Role of Rab GTPases in membrane traffic and cell physiology

Physiological Reviews

Volumn 91, Issue 1, 2011, Pages 119-149

  Hutagalung, Alex H ^a   Novick, Peter J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXOCYST; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; MEMBRANE FUSION PROTEIN; PROTEIN SUBUNIT; RAB PROTEIN; RAB11 PROTEIN; RAB27A PROTEIN; RAB7 PROTEIN;

CELL FUNCTION; CELL MIGRATION; CHLAMYDIAL PNEUMONIA; EFFECTOR CELL; GOLGI COMPLEX; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; HUNTINGTON CHOREA; LEGIONELLA PNEUMOPHILA; MEMBRANE FUSION; NEOPLASM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW; SALMONELLA ENTERICA; TOOTH DISEASE;

ANIMALS; COMMUNICABLE DISEASES; HUMANS; INTRACELLULAR MEMBRANES; MOLECULAR STRUCTURE; NEOPLASMS; NERVOUS SYSTEM DISEASES; RAB GTP-BINDING PROTEINS; TRANSPORT VESICLES;

EID: 78751656754     PISSN: 00319333     EISSN: 15221210     Source Type: Journal    
DOI: 10.1152/physrev.00059.2009     Document Type: Review

References (497)

1. Aivazian D, Serrano R, Pfeffer S. TIP47 is a key effector for Rab9 localization. J Cell Biol 173: 917-926, 2006.
2. Alexandrov K, Horiuchi H, Steele-Mortimer O, Seabra M, Zerial M. Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes. EMBO J 13: 5262-5273, 1994.
3. Ali B, Seabra M. Targeting of Rab GTPases to cellular membranes. Biochem Soc Trans 33: 652-656, 2005. (Pubitemid 41160831)
4. Aligianis I, Johnson C, Gissen P, Chen D, Hampshire D, Hoffmann K, Maina E, Morgan N, Tee L, Morton J, Ainsworth J, Horn D, Rosser E, Cole T, Stolte-Dijkstra I, Fieggen K, Clayton- Smith J, Mégarbané A, Shield J, Newbury-Ecob R, Dobyns W, Graham JJ, Kjaer K, Warburg M, Bond J, Trembath R, Harris L, Takai Y, Mundlos S, Tannahill D, Woods C, Maher E. Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome. Nat Genet 37: 221-223, 2005.
5. Aligianis I, Morgan N, Mione M, Johnson C, Rosser E, Hennekam R, Adams G, Trembath R, Pilz D, Stoodley N, Moore A, Wilson S, Maher E. Mutation in Rab3 GTPase-activating protein (RAB3GAP) noncatalytic subunit in a kindred with Martsolf syndrome. Am J Hum Genet 78: 702-707, 2006.
6. Allan B, Moyer B, Balch W. Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion. Science 289: 444-448, 2000. (Pubitemid 30490455)
7. Alory C, Balch W. Molecular evolution of the Rab-escort-protein/guanine- nucleotide-dissociation-inhibitor superfamily. Mol Biol Cell 14: 3857-3867, 2003.
8. Alto N, Soderling J, Scott J. Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J Cell Biol 158: 659-668, 2002. (Pubitemid 34920105)
9. Amillet J, Ferbus D, Real F, Antony C, Muleris M, Gress T, Goubin G. Characterization of human Rab20 overexpressed in exocrine pancreatic carcinoma. Hum Pathol 37: 256-263, 2006. (Pubitemid 43277513)
10. An Y, Chen C, Moyer B, Rotkiewicz P, Elsliger M, Godzik A, Wilson I, Balch W. Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering. J Mol Biol 391: 26-41, 2009.
11. An Y, Shao Y, Alory C, Matteson J, Sakisaka T, Chen W, Gibbs R, Wilson I, Balch W. Geranylgeranyl switching regulates GDI-Rab GTPase recycling. Structure 11: 347-357, 2003.
12. Andag U, Neumann T, Schmitt H. The coatomer-interacting protein Dsl1p is required for Golgi-to-endoplasmic reticulum retrieval in yeast. J Biol Chem 276: 39150-39160, 2001.
13. Andag U, Schmitt H. Dsl1p, an essential component of the Golgi-endoplasmic reticulum retrieval system in yeast, uses the same sequence motif to interact with different subunits of the COPI vesicle coat. J Biol Chem 278: 51722-51734, 2003. (Pubitemid 38020418)
14. Andres D, Seabra M, Brown M, Armstrong S, Smeland T, Cremers F, Goldstein J. cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein. Cell 73: 1091-1099, 1993. (Pubitemid 23180484)
15. Ang A, Fölsch H, Koivisto U, Pypaert M, Mellman I. The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells. J Cell Biol 163: 339-350, 2003. (Pubitemid 37363134)
16. Ang A, Taguchi T, Francis S, Fölsch H, Murrells L, Pypaert M, Warren G, Mellman I. Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells. J Cell Biol 167: 531-543, 2004. (Pubitemid 39489060)
17. Arai S, Noda Y, Kainuma S, Wada I, Yoda K. Ypt11 functions in bud-directed transport of the Golgi by linking Myo2 to the coatomer subunit Ret2. Curr Biol 18: 987-991, 2008.
18. Babbey C, Ahktar N, Wang E, Chen C, Grant B, Dunn K. Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. Mol Biol Cell 17: 3156-3175, 2006. (Pubitemid 43993517)
19. Bacon R, Salminen A, Ruohola H, Novick P, Ferro-Novick S. The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants. J Cell Biol 109: 1015-1022, 1989. (Pubitemid 19220088)
20. Bahadoran P, Aberdam E, Mantoux F, Buscà R, Bille K, Yalman N, de Saint-Basile G, Casaroli-Marano R, Ortonne J, Ballotti R. Rab27a: a key to melanosome transport in human melanocytes. J Cell Biol 152: 843-850, 2001.
21. Bakowski M, Braun V, Brumell J. Salmonella-containing vacuoles: directing traffic and nesting to grow. Traffic 9: 2022-2031, 2008.
22. Bankaitis V, Johnson L, Emr S. Isolation of yeast mutants defective in protein targeting to the vacuole. Proc Natl Acad Sci USA 83: 9075-9079, 1986. (Pubitemid 17223539)
23. Banta L, Robinson J, Klionsky D, Emr S. Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting. J Cell Biol 107: 1369-1383, 1988.
24. Barisic N, Claeys K, Sirotković-Skerlev M, Löfgren A, Nelis E, De Jonghe P, Timmerman V. Charcot-Marie-Tooth disease: a clinico-genetic confrontation. Ann Hum Genet 72: 416-441, 2008.
25. Barr F. A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins. Curr Biol 9: 381-384, 1999. (Pubitemid 29194881)
26. Barr F, Nakamura N, Warren G. Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae. EMBO J 17: 3258-3268, 1998.
27. Bayer M, Fischer J, Kremerskothen J, Ossendorf E, Matanis T, Konczal M, Weide T, Barnekow A. Identification and characterization of Iporin as a novel interaction partner for rab1. BMC Cell Biol 6: 15, 2005. (Pubitemid 41357621)
28. Beard M, Satoh A, Shorter J, Warren G. A cryptic Rab1-binding site in the p115 tethering protein. J Biol Chem 280: 25840-25848, 2005.
29. Becker C, Creagh E, O'Neill L. RAB39A binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion. J Biol Chem 284: 34531-34537, 2009.
30. Benli M, Döring F, Robinson D, Yang X, Gallwitz D. Two GTPase isoforms, Ypt31p and Ypt32p, are essential for Golgi function in yeast. EMBO J 15: 6460-6475, 1996. (Pubitemid 26413779)
31. Benmerah A, Lamaze C. Clathrin-coated pits: vive la différence? Traffic 8: 970-982, 2007.
32. Bielli A, Thörnqvist P, Hendrick A, Finn R, Fitzgerald K, McCaffrey M. The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1. Biochem Biophys Res Commun 281: 1141-1153, 2001. (Pubitemid 32924539)
33. Bitoun M, Durieux A, Prudhon B, Bevilacqua J, Herledan A, Sakanyan V, Urtizberea A, Cartier L, Romero N, Guicheney P. Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis. Hum Mutat 30: 1419-1427, 2009.
34. Boldogh I, Ramcharan S, Yang H, Pon L. A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division. Mol Biol Cell 15: 3994-4002, 2004. (Pubitemid 39122005)
35. Bonifacino J. Insights into the biogenesis of lysosome-related organelles from the study of the Hermansky-Pudlak syndrome. Ann NY Acad Sci 1038: 103-114, 2004. (Pubitemid 40577450)
36. Bonifacino J, Hurley J. Retromer. Curr Opin Cell Biol 20: 427-436, 2008.
37. Bonifacino J, Rojas R. Retrograde transport from endosomes to the trans-Golgi network. Nat Rev Mol Cell Biol 7: 568-579, 2006. (Pubitemid 44325348)
38. Bos J, Rehmann H, Wittinghofer A. GEFs and GAPs: critical elements in the control of small G proteins. Cell 129: 865-877, 2007. (Pubitemid 46802708)
39. Boucrot E, Henry T, Borg J, Gorvel J, Méresse S. The intracellular fate of Salmonella depends on the recruitment of kinesin. Science 308: 1174-1178, 2005. (Pubitemid 40696435)
40. Brennwald P, Novick P. Interactions of three domains distinguishing the Ras-related GTP-binding proteins Ypt1 and Sec4. Nature 362: 560-563, 1993.
41. Brett C, Plemel R, Lobinger B, Vignali M, Fields S, Merz A. Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase. J Cell Biol 182: 1141-1151, 2008.
42. Brondyk W, McKiernan C, Fortner K, Stabila P, Holz R, Macara I. Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. Mol Cell Biol 15: 1137-1143, 1995.
43. Brumell J, Scidmore M. Manipulation of rab GTPase function by intracellular bacterial pathogens. Microbiol Mol Biol Rev 71: 636-652, 2007. (Pubitemid 350309181)
44. Bucci C, Thomsen P, Nicoziani P, McCarthy J, van Deurs B. Rab7: a key to lysosome biogenesis. Mol Biol Cell 11: 467-480, 2000.
45. Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M. ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells. Eur J Cell Biol 87: 197-209, 2008.
46. Bujny M, Ewels P, Humphrey S, Attar N, Jepson M, Cullen P. Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection. J Cell Sci 121: 2027-2036, 2008. (Pubitemid 352015200)
47. Burton J, Burns M, Gatti E, Augustine G, De Camilli P. Specific interactions of Mss4 with members of the Rab GTPase subfamily. EMBO J 13: 5547-5558, 1994. (Pubitemid 24363022)
48. Burton J, De Camilli P. A novel mammalian guanine nucleotide exchange factor (GEF) specific for rab proteins. Adv Second Messenger Phosphoprotein Res 29: 109-119, 1994.
49. Burton J, Roberts D, Montaldi M, Novick P, De Camilli P. A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4. Nature 361: 464-467, 1993. (Pubitemid 23050137)
50. Cabrera M, Ostrowicz C, Mari M, LaGrassa T, Reggiori F, Ungermann C. Vps41 phosphorylation and the Rab Ypt7 control the targeting of the HOPS complex to endosome-vacuole fusion sites. Mol Biol Cell 20: 1937-1948, 2009.
51. Cai H, Reinisch K, Ferro-Novick S. Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev Cell 12: 671-682, 2007. (Pubitemid 46667749)
52. Cai H, Yu S, Menon S, Cai Y, Lazarova D, Fu C, Reinisch K, Hay J, Ferro-Novick S. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23. Nature 445: 941-944, 2007.
53. Cai H, Zhang Y, Pypaert M, Walker L, Ferro-Novick S. Mutants in trs120 disrupt traffic from the early endosome to the late Golgi. J Cell Biol 171: 823-833, 2005. (Pubitemid 41746584)
54. Cai Y, Chin H, Lazarova D, Menon S, Fu C, Cai H, Sclafani A, Rodgers D, De La Cruz E, Ferro-Novick S, Reinisch K. The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes. Cell 133: 1202-1213, 2008. (Pubitemid 351852911)
55. Callaghan J, Nixon S, Bucci C, Toh B, Stenmark H. Direct interaction of EEA1 with Rab5b. Eur J Biochem 265: 361-366, 1999.
56. Callaghan J, Simonsen A, Gaullier J, Toh B, Stenmark H. The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer. Biochem J 338: 539-543, 1999.
57. Cantalupo G, Alifano P, Roberti V, Bruni C, Bucci C. Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J 20: 683-693, 2001. (Pubitemid 32167633)
58. Carlton J, Bujny M, Rutherford A, Cullen P. Sorting nexins-unifying trends and new perspectives. Traffic 6: 75-82, 2005.
59. Carr C, Grote E, Munson M, Hughson F, Novick P. Sec1p binds to SNARE complexes and concentrates at sites of secretion. J Cell Biol 146: 333-344, 1999. (Pubitemid 29369771)
60. Carroll K, Hanna J, Simon I, Krise J, Barbero P, Pfeffer S. Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. Science 292: 1373-1376, 2001. (Pubitemid 32476223)
61. Casanova J, Wang X, Kumar R, Bhartur S, Navarre J, Woodrum J, Altschuler Y, Ray G, Goldenring J. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell 10: 47-61, 1999. (Pubitemid 29156926)
62. Casavola E, Catucci A, Bielli P, Di Pentima A, Porcu G, Pennestri M, Cicero D, Ragnini-Wilson A. Ypt32p and Mlc1p bind within the vesicle binding region of the class V myosin Myo2p globular tail domain. Mol Microbiol 67: 1051-1066, 2008. (Pubitemid 351207333)
63. Caswell P, Spence H, Parsons M, White D, Clark K, Cheng K, Mills G, Humphries M, Messent A, Anderson K, McCaffrey M, Ozanne B, Norman J. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell 13: 496-510, 2007. (Pubitemid 47514517)
64. Cavanaugh L, Chen X, Richardson B, Ungar D, Pelczer I, Rizo J, Hughson F. Structural analysis of conserved oligomeric Golgi complex subunit 2. J Biol Chem 282: 23418-23426, 2007. (Pubitemid 47311945)
65. Chavrier P, Gorvel J, Stelzer E, Simons K, Gruenberg J, Zerial M. Hypervariable C-terminal domain of rab proteins acts as a targeting signal. Nature 353: 769-772, 1991. (Pubitemid 21912618)
66. Chavrier P, Parton R, Hauri H, Simons K, Zerial M. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Cell 62: 317-329, 1990. (Pubitemid 20233538)
67. Chen C, Balch W. The Hsp90 chaperone complex regulates GDI-dependent Rab recycling. Mol Biol Cell 17: 3494-3507, 2006. (Pubitemid 44156443)
68. Chen L, Hu J, Yun Y, Wang T. Rab36 regulates the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34. Mol Membr Biol 27: 24-31, 2010.
69. Chen S, Liang M, Chia J, Ngsee J, Ting A. Rab8b and its interacting partner TRIP8b are involved in regulated secretion in AtT20 cells. J Biol Chem 276: 13209-13216, 2001.
70. Chen T, Han Y, Yang M, Zhang W, Li N, Wan T, Guo J, Cao X. Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis. Biochem Biophys Res Commun 303: 1114-1120, 2003. (Pubitemid 36390260)
71. Chen Y, Stevens T. The VPS8 gene is required for localization and trafficking of the CPY sorting receptor in Saccharomyces cerevisiae. Eur J Cell Biol 70: 289-297, 1996. (Pubitemid 26268231)
72. Cheng K, Lahad J, Gray J, Mills G. Emerging role of RAB GTPases in cancer and human disease. Cancer Res 65: 2516-2519, 2005. (Pubitemid 40490043)
73. Cheng K, Lahad J, Kuo W, Lapuk A, Yamada K, Auersperg N, Liu J, Smith-McCune K, Lu K, Fishman D, Gray J, Mills G. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med 10: 1251-1256, 2004. (Pubitemid 39540444)
74. Cheviet S, Coppola T, Haynes L, Burgoyne R, Regazzi R. The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis. Mol Endocrinol 18: 117-126, 2004. (Pubitemid 38073159)
75. Chia W, Tang B. Emerging roles for Rab family GTPases in human cancer. Biochim Biophys Acta 1795: 110-116, 2009.
76. Christoforidis S, McBride H, Burgoyne R, Zerial M. The Rab5 effector EEA1 is a core component of endosome docking. Nature 397: 621-625, 1999. (Pubitemid 29091948)
77. Christoforidis S, Miaczynska M, Ashman K, Wilm M, Zhao L, Yip S, Waterfield M, Backer J, Zerial M. Phosphatidylinositol-3-OH kinases are Rab5 effectors. Nat Cell Biol 1: 249-252, 1999. (Pubitemid 129500945)
78. Cohen-Solal K, Sood R, Marin Y, Crespo-Carbone S, Sinsimer D, Martino J, Robbins C, Makalowska I, Trent J, Chen S. Identification and characterization of mouse Rab32 by mRNA and protein expression analysis. Biochim Biophys Acta 1651: 68-75, 2003.
79. Collins K, Wickner W. Trans-SNARE complex assembly and yeast vacuole membrane fusion. Proc Natl Acad Sci USA 104: 8755-8760, 2007.
80. Collins R. "Getting it on"-GDI displacement and small GTPase membrane recruitment. Mol Cell 12: 1064-1066, 2003.
81. Conibear E, Cleck J, Stevens T. Vps51p mediates the association of the GARP (Vps52/53/54) complex with the late Golgi t-SNARE Tlg1p. Mol Biol Cell 14: 1610-1623, 2003. (Pubitemid 36547426)
82. Cooper A, Gitler A, Cashikar A, Haynes C, Hill K, Bhullar B, Liu K, Xu K, Strathearn K, Liu F, Cao S, Caldwell K, Caldwell G, Marsischky G, Kolodner R, Labaer J, Rochet J, Bonini N, Lindquist S. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313: 324-328, 2006.
83. Coppola T, Frantz C, Perret-Menoud V, Gattesco S, Hirling H, Regazzi R. Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis. Mol Biol Cell 13: 1906-1915, 2002.
84. Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand- Brustel Y. A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic. Proc Natl Acad Sci USA 98: 1637-1642, 2001. (Pubitemid 32165550)
85. Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw T, Le Marchand-Brustel Y. CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. Traffic 4: 97-112, 2003. (Pubitemid 36621703)
86. Cortes C, Rzomp K, Tvinnereim A, Scidmore M, Wizel B. Chlamydia pneumoniae inclusion membrane protein Cpn0585 interacts with multiple Rab GTPases. Infect Immun 75: 5586-5596, 2007. (Pubitemid 350207795)
87. Cowles C, Odorizzi G, Payne G, Emr S. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91: 109-118, 1997. (Pubitemid 27431317)
88. Coxon F, Ebetino F, Mules E, Seabra M, McKenna C, Rogers M. Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo. Bone 37: 349-358, 2005. (Pubitemid 41160493)
89. Cremers F, Armstrong S, Seabra M, Brown M, Goldstein J. REP-2, a Rab escort protein encoded by the choroideremia-like gene. J Biol Chem 269: 2111-2117, 1994. (Pubitemid 24035421)
90. Croizet-Berger K, Daumerie C, Couvreur M, Courtoy P, van den Hove M. The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production. Proc Natl Acad Sci USA 99: 8277-8282, 2002.
91. D'Adamo P, Menegon A, Lo Nigro C, Grasso M, Gulisano M, Tamanini F, Bienvenu T, Gedeon A, Oostra B, Wu S, Tandon A, Valtorta F, Balch W, Chelly J, Toniolo D. Mutations in GDI1 are responsible for X-linked non-specific mental retardation. Nat Genet 19: 134-139, 1998. (Pubitemid 28248793)
92. D'Adamo P, Welzl H, Papadimitriou S, Raffaele di Barletta M, Tiveron C, Tatangelo L, Pozzi L, Chapman P, Knevett S, Ramsay M, Valtorta F, Leoni C, Menegon A, Wolfer D, Lipp H, Toniolo D. Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. Hum Mol Genet 11: 2567-2580, 2002.
93. Dalfó E, Gómez-Isla T, Rosa J, Nieto Bodelón M, Cuadrado Tejedor M, Barrachina M, Ambrosio S, Ferrer I. Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice. J Neuropathol Exp Neurol 63: 302-313, 2004. (Pubitemid 38429027)
94. De Graaf P, Zwart W, van Dijken R, Deneka M, Schulz T, Geijsen N, Coffer P, Gadella B, Verkleij A, van der Sluijs P, van Bergen en Henegouwen P. Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex. Mol Biol Cell 15: 2038-2047, 2004.
95. De Leeuw H, Koster P, Calafat J, Janssen H, van Zonneveld A, van Mourik J, Voorberg J. Small GTP-binding proteins in human endothelial cells. Br J Haematol 103: 15-19, 1998. (Pubitemid 28470793)
96. De Luca A, Progida C, Spinosa M, Alifano P, Bucci C. Characterization of the Rab7K157N mutant protein associated with Charcot-Marie-Tooth type 2B. Biochem Biophys Res Commun 372: 283-287, 2008.
97. De Renzis S, Sönnichsen B, Zerial M. Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. Nat Cell Biol 4: 124-133, 2002. (Pubitemid 34141478)
98. Dejgaard S, Murshid A, Erman A, Kizilay O, Verbich D, Lodge R, Dejgaard K, Ly-Hartig T, Pepperkok R, Simpson J, Presley J. Rab18 and Rab43 have key roles in ER-Golgi trafficking. J Cell Sci 121: 2768-2781, 2008.
99. Del Nery E, Miserey-Lenkei S, Falguières T, Nizak C, Johannes L, Perez F, Goud B. Rab6A and Rab6A' GTPases play non-overlapping roles in membrane trafficking. Traffic 7: 394-407, 2006.
100. Del Toro D, Alberch J, Lázaro-Diéguez F, Martín-Ibáñez R, Xifró X, Egea G, Canals J. Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus. Mol Biol Cell 20: 1478-1492, 2009.
101. Delprato A, Lambright D. Structural basis for Rab GTPase activation by VPS9 domain exchange factors. Nat Struct Mol Biol 14: 406-412, 2007. (Pubitemid 46685882)
102. Desnoyers L, Anant J, Seabra M. Geranylgeranylation of Rab proteins. Biochem Soc Trans 24: 699-703, 1996.
103. Di Paolo G, De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature 443: 651-657, 2006. (Pubitemid 44564702)
104. Di Pietro S, Dell'Angelica E. The cell biology of Hermansky-Pudlak syndrome: recent advances. Traffic 6: 525-533, 2005. (Pubitemid 40872355)
105. Diao A, Frost L, Morohashi Y, Lowe M. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. J Biol Chem 283: 6957-6967, 2008.
106. Diao A, Rahman D, Pappin D, Lucocq J, Lowe M. The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation. J Cell Biol 160: 201-212, 2003. (Pubitemid 36254954)
107. Díaz E, Pfeffer S. TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. Cell 93: 433-443, 1998.
108. Díaz E, Schimmöller F, Pfeffer S. A novel Rab9 effector required for endosome-to-TGN transport. J Cell Biol 138: 283-290, 1997. (Pubitemid 27323531)
109. DiFiglia M, Sapp E, Chase K, Schwarz C, Meloni A, Young C, Martin E, Vonsattel J, Carraway R, Reeves S. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 14: 1075-1081, 1995.
110. Dirac-Svejstrup A, Sumizawa T, Pfeffer S. Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI. EMBO J 16: 465-472, 1997. (Pubitemid 27067776)
111. Dong G, Hutagalung A, Fu C, Novick P, Reinisch K. The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif. Nat Struct Mol Biol 12: 1094-1100, 2005. (Pubitemid 41746780)
112. Dong G, Medkova M, Novick P, Reinisch K. A catalytic coiled coil: structural insights into the activation of the Rab GTPase Sec4p by Sec2p. Mol Cell 25: 455-462, 2007. (Pubitemid 46199290)
113. Dong J, Chen W, Welford A, Wandinger-Ness A. The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes. J Biol Chem 279: 21334-21342, 2004. (Pubitemid 38656541)
114. Du L, Novick P. Purification and properties of a GTPase-activating protein for yeast Rab GTPases. Methods Enzymol 329: 91-99, 2001. (Pubitemid 32107564)
115. Eathiraj S, Pan X, Ritacco C, Lambright D. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature 436: 415-419, 2005.
116. Echard A, Jollivet F, Martinez O, Lacapère J, Rousselet A, Janoueix-Lerosey I, Goud B. Interaction of a Golgi-associated kinesin-like protein with Rab6. Science 279: 580-585, 1998. (Pubitemid 28067290)
117. Eggenschwiler J, Espinoza E, Anderson K. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature 412: 194-198, 2001. (Pubitemid 32674717)
118. Eggers C, Schafer J, Goldenring J, Taylor S. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem 284: 32869-32880, 2009.
119. Eitzen G, Will E, Gallwitz D, Haas A, Wickner W. Sequential action of two GTPases to promote vacuole docking and fusion. EMBO J 19: 6713-6720, 2000. (Pubitemid 32011664)
120. Evans T, Ferguson C, Wainwright B, Parton R, Wicking C. Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway. Traffic 4: 869-884, 2003. (Pubitemid 37540589)
121. Faber P, Barnes G, Srinidhi J, Chen J, Gusella J, MacDonald M. Huntingtin interacts with a family of WW domain proteins. Hum Mol Genet 7: 1463-1474, 1998. (Pubitemid 28429928)
122. Fabrizi G, Ferrarini M, Cavallaro T, Cabrini I, Cerini R, Bertolasi L, Rizzuto N. Two novel mutations in dynamin-2 cause axonal Charcot-Marie-Tooth disease. Neurology 69: 291-295, 2007. (Pubitemid 47205692)
123. Fagarasanu A, Rachubinski R. Orchestrating organelle inheritance in Saccharomyces cerevisiae. Curr Opin Microbiol 10: 528-538, 2007. (Pubitemid 350180595)
124. Fischer J, Weide T, Barnekow A. The MICAL proteins and rab1: a possible link to the cytoskeleton? Biochem Biophys Res Commun 328: 415-423, 2005.
125. Fischer von Mollard G, Mignery G, Baumert M, Perin M, Hanson T, Burger P, Jahn R, Südhof T. rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles. Proc Natl Acad Sci USA 87: 1988-1992, 1990.
126. Forno L. Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol 55: 259-272, 1996.
127. Foulquier F. COG defects, birth and rise! Biochim Biophys Acta 1792: 896-902, 2008.
128. Fouraux M, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, van Venrooij W, van der Sluijs P, Pruijn G. Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. Mol Biol Cell 15: 611-624, 2004. (Pubitemid 38146478)
129. Fridmann-Sirkis Y, Siniossoglou S, Pelham H. TMF is a golgin that binds Rab6 and influences Golgi morphology. BMC Cell Biol 5: 18, 2004. (Pubitemid 39637279)
130. Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman E, De Camilli P, Unger V. Structural basis of membrane invagination by F-BAR domains. Cell 132: 807-817, 2008. (Pubitemid 351320580)
131. Fuchs E, Haas A, Spooner R, Yoshimura S, Lord J, Barr F. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol 177: 1133-1143, 2007. (Pubitemid 46955715)
132. Fukuda M. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. J Biol Chem 278: 15373-15380, 2003. (Pubitemid 36799876)
133. Fukuda M. Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A. J Biol Chem 277: 40118-40124, 2002. (Pubitemid 35191003)
134. Fukuda M, Itoh T. Direct link between Atg protein and small GTPase Rab: Atg16L functions as a potential Rab33 effector in mammals. Autophagy 4: 824-826, 2008.
135. Fukuda M, Kanno E, Ishibashi K, Itoh T. Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity. Mol Cell Proteomics 7: 1031-1042, 2008. (Pubitemid 351943951)
136. Fukuda M, Kanno E, Yamamoto A. Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells. J Biol Chem 279: 13065-13075, 2004. (Pubitemid 38445884)
137. Fukuda M, Kuroda T. Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. J Biol Chem 277: 43096-43103, 2002. (Pubitemid 35285692)
138. Fukuda M, Kuroda T, Mikoshiba K. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. J Biol Chem 277: 12432-12436, 2002. (Pubitemid 34952817)
139. Fukui K, Tamura S, Wada A, Kamada Y, Igura T, Kiso S, Hayashi N. Expression of Rab5a in hepatocellular carcinoma: possible involvement in epidermal growth factor signaling. Hepatol Res 37: 957-965, 2007. (Pubitemid 47399925)
140. Lee M, Mishra A, Lambright D. Structural mechanisms for regulation of membrane traffic by Rab GTPases. Traffic 10: 1377-1389, 2009.
141. Gasser T. Molecular pathogenesis of Parkinson disease: insights from genetic studies. Expert Rev Mol Med 11: e22, 2009.
142. Gedeon A, Colley A, Jamieson R, Thompson E, Rogers J, Sillence D, Tiller G, Mulley J, Gécz J. Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda. Nat Genet 22: 400-404, 1999. (Pubitemid 29369535)
143. Gedeon A, Tiller G, Le Merrer M, Heuertz S, Tranebjaerg L, Chitayat D, Robertson S, Glass I, Savarirayan R, Cole W, Rimoin D, Kousseff B, Ohashi H, Zabel B, Munnich A, Gecz J, Mulley J. The molecular basis of X-linked spondyloepiphyseal dysplasia tarda. Am J Hum Genet 68: 1386-1397, 2001.
144. Geppert M, Bolshakov V, Siegelbaum S, Takei K, De Camilli P, Hammer R, Südhof T. The role of Rab3A in neurotransmitter release. Nature 369: 493-497, 1994.
145. Geppert M, Goda Y, Stevens C, Südhof T. The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion. Nature 387: 810-814, 1997. (Pubitemid 27270907)
146. Gil J, Rego A. Mechanisms of neurodegeneration in Huntington's disease. Eur J Neurosci 27: 2803-2820, 2008.
147. Giovedu S, Darchen F, Valtorta F, Greengard P, Benfenati F. Synapsin is a novel Rab3 effector protein on small synaptic vesicles. II. Functional effects of the Rab3A-synapsin I interaction. J Biol Chem 279: 43769-43779, 2004. (Pubitemid 39390682)
148. Girod A, Storrie B, Simpson J, Johannes L, Goud B, Roberts L, Lord J, Nilsson T, Pepperkok R. Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum. Nat Cell Biol 1: 423-430, 1999. (Pubitemid 129502809)
149. Gitler A, Bevis B, Shorter J, Strathearn K, Hamamichi S, Su L, Caldwell K, Caldwell G, Rochet J, McCaffery J, Barlowe C, Lindquist S. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci USA 105: 145-150, 2008.
150. Goedert M. Neurofibrillary pathology of Alzheimer's disease and other tauopathies. Prog Brain Res 117: 287-306, 1998. (Pubitemid 28530696)
151. Goldenring J, Shen K, Vaughan H, Modlin I. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, lung. J Biol Chem 268: 18419-18422, 1993. (Pubitemid 23273765)
152. Gomes A, Ali B, Ramalho J, Godfrey R, Barral D, Hume A, Seabra M. Membrane targeting of Rab GTPases is influenced by the prenylation motif. Mol Biol Cell 14: 1882-1899, 2003.
153. Goody R, Rak A, Alexandrov K. The structural and mechanistic basis for recycling of Rab proteins between membrane compartments. Cell Mol Life Sci 62: 1657-1670, 2005. (Pubitemid 41176048)
154. Goud B, Salminen A, Walworth N, Novick P. A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast. Cell 53: 753-768, 1988.
155. Goud B, Zahraoui A, Tavitian A, Saraste J. Small GTP-binding protein associated with Golgi cisternae. Nature 345: 553-556, 1990.
156. Gournier H, Stenmark H, Rybin V, Lippé R, Zerial M. Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion. EMBO J 17: 1930-1940, 1998.
157. Graham M, Handley M, Barclay J, Ciufo L, Barrow S, Morgan A, Burgoyne R. A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3. Biochem J 409: 407-416, 2008. (Pubitemid 351184959)
158. Grigoriev I, Splinter D, Keijzer N, Wulf P, Demmers J, Ohtsuka T, Modesti M, Maly I, Grosveld F, Hoogenraad C, Akhmanova A. Rab6 regulates transport and targeting of exocytotic carriers. Dev Cell 13: 305-314, 2007. (Pubitemid 47163607)
159. Grosshans B, Andreeva A, Gangar A, Niessen S, Yates Brennwald P Jr,
160. Grosshans B, Ortiz D, Novick P. Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci USA 103: 11821-11827, 2006.
161. Grote E, Carr C, Novick P. Ordering the final events in yeast exocytosis. J Cell Biol 151: 439-452, 2000.
162. Grunebaum E, Arpaia E, MacKenzie J, Fitzpatrick J, Ray P, Roifman C. A missense mutation in the SEDL gene results in delayed onset of X linked spondyloepiphyseal dysplasia in a large pedigree. J Med Genet 38: 409-411, 2001. (Pubitemid 32554314)
163. Guignot J, Caron E, Beuzón C, Bucci C, Kagan J, Roy C, Holden D. Microtubule motors control membrane dynamics of Salmonella-containing vacuoles. J Cell Sci 117: 1033-1045, 2004. (Pubitemid 38456086)
164. Guo W, Roth D, Walch-Solimena C, Novick P. The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis. EMBO J 18: 1071-1080, 1999. (Pubitemid 29082285)
165. Guo W, Tamanoi F, Novick P. Spatial regulation of the exocyst complex by Rho1 GTPase. Nat Cell Biol 3: 353-360, 2001. (Pubitemid 32288442)
166. Günther T, Struwe M, Aguzzi A, Schughart K. Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Development 120: 3119-3130, 1994. (Pubitemid 24343244)
167. Haas A, Fuchs E, Kopajtich R, Barr F. A GTPase-activating protein controls Rab5 function in endocytic trafficking. Nat Cell Biol 7: 887-893, 2005. (Pubitemid 41486289)
168. Hagiwara M, Shirai Y, Nomura R, Sasaki M, Kobayashi K, Tadokoro T, Yamamoto Y. Caveolin-1 activates Rab5 and enhances endocytosis through direct interaction. Biochem Biophys Res Commun 378: 73-78, 2009.
169. Halachmi N, Lev Z. The Sec1 family: a novel family of proteins involved in synaptic transmission and general secretion. J Neurochem 66: 889-897, 1996. (Pubitemid 26065883)
170. Hales C, Griner R, Hobdy-Henderson K, Dorn M, Hardy D, Kumar R, Navarre J, Chan E, Lapierre L, Goldenring J. Identification and characterization of a family of Rab11-interacting proteins. J Biol Chem 276: 39067-39075, 2001.
171. Hales C, Vaerman J, Goldenring J. Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling. J Biol Chem 277: 50415-50421, 2002. (Pubitemid 36042193)
172. Hanna J, Carroll K, Pfeffer S. Identification of residues in TIP47 essential for Rab9 binding. Proc Natl Acad Sci USA 99: 7450-7454, 2002.
173. Harrison R, Brumell J, Khandani A, Bucci C, Scott C, Jiang X, Finlay B, Grinstein S. Salmonella impairs RILP recruitment to Rab7 during maturation of invasion vacuoles. Mol Biol Cell 15: 3146-3154, 2004. (Pubitemid 38850112)
174. Hattula K, Furuhjelm J, Arffman A, Peränen J. A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. Mol Biol Cell 13: 3268-3280, 2002. (Pubitemid 35034261)
175. Hattula K, Peränen J. FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. Curr Biol 10: 1603-1606, 2000. (Pubitemid 32062664)
176. Hayakawa A, Hayes S, Leonard D, Lambright D, Corvera S. Evolutionarily conserved structural and functional roles of the FYVE domain. Biochem Soc Symp 95-105, 2007.
177. Hayes G, Brown F, Haas A, Nottingham R, Barr F, Pfeffer S. Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi. Mol Biol Cell 20: 209-217, 2009.
178. 2+-regulated exocytosis in neuroendocrine cells. J Biol Chem 276: 9726-9732, 2001.
179. Heidrych P, Zimmermann U, Bress A, Pusch C, Ruth P, Pfister M, Knipper M, Blin N. Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form. Hum Mol Genet 17: 3814-3821, 2008.
180. Hennies H, Kornak U, Zhang H, Egerer J, Zhang X, Seifert W, Kühnisch J, Budde B, Nätebus M, Brancati F, Wilcox W, Müller D, Kaplan P, Rajab A, Zampino G, Fodale V, Dallapiccola B, Newman W, Metcalfe K, Clayton-Smith J, Tassabehji M, Steinmann B, Barr F, Nürnberg P, Wieacker P, Mundlos S. Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin. Nat Genet 40: 1410-1412, 2008.
181. Henry T, Couillault C, Rockenfeller P, Boucrot E, Dumont A, Schroeder N, Hermant A, Knodler L, Lecine P, Steele-Mortimer O, Borg J, Gorvel J, Méresse S. The Salmonella effector protein PipB2 is a linker for kinesin-1. Proc Natl Acad Sci USA 103: 13497-13502, 2006.
182. Hickson G, Matheson J, Riggs B, Maier V, Fielding A, Prekeris R, Sullivan W, Barr F, Gould G. Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout. Mol Biol Cell 14: 2908-2920, 2003. (Pubitemid 36873816)
183. Hidestrand P, Vasconez H, Cottrill C. Carpenter syndrome. J Craniofac Surg 20: 254-256, 2009.
184. Hill E, Clarke M, Barr F. The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. EMBO J 19: 5711-5719, 2000.
185. Ho L, Carmichael J, Swartz J, Wyttenbach A, Rankin J, Rubinsztein D. The molecular biology of Huntington's disease. Psychol Med 31: 3-14, 2001.
186. Horazdovsky B, Cowles C, Mustol P, Holmes M, Emr S. A novel RING finger protein, Vps8p, functionally interacts with the small GTPase, Vps21p, to facilitate soluble vacuolar protein localization. J Biol Chem 271: 33607-33615, 1996.
187. Horazdovsky B, Davies B, Seaman M, McLaughlin S, Yoon S, Emr S. A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor. Mol Biol Cell 8: 1529-1541, 1997. (Pubitemid 27385574)
188. Horiuchi H, Lippé R, McBride H, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M, Zerial M. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell 90: 1149-1159, 1997. (Pubitemid 27408528)
189. Houlden H, King R, Muddle J, Warner T, Reilly M, Orrell R, Ginsberg L. A novel RAB7 mutation associated with ulcero-mutilating neuropathy. Ann Neurol 56: 586-590, 2004. (Pubitemid 39319354)
190. Hsu S, Hazuka C, Roth R, Foletti D, Heuser J, Scheller R. Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron 20: 1111-1122, 1998. (Pubitemid 28293129)
191. Huber L, Pimplikar S, Parton R, Virta H, Zerial M, Simons K. Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. J Cell Biol 123: 35-45, 1993. (Pubitemid 23284860)
192. Hume A, Collinson L, Rapak A, Gomes A, Hopkins C, Seabra M. Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J Cell Biol 152: 795-808, 2001. (Pubitemid 34280164)
193. Hunziker W, Peters P. Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells. J Biol Chem 273: 15734-15741, 1998. (Pubitemid 28298193)
194. Hyvola N, Diao A, McKenzie E, Skippen A, Cockcroft S, Lowe M. Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases. EMBO J 25: 3750-3761, 2006. (Pubitemid 44300261)
195. Höning S, Ricotta D, Krauss M, Späte K, Spolaore B, Motley A, Robinson M, Robinson C, Haucke V, Owen D. Phosphatidylinositol-(4,5)- bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2. Mol Cell 18: 519-531, 2005.
196. Ibáñez P, Bonnet A, Débarges B, Lohmann E, Tison F, Pollak P, Agid Y, Dürr A, Brice A. Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet 364: 1169-1171.
197. Ignatev A, Kravchenko S, Rak A, Goody R, Pylypenko O. A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism. J Biol Chem 283: 18377-18384, 2008.
198. Iida H, Wang L, Nishii K, Ookuma A, Shibata Y. Identification of rab12 as a secretory granule-associated small GTP-binding protein in atrial myocytes. Circ Res 78: 343-347, 1996. (Pubitemid 26042842)
199. Ikonomov O, Sbrissa D, Mlak K, Deeb R, Fligger J, Soans A, Finley RJ, Shisheva A. Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40. J Biol Chem 278: 50863-50871, 2003.
200. Itoh T, Fujita N, Kanno E, Yamamoto A, Yoshimori T, Fukuda M. Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell 19: 2916-2925, 2008.
201. Itoh T, Watabe A, Toh-EA, Matsui Y. Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae. Mol Cell Biol 22: 7744-7757, 2002. (Pubitemid 35217286)
202. Itzen A, Pylypenko O, Goody R, Alexandrov K, Rak A. Nucleotide exchange via local protein unfolding: structure of Rab8 in complex with MSS4. EMBO J 25: 1445-1455, 2006.
203. Itzen A, Rak A, Goody R. Sec2 is a highly efficient exchange factor for the Rab protein Sec4. J Mol Biol 365: 1359-1367, 2007. (Pubitemid 46048839)
204. Jackson A, Flett A, Smythe C, Hufton L, Wettey F, Smythe E. Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor micro2 kinase. J Cell Biol 163: 231-236, 2003.
205. Jackson L, Nawabi P, Hentea C, Roark E, Haldar K. The Salmonella virulence protein SifA is a G protein antagonist. Proc Natl Acad Sci USA 105: 14141-14146, 2008.
206. Janoueix-Lerosey I, Jollivet F, Camonis J, Marche P, Goud B. Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6. J Biol Chem 270: 14801-14808, 1995.
207. Jasmin B, Goud B, Camus G, Cartaud J. The low molecular weight guanosine triphosphate-binding protein Rab6p associates with distinct post-Golgi vesicles in Torpedo marmorata electrocytes. Neuroscience 49: 849-855, 1992.
208. Jedd G, Mulholland J, Segev N. Two new Ypt GTPases are required for exit from the yeast trans-Golgi compartment. J Cell Biol 137: 563-580, 1997. (Pubitemid 27200661)
209. Jedd G, Richardson C, Litt R, Segev N. The Ypt1 GTPase is essential for the first two steps of the yeast secretory pathway. J Cell Biol 131: 583-590, 1995.
210. Jeffries T, Morgan G, Field M. TbRAB18, a developmentally regulated Golgi GTPase from Trypanosoma brucei. Mol Biochem Parasitol 121: 63-74, 2002. (Pubitemid 34457834)
211. Jenkins D, Seelow D, Jehee F, Perlyn C, Alonso L, Bueno D, Donnai D, Josifova D, Josifiova D, Mathijssen I, Morton J, Orstavik K, Sweeney E, Wall S, Marsh J, Nurnberg P, Passos-Bueno M, Wilkie A. RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. Am J Hum Genet 80: 1162-1170, 2007.
212. Johansson M, Lehto M, Tanhuanpää K, Cover T, Olkkonen V. The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments. Mol Biol Cell 16: 5480-5492, 2005. (Pubitemid 41752200)
213. Johansson M, Rocha N, Zwart W, Jordens I, Janssen L, Kuijl C, Olkkonen V, Neefjes J. Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, the receptor betalll spectrin. J Cell Biol 176: 459-471, 2007.
214. Jordens I, Fernandez-Borja M, Marsman M, Dusseljee S, Janssen L, Calafat J, Janssen H, Wubbolts R, Neefjes J. The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors. Curr Biol 11: 1680-1685, 2001. (Pubitemid 33037779)
215. Junutula J, De Maziére A, Peden A, Ervin K, Advani R, van Dijk S, Klumperman J, Scheller R. Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. Mol Biol Cell 15: 2218-2229, 2004. (Pubitemid 38580640)
216. Jäger D, Stockert E, Jäger E, Güre A, Scanlan M, Knuth A, Old L, Chen Y. Serological cloning of a melanocyte rab guanosine 5′-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library. Cancer Res 60: 3584-3591, 2000.
217. Kail M, Barnekow A. Identification and characterization of interacting partners of Rab GTPases by yeast two-hybrid analyses. Methods Mol Biol 440: 111-125, 2008.
218. Kanno E, Ishibashi K, Kobayashi H, Matsui T, Ohbayashi N, Fukuda M. Comprehensive screening for novel rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs. Traffic 11: 491-507, 2010.
219. Karki S, Holzbaur E. Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex. J Biol Chem 270: 28806-28811, 1995.
220. Kauppi M, Simonsen A, Bremnes B, Vieira A, Callaghan J, Stenmark H, Olkkonen V. The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. J Cell Sci 115: 899-911, 2002. (Pubitemid 34257375)
221. Kelly E, Horgan C, Adams C, Patzer T, Ní Shúilleabhá in D, Norman J, McCaffrey M. Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. Biol Cell 102: 51-62, 2009.
222. Kim D, Sacher M, Scarpa A, Quinn A, Ferro-Novick S. High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking. Mol Biol Cell 10: 3317-3329, 1999. (Pubitemid 29489564)
223. Kim Y, Raunser S, Munger C, Wagner J, Song Y, Cygler M, Walz T, Oh B, Sacher M. The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering. Cell 127: 817-830, 2006. (Pubitemid 44716247)
224. Kloer D, Rojas R, Ivan V, Moriyama K, van Vlijmen T, Murthy N, Ghirlando R, van der Sluijs P, Hurley J, Bonifacino J. Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. J Biol Chem 285: 7794-7804, 2010.
225. Kouranti I, Sachse M, Arouche N, Goud B, Echard A. Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis. Curr Biol 16: 1719-1725, 2006. (Pubitemid 44691778)
226. Kraynack B, Chan A, Rosenthal E, Essid M, Umansky B, Waters M, Schmitt H. Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast. Mol Biol Cell 16: 3963-3977, 2005.
227. Kuroda T, Fukuda M, Ariga H, Mikoshiba K. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Biochem Biophys Res Commun 293: 899-906, 2002. (Pubitemid 34694126)
228. Kuroda T, Fukuda M, Ariga H, Mikoshiba K. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. J Biol Chem 277: 9212-9218, 2002. (Pubitemid 34953001)
229. Köhler K, Louvard D, Zahraoui A. Rab13 regulates PKA signaling during tight junction assembly. J Cell Biol 165: 175-180, 2004. (Pubitemid 38544520)
230. Lapierre L, Kumar R, Hales C, Navarre J, Bhartur S, Burnette J, Provance DJ, Mercer J, Bähler M, Goldenring J. Myosin vb is associated with plasma membrane recycling systems. Mol Biol Cell 12: 1843-1857, 2001.
231. Larance M, Ramm G, Stöckli J, van Dam E, Winata S, Wasinger V, Simpson F, Graham M, Junutula J, Guilhaus M, James D. Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking. J Biol Chem 280: 37803-37813, 2005. (Pubitemid 41642391)
232. Laufman O, Kedan A, Hong W, Lev S. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. EMBO J 28: 2006-2017, 2009.
233. Lawe D, Patki V, Heller-Harrison R, Lambright D, Corvera S. The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization. J Biol Chem 275: 3699-3705, 2000. (Pubitemid 30083083)
234. Lawson M, Coulton L, Ebetino F, Vanderkerken K, Croucher P. Geranylgeranyl transferase type II inhibition prevents myeloma bone disease. Biochem Biophys Res Commun 377: 453-457, 2008.
235. Leaf D, Blum L. Analysis of rab10 localization in sea urchin embryonic cells by three-dimensional reconstruction. Exp Cell Res 243: 39-49, 1998. (Pubitemid 28397632)
236. Lee R, Iioka H, Ohashi M, Iemura S, Natsume T, Kinoshita N. XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway. EMBO J 26: 3592-3606, 2007. (Pubitemid 47236868)
237. Li L, Omata W, Kojima I, Shibata H. Direct interaction of Rab4 with syntaxin 4. J Biol Chem 276: 5265-5273, 2001.
238. Li X, Sapp E, Chase K, Comer-Tierney L, Masso N, Alexander J, Reeves P, Kegel K, Valencia A, Esteves M, Aronin N, Difiglia M. Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease. Neurobiol Dis 36: 374-383, 2009.
239. Li X, Sapp E, Valencia A, Kegel K, Qin Z, Alexander J, Masso N, Reeves P, Ritch J, Zeitlin S, Aronin N, Difiglia M. A function of huntingtin in guanine nucleotide exchange on Rab11. Neuroreport 19: 1643-1647, 2008.
240. Li X, Standley C, Sapp E, Valencia A, Qin Z, Kegel K, Yoder J, Comer-Tierney L, Esteves M, Chase K, Alexander J, Masso N, Sobin L, Bellve K, Tuft R, Lifshitz L, Fogarty K, Aronin N, DiFiglia M. Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity. Mol Cell Biol 29: 6106-6116, 2009.
241. Li Y, Meng X, Feng H, Zhang G, Liu C, Li P. Over-expression of the RAB5 gene in human lung adenocarcinoma cells with high metastatic potential. Chin Med Sci J 14: 96-101, 1999.
242. Li Y, Wandinger-Ness A, Goldenring J, Cover T. Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin. Mol Biol Cell 15: 1946-1959, 2004.
243. Lian J, Stone S, Jiang Y, Lyons P, Ferro-Novick S. Ypt1p implicated in v-SNARE activation. Nature 372: 698-701, 1994.
244. Liewen H, Meinhold-Heerlein I, Oliveira V, Schwarzenbacher R, Luo G, Wadle A, Jung M, Pfreundschuh M, Stenner-Liewen F. Characterization of the human GARP (Golgi associated retrograde protein) complex. Exp Cell Res 306: 24-34, 2005. (Pubitemid 40692768)
245. Lindsay A, Hendrick A, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey M. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. J Biol Chem 277: 12190-12199, 2002. (Pubitemid 34952785)
246. Lindsay A, McCaffrey M. Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain. J Biol Chem 277: 27193-27199, 2002. (Pubitemid 34951735)
247. Lipatova Z, Tokarev A, Jin Y, Mulholland J, Weisman L, Segev N. Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion. Mol Biol Cell 19: 4177-4187, 2008.
248. Lippé R, Miaczynska M, Rybin V, Runge A, Zerial M. Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex. Mol Biol Cell 12: 2219-2228, 2001.
249. Loftus S, Larson D, Baxter L, Antonellis A, Chen Y, Wu X, Jiang Y, Bittner M, Hammer Jr, Pavan W. Mutation of melanosome protein RAB38 in chocolate mice. Proc Natl Acad Sci USA 99: 4471-4476, 2002. (Pubitemid 34286009)
250. Lombardi D, Soldati T, Riederer M, Goda Y, Zerial M, Pfeffer S. Rab9 functions in transport between late endosomes and the trans Golgi network. EMBO J 12: 677-682, 1993. (Pubitemid 23073715)
251. Losev E, Reinke C, Jellen J, Strongin D, Bevis B, Glick B. Golgi maturation visualized in living yeast. Nature 441: 1002-1006, 2006.
252. Lynch-Day M, Bhandari D, Menon S, Huang J, Cai H, Bartholomew C, Brumell J, Ferro-Novick S, Klionsky D. Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc Natl Acad Sci USA 107: 7811-7816, 2010.
253. Lütcke A, Jansson S, Parton R, Chavrier P, Valencia A, Huber L, Lehtonen E, Zerial M. Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. J Cell Biol 121: 553-564, 1993. (Pubitemid 23131267)
254. Lütcke A, Olkkonen V, Dupree P, Lütcke H, Simons K, Zerial M. Isolation of a murine cDNA clone encoding Rab19, a novel tissue-specific small GTPase. Gene 155: 257-260, 1995.
255. Lütcke A, Parton R, Murphy C, Olkkonen V, Dupree P, Valencia A, Simons K, Zerial M. Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression. J Cell Sci 107: 3437-3448, 1994.
256. Machner M, Isberg R. A bifunctional bacterial protein links GDI displacement to Rab1 activation. Science 318: 974-977, 2007. (Pubitemid 350098993)
257. Machner M, Isberg R. Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila. Dev Cell 11: 47-56, 2006.
258. MacKenzie J, Fitzpatrick J, Babyn P, Ferrero G, Ballabio A, Billingsley G, Bulman D, Strasberg P, Ray P, Costa T. X linked spondyloepiphyseal dysplasia: a clinical, radiological, molecular study of a large kindred. J Med Genet 33: 823-828, 1996. (Pubitemid 26375789)
259. Mallard F, Tang B, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L. Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. J Cell Biol 156: 653-664, 2002. (Pubitemid 34839881)
260. Mammoto A, Ohtsuka T, Hotta I, Sasaki T, Takai Y. Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling. J Biol Chem 274: 25517-25524, 1999.
261. Martinez O, Antony C, Pehau-Arnaudet G, Berger E, Salamero J, Goud B. GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum. Proc Natl Acad Sci USA 94: 1828-1833, 1997.
262. Martinez O, Schmidt A, Salaméro J, Hoflack B, Roa M, Goud B. The small GTP-binding protein rab6 functions in intra-Golgi transport. J Cell Biol 127: 1575-1588, 1994. (Pubitemid 24380897)
263. Masuda E, Luo Y, Young C, Shen M, Rossi A, Huang B, Yu S, Bennett M, Payan D, Scheller R. Rab37 is a novel mast cell specific GTPase localized to secretory granules. FEBS Lett 470: 61-64, 2000. (Pubitemid 30155624)
264. Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw C, Barnekow A, Hoogenraad C. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat Cell Biol 4: 986-992, 2002. (Pubitemid 35469430)
265. Matesic L, Yip R, Reuss A, Swing D, O'Sullivan T, Fletcher C, Copeland N, Jenkins N. Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice. Proc Natl Acad Sci USA 98: 10238-10243, 2001. (Pubitemid 32803004)
266. Matsuura-Tokita K, Takeuchi M, Ichihara A, Mikuriya K, Nakano A. Live imaging of yeast Golgi cisternal maturation. Nature 441: 1007-1010, 2006.
267. Matteoli M, Takei K, Cameron R, Hurlbut P, Johnston P, Südhof T, Jahn R, De Camilli P. Association of Rab3A with synaptic vesicles at late stages of the secretory pathway. J Cell Biol 115: 625-633, 1991.
268. McGrail M, Gepner J, Silvanovich A, Ludmann S, Serr M, Hays T. Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex. J Cell Biol 131: 411-425, 1995.
269. Medkova M, France Y, Coleman J, Novick P. The rab exchange factor Sec2p reversibly associates with the exocyst. Mol Biol Cell 17: 2757-2769, 2006.
270. Meggouh F, Bienfait H, Weterman M, de Visser M, Baas F. Charcot-Marie-Tooth disease due to a de novo mutation of the RAB7 gene. Neurology 67: 1476-1478, 2006. (Pubitemid 44632079)
271. Menon S, Cai H, Lu H, Dong G, Cai Y, Reinisch K, Ferro-Novick S. mBET3 is required for the organization of the TRAPP complexes. Biochem Biophys Res Commun 350: 669-677, 2006. (Pubitemid 44547899)
272. Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler-Joseph S, Habermann B, Wilm M, Parton R, Zerial M. APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell 116: 445-456, 2004. (Pubitemid 38366320)
273. Mills I, Jones A, Clague M. Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes. Curr Biol 8: 881-884, 1998. (Pubitemid 28356049)
274. Mills I, Jones A, Clague M. Regulation of endosome fusion. Mol Membr Biol 16: 73-79, 1999.
275. Mir A, Kaufman L, Noor A, Motazacker M, Jamil T, Azam M, Kahrizi K, Rafiq M, Weksberg R, Nasr T, Naeem F, Tzschach A, Kuss A, Ishak G, Doherty D, Ropers H, Barkovich A, Najmabadi H, Ayub M, Vincent J. Identification of mutations in TRAPPC9, which encodes the NIK- and IKK-beta-binding protein, in nonsyndromic autosomal-recessive mental retardation. Am J Hum Genet 85: 909-915, 2009.
276. Miserey-Lenkei S, Waharte F, Boulet A, Cuif M, Tenza D, El Marjou A, Raposo G, Salamero J, Héliot L, Goud B, Monier S. Rab6-interacting protein 1 links Rab6 and Rab11 function. Traffic 8: 1385-1403, 2007. (Pubitemid 47394243)
277. Mizuno K, Kitamura A, Sasaki T. Rabring7, a novel Rab7 target protein with a RING finger motif. Mol Biol Cell 14: 3741-3752, 2003. (Pubitemid 37151623)
278. Mizuta R, LaSalle J, Cheng H, Shinohara A, Ogawa H, Copeland N, Jenkins N, Lalande M, Alt F. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proc Natl Acad Sci USA 94: 6927-6932, 1997. (Pubitemid 27281967)
279. Mochida G, Mahajnah M, Hill A, Basel-Vanagaite L, Gleason D, Hill R, Bodell A, Crosier M, Straussberg R, Walsh C. A truncating mutation of TRAPPC9 is associated with autosomal-recessive intellectual disability and postnatal microcephaly. Am J Hum Genet 85: 897-902, 2009.
280. Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B. Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport. Traffic 3: 289-297, 2002. (Pubitemid 34303261)
281. Moore B, Robinson H, Xu Z. The crystal structure of mouse Exo70 reveals unique features of the mammalian exocyst. J Mol Biol 371: 410-421, 2007. (Pubitemid 47048268)
282. Mosesson Y, Mills G, Yarden Y. Derailed endocytosis: an emerging feature of cancer. Nat Rev Cancer 8: 835-850, 2008.
283. Moya M, Roberts D, Novick P. DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function. Nature 361: 460-463, 1993. (Pubitemid 23050136)
284. Moyer B, Allan B, Balch W. Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis-Golgi tethering. Traffic 2: 268-276, 2001. (Pubitemid 32487557)
285. Mu F, Callaghan J, Steele-Mortimer O, Stenmark H, Parton R, Campbell P, McCluskey J, Yeo J, Tock E, Toh B. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. J Biol Chem 270: 13503-13511, 1995.
286. Munson M, Novick P. The exocyst defrocked, a framework of rods revealed. Nat Struct Mol Biol 13: 577-581, 2006. (Pubitemid 44036466)
287. Murata T, Delprato A, Ingmundson A, Toomre D, Lambright D, Roy C. The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor. Nat Cell Biol 8: 971-977, 2006. (Pubitemid 44314728)
288. Méresse S, Steele-Mortimer O, Finlay B, Gorvel J. The rab7 GTPase controls the maturation of Salmonella typhimurium-containing vacuoles in HeLa cells. EMBO J 18: 4394-4403, 1999. (Pubitemid 29391249)
289. Müller M, Peters H, Blümer J, Blankenfeldt W, Goody R, Itzen A. The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science 329: 946-949, 2010.
290. Nachury M, Loktev A, Zhang Q, Westlake C, Peränen J, Merdes A, Slusarski D, Scheller R, Bazan J, Sheffield V, Jackson P. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129: 1201-1213, 2007. (Pubitemid 46891037)
291. Nagelkerken B, Van Anken E, Van Raak M, Gerez L, Mohrmann K, Van Uden N, Holthuizen J, Pelkmans L, Van Der Sluijs P. Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles. Biochem J 346: 593-601, 2000. (Pubitemid 30171018)
292. Nakada-Tsukui K, Saito-Nakano Y, Ali V, Nozaki T. A retromer-like complex is a novel Rab7 effector that is involved in the transport of the virulence factor cysteine protease in the enteric protozoan parasite Entamoeba histolytica. Mol Biol Cell 16: 5294-5303, 2005. (Pubitemid 41566840)
293. Nakajima H, Hirata A, Ogawa Y, Yonehara T, Yoda K, Yamasaki M. A cytoskeleton-related gene, uso1, is required for intracellular protein transport in Saccharomyces cerevisiae. J Cell Biol 113: 245-260, 1991. (Pubitemid 21909690)
294. Nakamura N, Lowe M, Levine T, Rabouille C, Warren G. The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner. Cell 89: 445-455, 1997. (Pubitemid 27220889)
295. Nguyen U, Guo Z, Delon C, Wu Y, Deraeve C, Fränzel B, Bon R, Blankenfeldt W, Goody R, Waldmann H, Wolters D, Alexandrov K. Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol 5: 227-235, 2009.
296. Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M. Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. J Cell Biol 151: 601-612, 2000.
297. Nishimura N, Araki K, Shinahara W, Nakano Y, Nishimura K, Higashio H, Sasaki T. Interaction of Rab3B with microtubule-binding protein Gas8 in NIH 3T3 cells. Arch Biochem Biophys 474: 136-142, 2008.
298. Norris F, Wilson M, Wallis T, Galyov E, Majerus P. SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase. Proc Natl Acad Sci USA 95: 14057-14059, 1998.
299. Nuoffer C, Wu S, Dascher C, Balch W. Mss4 does not function as an exchange factor for Rab in endoplasmic reticulum to Golgi transport. Mol Biol Cell 8: 1305-1316, 1997. (Pubitemid 27310476)
300. Oka T, Ungar D, Hughson F, Krieger M. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. Mol Biol Cell 15: 2423-2435, 2004.
301. Olkkonen V, Dupree P, Killisch I, Lütcke A, Zerial M, Simons K. Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily. J Cell Sci 106: 1249-1261, 1993.
302. Olkkonen V, Peterson J, Dupree P, Lütcke A, Zerial M, Simons K. Isolation of a mouse cDNA encoding Rab23, a small novel GTPase expressed predominantly in the brain. Gene 138: 207-211, 1994. (Pubitemid 24087578)
303. Opdam F, Echard A, Croes H, van den Hurk J, van de Vorstenbosch R, Ginsel L, Goud B, Fransen J. The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus. J Cell Sci 113: 2725-2735, 2000.
304. Ortiz D, Medkova M, Walch-Solimena C, Novick P. Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles: evidence for a Rab cascade in yeast. J Cell Biol 157: 1005-1015, 2002.
305. Ostermeier C, Brunger A. Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. Cell 96: 363-374, 1999. (Pubitemid 29077590)
306. Ostrowicz C, Bröcker C, Ahnert F, Nordmann M, Lachmann J, Peplowska K, Perz A, Auffarth K, Engelbrecht-Vandré S, Ungermann C. Defined subunit arrangement and Rab interactions are required for functionality of the HOPS tethering complex. Traffic 2010.
307. Overmeyer J, Wilson A, Maltese W. Membrane targeting of a Rab GTPase that fails to associate with Rab escort protein (REP) or guanine nucleotide dissociation inhibitor (GDI). J Biol Chem 276: 20379-20386, 2001.
308. Owen D, Collins B, Evans P. Adaptors for clathrin coats: structure and function. Annu Rev Cell Dev Biol 20: 153-191, 2004. (Pubitemid 39488636)
309. Ozeki S, Cheng J, Tauchi-Sato K, Hatano N, Taniguchi H, Fujimoto T. Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane. J Cell Sci 118: 2601-2611, 2005. (Pubitemid 40932886)
310. Pal A, Severin F, Lommer B, Shevchenko A, Zerial M. Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease. J Cell Biol 172: 605-618, 2006. (Pubitemid 43243880)
311. Pan X, Eathiraj S, Munson M, Lambright D. TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature 442: 303-306, 2006. (Pubitemid 44114905)
312. Panic B, Perisic O, Veprintsev D, Williams R, Munro S. Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. Mol Cell 12: 863-874, 2003. (Pubitemid 37352780)
313. Park M, Serpinskaya A, Papalopulu N, Gelfand V. Rab32 regulates melanosome transport in Xenopus melanophores by protein kinase a recruitment. Curr Biol 17: 2030-2034, 2007.
314. Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen J, Ivaska J. Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. J Cell Biol 173: 767-780, 2006. (Pubitemid 46165584)
315. Peplowska K, Markgraf D, Ostrowicz C, Bange G, Ungermann C. The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis. Dev Cell 12: 739-750, 2007. (Pubitemid 46667746)
316. Pereira-Leal J, Seabra M. Evolution of the Rab family of small GTP-binding proteins. J Mol Biol 313: 889-901, 2001. (Pubitemid 33063434)
317. Pereira-Leal J, Seabra M. The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily. J Mol Biol 301: 1077-1087, 2000.
318. Pfeffer S. Rab GTPases: specifying and deciphering organelle identity and function. Trends Cell Biol 11: 487-491, 2001. (Pubitemid 33079141)
319. Pfeffer S. Structural clues to Rab GTPase functional diversity. J Biol Chem 280: 15485-15488, 2005. (Pubitemid 40616661)
320. Pierini R, Cottam E, Roberts R, Wileman T. Modulation of membrane traffic between endoplasmic reticulum, ERGIC and Golgi to generate compartments for the replication of bacteria and viruses. Semin Cell Dev Biol 20: 828-833, 2009.
321. 2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport. J Cell Biol 125: 239-252, 1994.
322. Plutner H, Cox A, Pind S, Khosravi-Far R, Bourne J, Schwaninger R, Der C, Balch W. Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. J Cell Biol 115: 31-43, 1991. (Pubitemid 21909891)
323. Prekeris R, Davies J, Scheller R. Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. J Biol Chem 276: 38966-38970, 2001.
324. Prekeris R, Klumperman J, Scheller R. A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. Mol Cell 6: 1437-1448, 2000. (Pubitemid 32045935)
325. Price A, Seals D, Wickner W, Ungermann C. The docking stage of yeast vacuole fusion requires the transfer of proteins from a cis-SNARE complex to a Rab/Ypt protein. J Cell Biol 148: 1231-1238, 2000.
326. Pylypenko O, Rak A, Durek T, Kushnir S, Dursina B, Thomae N, Constantinescu A, Brunsveld L, Watzke A, Waldmann H, Goody R, Alexandrov K. Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. EMBO J 25: 13-23, 2006. (Pubitemid 43077291)
327. Pérez-Victoria F, Abascal-Palacios G, Tascón I, Kajava A, Magadán J, Pioro E, Bonifacino J, Hierro A. Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex. Proc Natl Acad Sci USA 107: 12860-12865, 2010.
328. Pérez-Victoria F, Bonifacino J. Dual roles of the mammalian GARP Complex in tethering and SNARE complex assembly at the trans-Golgi network. Mol Cell Biol 2009.
329. Rak A, Fedorov R, Alexandrov K, Albert S, Goody R, Gallwitz D, Scheidig A. Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins. EMBO J 19: 5105-5113, 2000.
330. Rak A, Pylypenko O, Durek T, Watzke A, Kushnir S, Brunsveld L, Waldmann H, Goody R, Alexandrov K. Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science 302: 646-650, 2003. (Pubitemid 37310921)
331. Rak A, Pylypenko O, Niculae A, Goody R, Alexandrov K. Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1. J Struct Biol 141: 93-95, 2003. (Pubitemid 36269110)
332. Rak A, Pylypenko O, Niculae A, Pyatkov K, Goody R, Alexandrov K. Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell 117: 749-760, 2004. (Pubitemid 38748891)
333. Ramirez I, de Graffenried C, Ebersberger I, Yelinek J, He C, Price A, Warren G. TbG63, a golgin involved in Golgi architecture in Trypanosoma brucei. J Cell Sci 121: 1538-1546, 2008. (Pubitemid 351936318)
334. Reddy J, Burguete A, Sridevi K, Ganley I, Nottingham R, Pfeffer S. A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling. Mol Biol Cell 17: 4353-4363, 2006. (Pubitemid 44522054)
335. Rehling P, Darsow T, Katzmann D, Emr S. Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol 1: 346-353, 1999. (Pubitemid 129493576)
336. Ren M, Xu G, Zeng J, De Lemos-Chiarandini C, Adesnik M, Sabatini D. Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Proc Natl Acad Sci USA 95: 6187-6192, 1998. (Pubitemid 28248986)
337. Richardson B, Smith R, Ungar D, Nakamura A, Jeffrey P, Lupashin V, Hughson F. Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Proc Natl Acad Sci USA 106: 13329-13334, 2009.
338. Richardson P, Zon L. Molecular cloning of a cDNA with a novel domain present in the tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16. Oncogene 11: 1139-1148, 1995.
339. Rieder S, Emr S. A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole. Mol Biol Cell 8: 2307-2327, 1997. (Pubitemid 27469390)
340. Rink J, Ghigo E, Kalaidzidis Y, Zerial M. Rab conversion as a mechanism of progression from early to late endosomes. Cell 122: 735-749, 2005.
341. Rivera-Molina F, Novick P. A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway. Proc Natl Acad Sci USA 106: 14408-14413, 2009.
342. Robinson J, Klionsky D, Banta L, Emr S. Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol 8: 4936-4948, 1988. (Pubitemid 18261566)
343. Rodriguez-Gabin A, Cammer M, Almazan G, Charron M, Larocca J. Role of rRAB22b, an oligodendrocyte protein, in regulation of transport of vesicles from trans Golgi to endocytic compartments. J Neurosci Res 66: 1149-1160, 2001. (Pubitemid 33135601)
344. Rodriguez-Gabin A, Ortiz E, Demoliner K, Si Q, Almazan G, Larocca J. Interaction of Rab31 and OCRL-1 in oligodendrocytes: its role in transport of mannose 6-phosphate receptors. J Neurosci Res 88: 589-604, 2010.
345. Rojas R, van Vlijmen T, Mardones G, Prabhu Y, Rojas A, Mohammed S, Heck A, Raposo G, van der Sluijs P, Bonifacino J. Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7. J Cell Biol 183: 513-526, 2008.
346. Rosing M, Ossendorf E, Rak A, Barnekow A. Giantin interacts with both the small GTPase Rab6 and Rab1. Exp Cell Res 313: 2318-2325, 2007.
347. Rossi G, Kolstad K, Stone S, Palluault F, Ferro-Novick S. BET3 encodes a novel hydrophilic protein that acts in conjunction with yeast SNAREs. Mol Biol Cell 6: 1769-1780, 1995.
348. Rothman J, Howald I, Stevens T. Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae. EMBO J 8: 2057-2065, 1989. (Pubitemid 19273534)
349. Rothman J, Stevens T. Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway. Cell 47: 1041-1051, 1986. (Pubitemid 17005076)
350. Russell R. Bisphosphonates: mode of action and pharmacology. Pediatrics 119 Suppl 2: S150-162, 2007.
351. Rzomp K, Moorhead A, Scidmore M. The GTPase Rab4 interacts with Chlamydia trachomatis inclusion membrane protein CT229. Infect Immun 74: 5362-5373, 2006. (Pubitemid 44300456)
352. Rzomp K, Scholtes L, Briggs B, Whittaker G, Scidmore M. Rab GTPases are recruited to chlamydial inclusions in both a species-dependent and species-independent manner. Infect Immun 71: 5855-5870, 2003.
353. Sacher M, Jiang Y, Barrowman J, Scarpa A, Burston J, Zhang L, Schieltz D, Yates Abeliovich H Jr, Ferro-Novick S. TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J 17: 2494-2503, 1998. (Pubitemid 28221185)
354. Sacher M, Kim Y, Lavie A, Oh B, Segev N. The TRAPP complex: insights into its architecture and function. Traffic 9: 2032-2042, 2008.
355. Sahlender D, Roberts R, Arden S, Spudich G, Taylor M, Luzio J, Kendrick-Jones J, Buss F. Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. J Cell Biol 169: 285-295, 2005. (Pubitemid 40656566)
356. Salminen A, Novick P. A ras-like protein is required for a post-Golgi event in yeast secretion. Cell 49: 527-538, 1987.
357. Salminen A, Novick P. The Sec15 protein responds to the function of the GTP binding protein, Sec4, to control vesicular traffic in yeast. J Cell Biol 109: 1023-1036, 1989. (Pubitemid 19220089)
358. Sano H, Roach W, Peck G, Fukuda M, Lienhard G. Rab10 in insulin-stimulated GLUT4 translocation. Biochem J 411: 89-95, 2008.
359. Sapperstein S, Walter D, Grosvenor A, Heuser J, Waters M. p115 is a general vesicular transport factor related to the yeast endoplasmic reticulum to Golgi transport factor Uso1p. Proc Natl Acad Sci USA 92: 522-526, 1995.
360. Sasaki T, Kikuchi A, Araki S, Hata Y, Isomura M, Kuroda S, Takai Y. Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein. J Biol Chem 265: 2333-2337, 1990.
361. Satoh A, Wang Y, Malsam J, Beard M, Warren G. Golgin-84 is a rab1 binding partner involved in Golgi structure. Traffic 4: 153-161, 2003. (Pubitemid 36621708)
362. Schardt A, Brinkmann B, Mitkovski M, Sereda M, Werner H, Nave K. The SNARE protein SNAP-29 interacts with the GTPase Rab3A: implications for membrane trafficking in myelinating glia. J Neurosci Res 87: 3465-3479, 2009.
363. Schnatwinkel C, Christoforidis S, Lindsay M, Uttenweiler-Joseph S, Wilm M, Parton R, Zerial M. The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms. PLoS Biol 2: E261, 2004.
364. Schuck S, Gerl M, Ang A, Manninen A, Keller P, Mellman I, Simons K. Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells. Traffic 8: 47-60, 2007. (Pubitemid 44921882)
365. Seabra M, Brown M, Goldstein J. Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase. Science 259: 377-381, 1993. (Pubitemid 23055682)
366. Seabra M, Ho Y, Anant J. Deficient geranylgeranylation of Ram/Rab27 in choroideremia. J Biol Chem 270: 24420-24427, 1995.
367. Seabra M, Mules E, Hume A. Rab GTPases, intracellular traffic and disease. Trends Mol Med 8: 23-30, 2002.
368. Seachrist J, Laporte S, Dale L, Babwah A, Caron M, Anborgh P, Ferguson S. Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion. J Biol Chem 277: 679-685, 2002. (Pubitemid 34952107)
369. Seals D, Eitzen G, Margolis N, Wickner W, Price A. A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc Natl Acad Sci USA 97: 9402-9407, 2000. (Pubitemid 30650787)
370. Seaman M, McCaffery J, Emr S. A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol 142: 665-681, 1998. (Pubitemid 28381486)
371. Segev N. Mediation of the attachment or fusion step in vesicular transport by the GTP-binding Ypt1 protein. Science 252: 1553-1556, 1991. (Pubitemid 21917076)
372. Segev N. Ypt/rab GTPases: regulators of protein trafficking. Sci STKE 2001: RE11, 2001.
373. Segev N, Mulholland J, Botstein D. The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery. Cell 52: 915-924, 1988. (Pubitemid 18095350)
374. Semerdjieva S, Shortt B, Maxwell E, Singh S, Fonarev P, Hansen J, Schiavo G, Grant B, Smythe E. Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6. J Cell Biol 183: 499-511, 2008.
375. Seog D, Kito M, Igarashi K, Yoda K, Yamasaki M. Molecular characterization of the USO1 gene product which is essential for vesicular transport in Saccharomyces cerevisiae. Biochem Biophys Res Commun 200: 647-653, 1994. (Pubitemid 24183656)
376. Seog D, Kito M, Yoda K, Yamasaki M. Uso1 protein contains a coiled-coil rod region essential for protein transport from the ER to the Golgi apparatus in Saccharomyces cerevisiae. J Biochem 116: 1341-1345, 1994.
377. Shen J, Tareste D, Paumet F, Rothman J, Melia T. Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell 128: 183-195, 2007.
378. Shestakova A, Suvorova E, Pavliv O, Khaidakova G, Lupashin V. Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability. J Cell Biol 179: 1179-1192, 2007. (Pubitemid 350277737)
379. Shin H, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk M, Modregger J, Uttenweiler-Joseph S, Wilm M, Nystuen A, Frankel W, Solimena M, De Camilli P, Zerial M. An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol 170: 607-618, 2005.
380. Shintani M, Tada M, Kobayashi T, Kajiho H, Kontani K, Katada T. Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase. Biochem Biophys Res Commun 357: 661-667, 2007. (Pubitemid 46653830)
381. Shirakawa R, Higashi T, Tabuchi A, Yoshioka A, Nishioka H, Fukuda M, Kita T, Horiuchi H. Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets. J Biol Chem 279: 10730-10737, 2004. (Pubitemid 38372686)
382. Shirane M, Nakayama K. Protrudin induces neurite formation by directional membrane trafficking. Science 314: 818-821, 2006. (Pubitemid 44706648)
383. Shirataki H, Kaibuchi K, Sakoda T, Kishida S, Yamaguchi T, Wada K, Miyazaki M, Takai Y. Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin. Mol Cell Biol 13: 2061-2068, 1993. (Pubitemid 23097685)
384. Short B, Haas A, Barr F. Golgins and GTPases, giving identity and structure to the Golgi apparatus. Biochim Biophys Acta 1744: 383-395, 2005.
385. Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr F. A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. J Cell Biol 155: 877-883, 2001. (Pubitemid 34286239)
386. Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr F. The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes. Curr Biol 12: 1792-1795, 2002. (Pubitemid 35169798)
387. Simonsen A, Gaullier J, D'Arrigo A, Stenmark H. The Rab5 effector EEA1 interacts directly with syntaxin-6. J Biol Chem 274: 28857-28860, 1999.
388. Simonsen A, Lippé R, Christoforidis S, Gaullier J, Brech A, Callaghan J, Toh B, Murphy C, Zerial M, Stenmark H. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394: 494-498, 1998.
389. Simpson J, Griffiths G, Wessling-Resnick M, Fransen J, Bennett H, Jones A. A role for the small GTPase Rab21 in the early endocytic pathway. J Cell Sci 117: 6297-6311, 2004. (Pubitemid 40214558)
390. Singleton A, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, Cookson M, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, Gwinn-Hardy K. alpha-Synuclein locus triplication causes Parkinson's disease. Science 302: 841, 2003.
391. Siniossoglou S. Affinity purification of Ypt6 effectors and identification of TMF/ARA160 as a Rab6 interactor. Methods Enzymol 403: 599-607, 2005.
392. Siniossoglou S, Pelham H. An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes. EMBO J 20: 5991-5998, 2001. (Pubitemid 33049274)
393. Sinka R, Gillingham A, Kondylis V, Munro S. Golgi coiled-coil proteins contain multiple binding sites for Rab family G proteins. J Cell Biol 183: 607-615, 2008.
394. Sivaram M, Furgason M, Brewer D, Munson M. The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles. Nat Struct Mol Biol 13: 555-556, 2006. (Pubitemid 43848911)
395. Sivaram M, Saporita J, Furgason M, Boettcher A, Munson M. Dimerization of the exocyst protein Sec6p and its interaction with the t-SNARE Sec9p. Biochemistry 44: 6302-6311, 2005. (Pubitemid 40570724)
396. Sivars U, Aivazian D, Pfeffer S. Yip3 catalyses the dissociation of endosomal Rab-GDI complexes. Nature 425: 856-859, 2003. (Pubitemid 37351470)
397. Sönnichsen B, Lowe M, Levine T, Jämsä E, Dirac-Svejstrup B, Warren G. A role for giantin in docking COPI vesicles to Golgi membranes. J Cell Biol 140: 1013-1021, 1998.
398. Sorkin A. Cargo recognition during clathrin-mediated endocytosis: a team effort. Curr Opin Cell Biol 16: 392-399, 2004. (Pubitemid 38903145)
399. Speight P, Silverman M. Diacylglycerol-activated Hmunc13 serves as an effector of the GTPase Rab34. Traffic 6: 858-865, 2005. (Pubitemid 41309395)
400. Spillantini M, Crowther R, Jakes R, Hasegawa M, Goedert M. α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 95: 6469-6473, 1998. (Pubitemid 28249037)
401. Spillantini M, Goedert M. The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Ann NY Acad Sci 920: 16-27, 2000. (Pubitemid 32056547)
402. Spinosa M, Progida C, De Luca A, Colucci A, Alifano P, Bucci C. Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease. J Neurosci 28: 1640-1648, 2008. (Pubitemid 351287044)
403. Starai V, Hickey C, Wickner W. HOPS proofreads the trans-SNARE complex for yeast vacuole fusion. Mol Biol Cell 19: 2500-2508, 2008.
404. Steele-Mortimer O. The Salmonella-containing vacuole: moving with the times. Curr Opin Microbiol 11: 38-45, 2008.
405. Steele-Mortimer O, Méresse S, Gorvel J, Toh B, Finlay B. Biogenesis of Salmonella typhimurium-containing vacuoles in epithelial cells involves interactions with the early endocytic pathway. Cell Microbiol 1: 33-49, 1999. (Pubitemid 129667951)
406. Stein M, Feng Y, Cooper K, Welford A, Wandinger-Ness A. Human VPS34 and p150 are Rab7 interacting partners. Traffic 4: 754-771, 2003. (Pubitemid 37361856)
407. Stenmark H, Aasland R, Toh B, D'Arrigo A. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. J Biol Chem 271: 24048-24054, 1996.
408. Stenmark H, Vitale G, Ullrich O, Zerial M. Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. Cell 83: 423-432, 1995.
409. Strick D, Elferink L. Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. Mol Biol Cell 16: 5699-5709, 2005. (Pubitemid 41752219)
410. Strick D, Francescutti D, Zhao Y, Elferink L. Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis. J Biol Chem 277: 32722-32729, 2002. (Pubitemid 34984779)
411. Strom M, Hume A, Tarafder A, Barkagianni E, Seabra M. A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. J Biol Chem 277: 25423-25430, 2002. (Pubitemid 34951855)
412. Stroupe C, Collins K, Fratti R, Wickner W. Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p. EMBO J 25: 1579-1589, 2006.
413. Südhof T, Rothman J. Membrane fusion: grappling with SNARE and SM proteins. Science 323: 474-477, 2009.
414. Suh H, Lee D, Lee K, Ku B, Choi S, Woo J, Kim Y, Oh B. Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA. EMBO J 29: 496-504, 2010.
415. Sumakovic M, Hegermann J, Luo L, Husson S, Schwarze K, Olendrowitz C, Schoofs L, Richmond J, Eimer S. UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans. J Cell Biol 186: 897-914, 2009.
416. Sun P, Yamamoto H, Suetsugu S, Miki H, Takenawa T, Endo T. Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem 278: 4063-4071, 2003. (Pubitemid 36801141)
417. Suvorova E, Duden R, Lupashin V. The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins. J Cell Biol 157: 631-643, 2002. (Pubitemid 34839791)
418. Sweet D, Pelham H. The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p. EMBO J 12: 2831-2840, 1993. (Pubitemid 23218332)
419. Tamura K, Ohbayashi N, Maruta Y, Kanno E, Itoh T, Fukuda M. Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes. Mol Biol Cell 20: 2900-2908, 2009.
420. Teber I, Nagano F, Kremerskothen J, Bilbilis K, Goud B, Barnekow A. Rab6 interacts with the mint3 adaptor protein. Biol Chem 386: 671-677, 2005. (Pubitemid 41448169)
421. Terai T, Nishimura N, Kanda I, Yasui N, Sasaki T. JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. Mol Biol Cell 17: 2465-2475, 2006. (Pubitemid 44011759)
422. TerBush D, Maurice T, Roth D, Novick P. The exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J 15: 6483-6494, 1996. (Pubitemid 26413781)
423. Terebiznik M, Vazquez C, Torbicki K, Banks D, Wang T, Hong W, Blanke S, Colombo M, Jones N. Helicobacter pylori VacA toxin promotes bacterial intracellular survival in gastric epithelial cells. Infect Immun 74: 6599-6614, 2006. (Pubitemid 44913134)
424. Thomas C, Rousset R, Noselli S. JNK signalling influences intracellular trafficking during Drosophila morphogenesis through regulation of the novel target gene Rab30. Dev Biol 331: 250-260, 2009.
425. Tiller G, Hannig V, Dozier D, Carrel L, Trevarthen K, Wilcox W, Mundlos S, Haines J, Gedeon A, Gecz J. A recurrent RNA-splicing mutation in the SEDL gene causes X-linked spondyloepiphyseal dysplasia tarda. Am J Hum Genet 68: 1398-1407, 2001. (Pubitemid 32510615)
426. Tisdale E. Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation. J Biol Chem 278: 52524-52530, 2003. (Pubitemid 38035847)
427. Tisdale E, Kelly C, Artalejo C. Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity. J Biol Chem 279: 54046-54052, 2004. (Pubitemid 40053138)
428. Tripathi A, Ren Y, Jeffrey P, Hughson F. Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nat Struct Mol Biol 16: 114-123, 2009.
429. Ullrich O, Reinsch S, Urbé S, Zerial M, Parton R. Rab11 regulates recycling through the pericentriolar recycling endosome. J Cell Biol 135: 913-924, 1996. (Pubitemid 26403768)
430. Ullrich O, Stenmark H, Alexandrov K, Huber L, Kaibuchi K, Sasaki T, Takai Y, Zerial M. Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins. J Biol Chem 268: 18143-18150, 1993. (Pubitemid 23260335)
431. Ungar D, Oka T, Krieger M, Hughson F. Retrograde transport on the COG railway. Trends Cell Biol 16: 113-120, 2006.
432. Urbé S, Huber L, Zerial M, Tooze S, Parton R. Rab11, a small GTPase associated with both constitutive and regulated secretory pathways in PC12 cells. FEBS Lett 334: 175-182, 1993. (Pubitemid 23330577)
433. Utskarpen A, Slagsvold H, Iversen T, Wälchli S, Sandvig K. Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A'. Traffic 7: 663-672, 2006. (Pubitemid 43676975)
434. Valdivia R. Chlamydia effector proteins and new insights into chlamydial cellular microbiology. Curr Opin Microbiol 11: 53-59, 2008.
435. Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T. Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER. FEBS Lett 508: 201-209, 2001. (Pubitemid 33079246)
436. Van der Sluijs P, Hull M, Webster P, Mâle P, Goud B, Mellman I. The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway. Cell 70: 729-740, 1992.
437. Van der Sluijs P, Hull M, Zahraoui A, Tavitian A, Goud B, Mellman I. The small GTP-binding protein rab4 is associated with early endosomes. Proc Natl Acad Sci USA 88: 6313-6317, 1991. (Pubitemid 21914936)
438. Van Gele M, Dynoodt P, Lambert J. Griscelli syndrome: a model system to study vesicular trafficking. Pigment Cell Melanoma Res 22: 268-282, 2009.
439. Van Ijzendoorn S, Tuvim M, Weimbs T, Dickey B, Mostov K. Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. Dev Cell 2: 219-228, 2002. (Pubitemid 38351586)
440. Van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf P, Heck A, Hoogenraad C, van der Sluijs P. A unique residue in rab3c determines the interaction with novel binding protein Zwint-1. FEBS Lett 582: 2838-2842, 2008.
441. VanRheenen S, Cao X, Lupashin V, Barlowe C, Waters M. Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking. J Cell Biol 141: 1107-1119, 1998. (Pubitemid 28265606)
442. VanRheenen S, Cao X, Sapperstein S, Chiang E, Lupashin V, Barlowe C, Waters M. Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p. J Cell Biol 147: 729-742, 1999.
443. VanRheenen S, Reilly B, Chamberlain S, Waters M. Dsl1p, an essential protein required for membrane traffic at the endoplasmic reticulum/Golgi interface in yeast. Traffic 2: 212-231, 2001. (Pubitemid 32487552)
444. Vasan N, Hutagalung A, Novick P, Reinisch K. Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes. Proc Natl Acad Sci USA 107: 14176-14181, 2010.
445. Vaughan K, Vallee R. Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. J Cell Biol 131: 1507-1516, 1995.
446. Velier J, Kim M, Schwarz C, Kim T, Sapp E, Chase K, Aronin N, DiFiglia M. Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exp Neurol 152: 34-40, 1998.
447. Verhoeven K, De Jonghe P, Coen K, Verpoorten N, Auer-Grumbach M, Kwon J, FitzPatrick D, Schmedding E, De Vriendt E, Jacobs A, Van Gerwen V, Wagner K, Hartung H, Timmerman V. Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. Am J Hum Genet 72: 722-727, 2003. (Pubitemid 36255971)
448. Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M. Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5. EMBO J 17: 1941-1951, 1998.
449. Walch-Solimena C, Collins R, Novick P. Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J Cell Biol 137: 1495-1509, 1997. (Pubitemid 27282232)
450. Wang T, Hong W. Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein. Mol Biol Cell 13: 4317-4332, 2002. (Pubitemid 35471188)
451. Wang W, Ferro-Novick S. A Ypt32p exchange factor is a putative effector of Ypt1p. Mol Biol Cell 13: 3336-3343, 2002. (Pubitemid 35034267)
452. Wang W, Sacher M, Ferro-Novick S. TRAPP stimulates guanine nucleotide exchange on Ypt1p. J Cell Biol 151: 289-296, 2000.
453. Wang X, Kumar R, Navarre J, Casanova J, Goldenring J. Regulation of vesicle trafficking in Madin-Darby canine kidney cells by Rab11a and Rab25. J Biol Chem 275: 29138-29146, 2000.
454. Wang Y, Okamoto M, Schmitz F, Hofmann K, Südhof T. Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Nature 388: 593-598, 1997. (Pubitemid 27340010)
455. Wanschers B, van de Vorstenbosch R, Wijers M, Wieringa B, King S, Fransen J. Rab6 family proteins interact with the dynein light chain protein DYNLRB1. Cell Motil Cytoskeleton 65: 183-196, 2008.
456. Wasmeier C, Romao M, Plowright L, Bennett D, Raposo G, Seabra M. Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. J Cell Biol 175: 271-281, 2006. (Pubitemid 44631421)
457. Wassmer T, Attar N, Harterink M, van Weering J, Traer C, Oakley J, Goud B, Stephens D, Verkade P, Korswagen H, Cullen P. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell 17: 110-122, 2009.
458. Waterman-Storer C, Karki S, Holzbaur E. The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). Proc Natl Acad Sci USA 92: 1634-1638, 1995.
459. Waters M, Clary D, Rothman J. A novel 115-kD peripheral membrane protein is required for intercisternal transport in the Golgi stack. J Cell Biol 118: 1015-1026, 1992.
460. Weide T, Bayer M, Köster M, Siebrasse J, Peters R, Barnekow A. The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b. EMBO Rep 2: 336-341, 2001. (Pubitemid 32401530)
461. Weide T, Teuber J, Bayer M, Barnekow A. MICAL-1 isoforms, novel rab1 interacting proteins. Biochem Biophys Res Commun 306: 79-86, 2003.
462. Westlake C, Junutula J, Simon G, Pilli M, Prekeris R, Scheller R, Jackson P, Eldridge A. Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene. Proc Natl Acad Sci USA 104: 1236-1241, 2007. (Pubitemid 46183988)
463. White J, Johannes L, Mallard F, Girod A, Grill S, Reinsch S, Keller P, Tzschaschel B, Echard A, Goud B, Stelzer E. Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells. J Cell Biol 147: 743-760, 1999.
464. Whyte J, Munro S. The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. Dev Cell 1: 527-537, 2001. (Pubitemid 33586104)
465. Wiederkehr A, De Craene J, Ferro-Novick S, Novick P. Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p. J Cell Biol 167: 875-887, 2004. (Pubitemid 39628110)
466. Williams C, Choudhury R, McKenzie E, Lowe M. Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway. J Cell Sci 120: 3941-3951, 2007. (Pubitemid 350269400)
467. Wu H, Rossi G, Brennwald P. The ghost in the machine: small GTPases as spatial regulators of exocytosis. Trends Cell Biol 18: 397-404, 2008.
468. Wu M, Lu L, Hong W, Song H. Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1. Nat Struct Mol Biol 11: 86-94, 2004.
469. Wu S, Mehta S, Pichaud F, Bellen H, Quiocho F. Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo. Nat Struct Mol Biol 12: 879-885, 2005. (Pubitemid 41486711)
470. Wu S, Zeng K, Wilson I, Balch W. Structural insights into the function of the Rab GDI superfamily. Trends Biochem Sci 21: 472-476, 1996.
471. Wu X, Rao K, Bowers M, Copeland N, Jenkins N, Hammer J. Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle. J Cell Sci 114: 1091-1100, 2001. (Pubitemid 32288523)
472. Wu X, Rao K, Zhang H, Wang F, Sellers J, Matesic L, Copeland N, Jenkins N, Hammer J. Identification of an organelle receptor for myosin-Va. Nat Cell Biol 4: 271-278, 2002.
473. Wu Y, Tan K, Waldmann H, Goody R, Alexandrov K. Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators. Proc Natl Acad Sci USA 104: 12294-12299, 2007. (Pubitemid 47206131)
474. Wurmser A, Sato T, Emr S. New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion. J Cell Biol 151: 551-562, 2000.
475. Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T. The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions. Mol Biol Cell 19: 971-983, 2008. (Pubitemid 351481812)
476. Yamasaki A, Menon S, Yu S, Barrowman J, Meerloo T, Oorschot V, Klumperman J, Satoh A, Ferro-Novick S. mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI coated vesicles. Mol Biol Cell 20: 4205-4215, 2009.
477. Yang L, Clinton J, Blackburn M, Zhang Q, Zou J, Zielinska-Kwiatkowska A, Tang B, Chansky H. Rab23 regulates differentiation of ATDC5 chondroprogenitor cells. J Biol Chem 283: 10649-10657, 2008.
478. Yi Z, Yokota H, Torii S, Aoki T, Hosaka M, Zhao S, Takata K, Takeuchi T, Izumi T. The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol Cell Biol 22: 1858-1867, 2002.
479. Yoshie S, Imai A, Nashida T, Shimomura H. Expression, characterization, and localization of Rab26, a low molecular weight GTP-binding protein, in the rat parotid gland. Histochem Cell Biol 113: 259-263, 2000.
480. Yoshimura S, Egerer J, Fuchs E, Haas A, Barr F. Functional dissection of Rab GTPases involved in primary cilium formation. J Cell Biol 178: 363-369, 2007. (Pubitemid 47196146)
481. Young J, Stauber T, del Nery E, Vernos I, Pepperkok R, Nilsson T. Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A'. Mol Biol Cell 16: 162-177, 2005. (Pubitemid 40024300)
482. Yu S, Satoh A, Pypaert M, Mullen K, Hay J, Ferro-Novick S. mBet3p is required for homotypic COPII vesicle tethering in mammalian cells. J Cell Biol 174: 359-368, 2006. (Pubitemid 44156766)
483. Zacchi P, Stenmark H, Parton R, Orioli D, Lim F, Giner A, Mellman I, Zerial M, Murphy C. Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. J Cell Biol 140: 1039-1053, 1998. (Pubitemid 28128865)
484. Zahraoui A, Joberty G, Arpin M, Fontaine J, Hellio R, Tavitian A, Louvard D. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. J Cell Biol 124: 101-115, 1994.
485. Zeevaert R, Foulquier F, Jaeken J, Matthijs G. Deficiencies in subunits of the Conserved Oligomeric Golgi (COG) complex define a novel group of congenital disorders of glycosylation. Mol Genet Metab 93: 15-21, 2008. (Pubitemid 350236002)
486. Zeng J, Ren M, Gravotta D, De Lemos-Chiarandini C, Lui M, Erdjument-Bromage H, Tempst P, Xu G, Shen T, Morimoto T, Adesnik M, Sabatini D. Identification of a putative effector protein for rab11 that participates in transferrin recycling. Proc Natl Acad Sci USA 96: 2840-2845, 1999. (Pubitemid 29148805)
487. Zerial M, McBride H. Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2: 107-117, 2001.
488. Zhang J, Fonovic M, Suyama K, Bogyo M, Scott M. Rab35 controls actin bundling by recruiting fascin as an effector protein. Science 325: 1250-1254, 2009.
489. Zhang X, Bi E, Novick P, Du L, Kozminski K, Lipschutz J, Guo W. Cdc42 interacts with the exocyst and regulates polarized secretion. J Biol Chem 276: 46745-46750, 2001. (Pubitemid 37373040)
490. Zhang X, Ellis S, Sriratana A, Mitchell C, Rowe T. Sec15 is an effector for the Rab11 GTPase in mammalian cells. J Biol Chem 279: 43027-43034, 2004.
491. Zhang X, Wang P, Gangar A, Zhang J, Brennwald P, TerBush D, Guo W. Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis. J Cell Biol 170: 273-283, 2005.
492. Zheng J, Koda T, Fujiwara T, Kishi M, Ikehara Y, Kakinuma M. A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae. J Cell Sci 111: 1061-1069, 1998.
493. Zhu H, Liang Z, Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Mol Biol Cell 20: 4720-4729, 2009.
494. Zolov S, Lupashin V. Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells. J Cell Biol 168: 747-759, 2005.
495. Zoncu R, Perera R, Sebastian R, Nakatsu F, Chen H, Balla T, Ayala G, Toomre D, De Camilli P. Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci USA 104: 3793-3798, 2007. (Pubitemid 47181533)
496. Zuk P, Elferink L. Rab15 mediates an early endocytic event in Chinese hamster ovary cells. J Biol Chem 274: 22303-22312, 1999.
497. Züchner S, Noureddine M, Kennerson M, Verhoeven K, Claeys K, De Jonghe P, Merory J, Oliveira S, Speer M, Stenger J, Walizada G, Zhu D, Pericak-Vance M, Nicholson G, Timmerman V, Vance J. Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease. Nat Genet 37: 289-294, 2005.