Physiological and pathophysiological aspects of ceramide

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 290, Issue 1, 2006, Pages

  Gulbins, Erich ^a   Pin, Lan Li ^b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Acid sphingomyelinase; Membrane platforms; Rafts; Signal transduction

Indexed keywords

CERAMIDE; CYTOKINE; DEATH RECEPTOR; SPHINGOMYELIN PHOSPHODIESTERASE;

APOPTOSIS; BACTERIAL INFECTION; CARDIOVASCULAR FUNCTION; CELL ACTIVATION; CELL FUNCTION; CELL MEMBRANE; ENDOTHELIUM; ENDOTHELIUM CELL; HUMAN; ISCHEMIA; KIDNEY FUNCTION; MAMMAL CELL; MICROVASCULATURE; MULTIPLE ORGAN FAILURE; NONHUMAN; OXIDATIVE STRESS; PARASITOSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SEPSIS; SIGNAL TRANSDUCTION; STIMULUS; STROKE; VASODILATATION; VIRUS INFECTION; ANIMAL; CARDIOVASCULAR SYSTEM; CHEMISTRY; GENERAL ASPECTS OF DISEASE; METABOLISM; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CARDIOVASCULAR SYSTEM; CERAMIDES; DISEASE; MEMBRANE MICRODOMAINS;

EID: 33644840772     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00416.2005     Document Type: Review

References (186)

1. Abdel Shakor AB, Kwiatkowska K, and Sobota A. Cell surface ceramide generation precedes and controls FcγRII clustering and phosphorylation in rafts. J Biol Chem 279: 36778-36787, 2004.
2. Abe K, Rossman KL, Liu B, Ritola KD, Chiang D, Campbell SL, Burridge K, and Der CJ. Vav2 is an activator of Cdc42, Rac1, and RhoA. J Biol Chem 275: 10141-10149, 2000.
3. Adamson ED and Rees AR. Epidermal growth factor receptors. Mol Cell Biochem 34: 129-152, 1981.
4. Anderson RG. The caveolae membrane system. Annu Rev Biochem 67: 199-225, 1998.
5. Anes E, Kuhnel MP, Bos E, Moniz-Pereira J, Habermann A, and Griffiths G. Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria. Nat Cell Biol 5: 793-802, 2003.
6. Aouad SM, Cohen LY, Sharif-Askari E, Haddad EK, Alam A, and Sekaly RP. Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death. J Immunol 172: 2316-2323, 2004.
7. Auge N, Nikolova-Karakashian M, Carpentier S, Parthasarathy S, Negre-Salvayre A, Salvayre R, Merrill AH Jr, and Levade T. Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. J Biol Chem 274: 21533-21538, 1999.
8. Babior BM. NADPH oxidase: an update. Blood 93: 1464-1476, 1999.
9. Ballou LR, Chao CP, Holness MA, Barker SC, and Raghow R. Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. J Biol Chem 267: 20044-20050, 1992.
10. Bayraktutan U, Blayney L, and Shah AM. Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells. Arterioscler Thromb Vasc Biol 20: 1903-1911, 2000.
11. Belka C, Marini P, Budach W, Schulze-Osthoff K, Lang F, Gulbins E, and Bamberg M. Radiation-induced apoptosis in human lymphocytes and lymphoma cells critically relies on the up-regulation of CD95/Fas/APO-1 ligand. Radiat Res 149: 588-595, 1998.
12. Bezombes C, Grazide S, Garret C, Fabre C, Quillet-Mary A, Muller S, Jaffrezou JP, and Laurent G. Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains. Blood 104: 1166-1173, 2004.
13. Bhagat K and Vallance P. Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo. Circulation 96: 3042-3047, 1997.
14. Bhunia AK, Han H, Snowden A, and Chatterjee S. Redox-regulated signaling by lactosylceramide in the proliferation of human aortic smooth muscle cells. J Biol Chem 272: 15642-15649, 1997.
15. Bi K and Altman A. Membrane lipid microdomains and the role of PKCθ in T cell activation. Semin Immunol 13: 139-146, 2001.
16. Bielawska AE, Shapiro JP, Jiang L, Melkonyan HS, Piot C, Wolfe CL, Tomei LD, Hannun YA, and Umansky SR. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am J Pathol 151: 1257-1263, 1997.
17. Bischoff A, Czyborra P, Fetscher C, Meyer zu Heringdorf D, Jakobs KH, and Michel MC. Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. Br J Pharmacol 130: 1871-1877, 2000.
18. Bokoch GM and Diebold BA. Current molecular models for NADPH oxidase regulation by Rac GTPase. Blood 100: 2692-2696, 2002.
19. Boniface JJ, Rabinowitz JD, Wulfing C, Hampl J, Reich Z, Altman JD, Kantor RM, Beeson C, McConnell HM, and Davis MM. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands. Immunity 9: 459-466, 1998.
20. Bossaller C, Habib GB, Yamamoto H, Williams C, Wells S, and Henry PD. Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5′-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta. J Clin Invest 79: 170-174, 1987.
21. Boucher LM, Wiegmann K, Futterer A, Pfeffer K, Machleidt T, Schutze S, Mak TW, and Kronke M. CD28 signals through acidic sphingomyelinase. J Exp Med 181: 2059-2068, 1995.
22. Bourbon NA, Yun J, and Kester M. Ceramide directly activates protein kinase C ζ to regulate a stress-activated protein kinase signaling complex. J Biol Chem 275: 35617-35623, 2000.
23. Brown DA and London E. Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 14: 111-136, 1998.
24. Bulotta S, Barsacchi R, Rotiroti D, Borgese N, and Clementi E. Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-α. A novel feedback mechanism regulating cell death. J Biol Chem 276: 6529-6536, 2001.
25. Cain BS, Harken AH, and Meldrum DR. Therapeutic strategies to reduce TNF-α mediated cardiac contractile depression following ischemia and reperfusion. J Mol Cell Cardiol 31: 931-947, 1999.
26. Cain BS, Meldrum DR, Selzman CH, Cleveland JC Jr, Meng X, Sheridan BC, Banerjee A, and Harken AH. Surgical implications of vascular endothelial physiology. Surgery 122: 516-526, 1997.
27. Callahan JW, Jones CS, Davidson DJ, and Shankaran P. The active site of lysosomal sphingomyelinase: evidence for the involvement of hydrophobic and ionic groups. J Neurosci Res 10: 151-163, 1983.
28. Cannon CL, Kowalski MP, Stopak KS, and Pier GB. Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator. Am J Respir Cell Mol Biol 29: 188-197, 2003.
29. Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B, and Hannun YA. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem 277: 12587-12595, 2002.
30. Charruyer A, Gradize S, Bezombes C, Muller S, Laurent G, and Jaffrezou JP. UV-C induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal. J Biol Chem 280: 19196-19204, 2005.
31. Chatterjee S. Sphingolipids in atherosclerosis and vascular biology. Arterioscler Thromb Vasc Biol 18: 1523-1533, 1998.
32. 2+ influx. J Leukoc Biol 78: 266-278, 2005.
33. Cifone MG, De Maria R, Roncaioli P, Rippo MR, Azuma M, Lanier LL, Santoni A, and Testi R. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med 180: 1547-1552, 1994.
34. Contreras FX, Basanez G, Alonso A, Herrmann A, and Goni FM. Asymmetric addition of ceramides but not dihydroceramides promotes transbilayer (flip-flop) lipid motion in membranes. Biophys J 88: 348-359, 2005.
35. Cremesti A, Paris F, Grassme H, Holler N, Tschopp J, Fuks Z, Gulbins E, and Kolesnick R. Ceramide enables fas to cap and kill. J Biol Chem 276: 23954-23961, 2001.
36. Dbaibo GS, El-Assaad W, Krikorian A, Liu B, Diab K, Idriss NZ, El-Sabban M, Driscoll TA, Perry DK, and Hannun YA. Ceramide generation by two distinct pathways in tumor necrosis factor α-induced cell death. FEBS Lett 503: 7-12, 2001.
37. Delmas D, Rebe C, Micheau O, Athias A, Gambert P, Grazide S, Laurent G, Latruffe N, and Solary E. Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. Oncogene 23: 8979-8986, 2004.
38. Dobrowsky RT and Hannun YA. Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. Adv Lipid Res 25: 91-104, 1993.
39. Drobnik W, Liebisch G, Audebert FX, Frohlich D, Gluck T, Vogel P, Rothe G, and Schmitz G. Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients. J Lipid Res 44: 754-761, 2003.
40. Emmelot P and Van Hoeven RP. Phospholipid unsaturation and plasma membrane organization. Chem Phys Lipids 14: 236-246, 1975.
41. Erdreich-Epstein A, Tran LB, Cox OT, Huang E, Laug WE, Shimada H, and Millard M. Endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 involves ceramide metabolic pathways. Blood 105: 4353-4361, 2005.
42. Esen M, Schreiner B, Jendrossek V, Lang F, Fassbender K, Grassme H, and Gulbins E. Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells. Apoptosis 6: 431-439, 2001.
43. Fanzo JC, Lynch MP, Phee H, Hyer M, Cremesti A, Grassme H, Norris JS, Coggeshall KM, Rueda BR, Pernis AB, Kolesnick R, and Gulbins E. CD95 rapidly clusters in cells of diverse origins. Cancer Biol Ther 2: 392-395, 2003.
44. Flavahan NA. Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity. Circulation 85: 1927-1938, 1992.
45. Flavahan NA. Lysophosphatidylcholine modifies G protein-dependent signaling in porcine endothelial cells. Am J Physiol Heart Circ Physiol 264: H722-H727, 1993.
46. Frey RS, Rahman A, Kefer JC, Minshall RD, and Malik AB. PKCζ regulates TNF-α-induced activation of NADPH oxidase in endothelial cells. Circ Res 90: 1012-1019, 2002.
47. Galle J, Mulsch A, Busse R, and Bassenge E. Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor. Arterioscler Thromb 11: 198-203, 1991.
48. Garcia-Barros M, Lacorazza D, Petrie H, Haimovitz-Friedman A, Cardon-Cardo C, Nimer S, Fuks Z, and Kolesnick R. Host acid sphingomyelinase regulates microvascular function not tumor immunity. Cancer Res 64: 8285-8291, 2004.
49. Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, Fuks Z, and Kolesnick R. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300: 1155-1159, 2003.
50. Garcia-Ruiz C, Colell A, Mari M, Morales A, Calvo M, Enrich C, and Fernandez-Checa JC. Defective TNF-α-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J Clin Invest 111: 197-208, 2003.
51. Goggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, Brade L, Brade H, Ehlers S, Slutsky AS, Schutze S, Gulbins E, and Uhlig S. PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat Med 10: 155-160, 2004.
52. Gorlach A, Brandes RP, Nguyen K, Amidi M, Dehghani F, and Busse R. A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circ Res 87: 26-32, 2000.
53. Gottlieb RA and Engler RL. Apoptosis in myocardial ischemia-reperfusion. Ann NY Acad Sci 874: 412-426, 1999.
54. Grassme H, Cremesti A, Kolesnick R, and Gulbins E. Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene 22: 5457-5470, 2003.
55. Grassme H, Gulbins E, Brenner B, Ferlinz K, Sandhoff K, Harzer K, Lang F, and Meyer TF. Acidic sphingomyelinase mediates entry of N. gonorrhoeaeinto nonphagocytic cells. Cell 91: 605-615, 1997.
56. Grassme H, Jekle A, Riehle A, Schwarz H, Berger J, Sandhoff K, Kolesnick R, and Gulbins E. CD95 signaling via ceramide-rich membrane rafts. J Biol Chem 276: 20589-20596, 2001.
57. Grassme H, Jendrossek V, Bock J, Riehle A, and Gulbins E. Ceramide-rich membrane rafts mediate CD40 clustering. J Immunol 168: 298-307, 2002.
58. Grassme H, Jendrossek V, Riehle A, von Kurthy G, Berger J, Schwarz H, Weller M, Kolesnick R, and Gulbins E. Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat Med 9: 322-330, 2003.
59. Grassme H, Kirschnek S, Riethmueller J, Riehle A, von Kurthy G, Lang F, Weller M, and Gulbins E. CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa. Science 290: 527-530, 2000.
60. Grassme H, Schwarz H, and Gulbins E. Molecular mechanisms of ceramide-mediated CD95 clustering. Biochem Biophys Res Commun 284: 1016-1030, 2001.
61. Grassmé H, Riehle A, Wilker B, Gulbins E. Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms. J Biol Chem 80: 26256-26262, 2005.
62. Graziadei L, Riabowol K, and Bar-Sagi D. Co-capping of ras proteins with surface immunoglobulins in B lymphocytes. Nature 347: 396-400, 1990.
63. Griendling KK, Minieri CA, Ollerenshaw JD, and Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74: 1141-1148, 1994.
64. Griendling KK, Sorescu D, and Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 86: 494-501, 2000.
65. Gulbins E, Bissonnette R, Mahboubi A, Martin S, Nishioka W, Brunner T, Baier G, Baier-Bitterlich G, Byrd C, Lang F, Kolesnick R, Altman A, and Green DR. FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity 2: 341-351, 1995.
66. Gulbins E, Coggeshall KM, Baier G, Telford D, Langlet C, Baier-Bitterlich G, Bonnefoy-Berard N, Burn P, Wittinghofer A, and Altman A. Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides. Mol Cell Biol 14: 4749-4758, 1994.
67. Gulbins E, Szabo I, Baltzer K, and Lang F. Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases. Proc Natl Acad Sci USA 94: 7661-7666, 1997.
68. Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z, and Kolesnick RN. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med 180: 525-535, 1994.
69. Hanada K, Palacpac NM, Magistrado PA, Kurokawa K, Rai G, Sakata D, Hara T, Horii T, Nishijima M, and Mitamura T. Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy. J Exp Med 195: 23-34, 2002.
70. Hannun YA. The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem 269: 3125-3128, 1994.
71. Harada-Shiba M, Kinoshita M, Kamido H, and Shimokado K. Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms. J Biol Chem 273: 9681-9687, 1998.
72. Hauck CR, Grassme H, Bock J, Jendrossek V, Ferlinz K, Meyer TF, and Gulbins E. Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae. FEBS Lett 478: 260-266, 2000.
73. Hein TW and Kuo L. LDLs impair vasomotor function of the coronary microcirculation: role of superoxide anions. Circ Res 83: 404-414, 1998.
74. Heinrich M, Wickel M, Schneider-Brachert W, Sandberg C, Gahr J, Schwandner R, Weber T, Saftig P, Peters C, Brunner J, Kronke M, and Schutze S. Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J 18: 5252-5263, 1999.
75. Hernandez OM, Discher DJ, Bishopric NH, and Webster KA. Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes. Circ Res 86: 198-204, 2000.
76. Higashi H, Omori A, and Yamagata T. Calmodulin, a ganglioside-binding protein. Binding of gangliosides to calmodulin in the presence of calcium. J Biol Chem 267: 9831-9838, 1992.
77. Hirokawa M, Kitabayashi A, Kuroki J, and Miura AB. Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cells. Tohoku J Exp Med 191: 167-176, 2000.
78. Holmes TC, Fadool DA, and Levitan IB. Tyrosine phosphorylation of the Kv1.3 potassium channel. J Neurosci 16: 1581-1590, 1996.
79. Holopainen JM, Subramanian M, and Kinnunen PK. Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane. Biochemistry 37: 17562-17570, 1998.
80. Huwiler A, Johansen B, Skarstad A, and Pfeilschifter J. Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release. FASEB J 15: 7-9, 2001.
81. Huwiler A, Kolter T, Pfeilschifter J, and Sandhoff K. Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim Biophys Acta 1485: 63-99, 2000.
82. Igarashi J, Thatte HS, Prabhakar P, Golan DE, and Michel T. Calcium-independent activation of endothelial nitric oxide synthase by ceramide. Proc Natl Acad Sci USA 96: 12583-12588, 1999.
83. Jan JT, Chatterjee S, and Griffin DE. Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide. J Virol 74: 6425-6432, 2000.
84. Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Pushkareva M, Obeid LM, and Hannun YA. Role for ceramide in cell cycle arrest. J Biol Chem 270: 2047-2052, 1995.
85. Johns DG, Osborn H, and Webb RC. Ceramide: a novel cell signaling mechanism for vasodilation. Biochem Biophys Res Commun 237: 95-97, 1997.
86. 2-dependent ceramide signaling. Am J Physiol Heart Circ Physiol 275: H1592-H1598, 1998.
87. Junge S, Brenner B, Lepple-Wienhues A, Nilius B, Lang F, Linderkamp O, and Gulbins E. Intracellular mechanisms of L-selectin induced capping. Cell Signal 11: 301-308, 1999.
88. Kaushal GP, Singh AB, and Shah SV. Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury. Am J Physiol Renal Physiol 274: F587-F595, 1998.
89. Kaushal GP, Ueda N, and Shah SV. Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A. Kidney Int 52: 438-445, 1997.
90. Kim MY, Linardic C, Obeid L, and Hannun Y. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon: specific role in cell differentiation. J Biol Chem 266: 484-489, 1991.
91. Kirschnek S, Paris F, Weller M, Grassme H, Ferlinz K, Riehle A, Fuks Z, Kolesnick R, and Gulbins E. CD95-mediated apoptosis in vivo involves acid sphingomyelinase. J Biol Chem 275: 27316-27323, 2000.
92. Klemm P, Warner TD, Corder R, and Vane JR. Endothelin-1 mediates coronary vasoconstriction caused by exogenous and endogenous cytokines. J Cardiovasc Pharmacol 26, Suppl3: S419-S421, 1995.
93. Kolesnick RN, Goni FM, and Alonso A. Compartmentalization of ceramide signaling: physical foundations and biological effects. J Cell Physiol 184: 285-300, 2000.
94. Kowalski MP and Pier GB. Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activation. J Immunol 172: 418-425, 2004.
95. Kronke M. Involvement of sphingomyelinases in TNF signaling pathways. Chem Phys Lipids 102: 157-166, 1999.
96. Kupfer A and Kupfer H. Imaging immune cell interactions and functions: SMACs and the immunological synapse. Semin Immunol 15: 295-300, 2003.
97. Lacour S, Hammann A, Grazide S, Lagadic-Gossmann D, Athias A, Sergent O, Laurent G, Gambert P, Solary E, and Dimanche-Boitrel MT. Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells. Cancer Res 64: 3593-3598, 2004.
98. Lang PA, Kempe DS, Tanneur V, Eisele K, Klarl BA, Myssina S, Jendrossek V, Ishii S, Shimizu T, Waidmann M, Hessler G, Huber SM, Lang F, and Wieder T. Stimulation of erythrocyte ceramide formation by platelet-activating factor. J Cell Sci 118: 1233-1243, 2005.
99. Lefer AM and Ma XL. Cytokines and growth factors in endothelial dysfunction. Crit Care Med 21: S9-14, 1993.
100. Lepple-Wienhues A, Belka C, Laun T, Jekle A, Walter B, Wieland U, Welz M, Heil L, Kun J, Busch G, Weller M, Bamberg M, Gulbins E, and Lang F. Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids. Proc Natl Acad Sci USA 96: 13795-13800, 1999.
101. Leusen JH, Verhoeven AJ, and Roos D. Interactions between the components of the human NADPH oxidase: intrigues in the phox family. J Lab Clin Med 128: 461-476, 1996.
102. Levade T, Auge N, Veldman RJ, Cuvillier O, Negre-Salvayre A, and Salvayre R. Sphingolipid mediators in cardiovascular cell biology and pathology. Circ Res 89: 957-968, 2001.
103. Leventhal AR, Chen W, Tall AR, and Tabas I. Acid sphingomyelinase- deficient macrophages have defective cholesterol trafficking and efflux. J Biol Chem 276: 44976-44983, 2001.
104. Li JM, Mullen AM, Yun S, Wientjes F, Brouns GY, Thrasher AJ, and Shah AM. Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-α. Circ Res 90: 143-150, 2002.
105. Li JM and Shah AM. Differential NADPH versus NADH-dependent superoxide production by phagocyte-type endothelial cell NADPH oxidase. Cardiovasc Res 52: 477-486, 2001.
106. Li PL, Chodule JB, Chen YF, Zhang DX, Zou AP, Gulbins E, and Campbell WB. Aggregation of membrane lipid raft and acidic sphingomyelinase in coronary arterial endothelial cells (Abstract). FASEB J 17: A641, 2003.
107. Li PL, Zhang DX, Zou AP, and Campbell WB. Effect of ceramide on KCa channel activity and vascular tone in coronary arteries. Hypertension 33: 1441-1446, 1999.
108. Li YQ, Chen P, Haimovitz-Friedman A, Reilly RM, and Wong CS. Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation. Cancer Res 63: 5950-5956, 2003.
109. Liao JK and Clark SL. Regulation of G-protein αi2 subunit expression by oxidized low-density lipoprotein. J Clin Invest 95: 1457-1463, 1995.
110. Lin T, Genestier L, Pinkoski MJ, Castro A, Nicholas S, Mogil R, Paris F, Fuks Z, Schuchman EH, Kolesnick RN, and Green DR. Role of acidic sphingomyelinase in Fas/CD95-mediated cell death. J Biol Chem 275: 8657-8663, 2000.
111. Liu SF, Dewar A, Crawley DE, Barnes PJ, and Evans TW. Effect of tumor necrosis factor on hypoxic pulmonary vasoconstriction. J Appl Physiol 72: 1044-1049, 1992.
112. Li-Weber M and Krammer PH. Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system. Semin Immunol 15: 145-157, 2003.
113. Lozano J, Menendez S, Morales A, Ehleiter D, Liao WC, Wagman R, Haimovitz-Friedman A, Fuks Z, and Kolesnick R. Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts. J Biol Chem 276: 442-448, 2001.
114. Mallat Z and Tedgui A. Current perspective on the role of apoptosis in atherothrombotic disease. Circ Res 88: 998-1003, 2001.
115. Manes S, del Real G, and Martinez AC. Pathogens: raft hijackers. Nat Rev Immunol 3: 557-568, 2003.
116. Mathias S, Younes A, Kan CC, Orlow I, Joseph C, and Kolesnick RN. Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β. Science 259: 519-522, 1993.
117. Morita Y, Perez GI, Paris F, Miranda SR, Ehleiter D, Haimovitz-Friedman A, Fuks Z, Xie Z, Reed JC, Schuchman EH, Kolesnick RN, and Tilly JL. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med 6: 1109-1114, 2000.
118. Moskwa P, Dagher MC, Paclet MH, Morel F, and Ligeti E. Participation of Rac GTPase activating proteins in the deactivation of the phagocytic NADPH oxidase. Biochemistry 41: 10710-10716, 2002.
119. Muller G, Ayoub M, Storz P, Rennecke J, Fabbro D, and Pfizenmaier K. PKC ζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBO J 14: 1961-1969, 1995.
120. Murohara T, Kugiyama K, Ohgushi M, Sugiyama S, Ohta Y, and Yasue H. LPC in oxidized LDL elicits vasocontraction and inhibits endothelium-dependent relaxation. Am J Physiol Heart Circ Physiol 267: H2441-H2449, 1994.
121. Nakamura M, Yoshida H, Arakawa N, Saitoh S, Satoh M, and Hiramori K. Effects of tumor necrosis factor-α on basal and stimulated endothelium-dependent vasomotion in human resistance vessel. J Cardiovasc Pharmacol 36: 487-492, 2000.
122. Natoli G, Costanzo A, Guido F, Moretti F, and Levrero M. Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling. Biochem Pharmacol 56: 915-920, 1998.
123. Ni HT, Deeths MJ, Li W, Mueller DL, and Mescher MF. Signaling pathways activated by leukocyte function-associated Ag-1-dependent costimulation. J Immunol 162: 5183-5189, 1999.
124. Nurminen TA, Holopainen JM, Zhao H, and Kinnunen PK. Observation of topical catalysis by sphingomyelinase coupled to microspheres. J Am Chem Soc 124: 12129-12134, 2002.
125. Ohanian J, Liu G, Ohanian V, and Heagerty AM. Lipid second messengers derived from glycerolipids and sphingolipids, and their role in smooth muscle function. Acta Physiol Scand 164: 533-548, 1998.
126. Okazaki T, Bielawska A, Bell RM, and Hannun YA. Role of ceramide as a lipid mediator of 1α,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem 265: 15823-15831, 1990.
127. Oral H, Dorn GW, 2nd, and Mann DL. Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-α in the adult mammalian cardiac myocyte. J Biol Chem 272: 4836-4842, 1997.
128. Paris F, Fuks Z, Kang A, Capodieci P, Juan G, Ehleiter D, Haimovitz-Friedman A, Cordon-Cardo C, and Kolesnick R. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293: 293-297, 2001.
129. Paris F, Grassme H, Cremesti A, Zager J, Fong Y, Haimovitz-Friedman A, Fuks Z, Gulbins E, and Kolesnick R. Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes. J Biol Chem 276: 8297-8305, 2001.
130. Paris F, Perez GI, Fuks Z, Haimovitz-Friedman A, Nguyen H, Bose M, Ilagan A, Hunt PA, Morgan WF, Tilly JL, and Kolesnick R. Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med 8: 901-902, 2002.
131. Pena LA, Fuks Z, and Kolesnick RN. Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency. Cancer Res 60: 321-327, 2000.
132. Peralta Soler A, Mullin JM, Knudsen KA, and Marano CW. Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells. Am J Physiol Renal Fluid Electrolyte Physiol 270: F869-F879, 1996.
133. Perez GI, Jurisicova A, Matikainen T, Moriyama T, Kim MR, Takai Y, Pru JK, Kolesnick RN, and Tilly JL. A central role for ceramide in the age-related acceleration of apoptosis in the female germline. FASEB J 19: 860-862, 2005.
134. Pier GB, Grout M, Zaidi TS, Olsen JC, Johnson LG, Yankaskas JR, and Goldberg JB. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science 271: 64-67, 1996.
135. Qiu H, Edmunds T, Baker-Malcolm J, Karey KP, Estes S, Schwarz C, Hughes H, and Van Patten SM. Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine. J Biol Chem 278: 32744-32752, 2003.
136. Rosenman SJ, Ganji AA, Tedder TF, and Gallatin WM. Syn-capping of human T lymphocyte adhesion/activation molecules and their redistribution during interaction with endothelial cells. J Leukoc Biol 53: 1-10, 1993.
137. Rotolo JA, Zhang J, Donepudi M, Lee H, Fuks Z, and Kolesnick R. Caspase-dependent and-independent activation of acid sphingomyelinase signaling. J Biol Chem Apr 280: 26425-26434, 2005.
138. Santana P, Pena LA, Haimovitz-Friedman A, Martin S, Green D, McLoughlin M, Cordon-Cardo C, Schuchman EH, Fuks Z, and Kolesnick R. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86: 189-199, 1996.
139. Scheel-Toellner D, Wang K, Craddock R, Webb PR, McGettrick HM, Assi LK, Parkes N, Clough LE, Gulbins E, Salmon M, and Lord JM. Reactive oxygen species limit neutrophil life span by activating death receptor signaling. Blood 104: 2557-2564, 2004.
140. Schissel SL, Jiang X, Tweedie-Hardman J, Jeong T, Camejo EH, Najib J, Rapp JH, Williams KJ, and Tabas I. Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development. J Biol Chem 273: 2738-2746, 1998.
141. 2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene. J Biol Chem 271: 18431-18436, 1996.
142. Schneider-Brachert W, Tchikov V, Neumeyer J, Jakob M, Winoto-Morbach S, Held-Feindt J, Heinrich M, Merkel O, Ehrenschwender M, Adam D, Mentlein R, Kabelitz D, and Schutze S. Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21: 415-428, 2004.
143. Schutze S, Machleidt T, and Kronke M. The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction. J Leukoc Biol 56: 533-541, 1994.
144. Schutze S, Potthoff K, Machleidt T, Berkovic D, Wiegmann K, and Kronke M. TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 71: 765-776, 1992.
145. Siegel RM, Frederiksen JK, Zacharias DA, Chan FK, Johnson M, Lynch D, Tsien RY, and Lenardo MJ. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science 288: 2354-2357, 2000.
146. 2-terminal kinase. J Immunol 162: 5149-5155, 1999.
147. Simons K and Ehehalt R. Cholesterol lipid rafts, and disease. J Clin Invest 110: 597-603, 2002.
148. Simons K and Ikonen E. Functional rafts in cell membranes. Nature 387: 569-572, 1997.
149. Singer SJ and Nicolson GL. The fluid mosaic model of the structure of cell membranes. Science 175: 720-731, 1972.
150. Soeda S, Honda O, Shimeno H, and Nagamatsu A. Sphingomyelinase and cell-permeable ceramide analogs increase the release of plasminogen activator inhibitor-1 from cultured endothelial cells. Thromb Res 80: 509-518, 1995.
151. + channel in T lymphocytes upon Fas stimulation. J Biol Chem 271: 20465-20469, 1996.
152. Tsutsui M, Shimokawa H, Tanaka S, Kuwaoka I, Hase K, Nogami N, Nakanishi K, and Okamatsu S. Endothelial Gi protein in human coronary arteries. Eur Heart J 15: 1261-1266, 1994.
153. Ueda N, Kaushal GP, and Shah SV. Apoptotic mechanisms in acute renal failure. Am J Med 108: 403-415, 2000.
154. Wang P, Ba ZF, and Chaudry IH. Administration of tumor necrosis factor-α in vivo depresses endothelium-dependent relaxation. Am J Physiol Heart Circ Physiol 266: H2535-H2541, 1994.
155. Wang YM, Seibenhener ML, Vandenplas ML, and Wooten MW. Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-κB/JNK kinase and cell survival. J Neurosci Res 55: 293-302, 1999.
156. Wiegmann K, Schutze S, Machleidt T, Witte D, and Kronke M. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78: 1005-1015, 1994.
157. Xia P, Vadas MA, Rye KA, Barter PJ, and Gamble JR. High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway. A possible mechanism for protection against atherosclerosis by HDL. J Biol Chem 274: 33143-33147, 1999.
158. Xie J, Wang Y, Lippton H, Cai B, Nelson S, Kolls J, Summer WR, and Greenberg SS. Tumor necrosis factor inhibits stimulated but not basal release of nitric oxide. Am Rev Respir Dis 148: 627-636, 1993.
159. Xu J, Yeh CH, Chen S, He L, Sensi SL, Canzoniero LM, Choi DW, and Hsu CY. Involvement of de novo ceramide biosynthesis in tumor necrosis factor-α/cycloheximide-induced cerebral endothelial cell death. J Biol Chem 273: 16521-16526, 1998.
160. Yabu T, Tomimoto H, Taguchi Y, Yamaoka S, Igarashi Y, and Okazaki T. Thalidomide-induced anti-angiogenic action is mediated by ceramide through depletion of VEGF receptors, and antagonized by sphingosine-1-phosphate. Blood 106: 125-134, 2005.
161. Yao B, Zhang Y, Delikat S, Mathias S, Basu S, and Kolesnick R. Phosphorylation of Raf by ceramide-activated protein kinase. Nature 378: 307-310, 1995.
162. Yatomi Y, Yamamura S, Hisano N, Nakahara K, Igarashi Y, and Ozaki Y. Sphingosine 1-phosphate breakdown in platelets. J Biochem (Tokyo) 136: 495-502, 2004.
163. Yi F, Zhang AY, Janscha JL, Li PL, and Zou AP. Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells. Kidney Int 66: 1977-1987, 2004.
164. Yi F, Zhang AY, Li VX, Li N, Zou AP, and Li PL. Activation of Rac GTPase associated with hyperhomocysteinemia in rat kidney and mesangial cells (Abstract). Hypertension 44: p172, 2004.
165. Yin T, Sandhu G, Wolfgang CD, Burrier A, Webb RL, Rigel DF, Hai T, and Whelan J. Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney. J Biol Chem 272: 19943-19950, 1997.
166. Yu ZF, Nikolova-Karakashian M, Zhou D, Cheng G, Schuchman EH, and Mattson MP. Pivotal role of acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis. J Mol Neurosci 15: 85-97, 2000.
167. Zhang AY, Janscha JL, Campbell WB, Zou AP, and Li PL. Silencing of acidic sphingomyelinase gene by RNA interference in human coronary arterial endothelial cells (Abstract). FASEB J 18: A232, 2004.
168. Zhang AY, Teggatz EG, Campbell WB, Zou AP, and Li PL. Endostation-enhanced superoxide production and endothelial dysfunction in small bovine coronary arteries (Abstract). FASEB J 18: A597, 2004.
169. -. production in the intact coronary endothelium. Am J Physiol Heart Circ Physiol 288: H686-H694, 2005.
170. Zhang AY, Yi F, Zhang G, Gulbins E, and Li PL. Activation of endothelial NAD(P)H oxidase via lipid rafts clusterin in coronary arteries (Abstract). FASEB J 19: A521-A522, 2005.
171. Zhang AY, Yi F, Zhang G, Gulbins E, and Li PL. RNA interference of acidic sphingomyelinase gene restores endothelial function through inhibition of NAD(P)H oxidase activity (Abstract). FASEB J 19: A521, 2005.
172. Zhang AY, Zou AP, and Li PL. Lipid raft clustering and trafficking in coronary arterial endothelial cells: identification and functional significance. Hypertension 44: P16, 2004.
173. Zhang DX, Campbell WB, and Li PL. Characterization of the neutral and acidic sphingomyelinase in the myocardium of rats (Abstract). FASEB J 13: A1096, 1999.
174. Zhang DX, Campbell WB, and Li PL. Tumor necrosis factor-α reduces endothelium-dependent vasodilation through ceramide-mediated superoxide production in small bovine coronary arteries (Abstract). FASEB J 16: A934, 2002.
175. Zhang DX, Fryer RM, Hsu AK, Zou AP, Gross GJ, Campbell WB, and Li PL. Production and metabolism of ceramide in normal and ischemicreperfused myocardium of rats. Basic Res Cardiol 96: 267-274, 2001.
176. Zhang DX, Yi FX, Zou AP, and Li PL. Role of ceramide in TNF-α-induced impairment of endothelium-dependent vasorelaxation in coronary arteries. Am J Physiol Heart Circ Physiol 283: H1785-H1794, 2002.
177. Zhang DX, Zou AP, Campbell WB, and Li PL. Effect of ceramide on endothelium-dependent vasodilation in coronary arteries (Abstract). FASEB J 14: A164, 2000.
178. Zhang DX, Zou AP, Campbell WB, and Li PL. Ceramide decrease intracellular nitric oxide concentration in coronary arterial smooth muscle endothelium (Abstract). FASEB J 15: A933, 2001.
179. Zhang DX, Zou AP, Campbell WB, and Li PL. Role of NAD(P)H oxidase in ceramide-induced superoxide production and endothelial dysfunction in small coronary arteries (Abstract). FASEB J 16: A933, 2002.
180. Zhang DX, Zou AP, and Li PL. Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. Circ Res 88: 824-831, 2001.
181. Zhang DX, Zou AP, and Li PL. Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries. Am J Physiol Heart Circ Physiol 284: H605-H612, 2003.
182. Zhang Y, Mattjus P, Schmid PC, Dong Z, Zhong S, Ma WY, Brown RE, Bode AM, and Schmid HH. Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis. J Biol Chem 276: 11775-11782, 2001.
183. Zhang Y, Yao B, Delikat S, Bayoumy S, Lin XH, Basu S, McGinley M, Chan-Hui PY, Lichenstein H, and Kolesnick R. Kinase suppressor of Ras is ceramide-activated protein kinase. Cell 89: 63-72, 1997.
184. 2+ mobilization in rat aortic smooth muscle. Eur J Pharmacol 391: 127-135, 2000.
185. i in canine cerebral vascular muscle. Am J Physiol Heart Circ Physiol 278: H1421-H1428, 2000.
186. Zundel W, Swiersz LM, and Giaccia A. Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide. Mol Cell Biol 20: 1507-1514, 2000.