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Volumn 34, Issue SUPPL. 2, 2008, Pages

β-cell apoptosis in type 2 diabetes: quantitative and functional consequences

Author keywords

Apoptosis; Pancreatic cells; Type 2 diabetes

Indexed keywords

AMYLIN; CHLORPROPAMIDE; GLIBENCLAMIDE; GLIMEPIRIDE; GLUCOSAMINE PHOSPHATE ACETYLTRANSFERASE; GLUCOSE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; INSULIN; METFORMIN; SULFONYLUREA;

EID: 47149095278     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1262-3636(08)73396-2     Document Type: Article
Times cited : (73)

References (94)
  • 1
    • 0009781763 scopus 로고    scopus 로고
    • Insulin secretion in type-2 diabetes mellitus
    • Draznin B., and Rizza R. (Eds), Humana Press, Totowa, NJ
    • Kudva Y.C., and Butler P.C. Insulin secretion in type-2 diabetes mellitus. In: Draznin B., and Rizza R. (Eds). Clinical Research in Diabetes and Obesity. Diabetes and Obesity (1997), Humana Press, Totowa, NJ 119-136
    • (1997) Clinical Research in Diabetes and Obesity. Diabetes and Obesity , pp. 119-136
    • Kudva, Y.C.1    Butler, P.C.2
  • 2
    • 0024026298 scopus 로고
    • Lilly Lecture 1987: the triumvirate: cell, muscle, liver: a collusion responsible for NIDDM
    • DeFronzo R.A. Lilly Lecture 1987: the triumvirate: cell, muscle, liver: a collusion responsible for NIDDM. Diabetes 37 (1988) 667-687
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 3
    • 30844471395 scopus 로고    scopus 로고
    • Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?
    • Scheen A.J. Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?. Diabetes Metab 31 (2005) 5S27-5S34
    • (2005) Diabetes Metab , vol.31
    • Scheen, A.J.1
  • 4
    • 14744293406 scopus 로고    scopus 로고
    • Compensatory hyperinsulinemia and the development of an atherogenic lipoprotein profile: the price paid to maintain glucose homeostasis in insulin-resistant individuals
    • Reaven G.M. Compensatory hyperinsulinemia and the development of an atherogenic lipoprotein profile: the price paid to maintain glucose homeostasis in insulin-resistant individuals. Endocrinol Metab Clin North Am 34 (2005) 49-62
    • (2005) Endocrinol Metab Clin North Am , vol.34 , pp. 49-62
    • Reaven, G.M.1
  • 5
    • 0002274122 scopus 로고    scopus 로고
    • The natural history of diabetes-related complications: the UKPDS experience. United Kingdom Prospective Diabetes Study
    • Matthews D.R. The natural history of diabetes-related complications: the UKPDS experience. United Kingdom Prospective Diabetes Study. Diabetes Obes Metab 1 (1999) S7-S13
    • (1999) Diabetes Obes Metab , vol.1
    • Matthews, D.R.1
  • 6
    • 33746617223 scopus 로고    scopus 로고
    • Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans
    • Meyer C., Pimenta W., Woerle H.J., et al. Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans. Diabetes Care 29 (2006) 1909-1914
    • (2006) Diabetes Care , vol.29 , pp. 1909-1914
    • Meyer, C.1    Pimenta, W.2    Woerle, H.J.3
  • 7
    • 0031961242 scopus 로고    scopus 로고
    • Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the Belfast Diet Study
    • Levy J., Atkinson A.B., Bell P.M., McCance D.R., and Hadden D.R. Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the Belfast Diet Study. Diabet Med 15 (1998) 290-296
    • (1998) Diabet Med , vol.15 , pp. 290-296
    • Levy, J.1    Atkinson, A.B.2    Bell, P.M.3    McCance, D.R.4    Hadden, D.R.5
  • 8
    • 0035122212 scopus 로고    scopus 로고
    • No decrease of the beta-cell mass in type 2 diabetic patients
    • Guiot Y., Sempoux C., Moulin P., and Rahier J. No decrease of the beta-cell mass in type 2 diabetic patients. Diabetes 50 Suppl. 1 (2001) S188
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Guiot, Y.1    Sempoux, C.2    Moulin, P.3    Rahier, J.4
  • 9
    • 0019996086 scopus 로고
    • Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans
    • Stefan Y., Orci L., Malaisse-Lagae F., Perrelet A., Patel Y., and Unger R.H. Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes 31 (1982) 694-700
    • (1982) Diabetes , vol.31 , pp. 694-700
    • Stefan, Y.1    Orci, L.2    Malaisse-Lagae, F.3    Perrelet, A.4    Patel, Y.5    Unger, R.H.6
  • 10
    • 0020623615 scopus 로고
    • Cellular composition of the human diabetic pancreas
    • Rahier J., Goebbels R.M., and Henquin J.C. Cellular composition of the human diabetic pancreas. Diabetologia 24 (1983) 366-371
    • (1983) Diabetologia , vol.24 , pp. 366-371
    • Rahier, J.1    Goebbels, R.M.2    Henquin, J.C.3
  • 11
    • 20044390365 scopus 로고    scopus 로고
    • Functional and molecular defects of pancreatic islets in human type 2 diabetes
    • Del Guerra S., Lupi R., Marselli L., et al. Functional and molecular defects of pancreatic islets in human type 2 diabetes. Diabetes 54 (2005) 727-735
    • (2005) Diabetes , vol.54 , pp. 727-735
    • Del Guerra, S.1    Lupi, R.2    Marselli, L.3
  • 12
    • 8744272467 scopus 로고    scopus 로고
    • Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
    • Marchetti P., Del Guerra S., Marselli L., et al. Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. J Clin Endocrinol Metab 89 (2004) 5535-5541
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5535-5541
    • Marchetti, P.1    Del Guerra, S.2    Marselli, L.3
  • 13
    • 34249945638 scopus 로고    scopus 로고
    • Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training
    • Burns N., Finucane F.M., Hatunic M., et al. Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training. Diabetologia 50 (2007) 1500-1508
    • (2007) Diabetologia , vol.50 , pp. 1500-1508
    • Burns, N.1    Finucane, F.M.2    Hatunic, M.3
  • 14
    • 0042822112 scopus 로고    scopus 로고
    • Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid
    • Butler A.E., Janson J., Soeller W.C., and Butler P.C. Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes 52 (2003) 2304-2314
    • (2003) Diabetes , vol.52 , pp. 2304-2314
    • Butler, A.E.1    Janson, J.2    Soeller, W.C.3    Butler, P.C.4
  • 15
    • 34247362354 scopus 로고    scopus 로고
    • Pancreatic islet dysfunction in type 2 diabetes: a rational target for incretin-based therapies
    • Meece J. Pancreatic islet dysfunction in type 2 diabetes: a rational target for incretin-based therapies. Curr Med Res Opin 23 (2007) 933-944
    • (2007) Curr Med Res Opin , vol.23 , pp. 933-944
    • Meece, J.1
  • 16
    • 34249682591 scopus 로고    scopus 로고
    • Beta-cell failure in diabetes and preservation by clinical treatment
    • Wajchenberg B.L. Beta-cell failure in diabetes and preservation by clinical treatment. Endocr Rev 28 (2007) 187-218
    • (2007) Endocr Rev , vol.28 , pp. 187-218
    • Wajchenberg, B.L.1
  • 17
    • 0031913829 scopus 로고    scopus 로고
    • Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat
    • Pick A., Clark J., Kubstrup C., Levisetti Mpugh W., Bonner-Weir S., and Polonsky K.S. Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat. Diabetes 47 (1998) 358-364
    • (1998) Diabetes , vol.47 , pp. 358-364
    • Pick, A.1    Clark, J.2    Kubstrup, C.3    Levisetti Mpugh, W.4    Bonner-Weir, S.5    Polonsky, K.S.6
  • 18
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., and Butler P.C. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52 (2003) 102-110
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 19
    • 0037204952 scopus 로고    scopus 로고
    • The Fas signaling pathway: more than a paradigm
    • Wajant H. The Fas signaling pathway: more than a paradigm. Science 296 (2002) 1635-1636
    • (2002) Science , vol.296 , pp. 1635-1636
    • Wajant, H.1
  • 20
    • 0141853168 scopus 로고    scopus 로고
    • Live and let die: regulatory mechanisms in Fasmediated apoptosis
    • Curtin J.F., and Cotter T.G. Live and let die: regulatory mechanisms in Fasmediated apoptosis. Cell Signal 15 (2003) 983-992
    • (2003) Cell Signal , vol.15 , pp. 983-992
    • Curtin, J.F.1    Cotter, T.G.2
  • 21
    • 3142514196 scopus 로고    scopus 로고
    • Oxidative stress in neurodegeneration: cause or consequence?
    • Andersen J.K. Oxidative stress in neurodegeneration: cause or consequence?. Nat Med 10 (2004) S18-S25
    • (2004) Nat Med , vol.10
    • Andersen, J.K.1
  • 22
    • 10244255083 scopus 로고    scopus 로고
    • Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases
    • Gibson G.E., and Huang H.M. Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases. J Bioenerg Biomembr 36 (2004) 335-340
    • (2004) J Bioenerg Biomembr , vol.36 , pp. 335-340
    • Gibson, G.E.1    Huang, H.M.2
  • 23
    • 10444226462 scopus 로고    scopus 로고
    • ER stress and the unfolded protein response
    • Schroder M., and Kaufman R.J. ER stress and the unfolded protein response. Mutat Res 569 (2005) 29-63
    • (2005) Mutat Res , vol.569 , pp. 29-63
    • Schroder, M.1    Kaufman, R.J.2
  • 24
    • 0035736259 scopus 로고    scopus 로고
    • Organelle-specific initiation of cell death pathways
    • Ferri K.F., and Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 3 (2001) E255-E263
    • (2001) Nat Cell Biol , vol.3
    • Ferri, K.F.1    Kroemer, G.2
  • 25
    • 0038825044 scopus 로고    scopus 로고
    • Glucotoxicity and beta-cell failure in type 2 diabetes mellitus
    • Kaiser N., Leibowitz G., and Nesher R. Glucotoxicity and beta-cell failure in type 2 diabetes mellitus. J Pediatr Endocrinol Metab 16 (2003) 5-22
    • (2003) J Pediatr Endocrinol Metab , vol.16 , pp. 5-22
    • Kaiser, N.1    Leibowitz, G.2    Nesher, R.3
  • 26
    • 33947305767 scopus 로고    scopus 로고
    • Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose
    • Del Guerra S., Grupillo M., Masini M., et al. Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose. Diabetes Metab Res Rev 23 (2007) 234-238
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 234-238
    • Del Guerra, S.1    Grupillo, M.2    Masini, M.3
  • 27
    • 6944246692 scopus 로고    scopus 로고
    • Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells
    • D'Alessandris C., Andreozzi F., Federici M., et al. Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells. FASEB J 18 (2004) 959-961
    • (2004) FASEB J , vol.18 , pp. 959-961
    • D'Alessandris, C.1    Andreozzi, F.2    Federici, M.3
  • 28
    • 0036142812 scopus 로고    scopus 로고
    • Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation
    • Kralik S.F., Liu P., Leffler B.J., and Elmendorf J.S. Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation. Endocrinology 143 (2002) 37-46
    • (2002) Endocrinology , vol.143 , pp. 37-46
    • Kralik, S.F.1    Liu, P.2    Leffler, B.J.3    Elmendorf, J.S.4
  • 29
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: new perspectives on disease pathogenesis and treatment
    • Atkinson M.A., and Eisenbarth G.S. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 358 (2001) 221-229
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 30
    • 34548361965 scopus 로고    scopus 로고
    • Roles of cytokines in the pathogenesis and therapy of type 1 diabetes
    • Rabinovitch A., and Suarez-Pinzon W.L. Roles of cytokines in the pathogenesis and therapy of type 1 diabetes. Cell Biochem Biophys 48 (2007) 159-163
    • (2007) Cell Biochem Biophys , vol.48 , pp. 159-163
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2
  • 31
    • 0036738398 scopus 로고    scopus 로고
    • Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
    • Maedler K., Sergeev P., Ris F., et al. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110 (2002) 851-860
    • (2002) J Clin Invest , vol.110 , pp. 851-860
    • Maedler, K.1    Sergeev, P.2    Ris, F.3
  • 32
    • 33644669584 scopus 로고    scopus 로고
    • Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?
    • Welsh N., Cnop M., Kharroubi I., et al. Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?. Diabetes 54 (2005) 3238-3244
    • (2005) Diabetes , vol.54 , pp. 3238-3244
    • Welsh, N.1    Cnop, M.2    Kharroubi, I.3
  • 33
    • 20444363538 scopus 로고    scopus 로고
    • Beta-cells in type 2 diabetes: a loss of function and mass
    • Maedler K., and Donath M.Y. Beta-cells in type 2 diabetes: a loss of function and mass. Horm Res 62 (2004) 67-73
    • (2004) Horm Res , vol.62 , pp. 67-73
    • Maedler, K.1    Donath, M.Y.2
  • 34
    • 0035432491 scopus 로고    scopus 로고
    • Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets
    • Maedler K., Spinas G.A., Lehmann R., et al. Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes 50 (2001) 1683-1690
    • (2001) Diabetes , vol.50 , pp. 1683-1690
    • Maedler, K.1    Spinas, G.A.2    Lehmann, R.3
  • 35
    • 0036895383 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the development of diabetes: a review
    • Harding H.P., and Ron D. Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes 51 (2002) S455-S461
    • (2002) Diabetes , vol.51
    • Harding, H.P.1    Ron, D.2
  • 36
    • 47149110375 scopus 로고    scopus 로고
    • Deleted.
    • Deleted.
  • 37
    • 33645996396 scopus 로고    scopus 로고
    • Protein folding in the endoplasmic reticulum and the unfolded protein response
    • Zhang K., and Kaufman R.J. Protein folding in the endoplasmic reticulum and the unfolded protein response. Handb Exp Pharmacol 172 (2006) 69-91
    • (2006) Handb Exp Pharmacol , vol.172 , pp. 69-91
    • Zhang, K.1    Kaufman, R.J.2
  • 38
    • 35848963392 scopus 로고    scopus 로고
    • The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
    • Marchetti P., Bugliani M., Lupi R., et al. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 50 (2007) 2486-2494
    • (2007) Diabetologia , vol.50 , pp. 2486-2494
    • Marchetti, P.1    Bugliani, M.2    Lupi, R.3
  • 39
    • 33644911756 scopus 로고    scopus 로고
    • The endocrine function of adipose tissue: an update
    • Ronti T., Lupattelli G., and Mannarino E. The endocrine function of adipose tissue: an update. Clin Endocrinol (Oxf) 64 (2006) 355-365
    • (2006) Clin Endocrinol (Oxf) , vol.64 , pp. 355-365
    • Ronti, T.1    Lupattelli, G.2    Mannarino, E.3
  • 40
    • 2542541353 scopus 로고    scopus 로고
    • Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets
    • Maedler K., Sergeev P., Ehses J.A., et al. Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets. Proc Natl Acad Sci USA 101 (2004) 8138-8143
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8138-8143
    • Maedler, K.1    Sergeev, P.2    Ehses, J.A.3
  • 41
    • 0345354674 scopus 로고    scopus 로고
    • Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function
    • Maedler K., Oberholzer J., Bucher P., Spinas G.A., and Donath M.Y. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 52 (2003) 726-733
    • (2003) Diabetes , vol.52 , pp. 726-733
    • Maedler, K.1    Oberholzer, J.2    Bucher, P.3    Spinas, G.A.4    Donath, M.Y.5
  • 42
    • 0036315888 scopus 로고    scopus 로고
    • Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
    • Lupi R., Dotta F., Marselli L., et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51 (2002) 1437-1442
    • (2002) Diabetes , vol.51 , pp. 1437-1442
    • Lupi, R.1    Dotta, F.2    Marselli, L.3
  • 43
    • 0037147215 scopus 로고    scopus 로고
    • Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1)
    • Wrede C.E., Dickson L.M., Lingohr M.K., Briaud I., and Rhodes C.J. Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 277 (2002) 49676-49684
    • (2002) J Biol Chem , vol.277 , pp. 49676-49684
    • Wrede, C.E.1    Dickson, L.M.2    Lingohr, M.K.3    Briaud, I.4    Rhodes, C.J.5
  • 44
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes
    • Shimabukuro M., Zhou Y.T., Levi M., and Unger R.H. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 95 (1998) 2498-2502
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.T.2    Levi, M.3    Unger, R.H.4
  • 45
    • 0030852877 scopus 로고    scopus 로고
    • Role of nitric oxide in obesity induced beta cell disease
    • Shimabukuro M., Ohneda M., Lee Y., and Unger R.H. Role of nitric oxide in obesity induced beta cell disease. J Clin Invest 100 (1997) 290-295
    • (1997) J Clin Invest , vol.100 , pp. 290-295
    • Shimabukuro, M.1    Ohneda, M.2    Lee, Y.3    Unger, R.H.4
  • 46
    • 43249114822 scopus 로고    scopus 로고
    • Glucolipotoxicity: fuel excess and β-cell dysfunction
    • Nov 29 [Epub ahead of print]
    • Poitout V., and Robertson R.P. Glucolipotoxicity: fuel excess and β-cell dysfunction. Endocr Rev (2007) Nov 29 [Epub ahead of print]
    • (2007) Endocr Rev
    • Poitout, V.1    Robertson, R.P.2
  • 47
    • 0024307842 scopus 로고
    • Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets
    • Lukinius A., Wilander E., Westermark G.T., Engstrom U., and Westermark P. Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets. Diabetologia 32 (1989) 240-244
    • (1989) Diabetologia , vol.32 , pp. 240-244
    • Lukinius, A.1    Wilander, E.2    Westermark, G.T.3    Engstrom, U.4    Westermark, P.5
  • 48
    • 0031895880 scopus 로고    scopus 로고
    • Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans
    • Kahn S.E., Verchere C.B., Andrikopoulos S., et al. Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans. Diabetes 47 (1998) 640-645
    • (1998) Diabetes , vol.47 , pp. 640-645
    • Kahn, S.E.1    Verchere, C.B.2    Andrikopoulos, S.3
  • 49
    • 0026512386 scopus 로고
    • Plasma islet amyloid polypeptide levels in obesity, impaired glucose tolerance and non-insulin-dependent diabetes mellitus
    • Enoki S., Mitsukawa T., Takemura J., Nakazato, et al. Plasma islet amyloid polypeptide levels in obesity, impaired glucose tolerance and non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 15 (1992) 97-102
    • (1992) Diabetes Res Clin Pract , vol.15 , pp. 97-102
    • Enoki, S.1    Mitsukawa, T.2    Takemura, J.3    Nakazato4
  • 50
    • 0023692891 scopus 로고
    • Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro
    • Leighton B., and Cooper C.J.S. Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro. Nature 335 (1988) 632-635
    • (1988) Nature , vol.335 , pp. 632-635
    • Leighton, B.1    Cooper, C.J.S.2
  • 51
    • 0025054691 scopus 로고
    • Inhibitory effect of rat amylin on the insulin responses to glucose and arginine in the perfused rat pancreas
    • Silvestre R.A., Peiró E., Dégano P., Miralles P., and Marco J. Inhibitory effect of rat amylin on the insulin responses to glucose and arginine in the perfused rat pancreas. Regul Pept 31 (1990) 23-31
    • (1990) Regul Pept , vol.31 , pp. 23-31
    • Silvestre, R.A.1    Peiró, E.2    Dégano, P.3    Miralles, P.4    Marco, J.5
  • 52
    • 0024804095 scopus 로고
    • Amylin and the amylin gene: structure, function and relationship to islet amyloid and to diabetes mellitus
    • Cooper G.J.S., Day A.J., Willis A.C., Roberts A.N., Reid K.B.M., and Leighton B. Amylin and the amylin gene: structure, function and relationship to islet amyloid and to diabetes mellitus. Biochem Biophys Acta 1014 (1989) 247-258
    • (1989) Biochem Biophys Acta , vol.1014 , pp. 247-258
    • Cooper, G.J.S.1    Day, A.J.2    Willis, A.C.3    Roberts, A.N.4    Reid, K.B.M.5    Leighton, B.6
  • 53
    • 0035125490 scopus 로고    scopus 로고
    • Human type 2 diabetes: Morphological evidence for abnormal beta-cell function
    • Sempoux C., Guiot Y., Dubois D., Moulin P., and Rahier J. Human type 2 diabetes: Morphological evidence for abnormal beta-cell function. Diabetes 50 (2001) S172-S177
    • (2001) Diabetes , vol.50
    • Sempoux, C.1    Guiot, Y.2    Dubois, D.3    Moulin, P.4    Rahier, J.5
  • 54
    • 0035122488 scopus 로고    scopus 로고
    • Endocrine pancreas plasticity under physiological and pathological conditions
    • Bernard-Kargar C., and Ktorza A. Endocrine pancreas plasticity under physiological and pathological conditions. Diabetes 50 (2001) S30-S35
    • (2001) Diabetes , vol.50
    • Bernard-Kargar, C.1    Ktorza, A.2
  • 55
    • 0034942447 scopus 로고    scopus 로고
    • Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications
    • Porte Jr. D. Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications. Diabetes Metab Res Rev 17 (2001) 181-188
    • (2001) Diabetes Metab Res Rev , vol.17 , pp. 181-188
    • Porte Jr., D.1
  • 56
    • 0032969276 scopus 로고    scopus 로고
    • Islet amyloid: A long-recognized but underappreciated pathological feature of type 2 diabetes
    • Kahn S.E., Andrikopoulos S., and Verchere C.B. Islet amyloid: A long-recognized but underappreciated pathological feature of type 2 diabetes. Diabetes 48 (1999) 241-253
    • (1999) Diabetes , vol.48 , pp. 241-253
    • Kahn, S.E.1    Andrikopoulos, S.2    Verchere, C.B.3
  • 57
    • 0345375618 scopus 로고    scopus 로고
    • β-cell deterioration -prospects for reversal or prevention
    • Finegood D., and Topp B. β-cell deterioration -prospects for reversal or prevention. Diabetes Obes Metab 3 (2001) S20-S27
    • (2001) Diabetes Obes Metab , vol.3
    • Finegood, D.1    Topp, B.2
  • 58
    • 0036632466 scopus 로고    scopus 로고
    • Islet redox stress: the manifold toxicities of insulin resistance, metabolic syndrome and amylin derived islet amyloid in type 2 diabetes mellitus
    • Hayden M., and Tyagi S. Islet redox stress: the manifold toxicities of insulin resistance, metabolic syndrome and amylin derived islet amyloid in type 2 diabetes mellitus. Pancreas 3 (2002) 86-108
    • (2002) Pancreas , vol.3 , pp. 86-108
    • Hayden, M.1    Tyagi, S.2
  • 59
    • 0033048453 scopus 로고    scopus 로고
    • The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles
    • Janson J., Ashley R., Harrison D., McIntyre S., and Butler P. The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 48 (1999) 491-498
    • (1999) Diabetes , vol.48 , pp. 491-498
    • Janson, J.1    Ashley, R.2    Harrison, D.3    McIntyre, S.4    Butler, P.5
  • 60
    • 0028303844 scopus 로고
    • Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
    • Lorenzo A., Razzaboni B., Weir G.C., and Yankner B.A. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368 (1994) 756-760
    • (1994) Nature , vol.368 , pp. 756-760
    • Lorenzo, A.1    Razzaboni, B.2    Weir, G.C.3    Yankner, B.A.4
  • 61
    • 0035514444 scopus 로고    scopus 로고
    • Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells
    • Wang F., Hull R., Vidal J., Cnop M., and Kahn S. Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells. Diabetes 50 (2001) 2514-2520
    • (2001) Diabetes , vol.50 , pp. 2514-2520
    • Wang, F.1    Hull, R.2    Vidal, J.3    Cnop, M.4    Kahn, S.5
  • 62
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352 (1998) 837-853
    • (1998) Lancet , vol.352 , pp. 837-853
  • 63
    • 33846642699 scopus 로고    scopus 로고
    • Change in pancreatic B-cell function (HOMA-B) varies in different populations with similar genetic backgrounds but different environments
    • Heald A.H., Anderson S.G., Patel J., et al. Change in pancreatic B-cell function (HOMA-B) varies in different populations with similar genetic backgrounds but different environments. Diabet Med 24 (2007) 145-153
    • (2007) Diabet Med , vol.24 , pp. 145-153
    • Heald, A.H.1    Anderson, S.G.2    Patel, J.3
  • 64
    • 34547658090 scopus 로고    scopus 로고
    • Sulfonylurea and glinide reduce insulin content, functional expression of K(ATP) channels, and accelerate apoptotic beta-cell death in the chronic phase
    • Takahashi A., Nagashima K., Hamasaki A., et al. Sulfonylurea and glinide reduce insulin content, functional expression of K(ATP) channels, and accelerate apoptotic beta-cell death in the chronic phase. Diabetes Res Clin Pract 77 (2007) 343-350
    • (2007) Diabetes Res Clin Pract , vol.77 , pp. 343-350
    • Takahashi, A.1    Nagashima, K.2    Hamasaki, A.3
  • 66
    • 0032509446 scopus 로고    scopus 로고
    • Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration
    • Efanova I.B., Zaitsev S.V., Zhivotovsky B., et al. Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration. J Biol Chem 273 (1998) 33501-33507
    • (1998) J Biol Chem , vol.273 , pp. 33501-33507
    • Efanova, I.B.1    Zaitsev, S.V.2    Zhivotovsky, B.3
  • 67
    • 11844298435 scopus 로고    scopus 로고
    • Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets
    • Del Guerra S., Marselli L., Lupi R., et al. Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets. J Diabetes Complications 19 (2005) 60-64
    • (2005) J Diabetes Complications , vol.19 , pp. 60-64
    • Del Guerra, S.1    Marselli, L.2    Lupi, R.3
  • 68
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y., Brown J., Martinez O.I., and Melton D.A. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429 (2004) 41-46
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 69
    • 24944591025 scopus 로고    scopus 로고
    • New sources of pancreatic beta-cells
    • Bonner-Weir S., and Weir G.C. New sources of pancreatic beta-cells. Nat Biotechnol 23 (2005) 857-861
    • (2005) Nat Biotechnol , vol.23 , pp. 857-861
    • Bonner-Weir, S.1    Weir, G.C.2
  • 71
    • 0031913829 scopus 로고    scopus 로고
    • Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat
    • Pick A., Clark J., Kubstrup C., Levisetti M., et al. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes 47 (1998) 358-364
    • (1998) Diabetes , vol.47 , pp. 358-364
    • Pick, A.1    Clark, J.2    Kubstrup, C.3    Levisetti, M.4
  • 72
    • 0018146301 scopus 로고
    • The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus
    • Westermark P., and Wilander E. The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus. Diabetologia 15 (1978) 417-421
    • (1978) Diabetologia , vol.15 , pp. 417-421
    • Westermark, P.1    Wilander, E.2
  • 73
    • 0017874785 scopus 로고
    • Morphometrical analysis on topographical difference in size distribution, number and volume of islets in the human pancreas
    • Saito K., Iwama N., and Takahashi T. Morphometrical analysis on topographical difference in size distribution, number and volume of islets in the human pancreas. Tohoku J Exp Med 124 (1978) 177-186
    • (1978) Tohoku J Exp Med , vol.124 , pp. 177-186
    • Saito, K.1    Iwama, N.2    Takahashi, T.3
  • 74
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., and Butler P.C. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52 (2003) 102-110
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 75
    • 8744272467 scopus 로고    scopus 로고
    • Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
    • Marchetti P., Del Guerra S., Marselli L., et al. Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. J Clin Endocrinol Metab 89 (2004) 5535-5541
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5535-5541
    • Marchetti, P.1    Del Guerra, S.2    Marselli, L.3
  • 76
    • 0025342504 scopus 로고
    • Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans
    • Kendall D.M., Sutherland D.E., Najarian J.S., Goetz F.C., and Robertson R.P. Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans. N Engl J Med 322 (1990) 898-903
    • (1990) N Engl J Med , vol.322 , pp. 898-903
    • Kendall, D.M.1    Sutherland, D.E.2    Najarian, J.S.3    Goetz, F.C.4    Robertson, R.P.5
  • 77
    • 0022458220 scopus 로고
    • Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes
    • Weir G.C., Leahy J.L., and Bonner-Weir S. Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes. Diabetes Metab Rev 2 (1986) 125-161
    • (1986) Diabetes Metab Rev , vol.2 , pp. 125-161
    • Weir, G.C.1    Leahy, J.L.2    Bonner-Weir, S.3
  • 78
    • 0035461929 scopus 로고    scopus 로고
    • Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonaemia in the minipig
    • Kjems L.L., Kirby B.M., Welsh E.M., et al. Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonaemia in the minipig. Diabetes 50 (2001) 2001-2012
    • (2001) Diabetes , vol.50 , pp. 2001-2012
    • Kjems, L.L.1    Kirby, B.M.2    Welsh, E.M.3
  • 79
    • 0025944135 scopus 로고
    • Deterioration of islet beta-cell function after hemipancreatectomy in dogs
    • Stagner J.I., and Samols E. Deterioration of islet beta-cell function after hemipancreatectomy in dogs. Diabetes 40 (1991) 1472-1479
    • (1991) Diabetes , vol.40 , pp. 1472-1479
    • Stagner, J.I.1    Samols, E.2
  • 80
    • 0024804289 scopus 로고
    • Decreased insulin- and glucagon-pulse amplitude accompanying beta-cell deficiency induced by streptozocin in baboons
    • Goodner C.J., Koerker D.J., Weigle D.S., and McCulloch D.K. Decreased insulin- and glucagon-pulse amplitude accompanying beta-cell deficiency induced by streptozocin in baboons. Diabetes 38 (1989) 925-931
    • (1989) Diabetes , vol.38 , pp. 925-931
    • Goodner, C.J.1    Koerker, D.J.2    Weigle, D.S.3    McCulloch, D.K.4
  • 81
    • 33749324476 scopus 로고    scopus 로고
    • Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy
    • Matveyenko A.V., Veldhuis J.D., and Butler P.C. Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy. Diabetes 55 (2006) 2347-2356
    • (2006) Diabetes , vol.55 , pp. 2347-2356
    • Matveyenko, A.V.1    Veldhuis, J.D.2    Butler, P.C.3
  • 82
    • 0035122304 scopus 로고    scopus 로고
    • Regulation of beta-cell mass by hormones and growth factors
    • Nielsen J.H., Galsgaard E.D., Møldrup A., et al. Regulation of beta-cell mass by hormones and growth factors. Diabetes 50 (2001) S25-S29
    • (2001) Diabetes , vol.50
    • Nielsen, J.H.1    Galsgaard, E.D.2    Møldrup, A.3
  • 83
    • 0014188893 scopus 로고
    • Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects
    • Perley M.J., and Kipnis D.M. Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest 46 (1967) 1954-1962
    • (1967) J Clin Invest , vol.46 , pp. 1954-1962
    • Perley, M.J.1    Kipnis, D.M.2
  • 84
    • 0014700091 scopus 로고
    • Plasma insulin responses to oral and venous glucose in various forms of diabetes mellitus
    • Mirouze J., Orsetti A., and Lapinski H. Plasma insulin responses to oral and venous glucose in various forms of diabetes mellitus. Acta Diabetol Lat 7 (1970) 55-67
    • (1970) Acta Diabetol Lat , vol.7 , pp. 55-67
    • Mirouze, J.1    Orsetti, A.2    Lapinski, H.3
  • 85
    • 0028296643 scopus 로고
    • Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal
    • D'Alessio D.A., Kahn S.E., Leusner C.R., and Ensinck J.W. Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. J Clin Invest 93 (1994) 2263-2266
    • (1994) J Clin Invest , vol.93 , pp. 2263-2266
    • D'Alessio, D.A.1    Kahn, S.E.2    Leusner, C.R.3    Ensinck, J.W.4
  • 86
    • 12244264206 scopus 로고    scopus 로고
    • The role of GLP-1 in the life and death of pancreatic beta cells
    • Perfetti R., and Hui H. The role of GLP-1 in the life and death of pancreatic beta cells. Horm Metab Res 36 (2004) 804-810
    • (2004) Horm Metab Res , vol.36 , pp. 804-810
    • Perfetti, R.1    Hui, H.2
  • 87
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu G., Stoffers D.A., Habener J.F., and Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48 (1999) 2270-2276
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 88
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers D.A., Kieffer T.J., Hussain M.A., et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49 (2000) 741-748
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3
  • 89
    • 0036828227 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
    • Farilla L., Hui H., Bertolotto C., et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 143 (2002) 4397-4408
    • (2002) Endocrinology , vol.143 , pp. 4397-4408
    • Farilla, L.1    Hui, H.2    Bertolotto, C.3
  • 90
    • 0037414781 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis
    • Li Y., Hansotia T., Yusta B., Ris F., Halban P.A., and Drucker D.J. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278 (2003) 471-478
    • (2003) J Biol Chem , vol.278 , pp. 471-478
    • Li, Y.1    Hansotia, T.2    Yusta, B.3    Ris, F.4    Halban, P.A.5    Drucker, D.J.6
  • 91
    • 0037386156 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway
    • Hui H., Nourparvar A., Zhao X., and Perfetti R. Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway. Endocrinology 144 (2003) 1444-1455
    • (2003) Endocrinology , vol.144 , pp. 1444-1455
    • Hui, H.1    Nourparvar, A.2    Zhao, X.3    Perfetti, R.4
  • 92
    • 0345374580 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
    • Farilla L., Bulotta A., Hirshberg B., et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology 144 (2003) 5149-5158
    • (2003) Endocrinology , vol.144 , pp. 5149-5158
    • Farilla, L.1    Bulotta, A.2    Hirshberg, B.3
  • 93
    • 33748039456 scopus 로고    scopus 로고
    • Therapies for the treatment of type 2 diabetes mellitus based on incretin action
    • Gallwitz B. Therapies for the treatment of type 2 diabetes mellitus based on incretin action. Minerva Endocrinol 31 (2006) 133-147
    • (2006) Minerva Endocrinol , vol.31 , pp. 133-147
    • Gallwitz, B.1
  • 94
    • 32944473560 scopus 로고    scopus 로고
    • Therapeutic approaches to preserve islet mass in type 2 diabetes
    • Baggio L.L., and Drucker D.J. Therapeutic approaches to preserve islet mass in type 2 diabetes. Annu Rev Med 57 (2006) 265-281
    • (2006) Annu Rev Med , vol.57 , pp. 265-281
    • Baggio, L.L.1    Drucker, D.J.2


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