FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates, cellular morphogenesis

Current Biology

Volumn 10, Issue 24, 2000, Pages 1603-1606

  Hattula, Katarina ^a   Peränen, Johan ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELL MEMBRANE TRANSPORT; CELL POLARITY; FIP 2 PROTEIN; GENETIC REGULATION; HUNTINGTON CHOREA; NERVE CELL; PROTEIN BINDING; PROTEIN INTERACTION; RAB PROTEIN; TUMOR NECROSIS FACTOR; TWO HYBRID SYSTEM;

EID: 0034649661     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00864-2     Document Type: Article

References (18)

1. Analysis of the Huntingtin gene reveals a trinucleotide-length polymorphism in the region of the gene that contains two CCG-rich stretches and a correlation between decreased age of onset of Huntington disease and CAG repeat number
2. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
3. Wild-type and mutant Huntingtins function in vesicle trafficking in the secretory and endocytic pathways
4. Role of Rab GTPases in membrane traffic
5. Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts
6. Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains
7. Phorbol esters and cytokines regulate the expression of the NEMO-related protein, a molecule involved in a NF-κB-independent pathway
8. Huntingtin interacts with a family of WW domain proteins
9. Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3
10. Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane
11. Expression of Huntingtin-associated protein-1 in neuronal cells implicates a role in neuritic growth
12. Glued subunit of dynactin
13. Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain
14. HIP-1: A Huntingtin interacting protein isolated by the yeast two-hybrid system
15. In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase
16. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington disease gene
17. Wild-type Huntingtin protects from apoptosis upstream of caspase-3
18. Decreased expression of striatal signaling genes in a mouse model of Huntington's disease