A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor

Molecular Biology of the Cell

Volumn 8, Issue 8, 1997, Pages 1529-1541

  Horazdovsky, Bruce F ^a   Davies, Brian A ^a   Seaman, Matthew N J ^b   McLaughlin, Steven A ^b   Yoon, Suk Hoon ^b   Emr, Scott D ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; PROTEASE NEXIN I; PROTEIN DERIVATIVE;

ARTICLE; CELL FRACTIONATION; CELL VACUOLE; CROSS LINKING; GENE DISRUPTION; GOLGI COMPLEX; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0030921812     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.8.8.1529     Document Type: Article

References (54)

1. Bankaitis, V.A., Johnson, L.M., and Emr, S.D. (1986). Isolation of yeast mutants defective in protein targeting to the vacuole. Proc. Natl. Acad. Sci. USA 83, 9075-9079.
2. Banta, L.M., Robinson, J.S., Klionsky, D.J., and Emr, S.D. (1988). Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting. J. Cell Biol. 107, 1369-1383.
3. Becherer, K.A., Rieder, S.E., Emr, S.D., and Jones, E.W. (1996). Novel syntain homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast. Mol. Biol. Cell 7, 579-594.
4. Cereghino, J.L., Marcusson, E.G., and Emr, S.D. (1995). The cytoplasmic tail of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization. Mol. Biol. Cell 6, 1089-1102.
5. Cooper, A.A., and Stevens, T.H. (1996). Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple vacuolar hydrolases. J. Cell Biol. 133, 529-541.
6. Cowles, C.R., Emr, S.D., and Horazdovsky, B.F. (1994). Mutations in the VPS45 gene, a SEC1 homologue, are defective for vacuolar protein sorting and accumulate clusters of membrane vesicles. J. Cell Sci. 107, 3449-3459.
7. Dieckmann, C.L., and Tzagoloff, A. (1985). Assembly of the mitochondrial membrane system. J. Biol. Chem. 260, 1513-1520.
8. Ekena, K., and Stevens, T.H. (1995). The Saccharomyces cerevisiae MVP1 gene interacts with VPS1 and is required for vacuolar protein sorting. Mol. Cell. Biol. 15, 1671-1678.
9. Graham, T.R., and Emr, S.D. (1991). The Sec18/NSF protein is required at multiple steps in the secretory pathway: mutants define compartmental organization of protein modification and sorting events in the yeast Golgi. J. Cell Biol. 114, 207-218.
10. Guthrie, C., and Fink, G.R. (eds.) (1991). Guide to Yeast Genetics and Molecular Biology, Methods in Enzymology, New York: Academic Press.
11. Hanahan, D. (1983). Studies on transformation of Eschcrichia coli with plasmids. J. Mol. Biol. 166, 557-580.
12. Herman, P.K., and Emr, S.D. (1990). Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol. Cell. Biol. 10, 6742-6754.
13. Herman, P.K., Stack, J.H., DeModena, J.A., and Emr, S.D. (1991). A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole. Cell 64, 425-437.
14. Herman, P.K., Stack, J.H., and Emr, S.D. (1991). A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery. EMBO J. 10, 4049-4060.
15. Horazdovsky, B.F., Busch, G.R., and Emr, S.D. (1994). VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins. EMBO J. 13, 1297-1309.
16. Horazdovsky, B.F., DeWald, D.B., and Emr, S.D. (1995). Protein transport to the yeast vacuole. Curr. Opin. Cell Biol. 7, 544-551.
17. Ito, H., Fukada, Y., Murata, K., and Kimura, A. (1983). Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153, 163-168.
18. Johnson, L.M., Bankaitis, V.A., and Emr, S.D. (1987). Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protein. Cell 48, 875-885.
19. Jones, E. (1984). The synthesis and function of proteases in Saccharomyces: genetic approaches. Annu. Rev. Genet. 18, 233-270.
20. Jones, E.W. (1977). Proteinase mutants of Saccharomyces cerevisiae. Genetics 85, 23-33.
21. Kleid, D.G., Yansura, D., Small, B., Dowbenko, D., Moore, D.M., Grubman, M.J., McKercher, P.D., Morgan, D.O., Robertson, B.H., and Bachrach, H.L. (1981). Cloned viral protein vaccine for foot-and-mouth disease. Science 214, 1125-1129.
22. Klionsky, D.J., Banta, L.M., and Emr, S.D. (1988). Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information. Mol. Cell. Biol. 8, 2105-2116.
23. Klionsky, D.J., and Emr, S.D. (1989). Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase. EMBO J. 8, 2241-2250.
24. Klionsky, D.J., Herman, P.K., and Emr, S.D. (1990). The fungal vacuole: composition, function, and biogenesis. Microbiol. Rev. 54, 266-292.
25. Köhrer, K., and Emr, S.D. (1993). The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases. J. Biol. Chem. 268, 559-569.
26. Kornfeld, S. (1992). Structure and function of the mannose 6-phosphate/insulin like growth factor-II receptors. Annu. Rev. Biochem. 61, 307-330.
27. Kornfeld, S., and Mellman, I. (1989). The biogenesis of lysosomes. Annu. Rev. Cell Biol. 5, 483-525.
28. Kurten, R.C., Cadena, D.L., and Gill, G.N. (1996). Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science 272, 1008-1010.
29. Marcusson, E.G., Horazdovsky, B.F., Lin Cereghino, J., Gharakhanian, E., and Emr, S.D. (1994). The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell 77, 579-586.
30. Meisenhelder, J., and Hunter, T. (1991). Phosphorylation of phospholipase C in vivo and in vitro. Methods Enzymol. 197, 288-305.
31. Miller, J. (1972). Experiments in Molecular Genetics, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
32. Paravicini, G., Horazdovsky, B.F., and Emr, S.D. (1992). Alternative pathways for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases. Mol. Biol. Cell 3, 415-427.
33. Piper, R.C., Cooper, A.A., Yang, H., and Stevens, T.H. (1995). VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae. J. Cell Biol. 132, 603-617.
34. Raymond, C., O'Hara, P.J., Eichinger, G., Rothman, J.H., and Steven, T.H. (1990). Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle. J. Cell Biol. 111, 877-892.
35. Roberts, C.J., Raymond, C.K., Yamashiro, C.T., and Stevens, T.H. (1991). Methods for studying the yeast vacuole. In: Guide to Yeast Genetics and Molecular Biology, vol. 194, ed. C. Guthrie and G.R. Fink, New York: Academic Press, 644-661.
36. Robinson, J.S., Klionsky, D.J., Banta, L.M., and Emr, S.D. (1988). Protein sorting in Saccharonn/ces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol. Cell. Biol. 8, 4936-4948.
37. Rothman, J.H., Howald, I., and Stevens, T.H. (1989). Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae. EMBO J. 8, 2057-2065.
38. Rothman, J.H., Raymond, C.K., Gilbert, T., O'Hara, P.J., and Stevens, T.H. (1990). A putative GTP binding protein homologous to Iterferon-inducible Mx proteins performs an essential function in yeast protein sorting. Cell 61, 1063-1074.
39. Rothman, J.H., and Stevens, T.H. (1986). Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalization vacuolar proteins into the late secretory pathway. Cell 47, 1041-1051.
40. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
41. Seaman, M.N.J., Marcusson, E.G., Cereghino, J.L., and Emr, S.D. (1997). Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. J. Cell Biol. 137, 79-92.
42. Serafini, T., Stenbeck, G., Brecht, A., Lottspeich, F., Orci, L., Rothman, J.E., and Wieland, F.T. (1991). A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein B-adaptin. Nature 349, 215-220.
43. Sherman, F., Fink, G.R., and Lawrence, L.W. (1979). Methods in Yeast Genetics: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory,
44. Sikorski, R.S., and Hieter, P. (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
45. Stack, J., Horazdovsky, B., and Emr, S. (1995). Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteins. Annu. Rev. Cell Dev. Biol. 11, 1-33.
46. Stack, J.H., Herman, P.K., Schu, P.V., and Emr, S.D. (1993). A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO J. 12, 2195-2204.
47. Stevens, T., Esmon, B., and Schekman, R. (1982), Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole. Cell 30, 439-448.
48. Valls, L.A., Hunter, C.P., Rothman, J.H., and Stevens, T.H. (1987). Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide. Cell 48, 887-897.
49. Vater, C.A., Raymond, C.K., Ekena, K., Howald, S.I., and Stevens, T.H. (1992). The VPS1 protein, a homolog of dynamin required for vacuolar protein sorting in Saccharomyces cerevisiae, is a GTPase with 2 functionally separable domains. J. Cell Biol. 119, 773-786.
50. Vida, T.A., Graham, T.R., and Emr, S.D. (1990). In vitro reconstitution of intercompartmental protein transport to the yeast vacuole. J. Cell Biol. 111, 2871-2884.
51. Vida, T.A., Huyer, G., and Emr, S.D. (1993). Yeast vacuolar proenzymes are sorted in the late Golgi complex and transported to the vacuole via a prevacuolar endosome-like compartment. J. Cell Biol. 121, 1245-1256.
52. Vida, T.V., and Emr, S.D. (1995). A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast. J. Cell Biol. 128, 779-792.
53. Vogelstein, D., and Gillespie, D. (1979). Preparative and analytical purification of DNA from agarose. Proc. Natl. Acad. Sci. USA. 76, 615-619.
54. Wilsbach, K., and Payne, G.S. (1993). Vps1p, a member of the dynamin GTPase family, is necessary for Golgi membrane protein retention in Saccharomyces cerevisiae. EMBO J. 12, 3049-3059.