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Volumn 8, Issue 11, 2008, Pages 835-850

Derailed endocytosis: An emerging feature of cancer

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADAPTOR PROTEIN; ALPHAVBETA6 INTEGRIN; CADHERIN; CAVEOLIN; CBL PROTEIN; CELL SURFACE PROTEIN; CLATHRIN; GROWTH FACTOR RECEPTOR; GUANOSINE TRIPHOSPHATASE; INTEGRIN; PROTEIN TYROSINE KINASE; RAB PROTEIN; UBIQUITIN PROTEIN LIGASE NEDD4;

EID: 54549102284     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2521     Document Type: Review
Times cited : (601)

References (183)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57-70 (2000).
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0018746767 scopus 로고
    • Coated pits, coated vesicles, and receptor-mediated endocytosis
    • Goldstein, J. L., Anderson, R. G. & Brown, M. S. Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature 279, 679-685 (1979).
    • (1979) Nature , vol.279 , pp. 679-685
    • Goldstein, J.L.1    Anderson, R.G.2    Brown, M.S.3
  • 5
    • 4544375506 scopus 로고    scopus 로고
    • Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic
    • Pelkmans, L., Burli, T., Zerial, M. & Helenius, A. Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic. Cell 118, 767-780 (2004).
    • (2004) Cell , vol.118 , pp. 767-780
    • Pelkmans, L.1    Burli, T.2    Zerial, M.3    Helenius, A.4
  • 6
    • 0037598870 scopus 로고    scopus 로고
    • Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
    • Di Guglielmo, G. M., Le Roy, C., Goodfellow, A. F. & Wrana, J. L. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover. Nature Cell Biol. 5, 410-421 (2003).
    • (2003) Nature Cell Biol , vol.5 , pp. 410-421
    • Di Guglielmo, G.M.1    Le Roy, C.2    Goodfellow, A.F.3    Wrana, J.L.4
  • 7
    • 14544306526 scopus 로고    scopus 로고
    • Clathrin-independent endocytosis of ubiquitinated cargos
    • Sigismund, S. et al. Clathrin-independent endocytosis of ubiquitinated cargos. Proc. Natl Acad. Sci. USA 102, 2760-2765 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 2760-2765
    • Sigismund, S.1
  • 8
    • 0032498544 scopus 로고    scopus 로고
    • Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the Golgi apparatus
    • Llorente, A., Rapak, A., Schmid, S. L., van Deurs, B. & Sandvig, K. Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the Golgi apparatus. J. Cell Biol. 140, 553-563 (1998).
    • (1998) J. Cell Biol , vol.140 , pp. 553-563
    • Llorente, A.1    Rapak, A.2    Schmid, S.L.3    van Deurs, B.4    Sandvig, K.5
  • 9
    • 0029134736 scopus 로고
    • Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin
    • Damke, H., Baba, T., van der Bliek, A. M. & Schmid, S. L. Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin. J. Cell Biol. 131, 69-80 (1995).
    • (1995) J. Cell Biol , vol.131 , pp. 69-80
    • Damke, H.1    Baba, T.2    van der Bliek, A.M.3    Schmid, S.L.4
  • 10
    • 0035265834 scopus 로고    scopus 로고
    • Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway
    • Lamaze, C. et al. Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway. Mol. Cell 7, 661-671 (2001).
    • (2001) Mol. Cell , vol.7 , pp. 661-671
    • Lamaze, C.1
  • 11
    • 37749001768 scopus 로고    scopus 로고
    • ARF1 is directly involved in dynamin-independent endocytosis
    • Kumari, S. & Mayor, S. ARF1 is directly involved in dynamin-independent endocytosis. Nature Cell Biol. 10, 30-41 (2008).
    • (2008) Nature Cell Biol , vol.10 , pp. 30-41
    • Kumari, S.1    Mayor, S.2
  • 12
    • 27144493410 scopus 로고    scopus 로고
    • Abi1 regulates the activity of N.-WASP and WAVE in distinct actin-based processes
    • Innocenti, M. et al. Abi1 regulates the activity of N.-WASP and WAVE in distinct actin-based processes. Nature Cell Biol. 7, 969-976 (2005).
    • (2005) Nature Cell Biol , vol.7 , pp. 969-976
    • Innocenti, M.1
  • 13
    • 33645741605 scopus 로고    scopus 로고
    • Orth, J. D., Krueger, E. W., Weller, S. G. & McNiven, M. A. A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization. Cancer Res. 66, 3603-3610 (2006).
    • Orth, J. D., Krueger, E. W., Weller, S. G. & McNiven, M. A. A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization. Cancer Res. 66, 3603-3610 (2006).
  • 14
    • 2442650416 scopus 로고    scopus 로고
    • Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases
    • Lanzetti, L., Palamidessi, A., Areces, L., Scita, G. & Di Fiore, P. P. Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases. Nature 429, 309-314 (2004).
    • (2004) Nature , vol.429 , pp. 309-314
    • Lanzetti, L.1    Palamidessi, A.2    Areces, L.3    Scita, G.4    Di Fiore, P.P.5
  • 15
    • 0027977943 scopus 로고
    • E-cadherin gene mutations provide clues to diffuse type gastric carcinomas
    • Becker, K. F. et al. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res. 54, 3845-3852 (1994).
    • (1994) Cancer Res , vol.54 , pp. 3845-3852
    • Becker, K.F.1
  • 16
    • 10744227205 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3
    • Ohashi, M. et al. Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3. Virology 320, 52-62 (2004).
    • (2004) Virology , vol.320 , pp. 52-62
    • Ohashi, M.1
  • 17
    • 0037383848 scopus 로고    scopus 로고
    • Polarized epithelial membrane traffic: Conservation and plasticity
    • Mostov, K., Su, T. & ter Beest, M. Polarized epithelial membrane traffic: conservation and plasticity. Nature Cell Biol. 5, 287-293 (2003).
    • (2003) Nature Cell Biol , vol.5 , pp. 287-293
    • Mostov, K.1    Su, T.2    ter Beest, M.3
  • 18
    • 42049101203 scopus 로고    scopus 로고
    • Clathrin is a key regulator of basolateral polarity
    • This important paper describes for the first time a requirement for clathrin in polarized sorting of proteins to the basolateral membrane
    • Deborde, S. et al. Clathrin is a key regulator of basolateral polarity. Nature 452, 719-723 (2008). This important paper describes for the first time a requirement for clathrin in polarized sorting of proteins to the basolateral membrane.
    • (2008) Nature , vol.452 , pp. 719-723
    • Deborde, S.1
  • 19
    • 34548295310 scopus 로고    scopus 로고
    • Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic
    • Balklava, Z., Pant, S., Fares, H. & Grant, B. D. Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic. Nature Cell Biol. 9, 1066-1073 (2007).
    • (2007) Nature Cell Biol , vol.9 , pp. 1066-1073
    • Balklava, Z.1    Pant, S.2    Fares, H.3    Grant, B.D.4
  • 20
    • 0242666126 scopus 로고    scopus 로고
    • A genetic screen in Drosophila for metastatic behavior
    • Pagliarini, R. A. & Xu, T. A genetic screen in Drosophila for metastatic behavior. Science 302, 1227-1231 (2003).
    • (2003) Science , vol.302 , pp. 1227-1231
    • Pagliarini, R.A.1    Xu, T.2
  • 21
    • 33646136870 scopus 로고    scopus 로고
    • A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells
    • This interesting study identifies CDC42-associated proteins involved in the maintenance of TJs and trafficking of junctional proteins
    • Wells, C. D. et al. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell 125, 535-548 (2006). This interesting study identifies CDC42-associated proteins involved in the maintenance of TJs and trafficking of junctional proteins.
    • (2006) Cell , vol.125 , pp. 535-548
    • Wells, C.D.1
  • 22
    • 33745754458 scopus 로고    scopus 로고
    • JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin
    • Terai, T., Nishimura, N., Kanda, I., Yasui, N. & Sasaki, T. JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. Mol. Biol. Cell 17, 2465-2475 (2006).
    • (2006) Mol. Biol. Cell , vol.17 , pp. 2465-2475
    • Terai, T.1    Nishimura, N.2    Kanda, I.3    Yasui, N.4    Sasaki, T.5
  • 23
    • 3242699514 scopus 로고    scopus 로고
    • Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer
    • Kamai, T. et al. Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin. Cancer Res. 10, 4799-4805 (2004).
    • (2004) Clin. Cancer Res , vol.10 , pp. 4799-4805
    • Kamai, T.1
  • 24
    • 1542777034 scopus 로고    scopus 로고
    • Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
    • Baas, A. F. et al. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 116, 457-466 (2004).
    • (2004) Cell , vol.116 , pp. 457-466
    • Baas, A.F.1
  • 25
    • 20544459380 scopus 로고    scopus 로고
    • Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function
    • Gangar, A., Rossi, G., Andreeva, A., Hales, R. & Brennwald, P. Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function. Curr. Biol. 15, 1136-1142 (2005).
    • (2005) Curr. Biol , vol.15 , pp. 1136-1142
    • Gangar, A.1    Rossi, G.2    Andreeva, A.3    Hales, R.4    Brennwald, P.5
  • 26
    • 22944450057 scopus 로고    scopus 로고
    • Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis
    • Zhang, X. et al. Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis. J. Cell Biol. 170, 273-283 (2005).
    • (2005) J. Cell Biol , vol.170 , pp. 273-283
    • Zhang, X.1
  • 27
    • 24644490121 scopus 로고    scopus 로고
    • Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer
    • Eder, A. M. et al. Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc. Natl Acad. Sci. USA 102, 12519-12524 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 12519-12524
    • Eder, A.M.1
  • 28
    • 30044446588 scopus 로고    scopus 로고
    • Expression of Hugl-1 is strongly reduced in malignant melanoma
    • Kuphal, S. et al. Expression of Hugl-1 is strongly reduced in malignant melanoma. Oncogene 25, 103-110 (2006).
    • (2006) Oncogene , vol.25 , pp. 103-110
    • Kuphal, S.1
  • 29
    • 33750489040 scopus 로고    scopus 로고
    • Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling
    • Wang, Y. et al. Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. EMBO J. 25, 5058-5070 (2006).
    • (2006) EMBO J , vol.25 , pp. 5058-5070
    • Wang, Y.1
  • 30
    • 33750505436 scopus 로고    scopus 로고
    • Aranda, V. et al. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nature Cell Biol. 8, 1235-1245 (2006). This manuscript provides insights into the disruption of cell polarity by growth factor receptors, involving recruitment of the PAR6-aPKC complex to activated ERBB2.
    • Aranda, V. et al. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nature Cell Biol. 8, 1235-1245 (2006). This manuscript provides insights into the disruption of cell polarity by growth factor receptors, involving recruitment of the PAR6-aPKC complex to activated ERBB2.
  • 31
    • 0035941291 scopus 로고    scopus 로고
    • Okuda, H. et al. The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J. Biol. Chem. 276, 43611-43617 (2001).
    • Okuda, H. et al. The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J. Biol. Chem. 276, 43611-43617 (2001).
  • 32
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, β-catenin, and cadherin pathways
    • Nelson, W. J. & Nusse, R. Convergence of Wnt, β-catenin, and cadherin pathways. Science 303, 1483-1487 (2004).
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 33
    • 0345736990 scopus 로고    scopus 로고
    • Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
    • Lu, Z., Ghosh, S., Wang, Z. & Hunter, T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion. Cancer Cell 4, 499-515 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 499-515
    • Lu, Z.1    Ghosh, S.2    Wang, Z.3    Hunter, T.4
  • 34
    • 33744533446 scopus 로고    scopus 로고
    • Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin
    • Kimura, T., Sakisaka, T., Baba, T., Yamada, T. & Takai, Y. Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin. J. Biol. Chem. 281, 10598-10609 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 10598-10609
    • Kimura, T.1    Sakisaka, T.2    Baba, T.3    Yamada, T.4    Takai, Y.5
  • 35
    • 34250628372 scopus 로고    scopus 로고
    • EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin
    • Bryant, D. M. et al. EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. J. Cell Sci. 120, 1818-1828 (2007).
    • (2007) J. Cell Sci , vol.120 , pp. 1818-1828
    • Bryant, D.M.1
  • 36
    • 0036121308 scopus 로고    scopus 로고
    • Fujita, Y. et al. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nature Cell Biol. 4, 222-231 (2002). An interesting paper that identified the E3 ligase of E-cadherin and described a role for ubiquitin-dependent downregulation of E-cadherin in the breakdown of cell-cell junctions.
    • Fujita, Y. et al. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nature Cell Biol. 4, 222-231 (2002). An interesting paper that identified the E3 ligase of E-cadherin and described a role for ubiquitin-dependent downregulation of E-cadherin in the breakdown of cell-cell junctions.
  • 37
    • 33750529948 scopus 로고    scopus 로고
    • VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin
    • Gavard, J. & Gutkind, J. S. VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin. Nature Cell Biol. 8, 1223-1234 (2006).
    • (2006) Nature Cell Biol , vol.8 , pp. 1223-1234
    • Gavard, J.1    Gutkind, J.S.2
  • 38
    • 34347205268 scopus 로고    scopus 로고
    • Inhibition of tumor growth and metastasis by depletion of vesicular sorting protein Hrs: Its regulatory role on E-cadherin and β-catenin
    • Toyoshima, M. et al. Inhibition of tumor growth and metastasis by depletion of vesicular sorting protein Hrs: its regulatory role on E-cadherin and β-catenin. Cancer Res. 67, 5162-5171 (2007).
    • (2007) Cancer Res , vol.67 , pp. 5162-5171
    • Toyoshima, M.1
  • 39
    • 37848998838 scopus 로고    scopus 로고
    • Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia
    • Gavard, J., Patel, V. & Gutkind, J. S. Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev. Cell 14, 25-36 (2008).
    • (2008) Dev. Cell , vol.14 , pp. 25-36
    • Gavard, J.1    Patel, V.2    Gutkind, J.S.3
  • 40
    • 37749041462 scopus 로고    scopus 로고
    • Morishige, M. et al. GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. Nature Cell Biol. 10, 85-92 (2008). This key paper describes a direct interaction between the ARF6 GEF, GEP100, and activated EGFR, which is necessary for invasiveness of breast cancer cells.
    • Morishige, M. et al. GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. Nature Cell Biol. 10, 85-92 (2008). This key paper describes a direct interaction between the ARF6 GEF, GEP100, and activated EGFR, which is necessary for invasiveness of breast cancer cells.
  • 41
    • 41049110037 scopus 로고    scopus 로고
    • The N-Myc down regulated gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin
    • Kachhap, S. K. et al. The N-Myc down regulated gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin. PLoS ONE 2, e844 (2007).
    • (2007) PLoS ONE , vol.2
    • Kachhap, S.K.1
  • 42
    • 27844507514 scopus 로고    scopus 로고
    • E-cadherin endocytosis regulates the activity of Rap1: A traffic light GTPase at the crossroads between cadherin and integrin function
    • Balzac, F. et al. E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. J. Cell Sci. 118, 4765-4783 (2005).
    • (2005) J. Cell Sci , vol.118 , pp. 4765-4783
    • Balzac, F.1
  • 43
    • 29744437549 scopus 로고    scopus 로고
    • Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland
    • Davis, M. A. & Reynolds, A. B. Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland. Dev. Cell 10, 21-31 (2006).
    • (2006) Dev. Cell , vol.10 , pp. 21-31
    • Davis, M.A.1    Reynolds, A.B.2
  • 44
    • 0242456020 scopus 로고    scopus 로고
    • p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions
    • Chen, X., Kojima, S., Borisy, G. G. & Green, K. J. p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions. J. Cell Biol. 163, 547-557 (2003).
    • (2003) J. Cell Biol , vol.163 , pp. 547-557
    • Chen, X.1    Kojima, S.2    Borisy, G.G.3    Green, K.J.4
  • 46
    • 0035576259 scopus 로고    scopus 로고
    • Decreased expression of catenins (α and β), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas
    • Kallakury, B. V. et al. Decreased expression of catenins (α and β), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas. Cancer 92, 2786-2795 (2001).
    • (2001) Cancer , vol.92 , pp. 2786-2795
    • Kallakury, B.V.1
  • 47
    • 28244483194 scopus 로고    scopus 로고
    • Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease
    • Bellovin, D. I., Bates, R. C., Muzikansky, A., Rimm, D. L. & Mercurio, A. M. Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. Cancer Res. 65, 10938-10945 (2005).
    • (2005) Cancer Res , vol.65 , pp. 10938-10945
    • Bellovin, D.I.1    Bates, R.C.2    Muzikansky, A.3    Rimm, D.L.4    Mercurio, A.M.5
  • 48
    • 34047174559 scopus 로고    scopus 로고
    • A module of negative feedback regulators defines growth factor signaling
    • Amit, I. et al. A module of negative feedback regulators defines growth factor signaling. Nature Genet. 39, 503-512 (2007).
    • (2007) Nature Genet , vol.39 , pp. 503-512
    • Amit, I.1
  • 49
    • 0037213006 scopus 로고    scopus 로고
    • Computational modeling of the EGF-receptor system: A paradigm for systems biology
    • Wiley, H. S., Shvartsman, S. Y. & Lauffenburger, D. A. Computational modeling of the EGF-receptor system: a paradigm for systems biology. Trends Cell Biol. 13, 43-50 (2003).
    • (2003) Trends Cell Biol , vol.13 , pp. 43-50
    • Wiley, H.S.1    Shvartsman, S.Y.2    Lauffenburger, D.A.3
  • 51
    • 0033392493 scopus 로고    scopus 로고
    • Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
    • Levkowitz, G. et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol. Cell 4, 1029-1040 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 1029-1040
    • Levkowitz, G.1
  • 52
    • 14844349947 scopus 로고
    • Epidermal growth factor and transforming growth factor-α: Differential intracellular routing and processing of ligand-receptor complexes
    • Ebner, R. & Derynck, R. Epidermal growth factor and transforming growth factor-α: differential intracellular routing and processing of ligand-receptor complexes. Cell Reg. 2, 599-612 (1991).
    • (1991) Cell Reg , vol.2 , pp. 599-612
    • Ebner, R.1    Derynck, R.2
  • 53
    • 0037018146 scopus 로고    scopus 로고
    • Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies
    • Longva, K. E. et al. Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies. J. Cell Biol. 156, 843-854 (2002).
    • (2002) J. Cell Biol , vol.156 , pp. 843-854
    • Longva, K.E.1
  • 54
    • 35948986723 scopus 로고    scopus 로고
    • Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathways
    • Belleudi, F. et al. Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathways. Traffic 8, 1854-1872 (2007).
    • (2007) Traffic , vol.8 , pp. 1854-1872
    • Belleudi, F.1
  • 56
    • 0028224965 scopus 로고
    • Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions
    • French, A. R., Sudlow, G. P., Wiley, H. S. & Lauffenburger, D. A. Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions. J. Biol. Chem. 269, 15749-15755 (1994).
    • (1994) J. Biol. Chem , vol.269 , pp. 15749-15755
    • French, A.R.1    Sudlow, G.P.2    Wiley, H.S.3    Lauffenburger, D.A.4
  • 57
    • 0032526729 scopus 로고    scopus 로고
    • Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers
    • Lenferink, A. E. et al. Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J. 17, 3385-3397 (1998).
    • (1998) EMBO J , vol.17 , pp. 3385-3397
    • Lenferink, A.E.1
  • 58
    • 0033605560 scopus 로고    scopus 로고
    • ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors
    • Worthylake, R., Opresko, L. K. & Wiley, H. S. ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors. J. Biol. Chem. 274, 8865-8874 (1999).
    • (1999) J. Biol. Chem , vol.274 , pp. 8865-8874
    • Worthylake, R.1    Opresko, L.K.2    Wiley, H.S.3
  • 59
    • 1642422374 scopus 로고    scopus 로고
    • Association with membrane protrusions makes ErbB2 an internalization-resistant receptor
    • Hommelgaard, A. M., Lerdrup, M. & van Deurs, B. Association with membrane protrusions makes ErbB2 an internalization-resistant receptor. Mol. Biol. Cell 15, 1557-1567 (2004).
    • (2004) Mol. Biol. Cell , vol.15 , pp. 1557-1567
    • Hommelgaard, A.M.1    Lerdrup, M.2    van Deurs, B.3
  • 60
    • 12144266330 scopus 로고    scopus 로고
    • Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation
    • 1165-1170
    • Citri, A. et al. Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation. EMBO Rep. 5, 1165-1170 (2004).
    • (2004) EMBO Rep , vol.5
    • Citri, A.1
  • 61
    • 31644439697 scopus 로고    scopus 로고
    • Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way
    • Lerdrup, M., Hommelgaard, A. M., Grandal, M. & van Deurs, B. Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way. J. Cell Sci. 119, 85-95 (2006).
    • (2006) J. Cell Sci , vol.119 , pp. 85-95
    • Lerdrup, M.1    Hommelgaard, A.M.2    Grandal, M.3    van Deurs, B.4
  • 62
    • 0034714283 scopus 로고    scopus 로고
    • Geldanamycin induces ErbB-2 degradation by proteolytic fragmentation
    • Tikhomirov, O. & Carpenter, G. Geldanamycin induces ErbB-2 degradation by proteolytic fragmentation. J. Biol. Chem. 275, 26625-26631 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 26625-26631
    • Tikhomirov, O.1    Carpenter, G.2
  • 63
    • 0042208398 scopus 로고    scopus 로고
    • The Her-2/neu gene and protein in breast cancer 2003: Biomarker and target of therapy
    • Ross, J. S. et al. The Her-2/neu gene and protein in breast cancer 2003: biomarker and target of therapy. Oncologist 8, 307-325 (2003).
    • (2003) Oncologist , vol.8 , pp. 307-325
    • Ross, J.S.1
  • 64
    • 0033536637 scopus 로고    scopus 로고
    • The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
    • Joazeiro, C. A. et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286, 309-312 (1999).
    • (1999) Science , vol.286 , pp. 309-312
    • Joazeiro, C.A.1
  • 65
    • 33746797288 scopus 로고    scopus 로고
    • Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases
    • Oved, S. et al. Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases. J. Biol. Chem. 281, 21640-21651 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 21640-21651
    • Oved, S.1
  • 66
    • 0033615732 scopus 로고    scopus 로고
    • Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7
    • Yokouchi, M. et al. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J. Biol. Chem. 274, 31707-31712 (1999).
    • (1999) J. Biol. Chem , vol.274 , pp. 31707-31712
    • Yokouchi, M.1
  • 67
    • 0024593048 scopus 로고    scopus 로고
    • Langdon, W. Y., Hartley, J. W., Klinken, S. P., Ruscetti, S. K. & Morse, H. C. 3rd. v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc. Natl. Acad. Sci. USA 86, 1168-1172 (1989).
    • Langdon, W. Y., Hartley, J. W., Klinken, S. P., Ruscetti, S. K. & Morse, H. C. 3rd. v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc. Natl. Acad. Sci. USA 86, 1168-1172 (1989).
  • 68
    • 12044256844 scopus 로고
    • Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene
    • Andoniou, C. E., Thien, C. B. & Langdon, W. Y. Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J. 13, 4515-4523 (1994).
    • (1994) EMBO J , vol.13 , pp. 4515-4523
    • Andoniou, C.E.1    Thien, C.B.2    Langdon, W.Y.3
  • 69
    • 34547946211 scopus 로고    scopus 로고
    • Flt3-dependent transformation by inactivating c-Cbl mutations in AML
    • First description of a Cbl mutation in human cancer, correlating with impaired downregulation of the RTK FLT3
    • Sargin, B. et al. Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood 110, 1004-1012 (2007). First description of a Cbl mutation in human cancer, correlating with impaired downregulation of the RTK FLT3.
    • (2007) Blood , vol.110 , pp. 1004-1012
    • Sargin, B.1
  • 70
    • 34250375116 scopus 로고    scopus 로고
    • E3-independent monoubiquitination of ubiquitin-binding proteins
    • Hoeller, D. et al. E3-independent monoubiquitination of ubiquitin-binding proteins. Mol. Cell 26, 891-898 (2007).
    • (2007) Mol. Cell , vol.26 , pp. 891-898
    • Hoeller, D.1
  • 71
    • 34547730932 scopus 로고    scopus 로고
    • EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes
    • Grandal, M. V. et al. EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes. Carcinogenesis 28, 1408-1417 (2007).
    • (2007) Carcinogenesis , vol.28 , pp. 1408-1417
    • Grandal, M.V.1
  • 72
    • 33751109238 scopus 로고    scopus 로고
    • Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII
    • Han, W., Zhang, T., Yu, H., Foulke, J. G. & Tang, C. K. Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII. Cancer Biol. Ther. 5, 1361-1368 (2006).
    • (2006) Cancer Biol. Ther , vol.5 , pp. 1361-1368
    • Han, W.1    Zhang, T.2    Yu, H.3    Foulke, J.G.4    Tang, C.K.5
  • 73
    • 35549013373 scopus 로고    scopus 로고
    • Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling
    • Shtiegman, K. et al. Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling. Oncogene 26, 6968-6978 (2007).
    • (2007) Oncogene , vol.26 , pp. 6968-6978
    • Shtiegman, K.1
  • 74
    • 33746899628 scopus 로고    scopus 로고
    • Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors
    • Yang, S. et al. Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors. Cancer Res. 66, 6990-6997 (2006).
    • (2006) Cancer Res , vol.66 , pp. 6990-6997
    • Yang, S.1
  • 75
    • 40449095964 scopus 로고    scopus 로고
    • Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking
    • Khan, E. M., Lanir, R., Danielson, A. R. & Goldkorn, T. Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking. FASEB J. 22, 910-917 (2008).
    • (2008) FASEB J , vol.22 , pp. 910-917
    • Khan, E.M.1    Lanir, R.2    Danielson, A.R.3    Goldkorn, T.4
  • 76
    • 27144512084 scopus 로고    scopus 로고
    • Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation
    • Abella, J. V. et al. Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Mol. Cell. Biol. 25, 9632-9645 (2005).
    • (2005) Mol. Cell. Biol , vol.25 , pp. 9632-9645
    • Abella, J.V.1
  • 77
    • 11144244315 scopus 로고    scopus 로고
    • Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl)
    • Zeng, S., Xu, Z., Lipkowitz, S. & Longley, J. B. Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl). Blood 105, 226-232 (2005).
    • (2005) Blood , vol.105 , pp. 226-232
    • Zeng, S.1    Xu, Z.2    Lipkowitz, S.3    Longley, J.B.4
  • 78
    • 0037418192 scopus 로고    scopus 로고
    • Src promotes destruction of c-Cbl: Implications for oncogenic synergy between Src and growth factor receptors
    • Bao, J., Gur, G. & Yarden, Y. Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors. Proc. Natl Acad. Sci. USA 100, 2438-2443 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 2438-2443
    • Bao, J.1    Gur, G.2    Yarden, Y.3
  • 79
    • 0037034869 scopus 로고    scopus 로고
    • Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation
    • Howlett, C. J. & Robbins, S. M. Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation. Oncogene 21, 1707-1716 (2002).
    • (2002) Oncogene , vol.21 , pp. 1707-1716
    • Howlett, C.J.1    Robbins, S.M.2
  • 80
    • 0035860713 scopus 로고    scopus 로고
    • Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins
    • Yokouchi, M. et al. Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins. J. Biol. Chem. 276, 35185-35193 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 35185-35193
    • Yokouchi, M.1
  • 81
    • 0033573921 scopus 로고    scopus 로고
    • Mechanism of biological synergy between cellular Src and epidermal growth factor receptor
    • Tice, D. A., Biscardi, J. S., Nickles, A. L. & Parsons, S. J. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc. Natl Acad. Sci. USA 96, 1415-1420 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 1415-1420
    • Tice, D.A.1    Biscardi, J.S.2    Nickles, A.L.3    Parsons, S.J.4
  • 82
    • 0037160125 scopus 로고    scopus 로고
    • Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH
    • Courbard, J. R. et al. Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH. J. Biol. Chem. 277, 45267-45275 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 45267-45275
    • Courbard, J.R.1
  • 83
    • 0242290342 scopus 로고    scopus 로고
    • WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation
    • Magnifico, A. et al. WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation. J. Biol. Chem. 278, 43169-43177 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 43169-43177
    • Magnifico, A.1
  • 84
    • 0141426629 scopus 로고    scopus 로고
    • Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation
    • Wu, W. J., Tu, S. & Cerione, R. A. Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell 114, 715-725 (2003).
    • (2003) Cell , vol.114 , pp. 715-725
    • Wu, W.J.1    Tu, S.2    Cerione, R.A.3
  • 85
    • 0037048326 scopus 로고    scopus 로고
    • Rho GTPases in human breast tumours: Expression and mutation analyses and correlation with clinical parameters
    • Fritz, G., Brachetti, C., Bahlmann, F., Schmidt, M. & Kaina, B. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br. J. Cancer 87, 635-644 (2002).
    • (2002) Br. J. Cancer , vol.87 , pp. 635-644
    • Fritz, G.1    Brachetti, C.2    Bahlmann, F.3    Schmidt, M.4    Kaina, B.5
  • 86
    • 0037452567 scopus 로고    scopus 로고
    • hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl
    • Hall, A. B. et al. hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Curr. Biol. 13, 308-314 (2003).
    • (2003) Curr. Biol , vol.13 , pp. 308-314
    • Hall, A.B.1
  • 87
    • 0242684548 scopus 로고    scopus 로고
    • Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
    • Rubin, C. et al. Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops. Curr. Biol. 13, 297-307 (2003).
    • (2003) Curr. Biol , vol.13 , pp. 297-307
    • Rubin, C.1
  • 88
    • 4344660712 scopus 로고    scopus 로고
    • The ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer
    • Lo, T. L. et al. The ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer. Cancer Res. 64, 6127-6136 (2004).
    • (2004) Cancer Res , vol.64 , pp. 6127-6136
    • Lo, T.L.1
  • 89
    • 3142780658 scopus 로고    scopus 로고
    • The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer
    • Kwabi-Addo, B. et al. The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer. Cancer Res. 64, 4728-4735 (2004).
    • (2004) Cancer Res , vol.64 , pp. 4728-4735
    • Kwabi-Addo, B.1
  • 90
    • 0036714223 scopus 로고    scopus 로고
    • Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits
    • Merrifield, C. J., Feldman, M. E., Wan, L. & Almers, W. Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits. Nature Cell Biol. 4, 691-698 (2002).
    • (2002) Nature Cell Biol , vol.4 , pp. 691-698
    • Merrifield, C.J.1    Feldman, M.E.2    Wan, L.3    Almers, W.4
  • 91
    • 0344827286 scopus 로고    scopus 로고
    • A pathway for association of receptors, adaptors, and actin during endocytic internalization
    • Kaksonen, M., Sun, Y. & Drubin, D. G. A pathway for association of receptors, adaptors, and actin during endocytic internalization. Cell 115, 475-487 (2003).
    • (2003) Cell , vol.115 , pp. 475-487
    • Kaksonen, M.1    Sun, Y.2    Drubin, D.G.3
  • 92
    • 0037205440 scopus 로고    scopus 로고
    • HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain
    • Legendre-Guillemin, V. et al. HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain. J. Biol. Chem. 277, 19897-19904 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 19897-19904
    • Legendre-Guillemin, V.1
  • 93
    • 1642464687 scopus 로고    scopus 로고
    • RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery
    • Engqvist-Goldstein, A. E. et al. RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery. Mol. Biol. Cell 15, 1666-1679 (2004).
    • (2004) Mol. Biol. Cell , vol.15 , pp. 1666-1679
    • Engqvist-Goldstein, A.E.1
  • 94
    • 0036329137 scopus 로고    scopus 로고
    • Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival
    • Rao, D. S. et al. Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. J. Clin. Invest. 110, 351-360 (2002).
    • (2002) J. Clin. Invest , vol.110 , pp. 351-360
    • Rao, D.S.1
  • 95
    • 34248596012 scopus 로고    scopus 로고
    • Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor
    • Bradley, S. V. et al. Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor. Cancer Res. 67, 3609-3615 (2007).
    • (2007) Cancer Res , vol.67 , pp. 3609-3615
    • Bradley, S.V.1
  • 96
    • 1242266718 scopus 로고    scopus 로고
    • Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells
    • Rao, D. S. et al. Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells. Cancer Cell 3, 471-482 (2003).
    • (2003) Cancer Cell , vol.3 , pp. 471-482
    • Rao, D.S.1
  • 97
    • 17144399942 scopus 로고    scopus 로고
    • Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor
    • Timpson, P., Lynch, D. K., Schramek, D., Walker, F. & Daly, R. J. Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor. Cancer Res. 65, 3273-3280 (2005).
    • (2005) Cancer Res , vol.65 , pp. 3273-3280
    • Timpson, P.1    Lynch, D.K.2    Schramek, D.3    Walker, F.4    Daly, R.J.5
  • 98
    • 0000272957 scopus 로고
    • Isolation of yeast mutants defective in protein targeting to the vacuole
    • Bankaitis, V. A., Johnson, L. M. & Emr, S. D. Isolation of yeast mutants defective in protein targeting to the vacuole. Proc. Natl Acad. Sci. USA 83, 9075-9079 (1986).
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 9075-9079
    • Bankaitis, V.A.1    Johnson, L.M.2    Emr, S.D.3
  • 99
    • 0022470653 scopus 로고
    • Overproduction-induced mislocalization of a yeast vacuolar protein allows isolation of its structural gene
    • Rothman, J. H., Hunter, C. P., Valls, L. A. & Stevens, T. H. Overproduction-induced mislocalization of a yeast vacuolar protein allows isolation of its structural gene. Proc. Natl Acad. Sci. USA 83, 3248-3252 (1986).
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 3248-3252
    • Rothman, J.H.1    Hunter, C.P.2    Valls, L.A.3    Stevens, T.H.4
  • 100
    • 0027083496 scopus 로고
    • Morphological classification of the yeast vacuolar protein sorting mutants: Evidence for a prevacuolar compartment in class E vps mutants
    • Raymond, C. K., Howald-Stevenson, I., Vater, C. A. & Stevens, T. H. Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol. Biol. Cell 3, 1389-1402 (1992).
    • (1992) Mol. Biol. Cell , vol.3 , pp. 1389-1402
    • Raymond, C.K.1    Howald-Stevenson, I.2    Vater, C.A.3    Stevens, T.H.4
  • 101
  • 102
    • 33744768359 scopus 로고    scopus 로고
    • The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor
    • Bache, K. G. et al. The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol. Biol. Cell 17, 2513-2523 (2006).
    • (2006) Mol. Biol. Cell , vol.17 , pp. 2513-2523
    • Bache, K.G.1
  • 103
    • 23844481792 scopus 로고    scopus 로고
    • Depletion of TSG101 forms a mammalian 'Class E' compartment: A multicisternal early endosome with multiple sorting defects
    • Doyotte, A., Russell, M. R., Hopkins, C. R. & Woodman, P. G. Depletion of TSG101 forms a mammalian 'Class E' compartment: a multicisternal early endosome with multiple sorting defects. J. Cell Sci. 118, 3003-3017 (2005).
    • (2005) J. Cell Sci , vol.118 , pp. 3003-3017
    • Doyotte, A.1    Russell, M.R.2    Hopkins, C.R.3    Woodman, P.G.4
  • 104
    • 27644593284 scopus 로고    scopus 로고
    • Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth
    • Moberg, K. H., Schelble, S., Burdick, S. K. & Hariharan, I. K. Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev. Cell 9, 699-710 (2005).
    • (2005) Dev. Cell , vol.9 , pp. 699-710
    • Moberg, K.H.1    Schelble, S.2    Burdick, S.K.3    Hariharan, I.K.4
  • 105
    • 27644498439 scopus 로고    scopus 로고
    • Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila
    • Thompson, B. J. et al. Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev. Cell 9, 711-720 (2005).
    • (2005) Dev. Cell , vol.9 , pp. 711-720
    • Thompson, B.J.1
  • 106
    • 27644568520 scopus 로고    scopus 로고
    • The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking
    • Vaccari, T. & Bilder, D. The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev. Cell 9, 687-698 (2005).
    • (2005) Dev. Cell , vol.9 , pp. 687-698
    • Vaccari, T.1    Bilder, D.2
  • 107
    • 0029904430 scopus 로고    scopus 로고
    • Tsg101: A novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells
    • Li, L. & Cohen, S. N. Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. Cell 85, 319-329 (1996).
    • (1996) Cell , vol.85 , pp. 319-329
    • Li, L.1    Cohen, S.N.2
  • 108
    • 0037216740 scopus 로고    scopus 로고
    • Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues
    • Wagner, K. U. et al. Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Mol. Cell Biol. 23, 150-162 (2003).
    • (2003) Mol. Cell Biol , vol.23 , pp. 150-162
    • Wagner, K.U.1
  • 109
    • 4143110407 scopus 로고    scopus 로고
    • Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells
    • Carstens, M. J., Krempler, A., Triplett, A. A., Van Lohuizen, M. & Wagner, K. U. Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells. J. Biol. Chem. 279, 35984-35994 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 35984-35994
    • Carstens, M.J.1    Krempler, A.2    Triplett, A.A.3    Van Lohuizen, M.4    Wagner, K.U.5
  • 110
    • 1542510121 scopus 로고    scopus 로고
    • Reduction of TSG101 protein has a negative impact on tumor cell growth
    • Zhu, G. et al. Reduction of TSG101 protein has a negative impact on tumor cell growth. Int. J. Cancer 109, 541-547 (2004).
    • (2004) Int. J. Cancer , vol.109 , pp. 541-547
    • Zhu, G.1
  • 111
    • 35148830693 scopus 로고    scopus 로고
    • Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation
    • Oh, K. B., Stanton, M. J., West, W. W., Todd, G. L. & Wagner, K. U. Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. Oncogene 26, 5950-5959 (2007).
    • (2007) Oncogene , vol.26 , pp. 5950-5959
    • Oh, K.B.1    Stanton, M.J.2    West, W.W.3    Todd, G.L.4    Wagner, K.U.5
  • 112
    • 0242690219 scopus 로고    scopus 로고
    • HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein
    • Xu, Z., Liang, L., Wang, H., Li, T. & Zhao, M. HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein. Biochem. Biophys. Res. Commun. 311, 1057-1066 (2003).
    • (2003) Biochem. Biophys. Res. Commun , vol.311 , pp. 1057-1066
    • Xu, Z.1    Liang, L.2    Wang, H.3    Li, T.4    Zhao, M.5
  • 113
    • 33748466150 scopus 로고    scopus 로고
    • Endocytic recycling pathways: Emerging regulators of cell migration
    • Jones, M. C., Caswell, P. T. & Norman, J. C. Endocytic recycling pathways: emerging regulators of cell migration. Curr. Opin. Cell Biol. 18, 549-557 (2006).
    • (2006) Curr. Opin. Cell Biol , vol.18 , pp. 549-557
    • Jones, M.C.1    Caswell, P.T.2    Norman, J.C.3
  • 114
    • 0027232315 scopus 로고
    • The αvβ5 integrin receptor regulates receptor-mediated endocytosis of vitronectin
    • Panetti, T. S. & McKeown-Longo, P. J. The αvβ5 integrin receptor regulates receptor-mediated endocytosis of vitronectin. J. Biol. Chem. 268, 11492-11495 (1993).
    • (1993) J. Biol. Chem , vol.268 , pp. 11492-11495
    • Panetti, T.S.1    McKeown-Longo, P.J.2
  • 115
    • 0024349831 scopus 로고
    • Endocytosis and recycling of the fibronectin receptor in CHO cells
    • Bretscher, M. S. Endocytosis and recycling of the fibronectin receptor in CHO cells. EMBO J. 8, 1341-1348 (1989).
    • (1989) EMBO J , vol.8 , pp. 1341-1348
    • Bretscher, M.S.1
  • 116
    • 0037350449 scopus 로고    scopus 로고
    • Real-time analysis of clathrin-mediated endocytosis during cell migration
    • Rappoport, J. Z. & Simon, S. M. Real-time analysis of clathrin-mediated endocytosis during cell migration. J. Cell Sci. 116, 847-855 (2003).
    • (2003) J. Cell Sci , vol.116 , pp. 847-855
    • Rappoport, J.Z.1    Simon, S.M.2
  • 117
    • 0035908956 scopus 로고    scopus 로고
    • PDGF-regulated rab4-dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading
    • Roberts, M., Barry, S., Woods, A., van der Sluijs, P. & Norman, J. PDGF-regulated rab4-dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading. Curr. Biol. 11, 1392-1402 (2001).
    • (2001) Curr. Biol , vol.11 , pp. 1392-1402
    • Roberts, M.1    Barry, S.2    Woods, A.3    van der Sluijs, P.4    Norman, J.5
  • 118
    • 0036629339 scopus 로고    scopus 로고
    • Role of the β1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia
    • Gustavsson, A. et al. Role of the β1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia. J. Cell Sci. 115, 669-2678 (2002).
    • (2002) J. Cell Sci , vol.115 , pp. 669-2678
    • Gustavsson, A.1
  • 119
    • 0033799367 scopus 로고    scopus 로고
    • Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation
    • Sanlioglu, S. et al. Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation. J. Virol. 74, 9184-9196 (2000).
    • (2000) J. Virol , vol.74 , pp. 9184-9196
    • Sanlioglu, S.1
  • 120
    • 20444370219 scopus 로고    scopus 로고
    • Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
    • An important study that provides novel insights into the regulation of cell migration by microtubule-dependent dissolution of focal adhesions
    • Ezratty, E. J., Partridge, M. A. & Gundersen, G. G. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nature Cell Biol. 7, 581-590 (2005). An important study that provides novel insights into the regulation of cell migration by microtubule-dependent dissolution of focal adhesions.
    • (2005) Nature Cell Biol , vol.7 , pp. 581-590
    • Ezratty, E.J.1    Partridge, M.A.2    Gundersen, G.G.3
  • 121
    • 22944438407 scopus 로고    scopus 로고
    • FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation
    • Wu, X., Gan, B., Yoo, Y. & Guan, J. L. FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Dev. Cell 9, 185-196 (2005).
    • (2005) Dev. Cell , vol.9 , pp. 185-196
    • Wu, X.1    Gan, B.2    Yoo, Y.3    Guan, J.L.4
  • 122
    • 34250820373 scopus 로고    scopus 로고
    • Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3
    • This paper shows that an endocytic adaptor, NUMB, has an important role in polarized cell migration through direct binding to β1 and β3 integrins and regulating integrin trafficking
    • Nishimura, T. & Kaibuchi, K. Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev. Cell 13, 15-28 (2007). This paper shows that an endocytic adaptor, NUMB, has an important role in polarized cell migration through direct binding to β1 and β3 integrins and regulating integrin trafficking.
    • (2007) Dev. Cell , vol.13 , pp. 15-28
    • Nishimura, T.1    Kaibuchi, K.2
  • 123
    • 0742305342 scopus 로고    scopus 로고
    • Clustering induces a lateral redistribution of α2β1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization
    • Upla, P. et al. Clustering induces a lateral redistribution of α2β1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization. Mol. Biol. Cell 15, 625-636 (2004).
    • (2004) Mol. Biol. Cell , vol.15 , pp. 625-636
    • Upla, P.1
  • 124
    • 44649198353 scopus 로고    scopus 로고
    • Endocytic transport of integrins during cell migration and invasion
    • Caswell, P. & Norman, J. Endocytic transport of integrins during cell migration and invasion. Trends Cell Biol. 18, 257-263 (2008).
    • (2008) Trends Cell Biol , vol.18 , pp. 257-263
    • Caswell, P.1    Norman, J.2
  • 125
    • 27844444696 scopus 로고    scopus 로고
    • PKCε-mediated phosphorylation of vimentin controls integrin recycling and motility
    • Ivaska, J. et al. PKCε-mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J. 24, 3834-3845 (2005).
    • (2005) EMBO J , vol.24 , pp. 3834-3845
    • Ivaska, J.1
  • 126
    • 34547567210 scopus 로고    scopus 로고
    • An ACAP1-containing clathrin coat complex for endocytic recycling
    • Li, J. et al. An ACAP1-containing clathrin coat complex for endocytic recycling. J. Cell Biol. 178, 453-464 (2007).
    • (2007) J. Cell Biol , vol.178 , pp. 453-464
    • Li, J.1
  • 127
    • 0742306892 scopus 로고    scopus 로고
    • Stimulation-dependent recycling of integrin β1 regulated by ARF6 and Rab11
    • Powelka, A. M. et al. Stimulation-dependent recycling of integrin β1 regulated by ARF6 and Rab11. Traffic 5, 20-36 (2004).
    • (2004) Traffic , vol.5 , pp. 20-36
    • Powelka, A.M.1
  • 128
    • 33747447033 scopus 로고    scopus 로고
    • Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of β1-integrins
    • Pellinen, T. et al. Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of β1-integrins. J. Cell Biol. 173, 767-780 (2006).
    • (2006) J. Cell Biol , vol.173 , pp. 767-780
    • Pellinen, T.1
  • 129
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes, R. O. Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687 (2002).
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 131
    • 14944348752 scopus 로고    scopus 로고
    • Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
    • Bates, R. C. et al. Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J. Clin. Invest. 115, 339-347 (2005).
    • (2005) J. Clin. Invest , vol.115 , pp. 339-347
    • Bates, R.C.1
  • 132
    • 34347359740 scopus 로고    scopus 로고
    • Overexpression of the αvβ6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival
    • Hazelbag, S. et al. Overexpression of the αvβ6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival. J. Pathol. 212, 316-324 (2007).
    • (2007) J. Pathol , vol.212 , pp. 316-324
    • Hazelbag, S.1
  • 133
    • 34347230941 scopus 로고    scopus 로고
    • HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin αvβ6
    • Ramsay, A. G. et al. HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin αvβ6. Cancer Res. 67, 5275-5284 (2007).
    • (2007) Cancer Res , vol.67 , pp. 5275-5284
    • Ramsay, A.G.1
  • 134
    • 9144271680 scopus 로고    scopus 로고
    • Cheng, K. W. et al. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nature Med. 10, 1251-1256 (2004). This manuscript demonstrates frequent amplification of RAB25 in advanced ovarian and breast cancers, as well as a crucial role for RAB25 in tumorigenesis.
    • Cheng, K. W. et al. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nature Med. 10, 1251-1256 (2004). This manuscript demonstrates frequent amplification of RAB25 in advanced ovarian and breast cancers, as well as a crucial role for RAB25 in tumorigenesis.
  • 135
    • 22244432840 scopus 로고    scopus 로고
    • The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program
    • De Craene, B. et al. The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program. Cancer Res. 65, 6237-6244 (2005).
    • (2005) Cancer Res , vol.65 , pp. 6237-6244
    • De Craene, B.1
  • 136
    • 34848816931 scopus 로고    scopus 로고
    • Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments
    • Caswell, P. T. et al. Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments. Dev. Cell 13, 496-510 (2007).
    • (2007) Dev. Cell , vol.13 , pp. 496-510
    • Caswell, P.T.1
  • 137
    • 23444453060 scopus 로고    scopus 로고
    • A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes
    • Garcia, M. J. et al. A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. Oncogene 24, 5235-5245 (2005).
    • (2005) Oncogene , vol.24 , pp. 5235-5245
    • Garcia, M.J.1
  • 138
    • 0033405294 scopus 로고    scopus 로고
    • The hypoxic cell: A target for selective cancer therapy - eighteenth Bruce F. Cain Memorial Award lecture
    • Brown, J. M. The hypoxic cell: a target for selective cancer therapy - eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res. 59, 5863-5870 (1999).
    • (1999) Cancer Res , vol.59 , pp. 5863-5870
    • Brown, J.M.1
  • 139
    • 16844362958 scopus 로고    scopus 로고
    • Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the α6β4 integrin
    • A report that links hypoxia to cell invasiveness through integrin trafficking, involving stabilized, detyrosinated microtubules and Rab11
    • Yoon, S. O., Shin, S. & Mercurio, A. M. Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the α6β4 integrin. Cancer Res. 65, 2761-2769 (2005). A report that links hypoxia to cell invasiveness through integrin trafficking, involving stabilized, detyrosinated microtubules and Rab11.
    • (2005) Cancer Res , vol.65 , pp. 2761-2769
    • Yoon, S.O.1    Shin, S.2    Mercurio, A.M.3
  • 140
    • 0035393707 scopus 로고    scopus 로고
    • Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis
    • Mialhe, A. et al. Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis. Cancer Res. 61, 5024-5027 (2001).
    • (2001) Cancer Res , vol.61 , pp. 5024-5027
    • Mialhe, A.1
  • 141
    • 16844384058 scopus 로고    scopus 로고
    • Emerging role of RAB GTPases in cancer and human disease
    • Cheng, K. W., Lahad, J. P., Gray, J. W. & Mills, G. B. Emerging role of RAB GTPases in cancer and human disease. Cancer Res. 65, 2516-2519 (2005).
    • (2005) Cancer Res , vol.65 , pp. 2516-2519
    • Cheng, K.W.1    Lahad, J.P.2    Gray, J.W.3    Mills, G.B.4
  • 142
    • 0344010009 scopus 로고    scopus 로고
    • Molecular analysis of transitional cell carcinoma using cDNA microarray
    • Mor, O. et al. Molecular analysis of transitional cell carcinoma using cDNA microarray. Oncogene 22, 7702-7710 (2003).
    • (2003) Oncogene , vol.22 , pp. 7702-7710
    • Mor, O.1
  • 143
    • 46149125934 scopus 로고    scopus 로고
    • Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration
    • This study describes an interesting interplay between endocytosis and cell motility involving RAB5A-dependent activation of Rac in endosomes, and Rac recycling to regulate localized actin remodeling
    • Palamidessi, A. et al. Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration. Cell 134, 135-147 (2008). This study describes an interesting interplay between endocytosis and cell motility involving RAB5A-dependent activation of Rac in endosomes, and Rac recycling to regulate localized actin remodeling.
    • (2008) Cell , vol.134 , pp. 135-147
    • Palamidessi, A.1
  • 144
    • 0034695461 scopus 로고    scopus 로고
    • Phosphatidylinositol 4, 5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion
    • Raucher, D. et al. Phosphatidylinositol 4, 5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell 100, 221-228 (2000).
    • (2000) Cell , vol.100 , pp. 221-228
    • Raucher, D.1
  • 145
    • 37249000008 scopus 로고    scopus 로고
    • EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells
    • van Rheenen, J. et al. EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. J. Cell Biol. 179, 1247-1259 (2007).
    • (2007) J. Cell Biol , vol.179 , pp. 1247-1259
    • van Rheenen, J.1
  • 146
    • 0034597599 scopus 로고    scopus 로고
    • Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis
    • Malecz, N. et al. Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis. Curr. Biol. 10, 1383-1386 (2000).
    • (2000) Curr. Biol , vol.10 , pp. 1383-1386
    • Malecz, N.1
  • 148
  • 149
    • 33748928434 scopus 로고    scopus 로고
    • p38 MAP kinase mediates stress-induced internalization of EGFR: Implications for cancer chemotherapy
    • Zwang, Y. & Yarden, Y. p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy. EMBO J. 25, 4195-4206 (2006).
    • (2006) EMBO J , vol.25 , pp. 4195-4206
    • Zwang, Y.1    Yarden, Y.2
  • 150
    • 25144481466 scopus 로고    scopus 로고
    • Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis
    • Mace, G., Miaczynska, M., Zerial, M. & Nebreda, A. R. Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis. EMBO J. 24, 3235-3246 (2005).
    • (2005) EMBO J , vol.24 , pp. 3235-3246
    • Mace, G.1    Miaczynska, M.2    Zerial, M.3    Nebreda, A.R.4
  • 151
    • 0035105295 scopus 로고    scopus 로고
    • The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex
    • Cavalli, V. et al. The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex. Mol. Cell 7, 421-432 (2001).
    • (2001) Mol. Cell , vol.7 , pp. 421-432
    • Cavalli, V.1
  • 152
    • 34248641115 scopus 로고    scopus 로고
    • Cancer therapeutic antibodies come of age: Targeting minimal residual disease
    • Ben-Kasus, T., Schechter, B., Sela, M. & Yarden, Y. Cancer therapeutic antibodies come of age: targeting minimal residual disease. Mol. Oncol. 1, 42-54 (2007).
    • (2007) Mol. Oncol , vol.1 , pp. 42-54
    • Ben-Kasus, T.1    Schechter, B.2    Sela, M.3    Yarden, Y.4
  • 153
    • 13844306484 scopus 로고    scopus 로고
    • Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: Implications for cancer immunotherapy
    • Friedman, L. M. et al. Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: implications for cancer immunotherapy. Proc. Natl. Acad. Sci. USA 102, 1915-1920 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1915-1920
    • Friedman, L.M.1
  • 154
    • 36248938567 scopus 로고    scopus 로고
    • Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with, T
    • Baselga, J. et al. Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with, T. J. Clin. Oncol. 2007 ASCO Annu. Meet. Proc. Pt I 25, 1004 (2007).
    • (2007) J. Clin. Oncol. 2007 ASCO Annu. Meet. Proc. Pt I , vol.25 , pp. 1004
    • Baselga, J.1
  • 155
    • 0027965262 scopus 로고
    • Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma
    • Di Guglielmo, G. M., Baass, P. C., Ou, W. J., Posner, B. I. & Bergeron, J. J. Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma. EMBO J. 13, 4269-4277 (1994).
    • (1994) EMBO J , vol.13 , pp. 4269-4277
    • Di Guglielmo, G.M.1    Baass, P.C.2    Ou, W.J.3    Posner, B.I.4    Bergeron, J.J.5
  • 156
    • 0030461226 scopus 로고    scopus 로고
    • Control of EGF receptor signaling by clathrin-mediated endocytosis
    • Vieira, A. V., Lamaze, C. & Schmid, S. L. Control of EGF receptor signaling by clathrin-mediated endocytosis. Science 274, 2086-2088 (1996).
    • (1996) Science , vol.274 , pp. 2086-2088
    • Vieira, A.V.1    Lamaze, C.2    Schmid, S.L.3
  • 157
    • 0036899420 scopus 로고    scopus 로고
    • Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
    • Teis, D., Wunderlich, W. & Huber, L. A. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev. Cell 3, 803-814 (2002).
    • (2002) Dev. Cell , vol.3 , pp. 803-814
    • Teis, D.1    Wunderlich, W.2    Huber, L.A.3
  • 158
    • 0042130366 scopus 로고    scopus 로고
    • Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling
    • Pennock, S. & Wang, Z. Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling. Mol. Cell Biol. 23, 5803-5815 (2003).
    • (2003) Mol. Cell Biol , vol.23 , pp. 5803-5815
    • Pennock, S.1    Wang, Z.2
  • 159
    • 0035824391 scopus 로고    scopus 로고
    • γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
    • Ni, C. Y., Murphy, M. P., Golde, T. E. & Carpenter, G. γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294, 2179-2181 (2001).
    • (2001) Science , vol.294 , pp. 2179-2181
    • Ni, C.Y.1    Murphy, M.P.2    Golde, T.E.3    Carpenter, G.4
  • 160
    • 33749072714 scopus 로고    scopus 로고
    • Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain
    • Sardi, S. P., Murtie, J., Koirala, S., Patten, B. A. & Corfas, G. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 127, 185-197 (2006).
    • (2006) Cell , vol.127 , pp. 185-197
    • Sardi, S.P.1    Murtie, J.2    Koirala, S.3    Patten, B.A.4    Corfas, G.5
  • 161
    • 8444243682 scopus 로고    scopus 로고
    • The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
    • Williams, C. C. et al. The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J. Cell Biol. 167, 469-478 (2004).
    • (2004) J. Cell Biol , vol.167 , pp. 469-478
    • Williams, C.C.1
  • 162
    • 33746561717 scopus 로고    scopus 로고
    • Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin β1 and CRM1
    • Lo, H. W. et al. Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin β1 and CRM1. J. Cell Biochem. 98, 1570-1583 (2006).
    • (2006) J. Cell Biochem , vol.98 , pp. 1570-1583
    • Lo, H.W.1
  • 163
    • 4544376914 scopus 로고    scopus 로고
    • Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2
    • Wang, S. C. et al. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell 6, 251-261 (2004).
    • (2004) Cancer Cell , vol.6 , pp. 251-261
    • Wang, S.C.1
  • 164
    • 0036468899 scopus 로고    scopus 로고
    • Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer
    • Ristimaki, A. et al. Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res. 62, 632-635 (2002).
    • (2002) Cancer Res , vol.62 , pp. 632-635
    • Ristimaki, A.1
  • 165
    • 33745177802 scopus 로고    scopus 로고
    • Requirement of clathrin heavy chain for p53-mediated transcription
    • Enari, M., Ohmori, K., Kitabayashi, I. & Taya, Y. Requirement of clathrin heavy chain for p53-mediated transcription. Genes Dev. 20, 1087-1099 (2006).
    • (2006) Genes Dev , vol.20 , pp. 1087-1099
    • Enari, M.1    Ohmori, K.2    Kitabayashi, I.3    Taya, Y.4
  • 166
    • 1642417606 scopus 로고    scopus 로고
    • APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment
    • This paper uncovers a novel mitogenic signalling pathway in which RAB5-activated APPL proteins translocate from endosomes to the nucleus and interact with proteins involved in nucleosome remodeling
    • Miaczynska, M. et al. APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell 116, 445-456 (2004). This paper uncovers a novel mitogenic signalling pathway in which RAB5-activated APPL proteins translocate from endosomes to the nucleus and interact with proteins involved in nucleosome remodeling.
    • (2004) Cell , vol.116 , pp. 445-456
    • Miaczynska, M.1
  • 167
    • 54349105660 scopus 로고    scopus 로고
    • Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias
    • 12 Aug, doi:10.3324/haematol.13187
    • Abbas, S., Rotmans, G., Lowenberg, B. & Valk, P. J. Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias. Haematologica 12 Aug 2008 (doi:10.3324/haematol.13187).
    • (2008) Haematologica
    • Abbas, S.1    Rotmans, G.2    Lowenberg, B.3    Valk, P.J.4
  • 168
    • 34547950568 scopus 로고    scopus 로고
    • Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia
    • Caligiuri, M. A. et al. Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia. Blood 110, 1022-1024 (2007).
    • (2007) Blood , vol.110 , pp. 1022-1024
    • Caligiuri, M.A.1
  • 169
    • 0031864246 scopus 로고    scopus 로고
    • Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor β receptor (PDGFβR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2)
    • Ross, T. S., Bernard, O. A., Berger, R. & Gilliland, D. G. Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor β receptor (PDGFβR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2). Blood 91, 4419-4426 (1998).
    • (1998) Blood , vol.91 , pp. 4419-4426
    • Ross, T.S.1    Bernard, O.A.2    Berger, R.3    Gilliland, D.G.4
  • 170
    • 0038749488 scopus 로고    scopus 로고
    • Overexpression of βPix-a in human breast cancer tissues
    • Ahn, S. J. et al. Overexpression of βPix-a in human breast cancer tissues. Cancer Lett. 193, 99-107 (2003).
    • (2003) Cancer Lett , vol.193 , pp. 99-107
    • Ahn, S.J.1
  • 171
    • 34250170819 scopus 로고    scopus 로고
    • Roles of cortactin in tumor pathogenesis
    • Buday, L. & Downward, J. Roles of cortactin in tumor pathogenesis. Biochim. Biophys. Acta 1775, 263-273 (2007).
    • (2007) Biochim. Biophys. Acta , vol.1775 , pp. 263-273
    • Buday, L.1    Downward, J.2
  • 172
    • 0034879895 scopus 로고    scopus 로고
    • Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor
    • Bridge, J. A. et al. Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor. Am. J. Pathol. 159, 411-415 (2001).
    • (2001) Am. J. Pathol , vol.159 , pp. 411-415
    • Bridge, J.A.1
  • 173
    • 0041353435 scopus 로고    scopus 로고
    • A novel CLTC-TFE3 gene fusion in pediatric renal adenocarcinoma with t(X;17) (p11.2;q23)
    • Argani, P. et al. A novel CLTC-TFE3 gene fusion in pediatric renal adenocarcinoma with t(X;17) (p11.2;q23). Oncogene 22, 5374-5378 (2003).
    • (2003) Oncogene , vol.22 , pp. 5374-5378
    • Argani, P.1
  • 174
    • 0029953937 scopus 로고    scopus 로고
    • The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family
    • Dreyling, M. H. et al. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. Proc. Natl Acad. Sci. USA 93, 4804-4809 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 4804-4809
    • Dreyling, M.H.1
  • 175
    • 0042885909 scopus 로고    scopus 로고
    • Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias
    • So, C. W., Lin, M., Ayton, P. M., Chen, E. H. & Cleary, M. L. Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell 4, 99-110 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 99-110
    • So, C.W.1    Lin, M.2    Ayton, P.M.3    Chen, E.H.4    Cleary, M.L.5
  • 176
    • 2442720107 scopus 로고    scopus 로고
    • Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein
    • Liu, H. et al. Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein. Oncogene 23, 3385-3394 (2004).
    • (2004) Oncogene , vol.23 , pp. 3385-3394
    • Liu, H.1
  • 177
    • 33745605412 scopus 로고    scopus 로고
    • Sprouty and cancer: The first terms report
    • Lo, T. L. et al. Sprouty and cancer: the first terms report. Cancer Lett. 242, 141-150 (2006).
    • (2006) Cancer Lett , vol.242 , pp. 141-150
    • Lo, T.L.1
  • 178
    • 34547678149 scopus 로고    scopus 로고
    • Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder
    • Karam, J. A. et al. Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder. Clin. Cancer Res. 13, 4400-4406 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 4400-4406
    • Karam, J.A.1
  • 179
    • 38049046724 scopus 로고    scopus 로고
    • NUMB controls p53 tumour suppressor activity
    • Colaluca, I. et al. NUMB controls p53 tumour suppressor activity. Nature 451, 76-80 (2008).
    • (2008) Nature , vol.451 , pp. 76-80
    • Colaluca, I.1
  • 180
    • 0037447321 scopus 로고    scopus 로고
    • The Drg-1 gene suppresses tumor metastasis in prostate cancer
    • Bandyopadhyay, S. et al. The Drg-1 gene suppresses tumor metastasis in prostate cancer. Cancer Res. 63, 1731-1736 (2003).
    • (2003) Cancer Res , vol.63 , pp. 1731-1736
    • Bandyopadhyay, S.1
  • 181
    • 27644436744 scopus 로고    scopus 로고
    • Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1
    • van der Horst, E. H. et al. Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. Proc. Natl Acad. Sci. USA 102, 15901-15906 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15901-15906
    • van der Horst, E.H.1
  • 182
    • 0035463233 scopus 로고    scopus 로고
    • Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas
    • Fang, C. M. & Xu, Y. H. Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas. Cell Res. 11, 223-229 (2001).
    • (2001) Cell Res , vol.11 , pp. 223-229
    • Fang, C.M.1    Xu, Y.H.2
  • 183
    • 40049105221 scopus 로고    scopus 로고
    • Caveolin-1: A tumor-promoting role in human cancer
    • Shatz, M. & Liscovitch, M. Caveolin-1: a tumor-promoting role in human cancer. Int. J. Radiat. Biol. 84, 177-189 (2008).
    • (2008) Int. J. Radiat. Biol , vol.84 , pp. 177-189
    • Shatz, M.1    Liscovitch, M.2


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