The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles

Diabetes

Volumn 48, Issue 3, 1999, Pages 491-498

  Janson, Juliette ^a   Ashley, Richard H ^a   Harrison, David ^a   McIntyre, Susan ^a   Butler, Peter C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID;

AMYLOIDOSIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CYTOPATHOGENIC EFFECT; DISEASE ASSOCIATION; HUMAN; MEMBRANE VESICLE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

EID: 0033048453     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.3.491     Document Type: Article

References (39)

1. Westermark P: Quantitative studies of amyloid in the islets of Langerhans. Ups J Med Sci 77:91-94, 1972
2. Clark A, Wells CA, Buley ID, Cruickshank JK, Vanhegan RI, Matthews DR, Cooper GJ, Holman RR, Turner RC: Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 9:151-159, 1988
3. Johnson KH, O'Brien TD, Betsholtz C, Westermark P: Islet amyloid, islet-amyloid polypeptide, and diabetes mellitus. N Engl J Med 321:513-518, 1989
4. Johnson KH, O'Brien TD, Betsholtz C, Westermark P: Islet amyloid polypeptide: mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus. Lab Invest 66:522-535, 1992
5. Westermark P, Wernstedt C, Wilander E, Hayden DW, O'Brien TD, Johnson KH: Amyloid fibrils in human insulinonia and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci U S A 84:3881-3885, 1987
6. Cooper GJS, Willis AC, Clark A, Turner RC, Sim RB, Reid KBM: Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci U S A 84:8628-9632, 1987
7. Betsholtz C, Christmansson L, Engström U, Rorsman F, Svensson V, Johnson KH, Westermark P: Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species. FEBS Lett 251:261-264, 1989
8. Westermark P, Engström U, Johnson KH, Westermark GT, Betsholtz C: Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc Natl Acad Sci USA 87:5036-5040, 1990
9. O'Brien TD, Butler PC, Kreutter DK, Kane LA, Eberhardt NL: Human islet amyloid polypeptide expression in COS-1 cells. A model of intracellular amyloidogenesis. Am J Pathol 147:609-616, 1995
10. Lorenzo A, Razzaboni B, Weir GC, Yankner BA: Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368:756-760, 1994
11. Clark A, Badman MK, Lowndes SA, Morris JF: Aggregated human islet amyloid polypeptide is not cytotoxic to mouse islets in vitro (Abstract). Diabetologia 38 (Suppl. 1):A91, 1995
12. Couce M, Kane LA, O'Brien TD, Charlesworth J, Soeller W, McNeish J, Kreutter D, Roche P, Butler PC: Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and β-cell dysfunction. Diabetes 45:1094-1101, 1996
13. Janson J, Soeller WC, Roche PC, Nelson RT, Torchia AJ, zKreutter DK, Butler PC: Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide. Proc Natl Acad Sci U S A 93:7283-7288, 1996
14. vy/a mice expressing human IAPP. Diabetes 47:743-750, 1998
15. Verchere CB, D'Alessio DA, Palmiter RD, Weir GC, Bonner-Weir S, Baskin DG, Kahn SE: Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic β cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci U S A 93:3492-3496, 1996
16. O'Brien TD, Butler AE, Roche PC, Johnson KH, Butler PC: Islet amyloid polypeptide in human insulinomas. Diabetes 43:329-336, 1994
17. Mirzabekov TA, Lin M, Kagan BL: Pore formation by the cytotoxic islet amyloid peptide amylin. J Biol Chem 271:1988-1992, 1996
18. Ricordi C, Scharp DW: Reversal of diabetes in nude mice after transplantation of fresh and 7-day-cultured (24°C) human pancreatic islets. Transplantation 45:994-996, 1988
19. El-Naggar MM, Elayat AA, Ardawi MSM, Tahir M: Isolated pancreatic islets of the rat: an immunohistochemical and morphometric study. Anat Rec 237:489-497, 1993
20. Kudva YC, Mueske C, Butler PC, Eberhardt NL: A novel in vitro assay of human islet amyloid polypeptide amyloidogenesis and effects of insulin secretory vesicle peptides on amyloid formation. Biochem J 321:809-813, 1998
21. Hattori T, Hosokawa Y, Sugihara H, Fukuda M: DNA content of diffusely infiltrative carcinomas in the stomach. Pathol Res Pract 180:615-618, 1985
22. Jones KH, Senft JA: An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide. J Histochem Cytochem 33:77-79, 1985
23. Pace CS, Sachs G: Glucose-induced proton uptake in secretory granules of β-cells in monolayer culture. Am J Physiol 242:C382-C387, 1982
24. Couce M, O'Brien TD, Moran A, Roche PC, Butler PC: Diabetes mellitus in cystic fibrosis is characterized by islet amyloidosis. J Clin Endocrinol Metab 81:1267-1272, 1996
25. McDowell EM, Trump BF: Histologic fixatives suitable for diagnostic light and electron microscopy. Arch Pathol Lab Med 100:405-414, 1976
26. Spurr AR: A low viscosity epoxy resin embedding medium for electron microscopy. J Ultrastruct Res 71:173-184, 1969
27. Howie SEM, Cotton GJ, Heslop I, Martin NJ, Harrison DJ, Ramage R: Synthetic peptides representing discontinuous CD4-binding epitopes of HIV-1 gp 120 that induce T cell apoptosis and block cell death induced by gp 120. FASEB J 12:991-998, 1998
28. Williams AJ: The measurement of the function of ion channels reconstituted into artificial membranes. In Ion Channels, A Practical Approach. Ashley RH, Ed. Oxford, U.K., IRL/Oxford University Press, 1995, p. 43-67
29. Berne BJ, Pecora R: Dynamic Light Scattering. New York, Wiley, 1976
30. Alvarez O: Setting up a bilayer system. In Ion Channel Reconstitution. C. Miller, Ed. New York, Plenum, 1986, p. 129
31. Higham CE, Lewis M, Morris JF, Clark A: Cytotoxicity of human islet amyloid polypeptide to β-TC cells is mediated via apoptosis and necrosis (Abstract). Diabetologia 655:A168, 1998
32. Davis-Salinas J, Van Nostrand WE: Amyloid β-protein aggregation nullifies its pathologic properties in cultured cerebrovascular smooth muscle cells. J Biol Chem 270:20887-20890, 1995
33. Westermark P: Fine structure of islets of Langerhans in insular amyloidosis. Virchows Arch 359:1-18, 1973
34. De Koning EJP, Morris ER, Hofhuis FMA, Posthuma G, Hoppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS: Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide. Proc Natl Acad Sci U S A 91:8467-8471, 1994
35. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW: Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci U S A 90:7951-7955, 1993
36. Behl C, Davis JB, Klier FG, Schubert D: Amyloid β peptide induces necrosis rather than apoptosis. Brain Res 645:253-264, 1994
37. Schubert D, Behl C, Lesley R, Brack A, Dargusch R, Sagara Y, Kimura H: Amyloid peptides are toxic via a common oxidative mechanism. Proc Natl Acad Sci U S A 92:1989-1993, 1995
38. Behl C, Davis JB, Lesley R, Schubert D: Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77:817-827, 1994
39. Dypbukt JM, Ankarcrona M, Burkitt M, Sjoholm A, Strom K, Orrenius S, Nicotera P: Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. J Biol Chem 269:30553-30560, 1994