-
1
-
-
33645530700
-
Regulation of the insulin gene by glucose and fatty acids
-
Poitout V, Hagman D, Stein R, Artner I, Robertson RP, Harmon JS: Regulation of the Insulin Gene by Glucose and Fatty Acids. J Nutr 2006;136:873-876.
-
(2006)
J Nutr
, vol.136
, pp. 873-876
-
-
Poitout, V.1
Hagman, D.2
Stein, R.3
Artner, I.4
Robertson, R.P.5
Harmon, J.S.6
-
2
-
-
77952931003
-
Ceramide in suicidal death of erythrocytes
-
Lang F, Gulbins E, Lang PA, Zappulla D, Föller M: Ceramide in suicidal death of erythrocytes. Cell Physiol Biochem 2010;26:21-28.
-
(2010)
Cell Physiol Biochem
, vol.26
, pp. 21-28
-
-
Lang, F.1
Gulbins, E.2
Lang, P.A.3
Zappulla, D.4
Föller, M.5
-
3
-
-
33646837114
-
Co-culture with fat cells induces cellular insulin resistance in primary hepatocytes
-
Wang Z, Lv J, Zhang R, Zhu Y, Zhu D, Sun Y, Zhu J, Han X: Co-culture with fat cells induces cellular insulin resistance in primary hepatocytes. Biochem Biophys Res Commun 2006;345:976-983.
-
(2006)
Biochem Biophys Res Commun
, vol.345
, pp. 976-983
-
-
Wang, Z.1
Lv, J.2
Zhang, R.3
Zhu, Y.4
Zhu, D.5
Sun, Y.6
Zhu, J.7
Han, X.8
-
4
-
-
0042531617
-
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
-
Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V: Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem 2003;278:30015-30021.
-
(2003)
J Biol Chem
, vol.278
, pp. 30015-30021
-
-
Kelpe, C.L.1
Moore, P.C.2
Parazzoli, S.D.3
Wicksteed, B.4
Rhodes, C.J.5
Poitout, V.6
-
5
-
-
21244442275
-
Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling
-
Chavez JA, Holland WL, Bär J, Sandhoff K, Summers SA: Acid Ceramidase Overexpression Prevents the Inhibitory Effects of Saturated Fatty Acids on Insulin Signaling. J Biol Chem 2005;280:20148-20153.
-
(2005)
J Biol Chem
, vol.280
, pp. 20148-20153
-
-
Chavez, J.A.1
Holland, W.L.2
Bär, J.3
Sandhoff, K.4
Summers, S.A.5
-
6
-
-
67449147119
-
Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER
-
Vacaru AM, Tafesse FG, Ternes P, Kondylis V, Hermansson M, Brouwers JF, Somerharju P, Rabouille C, Holthuis JC: Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. J Cell Biol 2009;185:1013-1027.
-
(2009)
J Cell Biol
, vol.185
, pp. 1013-1027
-
-
Vacaru, A.M.1
Tafesse, F.G.2
Ternes, P.3
Kondylis, V.4
Hermansson, M.5
Brouwers, J.F.6
Somerharju, P.7
Rabouille, C.8
Holthuis, J.C.9
-
7
-
-
34548177098
-
Ceramide kinase uses ceramide provided by ceramide transport protein: Localization to organelles of eicosanoid synthesis
-
Lamour NF, Stahelin RV, Wijesinghe DS, Maceyka M, Wang E, Allegood JC, Merrill AH Jr, Cho W, Chalfant CE: Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis. J Lipid Res 2007;48:1293-1304.
-
(2007)
J Lipid Res
, vol.48
, pp. 1293-1304
-
-
Lamour, N.F.1
Stahelin, R.V.2
Wijesinghe, D.S.3
MacEyka, M.4
Wang, E.5
Allegood, J.C.6
Merrill Jr., A.H.7
Cho, W.8
Chalfant, C.E.9
-
8
-
-
39049169151
-
Ceramide traffic in C6 glioma cells: Evidence for CERT-dependent and independent transport from ER to the Golgi apparatus
-
Giussani P, Colleoni T, Brioschi L, Bassi R, Hanada K, Tettamanti G, Riboni L, Viani P: Ceramide traffic in C6 glioma cells: evidence for CERT-dependent and independent transport from ER to the Golgi apparatus. Biochim Biophys Acta 2008;1781:40-51.
-
(2008)
Biochim Biophys Acta
, vol.1781
, pp. 40-51
-
-
Giussani, P.1
Colleoni, T.2
Brioschi, L.3
Bassi, R.4
Hanada, K.5
Tettamanti, G.6
Riboni, L.7
Viani, P.8
-
9
-
-
52049097027
-
The domain responsible for sphingomyelin synthase (SMS) activity
-
Yeang C, Varshney S, Wang R, Zhang Y, Ye D, Jiang XC: The domain responsible for sphingomyelin synthase (SMS) activity. Biochim Biophys Acta 2008;1781:610-617.
-
(2008)
Biochim Biophys Acta
, vol.1781
, pp. 610-617
-
-
Yeang, C.1
Varshney, S.2
Wang, R.3
Zhang, Y.4
Ye, D.5
Jiang, X.C.6
-
10
-
-
0347611095
-
Molecular machinery for non-vesicular trafficking of ceramide
-
Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M: Molecular machinery for non-vesicular trafficking of ceramide. Nature 2003;426:803-809.
-
(2003)
Nature
, vol.426
, pp. 803-809
-
-
Hanada, K.1
Kumagai, K.2
Yasuda, S.3
Miura, Y.4
Kawano, M.5
Fukasawa, M.6
Nishijima, M.7
-
11
-
-
20444402239
-
Molecular mechanisms and regulation of ceramide transport
-
Perry RJ, Ridgway ND: Molecular mechanisms and regulation of ceramide transport. Biochim Biophys Acta 2005;1734:220-234.
-
(2005)
Biochim Biophys Acta
, vol.1734
, pp. 220-234
-
-
Perry, R.J.1
Ridgway, N.D.2
-
12
-
-
38649131260
-
Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide
-
Kudo N, Kumagai K, Tomishige N, Yamaji T, Wakatsuki S, Nishijima M, Hanada K, Kato R: Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc Natl Acad Sci \USA 2008;105:488-493.
-
(2008)
Proc Natl Acad Sci \USA
, vol.105
, pp. 488-493
-
-
Kudo, N.1
Kumagai, K.2
Tomishige, N.3
Yamaji, T.4
Wakatsuki, S.5
Nishijima, M.6
Hanada, K.7
Kato, R.8
-
13
-
-
34347379940
-
Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein
-
Fugmann T, Hausser A, Schöffler P, Schmid S, Pfizenmaier K, Olayioye MA: Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. J Cell Biol 2007;178:15-22.
-
(2007)
J Cell Biol
, vol.178
, pp. 15-22
-
-
Fugmann, T.1
Hausser, A.2
Schöffler, P.3
Schmid, S.4
Pfizenmaier, K.5
Olayioye, M.A.6
-
14
-
-
44449129087
-
Protein phosphatase 2Ce is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes
-
Saito S, Matsui H, Kawano M, Kumagai K, Tomishige N, Hanada K, Echigo S, Tamura S, Kobayashi T: Protein phosphatase 2Ce is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes. J Biol Chem 2008;283:6584-6593.
-
(2008)
J Biol Chem
, vol.283
, pp. 6584-6593
-
-
Saito, S.1
Matsui, H.2
Kawano, M.3
Kumagai, K.4
Tomishige, N.5
Hanada, K.6
Echigo, S.7
Tamura, S.8
Kobayashi, T.9
-
15
-
-
33846005514
-
Phosphatidylinositol 4-Kinase IIIp Regulates the Transport of Ceramide between the Endoplasmic Reticulum and Golgi
-
Tóth B, Balla A, Ma H, Knight ZA, Shokat KM, Balla T: Phosphatidylinositol 4-Kinase IIIp Regulates the Transport of Ceramide between the Endoplasmic Reticulum and Golgi. J Biol Chem 2006;281:36369-36377.
-
(2006)
J Biol Chem
, vol.281
, pp. 36369-36377
-
-
Tóth, B.1
Balla, A.2
Ma, H.3
Knight, Z.A.4
Shokat, K.M.5
Balla, T.6
-
16
-
-
47749135898
-
Decreased ceramide transport protein, CERT, function alters sphingo-myelinproduction following UVB irradiation
-
Charruyer A, Bell SM, Kawano M, Douangpanya S, Yen TY, Macher BA, Kumagai K, Hanada K, Holleran WM, Uchida Y: Decreased ceramide transport protein, CERT, function alters sphingo-myelinproduction following UVB irradiation. J Biol Chem 2008;283:16682-16692.
-
(2008)
J Biol Chem
, vol.283
, pp. 16682-16692
-
-
Charruyer, A.1
Bell, S.M.2
Kawano, M.3
Douangpanya, S.4
Yen, T.Y.5
MacHer, B.A.6
Kumagai, K.7
Hanada, K.8
Holleran, W.M.9
Uchida, Y.10
-
17
-
-
51649088697
-
Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells
-
Lawrence MC, McGlynn K, Shao C, Duan L, Naziruddin B, Levy MF, Cobb MH: Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells. Proc Natl Acad Sci USA 2008;105:13315-13320.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 13315-13320
-
-
Lawrence, M.C.1
McGlynn, K.2
Shao, C.3
Duan, L.4
Naziruddin, B.5
Levy, M.F.6
Cobb, M.H.7
-
18
-
-
57249094223
-
Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest
-
Meng ZX, Nie J, Ling JJ, Sun JX, Zhu YX, Gao L, Lv JH, Zhu DY, Sun YJ, Han X: Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia 2009;52:125-135.
-
(2009)
Diabetologia
, vol.52
, pp. 125-135
-
-
Meng, Z.X.1
Nie, J.2
Ling, J.J.3
Sun, J.X.4
Zhu, Y.X.5
Gao, L.6
Lv, J.H.7
Zhu, D.Y.8
Sun, Y.J.9
Han, X.10
-
19
-
-
77949272720
-
Effect of forkhead box O1 (FOXO1) on beta cell development in the human fetal pancreas
-
Al-Masri M, Krishnamurthy M, Li J, Fellows GF, Dong HH, Goodyer CG, Wang R: Effect of forkhead box O1 (FOXO1) on beta cell development in the human fetal pancreas. Diabetologia 2010;53:699-711.
-
(2010)
Diabetologia
, vol.53
, pp. 699-711
-
-
Al-Masri, M.1
Krishnamurthy, M.2
Li, J.3
Fellows, G.F.4
Dong, H.H.5
Goodyer, C.G.6
Wang, R.7
-
20
-
-
34547622443
-
Expression of c-Kit receptor tyrosine kinase and effect on beta-cell development in the human fetal pancreas
-
Li J, Quirt J, Do HQ, Lyte K, Fellows F, Goodyer CG, Wang R: Expression of c-Kit receptor tyrosine kinase and effect on beta-cell development in the human fetal pancreas. Am J Physiol Endocrinol Metab 2007;293:E475-E483.
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
-
-
Li, J.1
Quirt, J.2
Do, H.Q.3
Lyte, K.4
Fellows, F.5
Goodyer, C.G.6
Wang, R.7
-
21
-
-
0032143958
-
Ceramide transport from endoplasmic reticulum to Golgi apparatus is not vesicle-mediated
-
Kok JW, Babia T, Klappe K, Egea G, Hoekstra D: Ceramide transport from endoplasmic reticulum to Golgi apparatus is not vesicle-mediated. Biochem J 1998;333:779-86.
-
(1998)
Biochem J
, vol.333
, pp. 779-786
-
-
Kok, J.W.1
Babia, T.2
Klappe, K.3
Egea, G.4
Hoekstra, D.5
-
22
-
-
2542501763
-
De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells
-
Dolgachev V, Farooqui MS, Kulaeva OI, Tainsky MA, Nagy B, Hanada K, Separovic D: De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells. J Biol Chem 2004;279:23238-23249.
-
(2004)
J Biol Chem
, vol.279
, pp. 23238-23249
-
-
Dolgachev, V.1
Farooqui, M.S.2
Kulaeva, O.I.3
Tainsky, M.A.4
Nagy, B.5
Hanada, K.6
Separovic, D.7
-
23
-
-
33751006408
-
Sustained activation of Src-family tyrosine kinases by ischemia: A potential mechanism mediating extracellular signal-regulated kinase cascades in hippocampal dentate gyrus
-
Guo J, Wu HW, Hu G, Han X, De W, Sun YJ: Sustained activation of Src-family tyrosine kinases by ischemia: a potential mechanism mediating extracellular signal-regulated kinase cascades in hippocampal dentate gyrus. Neurosci 2006;143:827-836.
-
(2006)
Neurosci
, vol.143
, pp. 827-836
-
-
Guo, J.1
Wu, H.W.2
Hu, G.3
Han, X.4
De W Sun, Y.J.5
-
24
-
-
0842326180
-
The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609
-
Perry RJ, Ridgway ND: The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609. J Lipid Res 2004;45:164-173.
-
(2004)
J Lipid Res
, vol.45
, pp. 164-173
-
-
Perry, R.J.1
Ridgway, N.D.2
-
25
-
-
42449091192
-
Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family
-
Chen J, Deng F, Li J, Wang QJ: Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family. Biochem J 2008;411:333-342.
-
(2008)
Biochem J
, vol.411
, pp. 333-342
-
-
Chen, J.1
Deng, F.2
Li, J.3
Wang, Q.J.4
-
26
-
-
52049119853
-
PDX-1 functions as a master factor in the pancreas
-
Kaneto H, Matsuoka TA, Miyatsuka T, Kawamori D, Katakami N, Yamasaki Y, Matsuhisa M: PDX-1 functions as a master factor in the pancreas. Front Biosci 2008;13:6406-6420.
-
(2008)
Front Biosci
, vol.13
, pp. 6406-6420
-
-
Kaneto, H.1
Matsuoka, T.A.2
Miyatsuka, T.3
Kawamori, D.4
Katakami, N.5
Yamasaki, Y.6
Matsuhisa, M.7
-
27
-
-
65749088871
-
Role of MafA in pancreatic beta-cells
-
Kaneto H, Matsuoka TA, Kawashima S, Yamamoto K, Kato K, Miyatsuka T, Katakami N, Matsuhisa M: Role of MafA in pancreatic beta-cells. Adv Drug Deliv Rev 2009;61:489-496.
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 489-496
-
-
Kaneto, H.1
Matsuoka, T.A.2
Kawashima, S.3
Yamamoto, K.4
Kato, K.5
Miyatsuka, T.6
Katakami, N.7
Matsuhisa, M.8
-
28
-
-
67349121773
-
Role of the transcriptional factor C/EBP p in free fatty acid-elicited p-cell failure
-
Plaisance V, Perret V, Favre D, Abderrahmani A, Yang JY, Widmann C, Regazzi R: Role of the transcriptional factor C/EBP p in free fatty acid-elicited p-cell failure. Mol Cell Endocrinol 2009;305:47-55.
-
(2009)
Mol Cell Endocrinol
, vol.305
, pp. 47-55
-
-
Plaisance, V.1
Perret, V.2
Favre, D.3
Abderrahmani, A.4
Yang, J.Y.5
Widmann, C.6
Regazzi, R.7
-
29
-
-
25444480496
-
Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans
-
Hagman DK, Hays LB, Parazzoli SD, Poitout V: Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans. J Biol Chem 2005;280:32413-32418.
-
(2005)
J Biol Chem
, vol.280
, pp. 32413-32418
-
-
Hagman, D.K.1
Hays, L.B.2
Parazzoli, S.D.3
Poitout, V.4
-
30
-
-
38949191625
-
SMS overexpression and knockdown: Impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis
-
Ding T, Li Z, Hailemariam T, Mukherjee S, Maxfield FR, Wu MP, Jiang XC: SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis. J Lipid Res 2008;49:376-385.
-
(2008)
J Lipid Res
, vol.49
, pp. 376-385
-
-
Ding, T.1
Li, Z.2
Hailemariam, T.3
Mukherjee, S.4
Maxfield, F.R.5
Wu, M.P.6
Jiang, X.C.7
-
31
-
-
49649124877
-
Sphingomyelin synthases regulate production of diacylglycerol at the Golgi
-
Villani M, Subathra M, Im YB, Choi Y, Signorelli P, Del Poeta M, Luberto C: Sphingomyelin synthases regulate production of diacylglycerol at the Golgi. Biochem J 2008;414:31-41.
-
(2008)
Biochem J
, vol.414
, pp. 31-41
-
-
Villani, M.1
Subathra, M.2
Im, Y.B.3
Choi, Y.4
Signorelli, P.5
Del Poeta, M.6
Luberto, C.7
-
32
-
-
36649027086
-
Free fatty acid-induced reduction in glucose-stimulated insulin secretion: Evidence for a role of oxidative stress in vitro and in vivo
-
Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A: Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo. Diabetes 2007;56:2927-2937.
-
(2007)
Diabetes
, vol.56
, pp. 2927-2937
-
-
Oprescu, A.I.1
Bikopoulos, G.2
Naassan, A.3
Allister, E.M.4
Tang, C.5
Park, E.6
Uchino, H.7
Lewis, G.F.8
Fantus, I.G.9
Rozakis-Adcock, M.10
Wheeler, M.B.11
Giacca, A.12
-
33
-
-
45449118936
-
Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells
-
Saitoh Y, Chun-ping C, Noma K, Ueno H, Mizuta M, Nakazato M: Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells. Diabetes Obes Metab 2008;10:564-573.
-
(2008)
Diabetes Obes Metab
, vol.10
, pp. 564-573
-
-
Saitoh, Y.1
Chun-Ping, C.2
Noma, K.3
Ueno, H.4
Mizuta, M.5
Nakazato, M.6
-
34
-
-
0031747119
-
A role for a wortmannin-sensitive phosphati-dylinositol-4-kinase in the endocytosis of muscarinic cholinergic receptors
-
Sorensen SD, Linseman DA, McEwen EL, Heacock AM, Fisher SK: A role for a wortmannin-sensitive phosphati-dylinositol-4-kinase in the endocytosis of muscarinic cholinergic receptors. Mol Pharmacol 1998;53:827-836.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 827-836
-
-
Sorensen, S.D.1
Linseman, D.A.2
McEwen, E.L.3
Heacock, A.M.4
Fisher, S.K.5
-
35
-
-
0037401894
-
Intracellular signal transduction pathways activated by ceramide and its metabolites
-
Ruvolo PP: Intracellular signal transduction pathways activated by ceramide and its metabolites. Pharmacol Res 2003;47:383-392.
-
(2003)
Pharmacol Res
, vol.47
, pp. 383-392
-
-
Ruvolo, P.P.1
-
36
-
-
10744227975
-
Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH( 2)-terminal kinase
-
Kawamori D, Kajimoto Y, Kaneto H, Umayahara Y, Fujitani Y, Miyatsuka T, Watada H, Leibiger IB, Yamasaki Y, Hori M: Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes 2003;52:2896-2904.
-
(2003)
Diabetes
, vol.52
, pp. 2896-2904
-
-
Kawamori, D.1
Kajimoto, Y.2
Kaneto, H.3
Umayahara, Y.4
Fujitani, Y.5
Miyatsuka, T.6
Watada, H.7
Leibiger, I.B.8
Yamasaki, Y.9
Hori, M.10
-
37
-
-
0344406769
-
Potentiation of lipopolysaccharide-inducible cyclo-oxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages
-
Cho YH, Lee CH, Kim SG: Potentiation of lipopolysaccharide-inducible cyclo-oxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages. Mol Pharmacol 2003;63:512-523.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 512-523
-
-
Cho, Y.H.1
Lee, C.H.2
Kim, S.G.3
-
38
-
-
4344614649
-
Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
-
Stratford S, Hoehn KL, Liu F, Summers SA: Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J Biol Chem 2004;279:36608-36615.
-
(2004)
J Biol Chem
, vol.279
, pp. 36608-36615
-
-
Stratford, S.1
Hoehn, K.L.2
Liu, F.3
Summers, S.A.4
-
39
-
-
22844446279
-
ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter
-
Lawrence MC, McGlynn K, Park BH, Cobb MH: ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter. J Biol Chem 2005;280:26751-26759.
-
(2005)
J Biol Chem
, vol.280
, pp. 26751-26759
-
-
Lawrence, M.C.1
McGlynn, K.2
Park, B.H.3
Cobb, M.H.4
|