siRNA-mediated depletion of endogenous protein phosphatase 2Acα markedly attenuates ceramide-activated protein phosphatase activity in insulin-secreting INS-832/13 cells

Biochemical and Biophysical Research Communications

Volumn 348, Issue 2, 2006, Pages 649-652

  Jangati, Giridhar Rao ^a,b   Veluthakal, Rajakrishnan ^a,b   Kowluru, Anjaneyulu ^a,b  

^a WAYNE STATE UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Isoform of protein phosphatase 2Ac; Apoptosis; Ceramide; Pancreatic cells; Protein phosphatase 2A

Indexed keywords

CERAMIDE; GLUCOSE; HOLOENZYME; INSULIN; ISOENZYME; LIPID; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE 2AC ALPHA; PROTEIN SUBUNIT; SMALL INTERFERING RNA; SPHINGOLIPID CERAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBUNIT; IMMUNOLOGICAL PROCEDURES; INSULIN RELEASE; INSULINOMA; METABOLIC DISORDER; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; RAT; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE;

ANIMALS; CELL LINE, TUMOR; CERAMIDES; INSULINOMA; OKADAIC ACID; PANCREATIC NEOPLASMS; PHOSPHOPROTEIN PHOSPHATASE; RATS; RNA, SMALL INTERFERING;

EID: 33746878783     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.07.100     Document Type: Article

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