.C.2    Xia, Y.3    Baer, R.J.4    German, M.S.5    Cobb, M.H.6
  • 20
    • 0028127761 scopus 로고
    • Glucose-induced transcription of the insulin gene is mediated by factors required for β-cell-type-specific expression
    • Sharma A, Stein R. Glucose-induced transcription of the insulin gene is mediated by factors required for β-cell-type-specific expression. Mol Cell Biol. 1994;14:871-9.
    • (1994) Mol Cell Biol , vol.14 , pp. 871-879
    • Sharma, A.1    Stein, R.2
  • 22
    • 0022346359 scopus 로고
    • Control of insulin gene expression in pancreatic β-cells and in an insulin producing cell line, RIN-5F cells. 2. Regulation of insulin mRNA stability
    • Welsh M, Nielsen DA, MacKrell AJ, Steiner DF. Control of insulin gene expression in pancreatic β-cells and in an insulin producing cell line, RIN-5F cells. 2. Regulation of insulin mRNA stability. J Biol Chem. 1985;260:13590-4.
    • (1985) J Biol Chem , vol.260 , pp. 13590-13594
    • Welsh, M.1    Nielsen, D.A.2    MacKrell, A.J.3    Steiner, D.F.4
  • 23
    • 0035933884 scopus 로고    scopus 로고
    • Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation
    • Wicksteed B, Herbert TP, Alarcon C, Lingohr MK, Moss LG, Rhodes CJ. Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation. J Biol Chem. 2001;276:22553-8.
    • (2001) J Biol Chem , vol.276 , pp. 22553-22558
    • Wicksteed, B.1    Herbert, T.P.2    Alarcon, C.3    Lingohr, M.K.4    Moss, L.G.5    Rhodes, C.J.6
  • 24
    • 0037059772 scopus 로고    scopus 로고
    • Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3′-untranslated region pyrimidine-rich sequence
    • Tillmar L, Carlsson C, Welsh N. Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3′-untranslated region pyrimidine-rich sequence. J Biol Chem. 2002;277:1099-106.
    • (2002) J Biol Chem , vol.277 , pp. 1099-1106
    • Tillmar, L.1    Carlsson, C.2    Welsh, N.3
  • 25
    • 0026757632 scopus 로고
    • Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations
    • Robertson RP, Zhang HJ, Pyzdrowski KL, Walseth TF. Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J Clin Invest. 1992;90:320-5.
    • (1992) J Clin Invest , vol.90 , pp. 320-325
    • Robertson, R.P.1    Zhang, H.J.2    Pyzdrowski, K.L.3    Walseth, T.F.4
  • 26
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes. 1995;44:863-70.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 27
    • 0036153256 scopus 로고    scopus 로고
    • Minireview: Secondary β-cell failure in type 2 diabetes - A convergence of glucotoxicity and lipotoxicity
    • Poitout V, Robertson RP. Minireview: secondary β-cell failure in type 2 diabetes - a convergence of glucotoxicity and lipotoxicity. Endocrinology. 2002;143:339-42.
    • (2002) Endocrinology , vol.143 , pp. 339-342
    • Poitout, V.1    Robertson, R.P.2
  • 29
    • 0029073426 scopus 로고
    • Reduction of insulin gene transcription in HIT-T15 cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression
    • U S A
    • Olson LK, Sharma A, Peshavaria M, Wright CVE, Towle HC, Robertson RP, Stein R. Reduction of insulin gene transcription in HIT-T15 cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. Proc Natl Acad Sci U S A. 1995;92: 9127-31.
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 9127-9131
    • Olson, L.K.1    Sharma, A.2    Peshavaria, M.3    Wright, C.V.E.4    Towle, H.C.5    Robertson, R.P.6    Stein, R.7
  • 32
    • 0032852505 scopus 로고    scopus 로고
    • In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression
    • Harmon JS, Gleason CE, Tanaka Y, Oseid EA, Hunter-Berger KK, Robertson RP. In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. Diabetes. 1999;48:1995-2000.
    • (1999) Diabetes , vol.48 , pp. 1995-2000
    • Harmon, J.S.1    Gleason, C.E.2    Tanaka, Y.3    Oseid, E.A.4    Hunter-Berger, K.K.5    Robertson, R.P.6
  • 33
    • 15744379018 scopus 로고    scopus 로고
    • Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic β cells
    • Harmon JS, Stein R, Robertson RP. Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic β cells. J Biol Chem. 2005;280:11107-13.
    • (2005) J Biol Chem , vol.280 , pp. 11107-11113
    • Harmon, J.S.1    Stein, R.2    Robertson, R.P.3
  • 35
    • 1842292177 scopus 로고    scopus 로고
    • Pancreatic β-cell-specific repression of insulin gene transcription by CCAAT/Enhancer-binding protein β. Inhibitory interactions with basic helix-loop-helix transcription factor E47
    • Lu M, Seufert J, Habener JF. Pancreatic β-cell-specific repression of insulin gene transcription by CCAAT/Enhancer-binding protein β. Inhibitory interactions with basic helix-loop-helix transcription factor E47. J Biol Chem. 1997; 272:28349-59.
    • (1997) J Biol Chem , vol.272 , pp. 28349-28359
    • Lu, M.1    Seufert, J.2    Habener, J.F.3
  • 36
    • 22844446279 scopus 로고    scopus 로고
    • ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter
    • Lawrence MC, McGlynn K, Park BH, Cobb MH. ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter. J Biol Chem. 2005;280:26751-9.
    • (2005) J Biol Chem , vol.280 , pp. 26751-26759
    • Lawrence, M.C.1    McGlynn, K.2    Park, B.H.3    Cobb, M.H.4
  • 37
    • 5644248079 scopus 로고    scopus 로고
    • Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet B cells in diabetes
    • Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet B cells in diabetes. J Biol Chem. 2004;279:42351-4.
    • (2004) J Biol Chem , vol.279 , pp. 42351-42354
    • Robertson, R.P.1
  • 38
    • 0032863183 scopus 로고    scopus 로고
    • Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
    • U S A
    • Tanaka Y, Gleason CE, Tran POT, Harmon JS, Robertson RP. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci U S A. 1999;96:10857-62.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 10857-10862
    • Tanaka, Y.1    Gleason, C.E.2    Tran, P.O.T.3    Harmon, J.S.4    Robertson, R.P.5
  • 39
    • 0035903192 scopus 로고    scopus 로고
    • Activation of the hexosamine pathway leads to deterioration of pancreatic β-cell function through the induction of oxidative stress
    • Kaneto H, Xu G, Song KH, Suzuma K, Bonner-Weir S, Sharma A, Weir GC. Activation of the hexosamine pathway leads to deterioration of pancreatic β-cell function through the induction of oxidative stress. J Biol Chem. 2001;276:31099-104.
    • (2001) J Biol Chem , vol.276 , pp. 31099-31104
    • Kaneto, H.1    Xu, G.2    Song, K.H.3    Suzuma, K.4    Bonner-Weir, S.5    Sharma, A.6    Weir, G.C.7
  • 40
    • 0037119417 scopus 로고    scopus 로고
    • Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
    • Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC. Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem. 2002;277:30010-8.
    • (2002) J Biol Chem , vol.277 , pp. 30010-30018
    • Kaneto, H.1    Xu, G.2    Fujii, N.3    Kim, S.4    Bonner-Weir, S.5    Weir, G.C.6
  • 41
    • 0028174029 scopus 로고
    • c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control
    • Henderson E, Stein R. c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control. Mol Cell Biol. 1994;14:655-62.
    • (1994) Mol Cell Biol , vol.14 , pp. 655-662
    • Henderson, E.1    Stein, R.2
  • 44
    • 0037066726 scopus 로고    scopus 로고
    • Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/B2-mediated transcriptional activation
    • Kaneto H, Sharma A, Suzuma K, Laybutt DR, Xu G, Bonner-Weir S, Weir GC. Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/B2-mediated transcriptional activation. J Biol Chem. 2002;277: 12998-3006.
    • (2002) J Biol Chem , vol.277 , pp. 12998-13006
    • Kaneto, H.1    Sharma, A.2    Suzuma, K.3    Laybutt, D.R.4    Xu, G.5    Bonner-Weir, S.6    Weir, G.C.7
  • 45
    • 0035145780 scopus 로고    scopus 로고
    • Lipotoxicity of the pancreatic β-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
    • Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V. Lipotoxicity of the pancreatic β-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes. 2001;50:315-21.
    • (2001) Diabetes , vol.50 , pp. 315-321
    • Briaud, I.1    Harmon, J.S.2    Kelpe, C.L.3    Segu, V.B.4    Poitout, V.5
  • 46
    • 25444480496 scopus 로고    scopus 로고
    • Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans
    • Hagman DK, Hays LB, Parazzoli SD, Poitout V. Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans. J Biol Chem. 2005;280:32413-8.
    • (2005) J Biol Chem , vol.280 , pp. 32413-32418
    • Hagman, D.K.1    Hays, L.B.2    Parazzoli, S.D.3    Poitout, V.4
  • 47
    • 0042531617 scopus 로고    scopus 로고
    • Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
    • Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V. Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem. 2003;278:30015-21.
    • (2003) J Biol Chem , vol.278 , pp. 30015-30021
    • Kelpe, C.L.1    Moore, P.C.2    Parazzoli, S.D.3    Wicksteed, B.4    Rhodes, C.J.5    Poitout, V.6
  • 48
    • 0030731946 scopus 로고    scopus 로고
    • Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
    • Gremlich S, Bonny C, Waeber G, Thorens B. Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. J Biol Chem. 1997;272:30261-9.
    • (1997) J Biol Chem , vol.272 , pp. 30261-30269
    • Gremlich, S.1    Bonny, C.2    Waeber, G.3    Thorens, B.4
  • 50
    • 0036720490 scopus 로고    scopus 로고
    • Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of Langerhans. A study using adenoviral expression of diacylglycerol acyltransferase
    • Kelpe CL, Johnson LM, Poitout V. Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of Langerhans. A study using adenoviral expression of diacylglycerol acyltransferase. Endocrinology. 2002;143:3326-32.
    • (2002) Endocrinology , vol.143 , pp. 3326-3332
    • Kelpe, C.L.1    Johnson, L.M.2    Poitout, V.3
  • 51
    • 4644287377 scopus 로고    scopus 로고
    • Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion
    • Moore PC, Ugas MA, Hagman DK, Parazzoli SD, Poitout V. Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion. Diabetes. 2004;53:2610-6.
    • (2004) Diabetes , vol.53 , pp. 2610-2616
    • Moore, P.C.1    Ugas, M.A.2    Hagman, D.K.3    Parazzoli, S.D.4    Poitout, V.5


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