Rab GTPases: Specifying and deciphering organelle identity and function

Trends in Cell Biology

Volumn 11, Issue 12, 2001, Pages 487-491

  Pfeffer, Suzanne R ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; PROTEIN; RAB PROTEIN;

CELL ORGANELLE; ENZYME SPECIFICITY; MAMMAL; MEMBRANE TRANSPORT; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW; YEAST;

ANIMALS; BIOLOGICAL TRANSPORT; CELL COMPARTMENTATION; CELL MEMBRANE; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; HUMANS; ORGANELLES; RAB GTP-BINDING PROTEINS; TRANSPORT VESICLES;

EID: 0035575616     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(01)02147-X     Document Type: Review

References (38)

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2. The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery
3. GTP-binding proteins in intracellular transport
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7. The translocon: A dynamic gateway at the ER membrane
8. The biogenesis of lysosomes
9. Transport-vesicle targeting: Tethers before SNAREs
10. Matrix proteins can generate the higher order architecture of the Golgi apparatus
11. Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis-Golgi tethering
12. The Golgi matrix protein GM130: A specific interacting partner of the small GTPase rab1b
13. Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion
14. Rab9 functions in transport between late endosomes and the trans Golgi network in vitro
15. Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes to the trans-Golgi network
16. TIP47: A cargo selection device for mannose 6-phosphate receptor trafficking
17. Role of the Rab9 GTPase in facilitating receptor recruitment by TIP47
18. GTPase activity of Rab5 acts as a timer for endocytic membrane fusion
19. A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast
20. Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p
21. TRAPP stimulates guanine nucleotide exchange on Ypt1p
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23. Rab3A GTPase-activating protein-inhibiting activity of Rabphilin 3A, a putative Rab3A target protein
24. A novel Rab9 effector required for endosome-to-TGN transport
25. Hypervariable C-terminal domain of Rab proteins acts as a targeting signal
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27. Interactions of three domains distinguishing the Ras-related GTP-binding proteins Ypt1 and Sec4
28. Specificity domains distinguish the Ras-related GTPases Ypt1 and Sec4
29. Structural basis of Rab effector specificity: Crystal structure of the small G protein Rab3A complexed with the effector domain of Rabphilin-3A
30. Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange
31. Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange
32. Mitotic phosphorylation of rab4 prevents binding to a specific receptor on endosome membranes
33. Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI
34. Crystal structures of a Rab protein in its inactive and active conformations
35. Rab GTPases: Master regulators of membrane trafficking
36. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
37. Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11
38. Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition