The COG and COPI Complexes Interact to Control the Abundance of GEARs, a Subset of Golgi Integral Membrane Proteins

Molecular Biology of the Cell

Volumn 15, Issue 5, 2004, Pages 2423-2435

  Oka, Toshihiko ^a   Ungar, Daniel ^b   Hughson, Frederick M ^b   Krieger, Monty ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COAT PROTEIN COMPLEX I; CONSERVED OLIGOMERIC GOLGI COMPLEX PROTEIN; CYTOPLASM PROTEIN; GIANTIN; GLYCOLIPID; GLYCOPROTEIN; GOLGIN 84; MANNOSIDASE II; MEMBRANE PROTEIN; PROTEIN CASP; PROTEIN GOS28; PROTEIN GPP130; PROTEIN GS15; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MUTANT; CELL SURFACE; COMPLEX FORMATION; CYTOPLASM; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; NONHUMAN; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

ACETYLCYSTEINE; ANIMALS; CHO CELLS; COAT PROTEIN COMPLEX I; CRICETINAE; CRICETULUS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; IMMUNOPRECIPITATION; INTRACELLULAR MEMBRANES; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MULTIPROTEIN COMPLEXES; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN TRANSPORT; RNA INTERFERENCE; SNARE PROTEINS; VESICULAR TRANSPORT PROTEINS;

ANIMALIA; MAMMALIA;

EID: 2342467375     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E03-09-0699     Document Type: Article

References (107)

1. Allan, V.J., and Kreis, T.E. (1986). A microtubule-binding protein associated with membranes of the Golgi apparatus. J. Cell Biol. 103, 2229-2239.
2. Aridor, M., Bannykh, S.I., Rowe, T., and Balch, W.E. (1995). Sequential coupling between COPII and COPI vesicle coats in endoplasmic reticulum to Golgi transport. J. Cell Biol. 131, 875-893.
3. Axelsson, M.A., Karlsson, N.G., Steel, D.M., Ouwendijk, J., Nilsson, T., and Hansson, G.C. (2001). Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins. Glycobiology 11, 633-644.
4. Bonifacino, J.S., and Weissman, A.M. (1998). Ubiquitin and the control of protein fate in the secretory and endocytic pathways. Annu. Rev. Cell Dev. Biol. 14, 19-57.
5. Barlowe, C. (2002). COPII-dependent transport from the endoplasmic reticulum. Curr. Opin. Cell Biol. 417-422.
6. Bascom, R.A., Srinivasan, S., and Nussbaum, R.L. (1999). Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain. J. Biol. Chem. 274, 2953-2962.
7. Berger, E.G. (2002). Ectopic localizations of Golgi glycosyltransferases. Glycobiology 12, 29R-36R.
8. Chatterton, J.E., Hirsch, D., Schwartz, J.J., Bickel, P.E., Rosenberg, R.D., Lodish, H.F., and Krieger, M. (1999). Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the 1d1Cp complex. Proc. Natl. Acad. Sci. USA 96, 915-920.
9. Chiu, R., Novikov, L., Mukherjee, S., and Shields, D. (2002). A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis. J. Cell Biol. 159, 637-648.
10. Conibear, E., Cleck, J.N., and Stevens, T.H. (2003). Vps51p mediates the association of the GARP (Vps52/53/54) complex with the late Golgi t-SNARE T1g1p. Mol. Biol. Cell 14, 1610-1623.
11. Diao, A., Rahman, D., Pappin, D.J., Lucocq, J., and Lowe, M. (2003). The coiled-coil membrane protein golgin-84 is a novel rab rab effector required for Golgi ribbon formation. J. Cell Biol. 160, 201-212.
12. Doms, R.W., Russ, G., and Yewdell, J.W. (1989). Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum. J. Cell Biol. 109, 61-72.
13. Donaldson, J.G., Lippincott-Schwartz, J., Bloom, G.S., Kreis, T.E., and Klausner, R.D. (1990). Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action. J. Cell Biol. 111, 2295-2306.
14. Drexler, H.C., Risau, W., and Konerding, M.A. (2000). Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells. FASEB J. 14, 65-77.
15. Duden, R., Kajikawa, L., Wuestehube, L., and Schekman, R. (1998). ε-COP is a structural component of coatomer that functions to stabilize α-COP. EMBO J. 17, 985-995.
16. Duden, R. (2003). ER-to-Golgi transport: COP I and COP II function. Mol. Membr. Biol. 20, 197-207.
17. Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. (2001). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498.
18. Farkas, R.M., Giansanti, M.G., Gatti, M., and Fuller, M.T. (2003). The Drosophila Cog5 homologue is required for cytokinesis, cell elongation, and assembly of specialized Golgi architecture during spermatogenesis. Mol. Biol. Cell 14, 190-200.
19. Gaynor, E.C., and Emr, S.D. (1997). COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants. J. Cell Biol. 136, 789-802.
20. Gaynor, E.C., Graham, T.R., and Emr, S.D. (1998). COPI in ER/Golgi and intra-Golgi transport: do yeast COPI mutants point the way? Biochim. Biophys. Acta 1404, 33-51.
21. Gillingham, A.K., Pfeifer, A.C., and Munro, S. (2002). CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin. Mol. Biol. Cell 13, 3761-3774.
22. Girod, A., Storrie, B., Simpson, J.C., Johannes, L., Goud, B., Roberts, L.M., Lord, J.M., Nilsson T., and Pepperkok, R. (1999). Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum. Nat Cell Biol. 1999 1, 423-430.
23. Glick, B.S., and Malhotra, V. (1998). The curious status of the Golgi apparatus. Cell 95, 883-889.
24. Gomez, M., Scales, S.J., Kreis, T.E., and Perez, F. (2000). Membrane recruitment of coatomer and binding to dilysine signals are separate events. J. Biol. Chem. 275, 29162-29169.
25. Guo, Q., Vasile, E., and Krieger, M. (1994). Disruptions in Golgi structure and membrane traffic in a conditional lethal mammalian cell mutant are corrected by epsilon-COP. J. Cell Biol. 125, 1213-1224.
26. Guo, Q., Penman, M., Trigatti, B.L., and Krieger, M. (1996). A single point mutation in epsilon-COP results in temperature-sensitive, lethal defects in membrane transport in a Chinese hamster ovary cell mutant. J. Biol. Chem. 271, 11191-11196.
27. Harris, S.L., and Waters, M.G. (1996). Localization of a yeast early Golgi mannosyltransferase, Och1p, involves retrograde transport. J. Cell Biol. 132, 985-998.
28. Hartmann, E., Sommer, T., Prehn, S., Gorlich, D., Jentsch, S., and Rapoport, T.A. (1994). Evolutionary conservation of components of the protein translocation complex. Nature 367, 654-657.
29. Hay, J.C., Klumperman, J., Oorschot, V., Steegmaier, M., Kuo, C.S., and Scheller, R.H. (1998). Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs. J. Cell Biol. 141, 1489-1502.
30. Hoffman, G.R., Rahl, P.B., Collins, R.N., and Cerione, R.A. (2003). Conserved structural motifs in intracellular trafficking pathways: structure of the gamma-COP appendage domain. Mol. Cell 12, 615-625.
31. Johnston, J.A., Ward, C.L., and Kopito, R.R. (1998). Aggresomes: a cellular response to misfolded proteins. J. Cell Biol. 143, 1883-1898.
32. Kim, D.-W., Massey, T., Sacher, M., Pypaert, M., and Ferro-Novick, S. (2001). Sgf1p, a new component of the Sec34p/Sec35p complex. Traffic 2, 820-830.
33. Kim, D.W., Sacher, M., Scarpa, A., Quinn, A.M., and Ferro-Novick, S. (1999). High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking. Mol. Biol. Cell. 10, 3317-3329.
34. Kim, J.-M., et al. (2003). Early mitochondrial hyperpolarization and intracellular alkalinization in lactacystin-induced apoptosis of retinal pigment epithelial cells. J. Pharmacol. Exp. Ther. 305, 474-481.
35. Kimata, Y., Lim, C.R., Kiriyama, T., Nara, A., Hirata, A., and Kohno, K. (1999). Mutation of the yeast epsilon-COP gene ANU2 causes abnormal nuclear morphology and defects in intracellular vesicular transport. Cell Struct. Funct. 24, 197-208.
36. Kostova, Z., and Wolf, D.H. (2003). For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection. EMBO J. 22, 2309-2317.
37. Kingsley, D.M., Kozarsky, K.F., Segal, M., and Krieger, M. (1986). Three types of low density lipoprotein receptor-deficient mutant have pleiotropic defects in the synthesis of N-linked, O-linked, and lipid-linked carbohydrate chains. J. Cell Biol. 102, 1576-1585.
38. Kozarsky, K.F., Brush, H.A., and Krieger, M. (1986). Unusual forms of low density lipoprotein receptors in hamster cell mutants with defects in the receptor structural gene. J. Cell Biol. 102, 1567-1575.
39. Krieger, M., Brown, M.S., and Goldstein, J.L. (1981). Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein. J. Mol. Biol. 150, 167-184.
40. Lane, J.D., Lucocq, J., Pryde, J., Barr, F.A., Woodman, P.G., Allan, V.J., and Lowe, M. (2001). Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis. J. Cell Biol. 156, 495-509.
41. Letourneur, F., Gaynor, E.C., Hennecke, S., Demolliere, C., Duden, R., Emr, S.D., Riezman, H., and Cosson, P. (1994). Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell 79, 1199-1207.
42. Linstedt, A.D., and Hauri, H.P. (1993). Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa. Mol. Biol. Cell 4, 679-693.
43. Linstedt, A.D., Mehta, A., Suhan, J., Reggio, H., and Hauri, H.P. (1997). Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein. Mol. Biol. Cell 8, 1073-1087.
44. Lippincott-Schwartz, J., Yuan, L.C., Bonifacino, JS., and Klausner, R.D. (1989). Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell 56, 801-813.
45. Lippincott-Schwartz, J., Roberts, T.H., and Hirschberg, K. (2000). Secretory protein trafficking and organelle dynamics in living cells. Annu. Rev. Cell Dev. Biol. 16, 557-589.
46. Loh, E., and Hong, W. (2002). Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and 1d1Bp. J. Biol. Chem. 277, 21955-21961.
47. Lowe, M., and Kreis, T.E. (1995). In vitro assembly and disassembly of coatomer. J. Biol. Chem 270, 31364-31371.
48. Lowe, S.L., Peter, F., Subramaniam, V.N., Wong, S.H., and Hong, W. (1997). A SNARE involved in protein transport through the Golgi apparatus. Nature 389, 881-884.
49. Mancini, M., Machamer, C.E., Roy, S., Nicholson, D.W., Thornberry, N.A., Casciola-Rosen, L.A., and Rosen, A. (2000). Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis. J. Cell Biol. 149, 603-612.
50. Martínez-Menárguez, J.A., Prekeris, R., Oorschot, V.M., Scheller, K., Slot, J.W., Geuze, H.J., and Klumperman, J. (2001). Peri-Golgi vesicles contain retrograde but not anterograde proteins consistent with the cisternal progression model of intra-Golgi transport. J. Cell Biol. 155, 1213-1224.
51. Mazzarella, R.A., Srinivasan, M., Haugejorden, S.M., and Green, M. (1990). ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase. J. Biol. Chem. 265, 1094-1101.
52. McCracken, A.A., and Brodsky, J.L. (2003). Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD). Bioessays 25, 868-877.
53. Miles, S., McManus, H., Forsten, K.E., and Storrie, B. (2001). Evidence that the entire Golgi apparatus cycles in interphase HeLa cells: sensitivity of Golgi matrix proteins to an ER exit block J. Cell Biol. 155, 543-555.
54. Mironov, A.A., et al. (2001). Small cargo proteins and large aggregates can traverse the Golgi by a common mechanism without leaving the lumen of cisternae. J. Cell Biol. 155, 1225-1238.
55. Morsomme, P., Prescianotto-Baschong, C., and Riezman, H. (2003). The ER v-SNAREs are required for GPI-anchored protein sorting from other secretory proteins upon exit from the ER. J. Cell Biol. 162, 403-412.
56. Morsomme, P., and Riezman, H. (2002). The Rab GTPase Ypt1p and tethering factors couple protein sorting at the ER to vesicle targeting to the Golgi apparatus. Dev. Cell 2, 307-317.
57. Moremen, K.W. (2002). Golgi alpha-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals. Biochim. Biophys. Acta 1573, 225-235.
58. Nagahama, M., Orci, L., Ravazzola, M., Amherdt, M., Lacomis, L., Tempst, P., Rothman, J.E., and Söllner, T.H. (1996). A v-SNARE implicated in intra-Golgi transport. J. Cell Biol. 133, 507-516.
59. Nakamura, N., Rabouille, C., Watson, R., Nilsson, T., Hui, N., Slusarewicz, P., Kreis, T.E., and Warren, G. (1995). Characterization of a cis-Golgi matrix protein, GM130. J. Cell Biol. 131, 1715-1726.
60. Novina, C.D., Murray, M.F., Dykxhoorn, D.M., Beresford, P.J., Riess, J., Lee, S.K., Collman, R.G., Lieberman, J., Shankar, P., and Sharp, P.A. (2002). siRNA-directed inhibition of HIV-1 infection. Nat. Med. 8, 681-686.
61. Oka, T., Nishikawa, S., and Nakano, A. (1991). Reconstitution of GTP-binding Sar1 protein function in ER to Golgi transport. J. Cell Biol. 114, 671-679.
62. Opat, A.S., van Vliet, C., and Gleeson, P.A. (2001). Trafficking and localisation of resident Golgi glycosylation enzymes. Biochimie 83, 763-773.
63. Orci, L., Ravazzola, M., Volchuk, A., Engel, T., Gmachl, M., Amherdt, M., Perrelet, A., Söllner, T.H., and Rothman, J.E. (2000). Anterograde flow of cargo across the Golgi stack potentially mediated via bidirectional "percolating" COPI vesicles. Proc. Natl. Acad. Sci. 97, 10400-10405.
64. Pelham, H.R., and Rothman, J.E. (2000). The debate about transport in the Golgi-two sides of the same coin? Cell 102, 713-719.
65. Perkel, V. S., Y. Miura, and J. A. Magner. (1989) Brefeldin A inhibits oligosaccharide processing of glycoproteins in mouse hypothyroid pituitary tissue at several subcellular sites. Proc. Soc. Exp. Biol. Med. 190, 286-293.
66. Podos, S.D., Reddy, P., Ashkenas, J., and Krieger, M. (1994). LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function. J. Cell Biol. 127, 679-691.
67. Puri, S., Bachert, C., Fimmel, CJ., and Linstedt, A.D. (2002). Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruption. Traffic 3, 641-653.
68. Ram, R.J., Li, B., and Kaiser, C.A. (2002). Identification of Sec36p, Sec37p and Sec38p: components of the yeast complex that contains Sec34p and Sec35p. Mol. Biol. Cell. 13, 1484-1500.
69. Reddy, P., and Krieger, M. (1989). Isolation and characterization of an extragenic suppressor of the low-density lipoprotein receptor-deficient phenotype of a Chinese hamster ovary cell mutant. Mol. Cell. Biol. 9, 4799-4806.
70. Roth, J. (2002). Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions. Chem. Rev. 102, 285-303.
71. Sacher, M., Jiang, Y., Barrowman, J., Scarpa, A., Burston, J., Zhang, L., Schieltz, D., Yates J.R. 3rd, Abeliovich, H., and Ferro-Novick, S. (1998). TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J. 17, 2494-2503.
72. Sampath, D., Varki, A., and Freeze, H.H. (1992). The spectrum of incomplete N-linked oligosaccharides synthesized by endothelial cells in the presence of brefeldin A. J. Biol. Chem. 267, 4440-4455.
73. Satoh, A., Wang, Y., Malsam, J., Beard, M.B., and Warren, G. (2003). Golgin-84 is a rab1 binding partner involved in Golgi structure. Traffic 4, 153-161.
74. Schekman, R., and Orci, L. (1996). Coat proteins and vesicle budding. Science 271, 1526-1533.
75. Seemann, J., E. Jokitalo, M. Pypaert, and G. Warren. 2000. Matrix proteins can generate the higher order architecture of the Golgi apparatus. Nature 407, 1022-1026.
76. Shorter, J., Beard, M.B., Seemann, J., Dirac-Svejstrup, A.B., and Warren, G. (2002). Sequential tethering of golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115. J. Cell Biol. 157, 45-62.
77. Shorter, J., and Warren, G. (2002). Golgi architecture and inheritance. Annu. Rev. Cell Dev. Biol. 18, 379-420.
78. Siniossoglou, S., and Pelham, H.R. (2001). An effector of Ypt6p binds the SNARE T1g1p and mediates selective fusion of vesicles with late Golgi membranes. EMBO J. 20, 5991-5998.
79. Skrincosky, D., Kain, R., El-Battari, A., Exner, M., Kerjaschki, D., and Fukuda, M. (1997). Altered Golgi localization of core 2 beta-1,6-N-acetylglucosaminyltransferase leads to decreased synthesis of branched O-glycans. J. Biol. Chem. 272, 22695-22702.
80. Sönnichsen, B., Lowe, M., Levine, T., Jamsa, E., Dirac-Svejstrup, B., and Warren, G. (1998). A role for giantin in docking COPI vesicles to Golgi membranes. J. Cell Biol. 140, 1013-1021.
81. Spelbrink, R.G., and Nothwehr, S.F. (1999). The yeast GRD20 gene Is required for protein sorting in the trans-Golgi network/endosomal system and for polarization of the actin cytoskeleton. Mol. Biol. Cell. 10, 4263-4281.
82. Storrie, B., White, J., Röttger, S., Stelzer, E.H., Suganuma, T., and Nilsson, T. (1998). Recycling of Golgi-resident glycosyltransferases through the ER reveals a novel pathway and provides an explanation for nocodazole-induced Golgi scattering. J. Cell Biol. 143, 1505-1521.
83. Storrie, B., Pepperkok, R., and Nilsson, T. (2000). Breaking the COPI monopoly on Golgi recycling. Trends Cell Biol. 10, 385-391.
84. Storrie, B., and Nilsson, T. (2002). The Golgi apparatus: balancing new with old. Traffic 3, 521-529.
85. Stroud, W.J., Jiang, S., Jack, G., and Storrie, B. (2003). Persistence of Golgi matrix distribution exhibits the same dependence on Sarlp activity as a Golgi glycosyltransferase. Traffic 4, 631-641.
86. Subramaniam, V.N., Krijnse-Locker, J., Tang, B.L., Ericsson, M., Yusoff, A.R., Griffithris, G., and Hong, W. (1995). Monoclonal antibody HFD9 identifies a novel 28 kDa integral membrane protein on the cis-Golgi. J. Cell Sci. 108, 5-14.
87. Subramaniam, V.N., Peter, F., Philp, R., Wong, S.H., and Hong, W. (1996). GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport. Science 272, 1161-1163.
88. Suvorova, E.S., Kurten, R.C., and Lupashin, V.V. (2001). Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery. J. Biol. Chem. 276, 22810-22818.
89. Suvorova, E.S., Duden, R., and Lupashin, V.V. (2002). The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins. J. Cell Biol. 157, 631-643.
90. Todorow, Z., Spang, A., Carmack, E., Yates, J., and Schekman, R. (2000). Active recycling of yeast Golgi mannosyltransferase complexes through the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 97, 13643-13648.
91. Ungar, D., Oka, T., Brittle, E.E., Vasile, E., Lupashin, V.V., Chatterton, J.E., Heuser, J.E., Krieger, M., and Waters, M.G. (2002). Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. J. Cell Biol. 157, 405-415.
92. van Echten, G., Iber, H., Stotz, H., Takatsuki, A., and Sandhoff, K. (1990). Uncoupling of ganglioside biosynthesis by brefeldin A. Eur. J. Cell Biol. 51, 135-139.
93. VanRheenen, S.M., Cao, X., Lupashin, V.V., Barlowe, C., and Waters, M.G. (1998). Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking. J. Cell Biol. 141, 1107-1119.
94. VanRheenen, S.M., Cao, X., Sapperstein, S.K., Chiang, E.C., Lupashin, V.V., Barlowe, C., and Waters, M.G. (1999). Sec34p and Sec35p are components of a protein complex required for vesicle tethering the yeast Golgi. J. Cell Biol. 147, 729-742.
95. Walter, D.M., Paul, K.S., and Waters, M.G. (1998). Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport. J. Biol. Chem. 273, 29565-29576.
96. Ward, T.H., Polishchuk, R.S., Caplan, S., Hirschberg, K., and Lippincott-Schwartz, J. (2001). Maintenance of Golgi structure and function depends on the integrity of ER export. J. Cell Biol. 155, 557-570.
97. Waters, M.G., Serafini, T., and Rothman, J.E. (1991). 'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles. Nature 349, 248-251.
98. Whyte, J.R.C., and Munro, S. (2001). The Sec34/35 Golgi Transport Complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. Dev. Cell 1, 527-537.
99. Wiertz, E.J., Jones, T.R., Sun, L., Bogyo, M., Geuze, HJ., and Ploegh, H.L. (1996b). The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell 84, 769-779.
100. Wiertz, E.J., Tortorella, D., Bogyo, M., Yu, J., Mothes, W., Jones, T.R., Rapoport, T.A., and Ploegh, H.L. (1996a). Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature 384, 432-438.
101. Whestehube, L.J., Duden, R., Eun, A., Harmamoto, S., Korn, R., Ram, R., and Schekman, R. (1996). New mutants of Saccharomyces cerevisiae affected in the transport of proteins from the endoplasmic reticulum to the Golgi complex. Genetics 142, 393-406.
102. Xu, Y., Wong, S.H., Zhang, T., Subramaniam, V.N., and Hong, W. (1997). GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1. J. Biol. Chem. 272, 20162-20166.
103. Xu, Y., Martin, S., James, D.E., and Hong, W. (2002). GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. Mol. Biol. Cell 13, 3493-3507.
104. Yoshimori, T., Yamamoto, A., Moriyama, Y., Futai, M., and Tashiro, Y. (1991). Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J. Biol. Chem. 266, 17707-17712.
105. Yuan, L., Barriocanal, J.G.; Bonifacino, J.S., and Sandoval, I.V. (1987). Two integral membrane proteins located in the cis-middle and trans-part of the Golgi system acquire sialylated N-linked carbohydrates and display different turnovers and sensitivity to cAMP-dependent phosphorylation. J. Cell Biol. 105, 215-227.
106. Zaal, K.J.M., et al. (1999). Golgi membranes are absorbed into and reemerge from the ER during mitosis. Cell 99, 589-601.
107. Zerfaoui, M., Fukuda, M., Langlet, C., Mathieu, S., Suzuki, M., Lombardo, D., and El-Battari, A. (2002). The cytosolic and transmembrane domains of the beta 1, 6 N-acetylglucosaminyltransferase (C2GnT) function as a cis to medial/Golgitargeting determinant. Glycobiology 12, 15-24.