Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 29, 2010, Pages 12860-12865

  Pérez Victoria, F Javier ^a   Abascal Palacios, Guillermo ^b   Tascón, Igor ^b   Kajava, Andrey ^c   Magadán, Javier G ^a   Pioro, Erik P ^d   Bonifacino, Juan S ^a   Hierro, Aitor ^b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b CIC BIOGUNE   (Spain)

^c Centre National de la Recherche Scientifique   (France)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Golgi apparatus; Protein stability; Vesicle trafficking; X ray crystallography

Indexed keywords

CELL MEMBRANE PROTEIN; CELL MEMBRANE PROTEIN GARP; LEUCINE; MEMBRANE PROTEIN; MEMBRANE PROTEIN VPS54; UNCLASSIFIED DRUG;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEGENERATIVE DISEASE; GENE FUNCTION; GENE MUTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ALLELES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; HELA CELLS; HUMANS; LEUCINE; MICE; MICE, NEUROLOGIC MUTANTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTANT PROTEINS; MUTATION; NEURODEGENERATIVE DISEASES; ORGAN SPECIFICITY; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; STRUCTURE-ACTIVITY RELATIONSHIP; VESICULAR TRANSPORT PROTEINS;

ANIMALIA;

EID: 77955594318     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1004756107     Document Type: Article

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