Vps41 phosphorylation and the rab ypt7 control the targeting of the HOPS complex to Endosome-Vacuole fusion Sites

Molecular Biology of the Cell

Volumn 20, Issue 7, 2009, Pages 1937-1948

  Cabrera, Margarita ^a   Ostrowicz, Clemens W ^a   Mari, Muriel ^b   Lagrassa, Tracy J ^a,c   Reggiori, Fulvio ^b   Ungermann, Christian ^a  

^a UNIVERSITY OF OSNABRÜCK   (Germany)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Jones Day   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; MUTANT PROTEIN; PROTEIN HOPS; PROTEIN SUBUNIT; PROTEIN VPS41; RAB PROTEIN; RAB YPT7 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; BIOGENESIS; CELL JUNCTION; CELL STRUCTURE; CELL VACUOLE; COMPLEX FORMATION; ENDOSOME; MEMBRANE FUSION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTEIN TARGETING; ULTRASTRUCTURE;

ADAPTOR PROTEIN COMPLEX 3; AMINO ACID SEQUENCE; CASEIN KINASE I; CELL MEMBRANE STRUCTURES; ENDOSOMES; GTPASE-ACTIVATING PROTEINS; MEMBRANE FUSION; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTANT PROTEINS; MUTATION; PHOSPHORYLATION; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; VACUOLES; VESICULAR TRANSPORT PROTEINS;

EID: 65249126973     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E08-09-0943     Document Type: Article

References (37)

1. Albert, S., and Gallwitz, D.(1999). Two new members of a family of Ypt/Rab GTPase activating proteins. Promiscuity of substrate recognition. J. Biol. Chem. 274, 33186 -33189.
2. Anand, V. C., Daboussi, L., Lorenz, T. C., and Payne, G. S.(2009). Genome- wide analysis of AP-3 dependent protein transport in yeast. Mol. Biol. Cell 20, 1592-1604.
3. Bonangelino, C. J., Nau, J. J., Duex, J. E., Brinkman, M., Wurmser, A. E., Gary, J. D., Emr, S. D., and Weisman, L. S.(2002). Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J. Cell Biol. 156, 1015-1028.
4. Bos, J. L., Rehmann, H., and Wittinghofer, A.(2007). GEFs and GAPs: critical elements in the control of small G proteins. Cell 129, 865-877.
5. Brett,C. L.,Plemel,R. L.,Lobinger,B. T.,Vignali,M.,Fields,S.,and Merz,A. J.(2008). Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase. J. Cell Biol. 182, 1141-1151.
6. Cai, H., Reinisch, K., and Ferro-Novick, S.(2007). Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev. Cell 12, 671-682.
7. Drin, G., Morello, V., Casella, J. F., Gounon, P., and Antonny, B.(2008). Asymmetric tethering of flat and curved lipid membranes by a golgin. Science 320, 670-673.
8. Griffith, J., Mari, M., De Maziere, A., and Reggiori, F.(2008). A cryosectioning procedure for the ultrastructural analysis and the immunogold labelling of yeast Saccharomyces cerevisiae. Traffic 9, 1060-1072.
9. Gross, S. D., and Anderson, R. A.(1998). Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family. Cell Signal. 10, 699-711.
10. Haas, A.(1995). A quantitative assay to measure homotypic vacuole fusion in vitro. Methods Cell Sci. 17, 283-294.
11. Hurley, J. H., and Emr, S. D.(2006). The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annu. Rev. Biophys. Biomol. Struct. 35, 277-298.
12. Janke, C., et al.(2004). A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes. Yeast 21, 947-962.
13. LaGrassa, T. J., and Ungermann, C.(2005). The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex. J. Cell Biol. 168, 401-414.
14. Langer, J. D., Stoops, E. H., Bethune, J., and Wieland, F. T.(2007). Conformational changes of coat proteins during vesicle formation. FEBS Lett. 581, 2083-2088.
15. Lu, S., Suzuki, T., Iizuka, N., Ohshima, S., Yabu, Y., Suzuki, M., Wen, L., and Ohta, N.(2007). Trypanosoma brucei vacuolar protein sorting 41(VPS41) is required for intracellular iron utilization and maintenance of normal cellular morphology. Parasitology 134, 1639-1647.
16. Markgraf, D. F., Peplowska, K., and Ungermann, C.(2007). Rab cascades and tethering factors in the endomembrane system. FEBS Lett. 581, 2125-2130.
17. Mayer, A., Wickner, W., and Haas, A.(1996). Sec18p(NSF)-driven release of Sec17p(alpha-SNAP) can precede docking and fusion of yeast vacuoles. Cell 85, 83-94.
18. Merz, A. J., and Wickner, W. T.(2004). Trans-SNARE interactions elicit Ca2 + efflux from the yeast vacuole lumen. J. Cell Biol. 164, 195-206.
19. Nakamura, N., Hirata, A., Ohsumi, Y., and Wada, Y.(1997). Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 272, 11344-11349.
20. Ostrowicz, C. W., Meiringer, C. T., and Ungermann, C.(2008). Yeast vacuole fusion: a model system for eukaryotic endomembrane dynamics. Autophagy 4, 5-19.
21. Peplowska, K., Markgraf, D. F., Ostrowicz, C. W., Bange, G., and Ungermann, C.(2007). The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis. Dev. Cell 12, 739-750.
22. Preisinger, C., and Barr, F. A.(2005). Kinases regulating Golgi apparatus structure and function. Biochem. Soc. Symp. 15-30.
23. Puig, O., Rutz, B., Luukkonen, B. G., Kandels-Lewis, S., Bragado-Nilsson, E., and Seraphin, B.(1998). New constructs and strategies for efficient PCR-based gene manipulations in yeast. Yeast 14, 1139-1146.
24. Raymond, C. K., Howald-Stevenson, I., Vater, C. A., and Stevens, T. H.(1992). Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol. Biol. Cell. 3, 1389-1402.
25. Reggiori, F., Black, M. W., and Pelham, H. R.(2000). Polar transmembrane domains target proteins to the interior of the yeast vacuole. Mol. Biol. Cell. 11, 3737-3749.
26. Rehling, P., Darsow, T., Katzmann, D. J., and Emr, S. D.(1999). Formation of AP-3 transport intermediates requires Vps41 function. Nat. Cell Biol. 1, 346353.
27. Rieder, S. E., Banta, L. M., Kohrer, K., McCaffery, J. M., and Emr, S. D.(1996). Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant. Mol. Biol. Cell. 7, 985-999.
28. Rieder, S. E., and Emr, S. D.(1997). A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole. Mol. Biol. Cell. 8, 2307-2327.
29. Rigaut, G., Shevchenko, A., Rutz, B., Wilm, M., Mann, M., and Seraphin, B.(1999). A generic protein purification method for protein complex characterization and proteome exploration. Nat. Biotechnol. 17, 1030-1032.
30. Rink, J., Ghigo, E., Kalaidzidis, Y., and Zerial, M.(2005). Rab conversion as a mechanism of progression from early to late endosomes. Cell 122, 735-749.
31. Seals, D. F., Eitzen, G., Margolis, N., Wickner, W. T., and Price, A.(2000). A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc. Natl. Acad. Sci. USA 97, 9402-9407.
32. Starai, V. J., Hickey, C. M., and Wickner, W.(2008). HOPS Proofreads the trans-SNARE Complex for Yeast Vacuole Fusion. Mol. Biol. Cell. 19, 2500-2508.
33. Stroupe, C., Collins, K. M., Fratti, R. A., and Wickner, W.(2006). Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p. EMBO J. 25, 1579-1589.
34. Sun, B., Chen, L., Cao, W., Roth, A. F., and Davis, N. G.(2004). The yeast casein kinase Yck3p is palmitoylated, then sorted to the vacuolar membrane with AP-3-dependent recognition of a YXXPhi adaptin sorting signal. Mol. Biol. Cell. 15, 1397-1406.
35. Wang, L., Merz, A. J., Collins, K. M., and Wickner, W.(2003). Hierarchy of protein assembly at the vertex ring domain for yeast vacuole docking and fusion. J. Cell Biol. 160, 365-374.
36. Whyte, J. R., and Munro, S.(2002). Vesicle tethering complexes in membrane traffic. J. Cell Sci. 115, 2627-2637.
37. Wurmser, A. E., Sato, T. K., and Emr, S. D.(2000). New component of the vacuolar class C-Vps complex couples nucleotide exchange on the ypt7 GT- Pase to SNARE-dependent docking and fusion. J. Cell Biol. 151, 551-562.