The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus

Journal of Cell Science

Volumn 113, Issue 15, 2000, Pages 2725-2735

  Opdam, F J M ^a   Echard, A ^a   Croes, H J E ^a   van den Hurk, J A J M ^a   van de Vorstenbosch, R A ^a   Ginsel, L A ^a   Goud, B ^a   Fransen, J A M ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

Golgi apparatus; Rab; Rabkinesin 6; Transport carrier

Indexed keywords

GUANOSINE TRIPHOSPHATASE; ISOPROTEIN; RAB PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SPECIFICITY; CELL TYPE; CELLULAR DISTRIBUTION; CHROMOSOME 3Q; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME BINDING; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INTRACELLULAR TRANSPORT; MEMBRANE TRANSPORT; MICROGLIA; NORTHERN BLOTTING; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PURKINJE CELL; REGULATORY MECHANISM; TISSUE SPECIFICITY;

ANIMALS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; BRAIN; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 2; CLONING, MOLECULAR; COS CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GOLGI APPARATUS; GTP PHOSPHOHYDROLASES; HT29 CELLS; HUMANS; KINESIN; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; NEURONS; RAB GTP-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0033841775     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Brain microglia constitutively express beta-2 integrins
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. Membrane fusion: Timing is everything
4. Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line. RBL. 2H3
5. Expression of Rab3D N135I inhibits regulated secretion of ACTH in AtT-20 cells
6. The Rab protein family: Genetic mapping of six Rab genes in the mouse
7. The role of ARF and rab GTPases in membrane transport
8. Molecular cloning of two novel rab genes from human melanocytes
9. RAB GTPases expressed in human melanoma cells
10. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets
11. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
12. The Rab5 effector EEA1 is a core component of endosome docking
13. Comparison of the effects on secretion in chromaffin and PC12 cells of Rab3 family members and mutants. Evidence that inhibitory effects are independent of direct interaction with Rabphilin3
14. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome
15. Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation
16. Interaction of a Golgi-associated kinesin-like protein with Rab6
17. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
18. Rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles
19. Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis
20. Role of protein disulphide-isomerase in the expression of native proteins
21. Evidence for copI-independent transport routes from the Golgi complex to the endoplasmic reticulum
22. Small GTP-binding protein associated with Golgi cisternae
23. A versatile in vivo and in vitro eukaryotic expression vector for protein engineering
24. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function
25. Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells
26. Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6
27. Golgi apparatus in chick skeletal muscle: Changes in its distribution during end plate development and after denervation
28. Characterization of monoclonal antibodies reactive to several biochemically distinct human cytomegalovirus glycoprotein complexes
29. Microinjected antibodies against the cytoplasmic domain of vesicular stomatitis virus glycoprotein block its transport to the cell surface
30. Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol
31. The small GTP-binding protein rab6 functions in intra-Golgi transport
32. GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum
33. Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13
34. Rab5 regulates motility of early endosomes on microtubules
35. A GDP-bound of rab1 inhibits protein export from the endoplasmic reticulum and transport between Golgi compartments
36. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab 21 is an apically located GTP-binding protein in polarised intestinal epithelial cells
37. Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (Fc epsilonRI)
38. Throttles and dampers: Controlling the engine of membrane fusion
39. Chromosome assignment of four RAS-related RAB genes
40. GTPase activity of Rab5 acts as a timer for endocytic membrane fusion
41. Expression of the smg p25A (a ras p21-like GTP-binding protein) gene in human neuroblastoma cell lines and tumor tissues
42. Rab GTPases, directors of vesicle docking
43. ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif
44. Propagation of the human polyomavirus, JCV, in human neuroblastoma cell lines
45. Rab3D protein is a specific marker for zymogen granules in gastric chief cells of rats and rabbits
46. GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex
47. The ras protein family: Evolutionary tree and role of conserved amino acids
48. Sec2p Mediates Nucleotide Exchange On Sec4p and is Involved in Polarized Delivery of Post Golgi Vesicles
49. Expression and polarized targeting of a rab3 isoform in epithelial cells
50. Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells
51. Comparison of the biochemical properties of unprocessed and processed forms of the small GTP-binding protein, rab6p
52. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion
53. Structure and expression of the mouse S10 gene
54. A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae