Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C 2-ceramide in CAD cells

European Journal of Neuroscience

Volumn 25, Issue 10, 2007, Pages 3030-3038

  Arboleda, Gonzalo ^a,d   Huang, Tze Jen ^a,e   Waters, Catherine ^a   Verkhratsky, Alex ^a   Fernyhough, Paul ^a,b,c   Gibson, Rosemary M ^a,f  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ST BONIFACE GENERAL HOSPITAL   (Canada)

^c UNIVERSITY OF MANITOBA   (Canada)

^d UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f HEALTH AND SAFETY LABORATORY   (United Kingdom)

Author keywords

Apoptosis; Glycolysis; Hexokinase; Mitochondria

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CERAMIDE; DOPAMINE; DOPAMINE BETA MONOOXYGENASE; HEXOKINASE; N ACETYL DEXTRO SPHINGOSINE; NORADRENALIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SOMATOMEDIN C; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ACIDIFICATION; ANALYTIC METHOD; ANIMAL CELL; APOPTOSIS; ARTICLE; CATECHOLAMINERGIC SYSTEM; CELL DEATH; CELL DIFFERENTIATION; CELL MEMBRANE POTENTIAL; CELL METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; ENZYME ACTIVITY; ENZYME RELEASE; EXTRACELLULAR SPACE; GLYCOLYSIS; MESENCEPHALON; METABOLIC INHIBITION; MITOCHONDRIAL MEMBRANE; MOUSE; NERVE CELL; NEURITE; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REDUCTION KINETICS; SERUM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BRAIN; CELL DIFFERENTIATION; CELL LINE, TUMOR; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENERGY METABOLISM; GLYCOLYSIS; INSULIN-LIKE GROWTH FACTOR I; MEMBRANE POTENTIAL, MITOCHONDRIAL; MESENCEPHALON; MICE; NERVE DEGENERATION; NEURONS; PARKINSON DISEASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 34250004321     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2007.05557.x     Document Type: Article

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