The rab5 effector EEA1 is a core component of endosome docking

Nature

Volumn 397, Issue 6720, 1999, Pages 621-625

  Christoforidis, Savvas ^a,b   McBride, Heidi M ^a,b   Burgoyne, Robert D ^c   Zerial, Marino ^a,b  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; PROTEIN;

ARTICLE; ENDOSOME; HUMAN; HUMAN CELL; MEMBRANE FUSION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CATTLE; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, AGAROSE; CYTOSOL; ENDOSOMES; GTP-BINDING PROTEINS; HELA CELLS; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE FUSION; MEMBRANE PROTEINS; PROTEIN BINDING; RAB5 GTP-BINDING PROTEINS; RECOMBINANT FUSION PROTEINS; SNARE PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 0033580299     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/17618     Document Type: Article

References (30)

1. Rothman, I. E. Mechanisms of intracellular protein transport. Nature 372, 55-63 (1994).
2. Weber, T. et al. SNAREpins: Minimal machinery for membrane fusion. Cell 92, 759-772 (1998).
3. Robinson, L. M. & Martin, T. F. J. Docking and fusion in neurosecretion. Curr. Opin. Cell Biol. 10, 483-492 (1998).
4. von Mollard, G. F., Nothwehr, S. F. & Stevens T. H. The yeast v-SNARE Vtilp mediates two vesicle transport pathways through interactions with the t-SNAREs Sed5p and Pept2p. J. Cell Biol. 137, 1511-1524 (1997).
5. Holthuis, J. C., Nichols, B. J., Dhruvakumar, S. & Pelham, H. R. Two syntaxin homologues in the TGN/endosomal system of yeast. EMBO J. 17, 113-126 (1998).
6. Hay, J. C. et al. Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs. J. Cell Biol. 141, 1489-1502 (1998).
7. Sapperstein, S. K., Lupashin, V. V., Schmitt, H. D. & Waters, M. G. Assembly of the ER to Golgi SNARE complex requires Uso1p. J. Cell Biol. 132, 755-767 (1996).
8. Cao, X., Ballew, N. & Barlowe, C. Initial docking of ER-derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins. EMBO J. 17, 2156-2165 (1998).
9. VanRheenen, S. M., Cao, X., Lupashin, V. V., Barlowe, C. & Waters, G. M. Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking. J. Cell Biol. 141, 1107-1119 (1998).
10. Novick, P. & Zerial, M. The diversity of Rab proteins in vesicle transport. Curr. Opin. Cell Biol. 9, 496-504 (1997).
11. Søgaard, M. et al. A Rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell 78, 937-948 (1994).
12. Lian, J. P., Stone, S., Jiang, Y., Lyons, P. & Ferro-Novick, S. Ypt1p implicated in v-SNARE activation. Nature 372, 698-701 (1994).
13. Mayer, A. & Wickner, W. Docking of yeast vacuoles is catalyzed by the Ras-like GTPase Ypt7p after symmetric pnming by Sec18p (NSF). J. Cell Biol. 136, 307-317 (1997).
14. Lupashin, V. V. & Waters, M. G. t-SNARE activation through transient interaction with a rab-like guanosine triphosphatase. Science 276, 1255-1258 (1997).
15. Gorvel, J.-P., Chavrier, P., Zerial, M. & Gruenberg, J. Rab5 controls early endosome fusion in vitro. Cell 64, 915-925 (1991).
16. Horiuchi, H. et al. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell 90, 1149-1159 (1997).
17. Gournier, H., Stenmark, H., Rybin, V., Lippe, R. & Zerial, M. Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion. EMBO J. 17, 1930-1940 (1998).
18. Simonsen, A. et al. EEA1 links phosphatidylinositol 3-kinase function to Rab5 regulation of endosome fusion. Nature 394, 494-498 (1998).
19. Emans, N. et al. Annexin II is a major component of fusogenic endosomal vesicles. J. Cell Biol. 120, 1357-1369 (1993).
20. Colombo, M. I., Beron, W. & Stahl, P. D. Calmodulin regulates endosome fusion. J. Biol. Chem. 272, 7707-7712 (1997).
21. Rodriguez, L., Stirling, C. J. & Woodman, P. G. Multiple N-ethylmaleimide-sensitive components are required for endosomal vesicle fusion. Mol. Biol. Cell 5, 773-783 (1994).
22. Colombo, M.I., Taddese, M., Whiteheart, S. W. & Stahl, P. D. A possible predocking attachment site for N-ethylmaldmide-sensitive fusion protein. Insights from in vitro endosome fusion. J. Biol. Chem. 271, 18810-18816 (1996).
23. Wiedemann, C. & Cockcroft, S. Vesicular transport: sticky fingers grab a lipid. Nature 394, 426-427 (1998).
24. Patki, V. et al. Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase. Proc. Natl Acad. Sci. USA 94, 7326-7330 (1997).
25. Barnard, R. J. O., Morgan, A. & Burgoyne, R. D. Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis. J. Cell Biol. 139, 875-883 (1997).
26. Mayer, A., Wickner, W. & Haas, A. Sec18p (NSF)-driven release of Sec17p (α-SNAP) can precede docking and fusion of yeast vacuoles. Cell 85, 83-94 (1996).
27. Sonnichsen, B. et al. A role for gianltn in docking COPI vesicles to Golgi membranes. J. Cell Biol. 140, 1013-1021 (1998).
28. Barlowe, C. Coupled ER to golgi transport reconstituted with purified cytosolic proteins. J. Cell Biol. 139, 1097-1108 (1997).
29. Mu, F. et al. EEA1, an early endosome-associated protein. J. Biol. Chem. 270, 13503-13511 (1995).
30. Stenmark, H., Aasland, R., Toh, B.H. & D'Arringo, A. Endosomal localization of the autoantigen EEA1 is mediated by zinc-binding FYVE finger. J. Biol. Chem. 271, 24048-24054 (1996).