메뉴 건너뛰기




Volumn 2, Issue 1, 2010, Pages 97-111

Differential activation of JAK enzymes in rheumatoid arthritis and autoimmune disorders by pro-inflammatory cytokines: Potential drug targets

Author keywords

Autoimmunity; Cytokines; Inflammation; Janus kinase; Signal transducers and activators of transcription; Small molecule inhibitors

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; JANUS KINASE; METALLOPROTEINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; STAT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TARGET OF RAPAMYCIN KINASE;

EID: 78649385348     PISSN: None     EISSN: 1179139X     Source Type: Book Series    
DOI: 10.2147/IJICMR.S9470     Document Type: Article
Times cited : (6)

References (227)
  • 2
    • 24944520787 scopus 로고    scopus 로고
    • The Jak-STAT pathway in rheumatoid arthritis
    • Walker JG, Smith MD. The Jak-STAT pathway in rheumatoid arthritis. J Rheumatol. 2005;32(9):1650-1653.
    • (2005) J Rheumatol , vol.32 , Issue.9 , pp. 1650-1653
    • Walker, J.G.1    Smith, M.D.2
  • 3
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT signaling pathway: Input and output integration
    • Murray PJ. The JAK-STAT signaling pathway: input and output integration. J Immunol. 2007;178(5):2623-2629.
    • (2007) J Immunol , vol.178 , Issue.5 , pp. 2623-2629
    • Murray, P.J.1
  • 4
    • 47249110406 scopus 로고    scopus 로고
    • Targeting cytokines, chemokines and adhesion molecules in rheumatoid arthritis
    • Malemud CJ, Reddy SK. Targeting cytokines, chemokines and adhesion molecules in rheumatoid arthritis. Curr Rheumatol Rev. 2008;4(4):219-234.
    • (2008) Curr Rheumatol Rev , vol.4 , Issue.4 , pp. 219-234
    • Malemud, C.J.1    Reddy, S.K.2
  • 5
    • 39649098693 scopus 로고    scopus 로고
    • Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new antidepression drugs
    • Malemud CJ, Miller AH. Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new antidepression drugs. Expert Opin Ther Targets. 2008;12(2):171-183.
    • (2008) Expert Opin Ther Targets , vol.12 , Issue.2 , pp. 171-183
    • Malemud, C.J.1    Miller, A.H.2
  • 6
    • 31144460322 scopus 로고    scopus 로고
    • Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: Unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis
    • Walker JG, Ahern MJ, Coleman M, et al. Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis. Ann Rheum Dis. 2006;65(2):149-156.
    • (2006) Ann Rheum Dis , vol.65 , Issue.2 , pp. 149-156
    • Walker, J.G.1    Ahern, M.J.2    Coleman, M.3
  • 7
    • 46249101392 scopus 로고    scopus 로고
    • Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility
    • Barton A, Thomson W, Ke X, et al. Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet. 2008;17(15):2274-2279.
    • (2008) Hum Mol Genet , vol.17 , Issue.15 , pp. 2274-2279
    • Barton, A.1    Thomson, W.2    Ke, X.3
  • 8
    • 34548427925 scopus 로고    scopus 로고
    • STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
    • Remmers EF, Plenge RM, Lee AT, et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med. 2007;357(10):977-986.
    • (2007) N Engl J Med , vol.357 , Issue.10 , pp. 977-986
    • Remmers, E.F.1    Plenge, R.M.2    Lee, A.T.3
  • 9
    • 66149094262 scopus 로고    scopus 로고
    • The immunopathogenesis of rheumatoid arthritis
    • Imboden JB. The immunopathogenesis of rheumatoid arthritis. Annu Rev Pathol. 2009;4:417-434.
    • (2009) Annu Rev Pathol , vol.4 , pp. 417-434
    • Imboden, J.B.1
  • 10
    • 0344665752 scopus 로고    scopus 로고
    • Type I interferon modulation of cellular responses to cytokines and infectious pathogens: Potential role in SLE pathogenesis
    • Ivashkiv LB. Type I interferon modulation of cellular responses to cytokines and infectious pathogens: potential role in SLE pathogenesis. Autoimmunity. 2003;36(8):473-479.
    • (2003) Autoimmunity , vol.36 , Issue.8 , pp. 473-479
    • Ivashkiv, L.B.1
  • 11
    • 77956407594 scopus 로고    scopus 로고
    • Evidence for STAT4 as a common autoimmune gene: Rs7574865 is associated with colonic Crohn's disease and early disease onset
    • Glas J, Seiderer J, Nagy M, et al. Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. PLoS One. 2010;5(4):e10373.
    • (2010) PLoS One , vol.5 , Issue.4
    • Glas, J.1    Seiderer, J.2    Nagy, M.3
  • 13
    • 0036694589 scopus 로고    scopus 로고
    • IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    • Ishihara K, Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 2002; 13(4-5):357-368.
    • (2002) Cytokine Growth Factor Rev , vol.13 , Issue.4-5 , pp. 357-368
    • Ishihara, K.1    Hirano, T.2
  • 14
    • 77953473493 scopus 로고    scopus 로고
    • Recent advances in neutralizing the IL-6 pathway in arthritis
    • Malemud CJ. Recent advances in neutralizing the IL-6 pathway in arthritis. Open Access Rheumatol Res Rev. 2009;1:133-150.
    • (2009) Open Access Rheumatol Res Rev , vol.1 , pp. 133-150
    • Malemud, C.J.1
  • 15
    • 67651096055 scopus 로고    scopus 로고
    • Regulation of T cell-dendritic cell interactions by IL-7 governs T-cell activation and homeostasis
    • Saini M, Pearson C, Seddon B. Regulation of T cell-dendritic cell interactions by IL-7 governs T-cell activation and homeostasis. Blood. 2009;113(23):5793-5800.
    • (2009) Blood , vol.113 , Issue.23 , pp. 5793-5800
    • Saini, M.1    Pearson, C.2    Seddon, B.3
  • 16
    • 65449185003 scopus 로고    scopus 로고
    • Novel function for interleukin-7 in dendritic cell development
    • Vogt TK, Link A, Perrin J, Finke D, Luther SA. Novel function for interleukin-7 in dendritic cell development. Blood. 2009;113(17): 3961-3968.
    • (2009) Blood , vol.113 , Issue.17 , pp. 3961-3968
    • Vogt, T.K.1    Link, A.2    Perrin, J.3    Finke, D.4    Luther, S.A.5
  • 17
    • 44849125718 scopus 로고    scopus 로고
    • Interleukin-7 in rheumatoid arthritis
    • Churchman SM, Ponchel F. Interleukin-7 in rheumatoid arthritis. Rheumatology (Oxford). 2008;47(6):753-759.
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.6 , pp. 753-759
    • Churchman, S.M.1    Ponchel, F.2
  • 18
    • 70149094177 scopus 로고    scopus 로고
    • Cutting edge: IL-7 regulates the peripheral pool of adult ROR γ+ lymphoid tissue inducer cells
    • Schmutz S, Bosco N, Chappaz S, et al. Cutting edge: IL-7 regulates the peripheral pool of adult ROR γ+ lymphoid tissue inducer cells. J Immunol. 2009;183(4):2217-2221.
    • (2009) J Immunol , vol.183 , Issue.4 , pp. 2217-2221
    • Schmutz, S.1    Bosco, N.2    Chappaz, S.3
  • 19
    • 77953643594 scopus 로고    scopus 로고
    • The discovery of novel experimental therapies for inflammatory arthritis
    • Malemud CJ. The discovery of novel experimental therapies for inflammatory arthritis. Mediators Inflam. 2009;2009:698769.
    • (2009) Mediators Inflam , vol.2009 , pp. 698769
    • Malemud, C.J.1
  • 20
    • 0034767689 scopus 로고    scopus 로고
    • Serum interleukin-12, interleukin-15, soluble CD26, and adenosine deaminase in patients with rheumatoid arthritis
    • Cordero OJ, Salgado FJ, Mera-Varela A, Nogueira M. Serum interleukin-12, interleukin-15, soluble CD26, and adenosine deaminase in patients with rheumatoid arthritis. Rheumatol Int. 2001;21(2): 69-74.
    • (2001) Rheumatol Int , vol.21 , Issue.2 , pp. 69-74
    • Cordero, O.J.1    Salgado, F.J.2    Mera-Varela, A.3    Nogueira, M.4
  • 21
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal S, Ghilardi N, Xie M-H, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003;278(3): 1910-1914.
    • (2003) J Biol Chem , vol.278 , Issue.3 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.-H.3    de Sauvage, F.J.4    Gurney, A.L.5
  • 22
    • 34547777299 scopus 로고    scopus 로고
    • 2 exacerbates collagen-induced arthritis in mice through the inflammatory interleukin-23/interleukin-17 axis
    • 2 exacerbates collagen-induced arthritis in mice through the inflammatory interleukin-23/interleukin-17 axis. Arthritis Rheum. 2007;56(8):2608-2619.
    • (2007) Arthritis Rheum , vol.56 , Issue.8 , pp. 2608-2619
    • Sheibanie, A.F.1    Khayrullina, T.2    Safadi, F.F.3    Ganea, D.4
  • 24
    • 0038518197 scopus 로고    scopus 로고
    • The role of IL-17 and family members in the pathogenesis of arthritis
    • Lubberts E. The role of IL-17 and family members in the pathogenesis of arthritis. Curr Opin Investig Drugs. 2003;4(5):572-577.
    • (2003) Curr Opin Investig Drugs , vol.4 , Issue.5 , pp. 572-577
    • Lubberts, E.1
  • 26
    • 33846249233 scopus 로고    scopus 로고
    • Interleukin-17 as a molecular target in immune-mediated arthritis: Immunoregulatory properties of genetically modified murine dendritic cells that secrete interleukin-4
    • Sarkar S, Tesmer LA, Hindnavis V, Endres JL, Fox DA. Interleukin-17 as a molecular target in immune-mediated arthritis: immunoregulatory properties of genetically modified murine dendritic cells that secrete interleukin-4. Arthritis Rheum. 2007;56(1):89-100.
    • (2007) Arthritis Rheum , vol.56 , Issue.1 , pp. 89-100
    • Sarkar, S.1    Tesmer, L.A.2    Hindnavis, V.3    Endres, J.L.4    Fox, D.A.5
  • 27
    • 77955445597 scopus 로고    scopus 로고
    • Role of IL-17 in the Th1 systemic defects in rheumatoid arthritis through selective IL-12Rβ2 inhibition
    • Toh ML, Kawashima M, Hot A, Miossec P, Miossec P. Role of IL-17 in the Th1 systemic defects in rheumatoid arthritis through selective IL-12Rβ2 inhibition. Ann Rheum Dis. 2010;69(8):1562-1567.
    • (2010) Ann Rheum Dis , vol.69 , Issue.8 , pp. 1562-1567
    • Toh, M.L.1    Kawashima, M.2    Hot, A.3    Miossec, P.4    Miossec, P.5
  • 28
    • 28744451019 scopus 로고    scopus 로고
    • The Jak-STAT pathway stimulated by interferon alpha or interferon beta
    • Horvath CM. The Jak-STAT pathway stimulated by interferon alpha or interferon beta. Sci STKE. 2004;2004(260):tr10.
    • (2004) Sci STKE , vol.2004 , Issue.260
    • Horvath, C.M.1
  • 29
    • 52949111844 scopus 로고    scopus 로고
    • Interferons pen the JAK-STAT pathway
    • Schindler C, Plumlee C. Interferons pen the JAK-STAT pathway. Semin Cell Dev Biol. 2008;19(4):311-318.
    • (2008) Semin Cell Dev Biol , vol.19 , Issue.4 , pp. 311-318
    • Schindler, C.1    Plumlee, C.2
  • 31
    • 70349736116 scopus 로고    scopus 로고
    • Cross-regulation of signaling pathways by interferon-γ: Implications for immune responses and autoimmune diseases
    • Hu X, Ivashkiv LB. Cross-regulation of signaling pathways by interferon-γ: implications for immune responses and autoimmune diseases. Immunity. 2009;31(4):539-550.
    • (2009) Immunity , vol.31 , Issue.4 , pp. 539-550
    • Hu, X.1    Ivashkiv, L.B.2
  • 33
    • 77149137827 scopus 로고    scopus 로고
    • Targeting JAK/STAT signaling pathway in inflammatory diseases
    • Malemud CJ, Pearlman E. Targeting JAK/STAT signaling pathway in inflammatory diseases. Curr Signal Transduct Ther. 2009; 4:201-221.
    • (2009) Curr Signal Transduct Ther , vol.4 , pp. 201-221
    • Malemud, C.J.1    Pearlman, E.2
  • 35
    • 77954622264 scopus 로고    scopus 로고
    • Trafficking properties of plasmacytoid dendritic cells in health and disease
    • Sozzani S, Vermi W, Prete AD, Fracchetti F. Trafficking properties of plasmacytoid dendritic cells in health and disease. Trends Immunol. 2010;31(7):270-277.
    • (2010) Trends Immunol , vol.31 , Issue.7 , pp. 270-277
    • Sozzani, S.1    Vermi, W.2    Prete, A.D.3    Fracchetti, F.4
  • 36
    • 77951433725 scopus 로고    scopus 로고
    • The type I IFN system in rheumatoid arthritis
    • Conigliaro P, Perricone C, Benson RA, et al. The type I IFN system in rheumatoid arthritis. Autoimmunity. 2010;43(3):220-225.
    • (2010) Autoimmunity , vol.43 , Issue.3 , pp. 220-225
    • Conigliaro, P.1    Perricone, C.2    Benson, R.A.3
  • 37
    • 33745190990 scopus 로고    scopus 로고
    • + regulatory T cells in health and disease
    • + regulatory T cells in health and disease. Clin Exp Pharmacol Physiol. 2006;33(5-6):519-524.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , Issue.5-6 , pp. 519-524
    • Liu, H.1    Leung, B.P.2
  • 38
    • 51449116424 scopus 로고    scopus 로고
    • + CD25 high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis
    • + CD25 high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis. Cell Immunol. 2008;253(1-2): 92-101.
    • (2008) Cell Immunol , vol.253 , Issue.1-2 , pp. 92-101
    • Han, G.M.1    O'neill-Andersen, N.J.2    Zurier, R.B.3    Lawrence, D.A.4
  • 40
    • 72949107811 scopus 로고    scopus 로고
    • Translational mini-review series on Th17 cells: Function and regulation of human T helper 17 cells in health and disease
    • Crome SQ, Wang AY, Levings MK. Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol. 2010;159(2):109-119.
    • (2010) Clin Exp Immunol , vol.159 , Issue.2 , pp. 109-119
    • Crome, S.Q.1    Wang, A.Y.2    Levings, M.K.3
  • 42
    • 33745211931 scopus 로고    scopus 로고
    • Defective regulatory and effector T cell functions in patients with FOXP3 mutations
    • Bacchetta R, Passerini L, Gambineri E, et al. Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest. 2006;116(6):1713-1722.
    • (2006) J Clin Invest , vol.116 , Issue.6 , pp. 1713-1722
    • Bacchetta, R.1    Passerini, L.2    Gambineri, E.3
  • 43
    • 0033945403 scopus 로고    scopus 로고
    • IL-4/IL-13 signaling beyond JAK/STAT
    • Jiang H, Harris MB, Rothman P. IL-4/IL-13 signaling beyond JAK/STAT. J Allergy Clin Immunol. 2000;105(6 Pt 1):1063-1070.
    • (2000) J Allergy Clin Immunol , vol.105 , Issue.6 Pt 1 , pp. 1063-1070
    • Jiang, H.1    Harris, M.B.2    Rothman, P.3
  • 44
    • 0032779561 scopus 로고    scopus 로고
    • The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes
    • Donnelly RP, Dickensheets H, Finbloom DS. The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. J Interferon Cytokine Res. 1999;19(6):563-573.
    • (1999) J Interferon Cytokine Res , vol.19 , Issue.6 , pp. 563-573
    • Donnelly, R.P.1    Dickensheets, H.2    Finbloom, D.S.3
  • 45
    • 0032996486 scopus 로고    scopus 로고
    • The Jak-STAT pathway: Cytokine signalling from the receptor to the nucleus
    • Heim MH. The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus. J Recept Signal Transduct Res. 1999;19(1-4):75-120.
    • (1999) J Recept Signal Transduct Res , vol.19 , Issue.1-4 , pp. 75-120
    • Heim, M.H.1
  • 46
    • 0035988802 scopus 로고    scopus 로고
    • Interleukin-13 in autoimmune rheumatic diseases: Relationship with autoantibody profile
    • Spadaro A, Rinaldi T, Riccieri V, Taccari E, Valesini G. Interleukin-13 in autoimmune rheumatic diseases: relationship with autoantibody profile. Clin Exp Rheumatol. 2002;20(2):213-216.
    • (2002) Clin Exp Rheumatol , vol.20 , Issue.2 , pp. 213-216
    • Spadaro, A.1    Rinaldi, T.2    Riccieri, V.3    Taccari, E.4    Valesini, G.5
  • 47
    • 0036157974 scopus 로고    scopus 로고
    • Interleukin 13 in synovial fluid and serum of patients with psoriatic arthritis
    • Spadaro A, Rinaldi T, Riccieri V, Valesini G, Taccari E. Interleukin 13 in synovial fluid and serum of patients with psoriatic arthritis. Ann Rheum Dis. 2002;61(2):174-176.
    • (2002) Ann Rheum Dis , vol.61 , Issue.2 , pp. 174-176
    • Spadaro, A.1    Rinaldi, T.2    Riccieri, V.3    Valesini, G.4    Taccari, E.5
  • 48
    • 0037072796 scopus 로고    scopus 로고
    • Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10
    • Lejuene D, Dumoutier L, Constantinescu S, Kruijer W, Schuringa JJ, Renauld JC. Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. J Biol Chem. 2002;277(37):33676-33682.
    • (2002) J Biol Chem , vol.277 , Issue.37 , pp. 33676-33682
    • Lejuene, D.1    Dumoutier, L.2    Constantinescu, S.3    Kruijer, W.4    Schuringa, J.J.5    Renauld, J.C.6
  • 49
    • 4143105721 scopus 로고    scopus 로고
    • STAT6 and Ets-1 form a stable complex that modulates Socs-1 expression by interleukin-4 in ketatinocytes
    • Travagli J, Letourneur M, Bertoglio J, Pierre J. STAT6 and Ets-1 form a stable complex that modulates Socs-1 expression by interleukin-4 in ketatinocytes. J Biol Chem. 2004;279(34):35183-35192.
    • (2004) J Biol Chem , vol.279 , Issue.34 , pp. 35183-35192
    • Travagli, J.1    Letourneur, M.2    Bertoglio, J.3    Pierre, J.4
  • 50
    • 33644888064 scopus 로고    scopus 로고
    • SOCS1: A potent and multifaceted regulator of cytokines and cell-mediated inflammation
    • Davey GM, Heath WR, Starr R. SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation. Tissue Antigens. 2006;67(1):1-9.
    • (2006) Tissue Antigens , vol.67 , Issue.1 , pp. 1-9
    • Davey, G.M.1    Heath, W.R.2    Starr, R.3
  • 51
    • 41549107522 scopus 로고    scopus 로고
    • Cytokine signaling modules in inflammatory responses
    • O'Shea JJ, Murray PJ. Cytokine signaling modules in inflammatory responses. Immunity. 2008;28(4):477-487.
    • (2008) Immunity , vol.28 , Issue.4 , pp. 477-487
    • O'Shea, J.J.1    Murray, P.J.2
  • 52
    • 38149077449 scopus 로고    scopus 로고
    • IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells, HOZOT
    • Tsuji-Takayama K, Suzuki M, Yamamoto M, et al. IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells, HOZOT. Exp Hematol. 2008;36(2):181-192.
    • (2008) Exp Hematol , vol.36 , Issue.2 , pp. 181-192
    • Tsuji-Takayama, K.1    Suzuki, M.2    Yamamoto, M.3
  • 54
    • 0034658024 scopus 로고    scopus 로고
    • Serine phosphorylation of STATs
    • Decker T, Kovarik P. Serine phosphorylation of STATs. Oncogene. 2000;19(21):2628-2637.
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2628-2637
    • Decker, T.1    Kovarik, P.2
  • 55
    • 4644261307 scopus 로고    scopus 로고
    • The STAT3 isoforms α and β have unique and special functions
    • Maritano D, Sugrue ML, Tininini S, et al. The STAT3 isoforms α and β have unique and special functions. Nat Immunol. 2004;5(4):401-409.
    • (2004) Nat Immunol , vol.5 , Issue.4 , pp. 401-409
    • Maritano, D.1    Sugrue, M.L.2    Tininini, S.3
  • 56
    • 33751555600 scopus 로고    scopus 로고
    • General nature of the STAT3-activated anti-inflammatory response
    • El Kasmi KC, Holst J, Coffre M, et al. General nature of the STAT3-activated anti-inflammatory response. J Immunol. 2006;177(11): 7880-7888.
    • (2006) J Immunol , vol.177 , Issue.11 , pp. 7880-7888
    • El Kasmi, K.C.1    Holst, J.2    Coffre, M.3
  • 57
    • 32844470034 scopus 로고    scopus 로고
    • The role of apoptosis in arthritis
    • Malemud CJ, Gillespie HJ. The role of apoptosis in arthritis. Curr Rheumatol Rev. 2005;1(2):131-142.
    • (2005) Curr Rheumatol Rev , vol.1 , Issue.2 , pp. 131-142
    • Malemud, C.J.1    Gillespie, H.J.2
  • 58
    • 33645871828 scopus 로고    scopus 로고
    • Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-γ through JAK/STAT pathway by translational regulation
    • Tamai M, Kawakami A, Tanaka F, et al. Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-γ through JAK/STAT pathway by translational regulation. J Lab Clin Med. 2006;147(4):182-190.
    • (2006) J Lab Clin Med , vol.147 , Issue.4 , pp. 182-190
    • Tamai, M.1    Kawakami, A.2    Tanaka, F.3
  • 59
    • 77953481128 scopus 로고    scopus 로고
    • + effector/memory T cells by upregulating Bcl-2 proteins and activating the JAK/STAT signalling pathway
    • + effector/memory T cells by upregulating Bcl-2 proteins and activating the JAK/STAT signalling pathway. Immunology. 2010;130(3):418-426.
    • (2010) Immunology , vol.130 , Issue.3 , pp. 418-426
    • Chetoui, N.1    Boisvert, M.2    Gendron, S.3    Aoudjit, F.4
  • 60
    • 77449128739 scopus 로고    scopus 로고
    • STAT1, STAT3 and p38MAPK are involved in the apoptotic effect induced by a chimeric cyclic interferon-α2b peptide
    • Blank VC, Peńa C, Roguin LP. STAT1, STAT3 and p38MAPK are involved in the apoptotic effect induced by a chimeric cyclic interferon-α2b peptide. Exp Cell Res. 2010;316(4):603-614.
    • (2010) Exp Cell Res , vol.316 , Issue.4 , pp. 603-614
    • Blank, V.C.1    Peńa, C.2    Roguin, L.P.3
  • 61
    • 20144367654 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling and immune responses by SOCS proteins
    • Yoshimura A, Nishinakamura H, Matsumura Y, Hanada T. Negative regulation of cytokine signaling and immune responses by SOCS proteins. Arthritis Res Ther. 2005;7(3):100-110.
    • (2005) Arthritis Res Ther , vol.7 , Issue.3 , pp. 100-110
    • Yoshimura, A.1    Nishinakamura, H.2    Matsumura, Y.3    Hanada, T.4
  • 62
    • 77954912266 scopus 로고    scopus 로고
    • Dysfunctional immune-mediated inflammation in rheumatoid arthritis dictates that development of anti-rheumatic disease drugs target multiple intracellular signaling pathways
    • In press
    • Malemud CJ. Dysfunctional immune-mediated inflammation in rheumatoid arthritis dictates that development of anti-rheumatic disease drugs target multiple intracellular signaling pathways. Anti Inflamm Anti Allergy Agents Med Chem. In press 2010.
    • (2010) Anti Inflamm Anti Allergy Agents Med Chem
    • Malemud, C.J.1
  • 63
    • 77953834479 scopus 로고    scopus 로고
    • Apoptotic regulators and RA
    • Hutcheson J, Perlman H. Apoptotic regulators and RA. Curr Rheumatol Rev. 2008;4(4):254-258.
    • (2008) Curr Rheumatol Rev , vol.4 , Issue.4 , pp. 254-258
    • Hutcheson, J.1    Perlman, H.2
  • 64
    • 78649390785 scopus 로고    scopus 로고
    • Targeting growth factors in arthritis: A rational for restoring the IGF-1 response in chondrocytes
    • van de Loo FA, Veenbergen S, van den Berg WB. Targeting growth factors in arthritis: a rational for restoring the IGF-1 response in chondrocytes. Curr Rheumatol Rev. 2008;4(4):266-276.
    • (2008) Curr Rheumatol Rev , vol.4 , Issue.4 , pp. 266-276
    • van de Loo, F.A.1    Veenbergen, S.2    van den Berg, W.B.3
  • 66
    • 11144243389 scopus 로고    scopus 로고
    • Tissue engineering of autologous cartilage grafts in three-dimensional in vitro macroaggregate culture system
    • Neumann A, Dennis JE, Aigner J, et al. Tissue engineering of autologous cartilage grafts in three-dimensional in vitro macroaggregate culture system. Tissue Eng. 2004;10(11-12):1695-1706.
    • (2004) Tissue Eng , vol.10 , Issue.11-12 , pp. 1695-1706
    • Neumann, A.1    Dennis, J.E.2    Aigner, J.3
  • 67
    • 33746139407 scopus 로고    scopus 로고
    • Janus kinase 2: A critical target in chronic myelogenous leukemia
    • Samanta AK, Lin H, Sun T, Kantarjian H, Arlinghaus RB. Janus kinase 2: a critical target in chronic myelogenous leukemia. Cancer Res. 2006;66(13):6468-6472.
    • (2006) Cancer Res , vol.66 , Issue.13 , pp. 6468-6472
    • Samanta, A.K.1    Lin, H.2    Sun, T.3    Kantarjian, H.4    Arlinghaus, R.B.5
  • 68
    • 77952315859 scopus 로고    scopus 로고
    • Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of pancreatic cancer cells in vitro
    • Huang C, Yang C, Jiang T, Huang K, Cao J, Qiu Z. Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of pancreatic cancer cells in vitro. J Exp Clin Cancer Res. 2010;29(1):51.
    • (2010) J Exp Clin Cancer Res , vol.29 , Issue.1 , pp. 51
    • Huang, C.1    Yang, C.2    Jiang, T.3    Huang, K.4    Cao, J.5    Qiu, Z.6
  • 69
    • 0033861096 scopus 로고    scopus 로고
    • JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells
    • de Vos J, Jourdan M, Tarte K, Jasmin C, Klein B. JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells. Br J Haematol. 2000;109(4):823-828.
    • (2000) Br J Haematol , vol.109 , Issue.4 , pp. 823-828
    • de Vos, J.1    Jourdan, M.2    Tarte, K.3    Jasmin, C.4    Klein, B.5
  • 70
    • 67649383498 scopus 로고    scopus 로고
    • Janus kinase 2 inhibitor AG490 inhibits the STAT3 signaling pathway by suppressing protein translation of gp130
    • Seo IA, Lee HK, Shin YK, et al. Janus kinase 2 inhibitor AG490 inhibits the STAT3 signaling pathway by suppressing protein translation of gp130. Korean J Physiol Pharmacol. 2009;13(4):131-138.
    • (2009) Korean J Physiol Pharmacol , vol.13 , Issue.4 , pp. 131-138
    • Seo, I.A.1    Lee, H.K.2    Shin, Y.K.3
  • 71
    • 78649376514 scopus 로고    scopus 로고
    • New organ-specific pharmacological strategies interfering with signaling pathways in inflammatory disorders/autoimmune disorders
    • In press
    • Wisler BA, Dennis JE, Malemud CJ. New organ-specific pharmacological strategies interfering with signaling pathways in inflammatory disorders/autoimmune disorders. Curr Signal Transduct Ther. In press 2010.
    • (2010) Curr Signal Transduct Ther
    • Wisler, B.A.1    Dennis, J.E.2    Malemud, C.J.3
  • 72
    • 22244489988 scopus 로고    scopus 로고
    • Role of interleukin 6 (IL-6)/IL-6R-induced signal transducers and activators of transcription and mitogen-activated protein kinase/extracellular
    • Legendre F, Bogdanowicz P, Boumediene K, Pujol J-P. Role of interleukin 6 (IL-6)/IL-6R-induced signal transducers and activators of transcription and mitogen-activated protein kinase/extracellular. J Rheumatol. 2005;32(7):1307-1316.
    • (2005) J Rheumatol , vol.32 , Issue.7 , pp. 1307-1316
    • Legendre, F.1    Bogdanowicz, P.2    Boumediene, K.3    Pujol, J.-P.4
  • 73
    • 34547736572 scopus 로고    scopus 로고
    • Crosstalk between Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation
    • Hu X, Chen J, Wang L, Ivashkiv LB. Crosstalk between Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. J Leukoc Biol. 2007;82(2):237-243.
    • (2007) J Leukoc Biol , vol.82 , Issue.2 , pp. 237-243
    • Hu, X.1    Chen, J.2    Wang, L.3    Ivashkiv, L.B.4
  • 74
    • 34247871586 scopus 로고    scopus 로고
    • The expanding role for ITAM-based signaling pathways in immune cells
    • Abram CL, Lowell CA. The expanding role for ITAM-based signaling pathways in immune cells. Sci STKE. 2007;2007(377): re2.
    • (2007) Sci STKE , vol.2007 , Issue.377
    • Abram, C.L.1    Lowell, C.A.2
  • 75
    • 76749084297 scopus 로고    scopus 로고
    • JAK2 kinase inhibitors and myeloproliferative disorders
    • Chen AT, Prchal JT. JAK2 kinase inhibitors and myeloproliferative disorders. Curr Opin Hematol. 2010;17(2):110-116.
    • (2010) Curr Opin Hematol , vol.17 , Issue.2 , pp. 110-116
    • Chen, A.T.1    Prchal, J.T.2
  • 76
    • 70349756855 scopus 로고    scopus 로고
    • Will Jill come tumbling after? The case for a JAK2-type mutation as a prequel to the connective tissue disorders
    • McQueen FM, Dalbeth N. Will Jill come tumbling after? The case for a JAK2-type mutation as a prequel to the connective tissue disorders. Med Hypotheses. 2009;73(5):651-654.
    • (2009) Med Hypotheses , vol.73 , Issue.5 , pp. 651-654
    • McQueen, F.M.1    Dalbeth, N.2
  • 77
    • 33748110308 scopus 로고    scopus 로고
    • Interleukin-6: A new therapeutic target
    • Smolen JS, Maini RN. Interleukin-6: a new therapeutic target. Arthritis Res Ther. 2006;8 Suppl 2:S5.
    • (2006) Arthritis Res Ther , vol.8 , Issue.SUPPL. 2
    • Smolen, J.S.1    Maini, R.N.2
  • 78
    • 35348989327 scopus 로고    scopus 로고
    • Interleukin-6 receptor antagonist as therapy for rheumatoid arthritis
    • Crawford M, Moreland L. Interleukin-6 receptor antagonist as therapy for rheumatoid arthritis. Curr Rheumatol Rep. 2007;9(5):393-394.
    • (2007) Curr Rheumatol Rep , vol.9 , Issue.5 , pp. 393-394
    • Crawford, M.1    Moreland, L.2
  • 79
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 1994;264(5164):1415-1421.
    • (1994) Science , vol.264 , Issue.5164 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 80
    • 17944381636 scopus 로고    scopus 로고
    • A completely foreign receptor can mediate an interferon-γ response
    • Strobl B, Arulampalam V, Is'harc H, et al. A completely foreign receptor can mediate an interferon-γ response. EMBO J. 2001;20(19): 5431-5442.
    • (2001) EMBO J , vol.20 , Issue.19 , pp. 5431-5442
    • Strobl, B.1    Arulampalam, V.2    Is'harc, H.3
  • 81
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: Biological implications
    • Leonard WJ, O'Shea JJ. Jaks and STATs: biological implications. Annu Rev Immunol. 1998;16:293-322.
    • (1998) Annu Rev Immunol , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 82
    • 52949104437 scopus 로고    scopus 로고
    • Paradigm shifts in the cell biology of STAT signaling
    • Sehgal PB. Paradigm shifts in the cell biology of STAT signaling. Semin Cell Dev Biol. 2008;19(4):329-340.
    • (2008) Semin Cell Dev Biol , vol.19 , Issue.4 , pp. 329-340
    • Sehgal, P.B.1
  • 83
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription of binding to NFκB
    • Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription of binding to NFκB. Genes Dev. 2007;21(11): 1396-1408.
    • (2007) Genes Dev , vol.21 , Issue.11 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 84
    • 67249144899 scopus 로고    scopus 로고
    • Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes
    • Cheon H, Stark GR. Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes. Proc Natl Acad Sci U S A. 2009;106(23):9373-9378.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.23 , pp. 9373-9378
    • Cheon, H.1    Stark, G.R.2
  • 85
    • 77954932117 scopus 로고    scopus 로고
    • Suppression of autoimmune arthritis by small molecule inhibitors of the JAK/STAT pathway
    • Malemud CJ. Suppression of autoimmune arthritis by small molecule inhibitors of the JAK/STAT pathway. Pharmaceuticals. 2010;3(5): 1446-1455.
    • (2010) Pharmaceuticals , vol.3 , Issue.5 , pp. 1446-1455
    • Malemud, C.J.1
  • 86
    • 33748209244 scopus 로고    scopus 로고
    • IL-6 signaling via the STAT3/SOCS3 pathway: Functional analysis of the conserved STAT3 N-domain
    • Zhang L, Badgwell DB, Bevers JJ 3rd, et al. IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain. Mol Cell Biochem. 2006;288(1-2):179-189.
    • (2006) Mol Cell Biochem , vol.288 , Issue.1-2 , pp. 179-189
    • Zhang, L.1    Badgwell, D.B.2    Bevers III, J.J.3
  • 87
    • 4544341121 scopus 로고    scopus 로고
    • STAT2 nuclear trafficking
    • Banninger G, Reich NC. STAT2 nuclear trafficking. J Biol Chem. 2004;279(38):39199-39206.
    • (2004) J Biol Chem , vol.279 , Issue.38 , pp. 39199-39206
    • Banninger, G.1    Reich, N.C.2
  • 88
    • 0030840464 scopus 로고    scopus 로고
    • STATS and gene regulation
    • Darnell JE Jr. STATS and gene regulation. Science. 1997;277(5332): 1630-1635.
    • (1997) Science , vol.277 , Issue.5332 , pp. 1630-1635
    • Darnell Jr., J.E.1
  • 89
    • 7044235774 scopus 로고    scopus 로고
    • IFN-γ/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: A critical role of IRF-1
    • Jaruga B, Hong F, Kim W-H, Gao B. IFN-γ/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1. Am J Physiol Gastrointest Liver Physiol. 2004;287(5):G1044-G1052.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287 , Issue.5
    • Jaruga, B.1    Hong, F.2    Kim, W.-H.3    Gao, B.4
  • 91
    • 20744454264 scopus 로고    scopus 로고
    • Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes
    • Gimeno R, Lee CK, Schindler C, Levy DE. Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes. Mol Cell Biol. 2005;25(13):5456-5465.
    • (2005) Mol Cell Biol , vol.25 , Issue.13 , pp. 5456-5465
    • Gimeno, R.1    Lee, C.K.2    Schindler, C.3    Levy, D.E.4
  • 92
    • 69449106110 scopus 로고    scopus 로고
    • IL-1 family members and STAT activators induce cytokine production by Th2, Th17 and Th1 cells
    • Guo L, Wei G, Zhu J, et al. IL-1 family members and STAT activators induce cytokine production by Th2, Th17 and Th1 cells. Proc Natl Acad Sci U S A. 2009;106(32):13463-13468.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.32 , pp. 13463-13468
    • Guo, L.1    Wei, G.2    Zhu, J.3
  • 93
    • 0035877106 scopus 로고    scopus 로고
    • Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion
    • Zhu J, Guo L, Watson CJ, Hu-Li J, Paul WE. Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion. J Immunol. 2001;166(12):7276-7281.
    • (2001) J Immunol , vol.166 , Issue.12 , pp. 7276-7281
    • Zhu, J.1    Guo, L.2    Watson, C.J.3    Hu-Li, J.4    Paul, W.E.5
  • 94
    • 18244392419 scopus 로고    scopus 로고
    • STAT4. A critical regulator of inflammation in vivo
    • Kaplan MH. STAT4. A critical regulator of inflammation in vivo. Immunol Res. 2005;31(3):231-242.
    • (2005) Immunol Res , vol.31 , Issue.3 , pp. 231-242
    • Kaplan, M.H.1
  • 95
    • 0031432550 scopus 로고    scopus 로고
    • IL-6-regulated transcription factors
    • Akira S. IL-6-regulated transcription factors. Int J Biochem Cell Biol. 1997;29(12):1401-1418.
    • (1997) Int J Biochem Cell Biol , vol.29 , Issue.12 , pp. 1401-1418
    • Akira, S.1
  • 96
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
    • Heinrich PC, Behrmann I, Müller-Newen G, Schaper F, Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J. 1998;334(Pt 2):297-314.
    • (1998) Biochem J , vol.334 , Issue.Pt 2 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Müller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 97
    • 58149192454 scopus 로고    scopus 로고
    • Oncostatin-M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression
    • Hintzen C, Haan C, Tuckermann JP, Heinrich PC, Hermanns HM. Oncostatin-M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression. J Immunol. 2008;181(10):7341-7349.
    • (2008) J Immunol , vol.181 , Issue.10 , pp. 7341-7349
    • Hintzen, C.1    Haan, C.2    Tuckermann, J.P.3    Heinrich, P.C.4    Hermanns, H.M.5
  • 98
    • 65649152349 scopus 로고    scopus 로고
    • Co-activator SRC-1 is dispensable for transcriptional control by STAT3
    • Cvijic H, Bauer K, Löffler D, et al. Co-activator SRC-1 is dispensable for transcriptional control by STAT3. Biochem J. 2009;420(1): 123-132.
    • (2009) Biochem J , vol.420 , Issue.1 , pp. 123-132
    • Cvijic, H.1    Bauer, K.2    Löffler, D.3
  • 99
    • 60849131725 scopus 로고    scopus 로고
    • Antirheumatic drug response signatures in human chondrocytes: Potential molecular targets to stimulate cartilage regeneration
    • Andreas K, Häupl T, Lübke C, et al. Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
    • (2009) Arthritis Res Ther , vol.11 , Issue.1
    • Andreas, K.1    Häupl, T.2    Lübke, C.3
  • 101
    • 0037474320 scopus 로고    scopus 로고
    • JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R downregulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression
    • Legendre F, Dudhia J, Pujol J-P, Bogdanowicz P. JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R downregulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression. J Biol Chem. 2003;278(5):2903-2912.
    • (2003) J Biol Chem , vol.278 , Issue.5 , pp. 2903-2912
    • Legendre, F.1    Dudhia, J.2    Pujol, J.-P.3    Bogdanowicz, P.4
  • 102
    • 33751336068 scopus 로고    scopus 로고
    • BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription
    • Brocke-Heidrich K, Ge B, Cvijic H, et al. BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription. Oncogene. 2006;25(55):7297-7304.
    • (2006) Oncogene , vol.25 , Issue.55 , pp. 7297-7304
    • Brocke-Heidrich, K.1    Ge, B.2    Cvijic, H.3
  • 103
    • 42949120754 scopus 로고    scopus 로고
    • Identification of novel Stat3 target genes for control of growth and differentiation
    • Snyder M, Huang XY, Zhang JJ. Identification of novel Stat3 target genes for control of growth and differentiation. J Biol Chem. 2008;283(7):3791-3798.
    • (2008) J Biol Chem , vol.283 , Issue.7 , pp. 3791-3798
    • Snyder, M.1    Huang, X.Y.2    Zhang, J.J.3
  • 104
    • 38449113410 scopus 로고    scopus 로고
    • Oncostatin M-induced genes in human astrocytoma
    • Krona A, Aman P, Orndal C, Josefsson A. Oncostatin M-induced genes in human astrocytoma. Int J Oncol. 2007;31(6):1457-1463.
    • (2007) Int J Oncol , vol.31 , Issue.6 , pp. 1457-1463
    • Krona, A.1    Aman, P.2    Orndal, C.3    Josefsson, A.4
  • 105
    • 69249107379 scopus 로고    scopus 로고
    • Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog
    • Bourillot PY, Aksoy I, Schreiber V, et al. Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog. Stem Cells. 2009;27(8): 1760-1771.
    • (2009) Stem Cells , vol.27 , Issue.8 , pp. 1760-1771
    • Bourillot, P.Y.1    Aksoy, I.2    Schreiber, V.3
  • 106
    • 33845923061 scopus 로고    scopus 로고
    • IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naïve CD4 T cell survival in peripheral lymphoid organs
    • Seki Y, Yang J, Okamoto M, et al. IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naïve CD4 T cell survival in peripheral lymphoid organs. J Immunol. 2007;178(1): 262-270.
    • (2007) J Immunol , vol.178 , Issue.1 , pp. 262-270
    • Seki, Y.1    Yang, J.2    Okamoto, M.3
  • 107
    • 2542497114 scopus 로고    scopus 로고
    • The interleukin (IL)-2 family cytokines: Survival and proliferation signaling pathways in T lymphocytes
    • Benczik M, Gaffen SL. The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes. Immunol Invest. 2004;33(2):109-142.
    • (2004) Immunol Invest , vol.33 , Issue.2 , pp. 109-142
    • Benczik, M.1    Gaffen, S.L.2
  • 108
    • 0036849781 scopus 로고    scopus 로고
    • Bax deficiency partially corrects interleukin-7 receptor α deficiency
    • Khaled AR, Li WQ, Huang J. Bax deficiency partially corrects interleukin-7 receptor α deficiency. Immunity. 2002;17(5):561-573.
    • (2002) Immunity , vol.17 , Issue.5 , pp. 561-573
    • Khaled, A.R.1    Li, W.Q.2    Huang, J.3
  • 109
    • 0037833701 scopus 로고    scopus 로고
    • Death and Baxes: Mechanisms of lymphotrophic cytokines
    • Khaled AR, Durum SK. Death and Baxes: mechanisms of lymphotrophic cytokines. Immunol Rev. 2003;193:48-57.
    • (2003) Immunol Rev , vol.193 , pp. 48-57
    • Khaled, A.R.1    Durum, S.K.2
  • 110
    • 55349112529 scopus 로고    scopus 로고
    • IL-7 and IL-15: Biology and roles in T cell immunity in health and disease
    • Kim H-R, Hwang K-A, Park S-H, Kang I. IL-7 and IL-15: biology and roles in T cell immunity in health and disease. Crit Rev Immunol. 2008;28(4):325-339.
    • (2008) Crit Rev Immunol , vol.28 , Issue.4 , pp. 325-339
    • Kim, H.-R.1    Hwang, K.-A.2    Park, S.-H.3    Kang, I.4
  • 112
    • 0034662921 scopus 로고    scopus 로고
    • Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids
    • Bianchi M, Meng C, Ivashkiv LB. Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids. Proc Natl Acad Sci U S A. 2000;97(17):9573-9578.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.17 , pp. 9573-9578
    • Bianchi, M.1    Meng, C.2    Ivashkiv, L.B.3
  • 113
    • 34548821866 scopus 로고    scopus 로고
    • Direct interaction between Kit and the interleukin-7 receptor
    • Jahn T, Sindhu S, Gooch S, et al. Direct interaction between Kit and the interleukin-7 receptor. Blood. 2007;110(6):1840-1847.
    • (2007) Blood , vol.110 , Issue.6 , pp. 1840-1847
    • Jahn, T.1    Sindhu, S.2    Gooch, S.3
  • 114
    • 0032939156 scopus 로고    scopus 로고
    • Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
    • Chabaud M, Durand JM, Buchs N, et al. Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. 1999;42(5):963-970.
    • (1999) Arthritis Rheum , vol.42 , Issue.5 , pp. 963-970
    • Chabaud, M.1    Durand, J.M.2    Buchs, N.3
  • 115
    • 13444256307 scopus 로고    scopus 로고
    • The role of T-cell interleukin-17 in conducting destructive arthritis: Lessons from animal models
    • Lubberts E, Koenders MI, van den Berg WB. The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther. 2005;7(1):29-37.
    • (2005) Arthritis Res Ther , vol.7 , Issue.1 , pp. 29-37
    • Lubberts, E.1    Koenders, M.I.2    van den Berg, W.B.3
  • 116
    • 33646490259 scopus 로고    scopus 로고
    • Interleukin-17 acts independently of TNF-alpha under arthritic conditions
    • Koenders MI, Lubberts E, van de Loo FAJ, et al. Interleukin-17 acts independently of TNF-alpha under arthritic conditions. J Immunol. 2006;176(10):6262-6269.
    • (2006) J Immunol , vol.176 , Issue.10 , pp. 6262-6269
    • Koenders, M.I.1    Lubberts, E.2    van de Loo, F.A.J.3
  • 117
    • 55149087226 scopus 로고    scopus 로고
    • From interleukin-23 to T-helper 17 cells: Human T-helper cell differentiation revisited
    • Boniface K, Blom B, Liu YJ, de Waal Malefyt R. From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited. Immunol Rev. 2008;226:132-146.
    • (2008) Immunol Rev , vol.226 , pp. 132-146
    • Boniface, K.1    Blom, B.2    Liu, Y.J.3    de Waal, M.R.4
  • 118
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ
    • Yang XO, Pappu BP, Nurieva R, et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ. Immunity. 2008;28(1):29-39.
    • (2008) Immunity , vol.28 , Issue.1 , pp. 29-39
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3
  • 119
    • 57649188886 scopus 로고    scopus 로고
    • New complexities in helper T cell fate determination and the implications for autoimmune diseases
    • Takatori H, Kanno Y, Chen Z, O'Shea JJ. New complexities in helper T cell fate determination and the implications for autoimmune diseases. Mod Rheumatol. 2008;18(6):533-541.
    • (2008) Mod Rheumatol , vol.18 , Issue.6 , pp. 533-541
    • Takatori, H.1    Kanno, Y.2    Chen, Z.3    O'Shea, J.J.4
  • 122
    • 46949086109 scopus 로고    scopus 로고
    • Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells
    • de Beaucoudrey L, Puel A, Filipe-Santos O, et al. Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells. J Exp Med. 2008;205(7):1543-1550.
    • (2008) J Exp Med , vol.205 , Issue.7 , pp. 1543-1550
    • de Beaucoudrey, L.1    Puel, A.2    Filipe-Santos, O.3
  • 123
    • 70049113279 scopus 로고    scopus 로고
    • + regulatory T cells control TH17 responses in a Stat3-dependent manner
    • + regulatory T cells control TH17 responses in a Stat3-dependent manner. Science. 2009; 326(5955):986-991.
    • (2009) Science , vol.326 , Issue.5955 , pp. 986-991
    • Chaudhry, A.1    Rudra, D.2    Treuting, P.3
  • 124
    • 77954630976 scopus 로고    scopus 로고
    • Prediction of regulatory transcription factors in T helper cell differentiation and maintenance
    • Lee Y-H, Benary M, Baumgrass R, Herzel H. Prediction of regulatory transcription factors in T helper cell differentiation and maintenance. Genome Inform. 2010;22:84-94.
    • (2010) Genome Inform , vol.22 , pp. 84-94
    • Lee, Y.-H.1    Benary, M.2    Baumgrass, R.3    Herzel, H.4
  • 125
    • 5644289875 scopus 로고    scopus 로고
    • IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB and PI3-kinase/Akt-dependent pathways
    • Hwang SY, Kim JY, Kim KW, et al. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB and PI3-kinase/Akt-dependent pathways. Arthritis Res Ther. 2004;6(2):R120-R128.
    • (2004) Arthritis Res Ther , vol.6 , Issue.2
    • Hwang, S.Y.1    Kim, J.Y.2    Kim, K.W.3
  • 126
    • 64849100544 scopus 로고    scopus 로고
    • Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes
    • Zrioual S, Ecochard R, Tournadre A, Lenief V, Cazalis M-A, Miossec P. Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes. J Immunol. 2009; 182(5):3112-3120.
    • (2009) J Immunol , vol.182 , Issue.5 , pp. 3112-3120
    • Zrioual, S.1    Ecochard, R.2    Tournadre, A.3    Lenief, V.4    Cazalis, M.-A.5    Miossec, P.6
  • 127
    • 58149216715 scopus 로고    scopus 로고
    • Th memory for interleukin-17 expression is stable in vivo
    • Lexberg MH, Taubner A, Förster A, et al. Th memory for interleukin-17 expression is stable in vivo. Eur J Immunol. 2008;38(10):2654-2664.
    • (2008) Eur J Immunol , vol.38 , Issue.10 , pp. 2654-2664
    • Lexberg, M.H.1    Taubner, A.2    Förster, A.3
  • 128
    • 69749101475 scopus 로고    scopus 로고
    • The IL-12 family of cytokines in infection, inflammation and autoimmune disorders
    • Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A. The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm Allergy Drug Targets. 2009;8(1):40-52.
    • (2009) Inflamm Allergy Drug Targets , vol.8 , Issue.1 , pp. 40-52
    • Gee, K.1    Guzzo, C.2    Che, M.N.F.3    Ma, W.4    Kumar, A.5
  • 129
    • 0036604306 scopus 로고    scopus 로고
    • A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R
    • Partham C, Chirica M, Timans J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 2002;168(11):5699-5708.
    • (2002) J Immunol , vol.168 , Issue.11 , pp. 5699-5708
    • Partham, C.1    Chirica, M.2    Timans, J.3
  • 130
    • 33846864685 scopus 로고    scopus 로고
    • Selective abrogation of the Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor
    • Wada Y, Lu R, Zhou D, et al. Selective abrogation of the Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood. 2007;109(3): 1156-1164.
    • (2007) Blood , vol.109 , Issue.3 , pp. 1156-1164
    • Wada, Y.1    Lu, R.2    Zhou, D.3
  • 131
    • 33845576001 scopus 로고    scopus 로고
    • Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase, NFκB and p38 MAPK-dependent signaling pathways
    • Kim H-R, Cho M-L, Kim K-W, et al. Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase, NFκB and p38 MAPK-dependent signaling pathways. Rheumatology (Oxford). 2007;46(1):57-64.
    • (2007) Rheumatology (Oxford) , vol.46 , Issue.1 , pp. 57-64
    • Kim, H.-R.1    Cho, M.-L.2    Kim, K.-W.3
  • 132
    • 34547852171 scopus 로고    scopus 로고
    • Interleukin (IL)-23p19 expression induced by IL-1β in human fibroblast-synoviocytes with rheumatoid arthritis via active nuclear factor κB and AP-1 dependent pathway
    • Liu FL, Chen CH, Chu SJ, et al. Interleukin (IL)-23p19 expression induced by IL-1β in human fibroblast-synoviocytes with rheumatoid arthritis via active nuclear factor κB and AP-1 dependent pathway. Rheumatology (Oxford). 2007;46(8):1266-1273.
    • (2007) Rheumatology (Oxford) , vol.46 , Issue.8 , pp. 1266-1273
    • Liu, F.L.1    Chen, C.H.2    Chu, S.J.3
  • 133
    • 12544252206 scopus 로고    scopus 로고
    • Interleukin-12-induced interferon-γ production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR)
    • Kusaba H, Ghosh P, Derin R, et al. Interleukin-12-induced interferon-γ production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR). J Biol Chem. 2005;280(2):1037-1043.
    • (2005) J Biol Chem , vol.280 , Issue.2 , pp. 1037-1043
    • Kusaba, H.1    Ghosh, P.2    Derin, R.3
  • 134
    • 33846017974 scopus 로고    scopus 로고
    • IL-12 p35 silenced dendritic cells modulate immune responses by blocking IL-12 signaling through JAK-STAT pathways in T lymphocytes
    • Xu H, Zhang Y, Hua Y, Chen T, Wang H, Wu W. IL-12 p35 silenced dendritic cells modulate immune responses by blocking IL-12 signaling through JAK-STAT pathways in T lymphocytes. Biochem Biophys Res Commun. 2007;353(3):812-816.
    • (2007) Biochem Biophys Res Commun , vol.353 , Issue.3 , pp. 812-816
    • Xu, H.1    Zhang, Y.2    Hua, Y.3    Chen, T.4    Wang, H.5    Wu, W.6
  • 135
    • 2442711457 scopus 로고    scopus 로고
    • Early target genes of IL-12 and STAT4 signaling in Th cells
    • Lund R, Chen Z, Scheinin J, Lahesmaa R. Early target genes of IL-12 and STAT4 signaling in Th cells. J Immunol. 2004;172(11): 6775-6782.
    • (2004) J Immunol , vol.172 , Issue.11 , pp. 6775-6782
    • Lund, R.1    Chen, Z.2    Scheinin, J.3    Lahesmaa, R.4
  • 136
    • 36148976803 scopus 로고    scopus 로고
    • Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3α in patients with rheumatoid arthritis
    • Kageyama Y, Ichikawa T, Nagafusa T, Torikai E, Shimazu M, Nagano A. Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3α in patients with rheumatoid arthritis. Rheumatol Int. 2007;28(2):137-143.
    • (2007) Rheumatol Int , vol.28 , Issue.2 , pp. 137-143
    • Kageyama, Y.1    Ichikawa, T.2    Nagafusa, T.3    Torikai, E.4    Shimazu, M.5    Nagano, A.6
  • 137
    • 77951463979 scopus 로고    scopus 로고
    • Type I interferons interferons in systemic autoimmunity
    • Sozzani S, Bosisio D, Scarsi M, Tincani A. Type I interferons in systemic autoimmunity. Autoimmunity. 2010;43(3):196-203.
    • (2010) Autoimmunity , vol.43 , Issue.3 , pp. 196-203
    • Sozzani, S.1    Bosisio, D.2    Scarsi, M.3    Tincani, A.4
  • 138
    • 73249136480 scopus 로고    scopus 로고
    • IRF4 and its regulators: Insights into the pathogenesis of inflammatory arthritis
    • Biswas PS, Bhagat G, Pernis AB. IRF4 and its regulators: insights into the pathogenesis of inflammatory arthritis. Immunol Rev. 2010; 233(1):79-96.
    • (2010) Immunol Rev , vol.233 , Issue.1 , pp. 79-96
    • Biswas, P.S.1    Bhagat, G.2    Pernis, A.B.3
  • 139
    • 34347259525 scopus 로고    scopus 로고
    • IL-28 and IL-29: Newcomers to the interferon family
    • Uzé G, Monneron D. IL-28 and IL-29: newcomers to the interferon family. Biochimie. 2007;89(6-7):729-734.
    • (2007) Biochimie , vol.89 , Issue.6-7 , pp. 729-734
    • Uzé, G.1    Monneron, D.2
  • 140
    • 33847419628 scopus 로고    scopus 로고
    • Activation of STAT1 signalling pathway in lupus nephritis in MRL/lpr mice
    • Dong J, Wang QX, Zhou CY, Ma XF, Zhang YC. Activation of STAT1 signalling pathway in lupus nephritis in MRL/lpr mice. Lupus. 2007;16(2):101-109.
    • (2007) Lupus , vol.16 , Issue.2 , pp. 101-109
    • Dong, J.1    Wang, Q.X.2    Zhou, C.Y.3    Ma, X.F.4    Zhang, Y.C.5
  • 141
    • 77953555514 scopus 로고    scopus 로고
    • Cytokines as therapeutic targets in SLE
    • Rönnblom L, Elkon KB. Cytokines as therapeutic targets in SLE. Nat Rev Rheumatol. 2010;6(6):339-347.
    • (2010) Nat Rev Rheumatol , vol.6 , Issue.6 , pp. 339-347
    • Rönnblom, L.1    Elkon, K.B.2
  • 142
    • 77953727883 scopus 로고    scopus 로고
    • Cytokines in Sjögren's syndrome: Potential therapeutic targets
    • Roescher N, Tak PP, Illei GG. Cytokines in Sjögren's syndrome: potential therapeutic targets. Ann Rheum Dis. 2010;69(6): 945-948.
    • (2010) Ann Rheum Dis , vol.69 , Issue.6 , pp. 945-948
    • Roescher, N.1    Tak, P.P.2    Illei, G.G.3
  • 143
    • 35548965486 scopus 로고    scopus 로고
    • P-STAT1 mediates higher-order chromatin remodeling of the human MHC in response to IFNγ
    • Christova R, Jones T, Wu PJ, et al. P-STAT1 mediates higher-order chromatin remodeling of the human MHC in response to IFNγ. J Cell Sci. 2007;120(Pt 18):3262-3270.
    • (2007) J Cell Sci , vol.120 , Issue.Pt 18 , pp. 3262-3270
    • Christova, R.1    Jones, T.2    Wu, P.J.3
  • 144
    • 77952649835 scopus 로고    scopus 로고
    • Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes
    • Vogl C, Flatt T, Fuhrmann B, et al. Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes. BMC Genomics. 2010;11:199.
    • (2010) BMC Genomics , vol.11 , pp. 199
    • Vogl, C.1    Flatt, T.2    Fuhrmann, B.3
  • 146
    • 78249277326 scopus 로고    scopus 로고
    • Mechanisms of mRNA translation of the interferon stimulated genes
    • Joshi S, Kaur S, Kroczynska B, Platanias LC. Mechanisms of mRNA translation of the interferon stimulated genes. Cytokine. 2010;52 (1-2):123-127.
    • (2010) Cytokine , vol.52 , Issue.1-2 , pp. 123-127
    • Joshi, S.1    Kaur, S.2    Kroczynska, B.3    Platanias, L.C.4
  • 147
    • 70349673724 scopus 로고    scopus 로고
    • IRF9 is a key factor for eliciting the anti-proliferative activity of IFN-α
    • Tsuno T, Mejido J, Zhao T, Schmeisser H, Morrow A, Zoon KC. IRF9 is a key factor for eliciting the anti-proliferative activity of IFN-α. J Immunother. 2009;32(8):803-816.
    • (2009) J Immunother , vol.32 , Issue.8 , pp. 803-816
    • Tsuno, T.1    Mejido, J.2    Zhao, T.3    Schmeisser, H.4    Morrow, A.5    Zoon, K.C.6
  • 148
    • 30344464664 scopus 로고    scopus 로고
    • The PI3' kinase pathway in interferon signaling
    • Kaur S, Uddin S, Platanias LC. The PI3' kinase pathway in interferon signaling. J Interferon Cytokine Res. 2005;25(12):780-787.
    • (2005) J Interferon Cytokine Res , vol.25 , Issue.12 , pp. 780-787
    • Kaur, S.1    Uddin, S.2    Platanias, L.C.3
  • 149
    • 42449150892 scopus 로고    scopus 로고
    • Role of the Akt pathway in mRNA translation of interferon-stimulated genes
    • Kaur S, Sassano A, Dolniak B, et al. Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc Natl Acad Sci U S A. 2008;105(12):4808-4813.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.12 , pp. 4808-4813
    • Kaur, S.1    Sassano, A.2    Dolniak, B.3
  • 150
    • 47749140740 scopus 로고    scopus 로고
    • Akt and mRNA translation by interferons
    • Kaur S, Katsoulidis E, Platanias LC. Akt and mRNA translation by interferons. Cell Cycle. 2008;7(14):2112-2116.
    • (2008) Cell Cycle , vol.7 , Issue.14 , pp. 2112-2116
    • Kaur, S.1    Katsoulidis, E.2    Platanias, L.C.3
  • 151
    • 58149179174 scopus 로고    scopus 로고
    • Dual regulatory roles of phosphatidylinositol-3-kinase in IFN-signaling
    • Kaur S, Sassano A, Joseph AM, et al. Dual regulatory roles of phosphatidylinositol-3-kinase in IFN-signaling. J Immunol. 2008; 181(10):7316-7323.
    • (2008) J Immunol , vol.181 , Issue.10 , pp. 7316-7323
    • Kaur, S.1    Sassano, A.2    Joseph, A.M.3
  • 152
    • 39049144388 scopus 로고    scopus 로고
    • Key regulatory molecules of cartilage destruction in rheumatoid arthritis: An in vitro study
    • Andreas K, Lübke C, Häupl T, et al. Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study. Arthritis Res Ther. 2008;10(1):R9.
    • (2008) Arthritis Res Ther , vol.10 , Issue.1
    • Andreas, K.1    Lübke, C.2    Häupl, T.3
  • 153
    • 78649342284 scopus 로고    scopus 로고
    • Signaling pathways in rheumatoid arthritis
    • In: Tak P-P, editor, Basel, Switzerland: Birkhäuser
    • Waldburger J-M, Firestein GS. Signaling pathways in rheumatoid arthritis. In: Tak P-P, editor. Progress in Inflammation Research. Basel, Switzerland: Birkhäuser; 2009:155-180.
    • (2009) Progress in Inflammation Research , pp. 155-180
    • Waldburger, J.-M.1    Firestein, G.S.2
  • 154
    • 60849097848 scopus 로고    scopus 로고
    • Interactions among type I and type II interferon, tumor necrosis factor, and β-estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus
    • Lee HM, Mima T, Sugino H, et al. Interactions among type I and type II interferon, tumor necrosis factor, and β-estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus. Arthritis Res Ther. 2009;11(1):R1.
    • (2009) Arthritis Res Ther , vol.11 , Issue.1
    • Lee, H.M.1    Mima, T.2    Sugino, H.3
  • 155
    • 61349166620 scopus 로고    scopus 로고
    • CXCL10 and autoimmune diseases
    • Lee EY, Lee ZH, Song YW. CXCL10 and autoimmune diseases. Autoimmun Rev. 2009;8(5):379-383.
    • (2009) Autoimmun Rev , vol.8 , Issue.5 , pp. 379-383
    • Lee, E.Y.1    Lee, Z.H.2    Song, Y.W.3
  • 156
    • 77953633063 scopus 로고    scopus 로고
    • Synoviocyte innate immune responses. II. Pivotal role of IFN regulatory factor 3
    • Sweeney SE, Kimbler TB, Firestein GS. Synoviocyte innate immune responses. II. Pivotal role of IFN regulatory factor 3. J Immunol. 2010;184(12):7162-7168.
    • (2010) J Immunol , vol.184 , Issue.12 , pp. 7162-7168
    • Sweeney, S.E.1    Kimbler, T.B.2    Firestein, G.S.3
  • 157
    • 35748976569 scopus 로고    scopus 로고
    • IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-λ) genes
    • Österlund PI, Pietilä TE, Veckman V, Kotenko SV, Julkunen I. IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-λ) genes. J Immunol. 2007;179(6):3434-3442.
    • (2007) J Immunol , vol.179 , Issue.6 , pp. 3434-3442
    • Österlund, P.I.1    Pietilä, T.E.2    Veckman, V.3    Kotenko, S.V.4    Julkunen, I.5
  • 158
    • 0034658583 scopus 로고    scopus 로고
    • Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes
    • Kotenko SV, Pestka S. Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes. Oncogene. 2000;19(21):2557-2565.
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2557-2565
    • Kotenko, S.V.1    Pestka, S.2
  • 159
    • 0346103717 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is the dominant mediator of anti-inflammatory effects of IL-10 in human macrophages
    • Williams L, Bradley L, Smith A, Foxwell B. Signal transducer and activator of transcription 3 is the dominant mediator of anti-inflammatory effects of IL-10 in human macrophages. J Immunol. 2004;172(1): 567-576.
    • (2004) J Immunol , vol.172 , Issue.1 , pp. 567-576
    • Williams, L.1    Bradley, L.2    Smith, A.3    Foxwell, B.4
  • 160
    • 13444269091 scopus 로고    scopus 로고
    • Interleukin-24 and its receptors
    • Wang M, Liang P. Interleukin-24 and its receptors. Immunology. 2005;114(2):166-170.
    • (2005) Immunology , vol.114 , Issue.2 , pp. 166-170
    • Wang, M.1    Liang, P.2
  • 164
    • 9644262463 scopus 로고    scopus 로고
    • Signaling pathways in Th2 development
    • Mowen KA, Glimcher LM. Signaling pathways in Th2 development. Immunol Rev. 2004;202:203-222.
    • (2004) Immunol Rev , vol.202 , pp. 203-222
    • Mowen, K.A.1    Glimcher, L.M.2
  • 165
    • 33646196946 scopus 로고    scopus 로고
    • Regulation of Th2 differentiation and IL4 locus susceptibility
    • Ansel KM, Djuretic I, Tanasa B, Rao A. Regulation of Th2 differentiation and IL4 locus susceptibility. Annu Rev Immunol. 2006;24: 607-656.
    • (2006) Annu Rev Immunol , vol.24 , pp. 607-656
    • Ansel, K.M.1    Djuretic, I.2    Tanasa, B.3    Rao, A.4
  • 166
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORγ t directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORγ t directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006;126(6):1121-1133.
    • (2006) Cell , vol.126 , Issue.6 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3
  • 167
    • 77956805951 scopus 로고    scopus 로고
    • Memory Th1/Th2 cell generation controlled by Schnurri-2
    • In: Zanetti M, Schoenberger SP, editors, New York, NY: Springer Science
    • Nakayama T, Kimura MY. Memory Th1/Th2 cell generation controlled by Schnurri-2. In: Zanetti M, Schoenberger SP, editors. Memory T Cells. New York, NY: Springer Science; 2010:1-9.
    • (2010) Memory T Cells , pp. 1-9
    • Nakayama, T.1    Kimura, M.Y.2
  • 168
    • 70350167868 scopus 로고    scopus 로고
    • IL10R1 loss-of-function alleles in rheumatoid arthritis and systemic lupus erythematosus
    • Hermann J, Gruber S, Neufeld JB, et al. IL10R1 loss-of-function alleles in rheumatoid arthritis and systemic lupus erythematosus. Clin Exp Rheumatol. 2009;27(4):603-608.
    • (2009) Clin Exp Rheumatol , vol.27 , Issue.4 , pp. 603-608
    • Hermann, J.1    Gruber, S.2    Neufeld, J.B.3
  • 169
    • 0033523019 scopus 로고    scopus 로고
    • Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action
    • Riley JK, Takeda K, Akira S, Schreiber RD. Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action. J Biol Chem. 1999;274(23):16513-16521.
    • (1999) J Biol Chem , vol.274 , Issue.23 , pp. 16513-16521
    • Riley, J.K.1    Takeda, K.2    Akira, S.3    Schreiber, R.D.4
  • 170
    • 0034327736 scopus 로고    scopus 로고
    • Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways
    • Ahmed ST, Ivashkiv LB. Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways. J Immunol. 2000; 165(9):5227-5237.
    • (2000) J Immunol , vol.165 , Issue.9 , pp. 5227-5237
    • Ahmed, S.T.1    Ivashkiv, L.B.2
  • 171
    • 0242412335 scopus 로고    scopus 로고
    • Reprogramming of IL-10 activity and signaling by IFN-γ
    • Herrero C, Hu X, Li WP, et al. Reprogramming of IL-10 activity and signaling by IFN-γ. J Immunol. 2003;171(10):5034-5041.
    • (2003) J Immunol , vol.171 , Issue.10 , pp. 5034-5041
    • Herrero, C.1    Hu, X.2    Li, W.P.3
  • 172
    • 0037606153 scopus 로고    scopus 로고
    • Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis
    • Ji JD, Tassiulas I, Park-Min KH, et al. Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis. J Exp Med. 2003;197(11):1573-1583.
    • (2003) J Exp Med , vol.197 , Issue.11 , pp. 1573-1583
    • Ji, J.D.1    Tassiulas, I.2    Park-Min, K.H.3
  • 173
    • 12444266884 scopus 로고    scopus 로고
    • Interleukin 10 treatment of patients with rheumatoid arthritis enhances Fc γ receptor expression on monocytes and responsiveness to immune complex stimulation
    • van Roon J, Wijngaarden S, Lafeber FP, Damen C, van de Winkel J, Bijlsma JW. Interleukin 10 treatment of patients with rheumatoid arthritis enhances Fc γ receptor expression on monocytes and responsiveness to immune complex stimulation. J Rheumatol. 2003;30(4): 648-651.
    • (2003) J Rheumatol , vol.30 , Issue.4 , pp. 648-651
    • van Roon, J.1    Wijngaarden, S.2    Lafeber, F.P.3    Damen, C.4    van de Winkel, J.5    Bijlsma, J.W.6
  • 174
    • 44449140104 scopus 로고    scopus 로고
    • IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38
    • Kalliolias GD, Ivashkiv LB. IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38. J Immunol. 2008;180(9):6325-6333.
    • (2008) J Immunol , vol.180 , Issue.9 , pp. 6325-6333
    • Kalliolias, G.D.1    Ivashkiv, L.B.2
  • 176
    • 0038517976 scopus 로고    scopus 로고
    • Interleukin-4 and interleukin-13 signaling connection maps
    • Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD. Interleukin-4 and interleukin-13 signaling connection maps. Science. 2003;300(5625):1527-1528.
    • (2003) Science , vol.300 , Issue.5625 , pp. 1527-1528
    • Kelly-Welch, A.E.1    Hanson, E.M.2    Boothby, M.R.3    Keegan, A.D.4
  • 177
    • 34247874430 scopus 로고    scopus 로고
    • Molecular mechanisms involved in interleukin-4-induced human neutrophils: Expression and regulation of suppressor of cytokine signaling
    • Ratthé C, Pelletier M, Chiasson S, Girard D. Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling. J Leukoc Biol. 2007;81(5):1287-1296.
    • (2007) J Leukoc Biol , vol.81 , Issue.5 , pp. 1287-1296
    • Ratthé, C.1    Pelletier, M.2    Chiasson, S.3    Girard, D.4
  • 178
    • 3142622926 scopus 로고    scopus 로고
    • STAT-1 is activated by IL-4 and IL-13 in multiple cell types
    • Wang IM, Lin H, Goldman SJ, Kobayashi M. STAT-1 is activated by IL-4 and IL-13 in multiple cell types. Mol Immunol. 2004;41(9): 873-884.
    • (2004) Mol Immunol , vol.41 , Issue.9 , pp. 873-884
    • Wang, I.M.1    Lin, H.2    Goldman, S.J.3    Kobayashi, M.4
  • 179
    • 0034467817 scopus 로고    scopus 로고
    • Differential in vitro effects of IL-4, IL-10, and IL-13 on proinflammatory cytokine production and fibroblast proliferation in rheumatoid synovium
    • Morita Y, Yamamura M, Kawashima M, et al. Differential in vitro effects of IL-4, IL-10, and IL-13 on proinflammatory cytokine production and fibroblast proliferation in rheumatoid synovium. Rheumatol Int. 2001;20(2):49-54.
    • (2001) Rheumatol Int , vol.20 , Issue.2 , pp. 49-54
    • Morita, Y.1    Yamamura, M.2    Kawashima, M.3
  • 180
    • 0035863813 scopus 로고    scopus 로고
    • IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis
    • Woods JM, Katschke KJ, Volin MV, et al. IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis. J Immunol. 2001;166(2):1214-1222.
    • (2001) J Immunol , vol.166 , Issue.2 , pp. 1214-1222
    • Woods, J.M.1    Katschke, K.J.2    Volin, M.V.3
  • 181
    • 26444593757 scopus 로고    scopus 로고
    • Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation
    • Nabbe KC, van Lent PL, Holthuysen AE, et al. Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation. Arthritis Res Ther. 2005;7(2):R392-R401.
    • (2005) Arthritis Res Ther , vol.7 , Issue.2
    • Nabbe, K.C.1    van Lent, P.L.2    Holthuysen, A.E.3
  • 182
    • 0035865347 scopus 로고    scopus 로고
    • IL-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis
    • Relic B, Guicheux J, Mezin F, et al. IL-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis. J Immunol. 2001;166(4): 2775-2782.
    • (2001) J Immunol , vol.166 , Issue.4 , pp. 2775-2782
    • Relic, B.1    Guicheux, J.2    Mezin, F.3
  • 183
    • 0036194273 scopus 로고    scopus 로고
    • High levels of interleukin-13 in rheumatoid arthritis sera are modulated by tumor necrosis factor antagonist therapy: Association with dendritic cell growth activity
    • Tokayer A, Carsons SE, Chokshi B, Santiago-Schwarz F. High levels of interleukin-13 in rheumatoid arthritis sera are modulated by tumor necrosis factor antagonist therapy: association with dendritic cell growth activity. J Rheumatol. 2002;29(3):454-461.
    • (2002) J Rheumatol , vol.29 , Issue.3 , pp. 454-461
    • Tokayer, A.1    Carsons, S.E.2    Chokshi, B.3    Santiago-Schwarz, F.4
  • 184
    • 0037202907 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor promotes the survival of osteoclast precursors by up-regulating Bcl-X(L)
    • Woo KM, Kim HM, Ko JS. Macrophage colony-stimulating factor promotes the survival of osteoclast precursors by up-regulating Bcl-X(L). Exp Mol Med. 2002;34(5):340-346.
    • (2002) Exp Mol Med , vol.34 , Issue.5 , pp. 340-346
    • Woo, K.M.1    Kim, H.M.2    Ko, J.S.3
  • 185
    • 59549102157 scopus 로고    scopus 로고
    • M-CSF and GM-CSF regulation of STAT5 activation and DNA binding in myeloid cell differentiation is disrupted in nonobese diabetic mice
    • Rumore-Maton B, Elf J, Belkin N, et al. M-CSF and GM-CSF regulation of STAT5 activation and DNA binding in myeloid cell differentiation is disrupted in nonobese diabetic mice. Clin Dev Immunol. 2008;2008:769795.
    • (2008) Clin Dev Immunol , pp. 769795
    • Rumore-Maton, B.1    Elf, J.2    Belkin, N.3
  • 186
    • 33747026687 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by interleukin-4 therapy in rat adjuvant-induced arthritis
    • Haas CS, Amin MA, Allen BB, et al. Inhibition of angiogenesis by interleukin-4 therapy in rat adjuvant-induced arthritis. Arthritis Rheum. 2006;54(8):2402-2414.
    • (2006) Arthritis Rheum , vol.54 , Issue.8 , pp. 2402-2414
    • Haas, C.S.1    Amin, M.A.2    Allen, B.B.3
  • 187
    • 34547770721 scopus 로고    scopus 로고
    • In vivo inhibition of angiogenesis by interleukin-13 gene therapy in a rat model of rheumatoid arthritis
    • Haas CS, Amin MA, Ruth JH, et al. In vivo inhibition of angiogenesis by interleukin-13 gene therapy in a rat model of rheumatoid arthritis. Arthritis Rheum. 2007;56(8):2535-2548.
    • (2007) Arthritis Rheum , vol.56 , Issue.8 , pp. 2535-2548
    • Haas, C.S.1    Amin, M.A.2    Ruth, J.H.3
  • 188
    • 33644888261 scopus 로고    scopus 로고
    • CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent on the MAPK pathway
    • Ruth JH, Haas CS, Park CC, et al. CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent on the MAPK pathway. Arthritis Rheum. 2006;54(3): 765-778.
    • (2006) Arthritis Rheum , vol.54 , Issue.3 , pp. 765-778
    • Ruth, J.H.1    Haas, C.S.2    Park, C.C.3
  • 189
    • 32844455072 scopus 로고    scopus 로고
    • + regulatory T cells: CD25 and IL-2
    • + regulatory T cells: CD25 and IL-2. Front Biosci. 2006;11:921-927.
    • (2006) Front Biosci , vol.11 , pp. 921-927
    • Thornton, A.M.1
  • 190
    • 0034657396 scopus 로고    scopus 로고
    • The role of Stat5a and Stat5b in signaling by IL-2 family cytokines
    • Lin JX, Leonard WJ. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene. 2000;19(21):2566-2576.
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2566-2576
    • Lin, J.X.1    Leonard, W.J.2
  • 191
    • 33845702595 scopus 로고    scopus 로고
    • Upregulation of Foxp3 expression in mouse and human Treg is IL-2/STAT5 dependent: Implications for the NOD STAT5B mutation in diabetes pathogenesis
    • Murawski MR, Litherland SA, Clare-Salzler MJ, Davoodi-Semiromi A. Upregulation of Foxp3 expression in mouse and human Treg is IL-2/STAT5 dependent: implications for the NOD STAT5B mutation in diabetes pathogenesis. Ann N Y Acad Sci. 2006;1079:198-204.
    • (2006) Ann N Y Acad Sci , vol.1079 , pp. 198-204
    • Murawski, M.R.1    Litherland, S.A.2    Clare-Salzler, M.J.3    Davoodi-Semiromi, A.4
  • 193
    • 65649139622 scopus 로고    scopus 로고
    • + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV
    • + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J Clin Invest. 2009;119(3):551-564.
    • (2009) J Clin Invest , vol.119 , Issue.3 , pp. 551-564
    • Franceschini, D.1    Paroli, M.2    Francavilla, V.3
  • 195
    • 67650360177 scopus 로고    scopus 로고
    • Epigenetic control in rheumatoid arthritis synovial fibroblasts
    • Karouzakis E, Gay RE, Gay S, Neidhart M. Epigenetic control in rheumatoid arthritis synovial fibroblasts. Nat Rev Rheumatol. 2009;5(5):266-272.
    • (2009) Nat Rev Rheumatol , vol.5 , Issue.5 , pp. 266-272
    • Karouzakis, E.1    Gay, R.E.2    Gay, S.3    Neidhart, M.4
  • 197
    • 54049101441 scopus 로고    scopus 로고
    • Canonical and non-canonical JAK-STAT signaling
    • Li WX. Canonical and non-canonical JAK-STAT signaling. Trends Cell Biol. 2008;18(11):545-551.
    • (2008) Trends Cell Biol , vol.18 , Issue.11 , pp. 545-551
    • Li, W.X.1
  • 198
    • 28244484054 scopus 로고    scopus 로고
    • STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism
    • Shin HJ, Park HY, Jeong SJ, et al. STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism. J Immunol. 2005;175(11):7143-7150.
    • (2005) J Immunol , vol.175 , Issue.11 , pp. 7143-7150
    • Shin, H.J.1    Park, H.Y.2    Jeong, S.J.3
  • 199
    • 78049518996 scopus 로고    scopus 로고
    • DNA methylation and not allelic variation regulates STAT6 expression in human T cells
    • Kim EG, Shin HJ, Lee CG, et al. DNA methylation and not allelic variation regulates STAT6 expression in human T cells. Clin Exp Med. 2010;10(3):143-152.
    • (2010) Clin Exp Med , vol.10 , Issue.3 , pp. 143-152
    • Kim, E.G.1    Shin, H.J.2    Lee, C.G.3
  • 200
    • 33748308794 scopus 로고    scopus 로고
    • JAK signaling globally counteracts heterochromatin gene silencing
    • Shi S, Calhoun HC, Xia F, Li J, Le L, Li WX. JAK signaling globally counteracts heterochromatin gene silencing. Nat Genet. 2006; 38(9):1071-1076.
    • (2006) Nat Genet , vol.38 , Issue.9 , pp. 1071-1076
    • Shi, S.1    Calhoun, H.C.2    Xia, F.3    Li, J.4    Le, L.5    Li, W.X.6
  • 201
    • 49449106856 scopus 로고    scopus 로고
    • Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis
    • Nile CJ, Read AC, Akil M, Duff GW, Wilson AG. Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis Rheum. 2008;58(9): 2686-2693.
    • (2008) Arthritis Rheum , vol.58 , Issue.9 , pp. 2686-2693
    • Nile, C.J.1    Read, A.C.2    Akil, M.3    Duff, G.W.4    Wilson, A.G.5
  • 202
    • 70349968220 scopus 로고    scopus 로고
    • IL-17 as a future therapeutic target for rheumatoid arthritis
    • van den Berg WB, Miossec P. IL-17 as a future therapeutic target for rheumatoid arthritis. Nat Rev Rheumatol. 2009;5(10): 549-553.
    • (2009) Nat Rev Rheumatol , vol.5 , Issue.10 , pp. 549-553
    • van den Berg, W.B.1    Miossec, P.2
  • 203
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, doubleblind, placebo-controlled, proof-of-concept study
    • Genovese MC, van den Bosch F, Roberson SA, et al. LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, doubleblind, placebo-controlled, proof-of-concept study. Arthritis Rheum. 2010;62(4):929-939.
    • (2010) Arthritis Rheum , vol.62 , Issue.4 , pp. 929-939
    • Genovese, M.C.1    van den Bosch, F.2    Roberson, S.A.3
  • 204
    • 43549087865 scopus 로고    scopus 로고
    • ABT-874, a fully human monoclonal anti-IL-12/ IL-23 antibody for the potential treatment of autoimmune diseases
    • Ding C, Xu J, Li J. ABT-874, a fully human monoclonal anti-IL-12/ IL-23 antibody for the potential treatment of autoimmune diseases. Curr Opin Investig Drugs. 2008;9(5):515-522.
    • (2008) Curr Opin Investig Drugs , vol.9 , Issue.5 , pp. 515-522
    • Ding, C.1    Xu, J.2    Li, J.3
  • 206
    • 73849124607 scopus 로고    scopus 로고
    • Ustekinumab: Lessons learned from targeting interleukin-12/23p40 in immune-mediated diseases
    • Elliott M, Benson J, Blank M, et al. Ustekinumab: lessons learned from targeting interleukin-12/23p40 in immune-mediated diseases. Ann N Y Acad Sci. 2009;1182:97-110.
    • (2009) Ann N Y Acad Sci , vol.1182 , pp. 97-110
    • Elliott, M.1    Benson, J.2    Blank, M.3
  • 207
    • 69449099657 scopus 로고    scopus 로고
    • Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis
    • Hartgring SAY, van Roon JAG, Wijk MWV, et al. Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis. Arthritis Rheum. 2009;60(9):2595-2605.
    • (2009) Arthritis Rheum , vol.60 , Issue.9 , pp. 2595-2605
    • Hartgring, S.A.Y.1    van Roon, J.A.G.2    Wijk, M.W.V.3
  • 208
    • 78149487035 scopus 로고    scopus 로고
    • Generation and characterization of therapeutic tolerogenic dendritic cells for rheumatoid arthritis
    • Jun 15. [Epub ahead of print] PMID: 20551157
    • Harry RA, Anderson AE, Isaacs JD, Hilkens CM. Generation and characterization of therapeutic tolerogenic dendritic cells for rheumatoid arthritis. Ann Rheum Dis. 2010 Jun 15. [Epub ahead of print] PMID: 20551157.
    • (2010) Ann Rheum Dis
    • Harry, R.A.1    Anderson, A.E.2    Isaacs, J.D.3    Hilkens, C.M.4
  • 209
    • 3543141120 scopus 로고    scopus 로고
    • A new modality for immunosuppression: Targeting the JAK/STAT pathway
    • O'Shea JJ, Pesu M, Borie DC, Changelian PS. A new modality for immunosuppression: targeting the JAK/STAT pathway. Nat Rev Drug Discov. 2004;3(7):555-564.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.7 , pp. 555-564
    • O'Shea, J.J.1    Pesu, M.2    Borie, D.C.3    Changelian, P.S.4
  • 210
    • 77955339521 scopus 로고    scopus 로고
    • New and emerging therapies for the treatment of rheumatoid arthritis
    • Feely MG. New and emerging therapies for the treatment of rheumatoid arthritis. Open Access Rheumatol Res Rev. 2010;2:35-43.
    • (2010) Open Access Rheumatol Res Rev , vol.2 , pp. 35-43
    • Feely, M.G.1
  • 211
    • 67650093218 scopus 로고    scopus 로고
    • The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP690,550 versus placebo
    • Kremer JM, Bloom BJ, Breedveld FC, et al. The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP690,550 versus placebo. Arthritis Rheum. 2009;60(7):1895-1905.
    • (2009) Arthritis Rheum , vol.60 , Issue.7 , pp. 1895-1905
    • Kremer, J.M.1    Bloom, B.J.2    Breedveld, F.C.3
  • 212
    • 75749127860 scopus 로고    scopus 로고
    • Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP690,550, an orally active Janus kinase (JAK) inhibitor: Results from a randomised, double-blind, placebo-controlled trial
    • Coombs JH, Bloom BJ, Breedveld FC, et al. Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial. Ann Rheum Dis. 2010;69(2):413-416.
    • (2010) Ann Rheum Dis , vol.69 , Issue.2 , pp. 413-416
    • Coombs, J.H.1    Bloom, B.J.2    Breedveld, F.C.3
  • 213
    • 72249115144 scopus 로고    scopus 로고
    • MS-1020 is a novel small molecule that selectively inhibits JAK3 activity
    • Kim BH, Oh SR, Yin CH, et al. MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. Br J Haematol. 2010;148(1): 132-143.
    • (2010) Br J Haematol , vol.148 , Issue.1 , pp. 132-143
    • Kim, B.H.1    Oh, S.R.2    Yin, C.H.3
  • 214
    • 77950684805 scopus 로고    scopus 로고
    • Preclinical characterization of the selective JAK1/JAK2 inhibitor ICNB018424: Therapeutic implications for the treatment of myeloproliferative neoplasms
    • Quintás-Cardama A, Vaddi K, Liu P, et al. Preclinical characterization of the selective JAK1/JAK2 inhibitor ICNB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood. 2010;115(15):3109-3117.
    • (2010) Blood , vol.115 , Issue.15 , pp. 3109-3117
    • Quintás-Cardama, A.1    Vaddi, K.2    Liu, P.3
  • 215
    • 77954531991 scopus 로고    scopus 로고
    • Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: Preclinical characterization of INCB028050
    • Fridman JS, Scherle PA, Collins R, et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol. 2010;184(9):5298-5307.
    • (2010) J Immunol , vol.184 , Issue.9 , pp. 5298-5307
    • Fridman, J.S.1    Scherle, P.A.2    Collins, R.3
  • 217
    • 77954680141 scopus 로고    scopus 로고
    • CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms
    • Tyner JW, Bumm TG, Deininger J, et al. CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood. 2010;115(25):5232-5240.
    • (2010) Blood , vol.115 , Issue.25 , pp. 5232-5240
    • Tyner, J.W.1    Bumm, T.G.2    Deininger, J.3
  • 218
    • 41249099841 scopus 로고    scopus 로고
    • Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617Finduced polycythemia vera
    • Wernig G, Kharas MG, Okabe R, et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617Finduced polycythemia vera. Cancer Cell. 2008;13(4):311-320.
    • (2008) Cancer Cell , vol.13 , Issue.4 , pp. 311-320
    • Wernig, G.1    Kharas, M.G.2    Okabe, R.3
  • 219
    • 41249098776 scopus 로고    scopus 로고
    • Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors
    • Geron I, Abrahamsson AE, Barroga CF, et al. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell. 2008;13(4):321-330.
    • (2008) Cancer Cell , vol.13 , Issue.4 , pp. 321-330
    • Geron, I.1    Abrahamsson, A.E.2    Barroga, C.F.3
  • 220
    • 18844370367 scopus 로고    scopus 로고
    • Cucurbitacin Q: A selective STAT3 activation inhibitor with potent antitumor activity
    • Sun J, Blaskovich MA, Jove R, et al. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. 2005;24(20): 3236-3245.
    • (2005) Oncogene , vol.24 , Issue.20 , pp. 3236-3245
    • Sun, J.1    Blaskovich, M.A.2    Jove, R.3
  • 221
    • 77952888131 scopus 로고    scopus 로고
    • STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma
    • Horiguchi A, Asano T, Kuroda K, et al. STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma. Br J Cancer. 2010;102(11):1592-1599.
    • (2010) Br J Cancer , vol.102 , Issue.11 , pp. 1592-1599
    • Horiguchi, A.1    Asano, T.2    Kuroda, K.3
  • 222
    • 70349097179 scopus 로고    scopus 로고
    • Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice
    • Zhang L, Alizadeh D, van Handel M, Kortylewski M, Yu H, Badie B. Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice. Glia. 2009;57(13):1458-1467.
    • (2009) Glia , vol.57 , Issue.13 , pp. 1458-1467
    • Zhang, L.1    Alizadeh, D.2    van Handel, M.3    Kortylewski, M.4    Yu, H.5    Badie, B.6
  • 223
    • 0037166313 scopus 로고    scopus 로고
    • Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesis
    • Spagnoli A, Torello M, Nagalla SR, et al. Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesis. J Biol Chem. 2002;277(21):18860-18867.
    • (2002) J Biol Chem , vol.277 , Issue.21 , pp. 18860-18867
    • Spagnoli, A.1    Torello, M.2    Nagalla, S.R.3
  • 224
    • 0041842552 scopus 로고    scopus 로고
    • Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) α and PPARγ
    • Shipley JM, Waxman DJ. Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) α and PPARγ. Mol Pharmacol. 2003;64(2):355-364.
    • (2003) Mol Pharmacol , vol.64 , Issue.2 , pp. 355-364
    • Shipley, J.M.1    Waxman, D.J.2
  • 225
    • 77953236170 scopus 로고    scopus 로고
    • The α-isoform of p38 kinase MAPK specifically regulates arthritic bone loss
    • Böhm C, Hayer S, Kilian A, et al. The α-isoform of p38 kinase MAPK specifically regulates arthritic bone loss. J Immunol. 2009;183(9): 5938-5947.
    • (2009) J Immunol , vol.183 , Issue.9 , pp. 5938-5947
    • Böhm, C.1    Hayer, S.2    Kilian, A.3
  • 226
    • 59649127763 scopus 로고    scopus 로고
    • Inhibition of p38: Has the fat lady sung?
    • Genovese MC. Inhibition of p38: has the fat lady sung? Arthritis Rheum. 2009;60(2):317-320.
    • (2009) Arthritis Rheum , vol.60 , Issue.2 , pp. 317-320
    • Genovese, M.C.1
  • 227
    • 75749092187 scopus 로고    scopus 로고
    • Go upstream, young man: Lessons learned from the p38 saga
    • Hammaker D, Firestein GS. Go upstream, young man: lessons learned from the p38 saga. Ann Rheum Dis. 2010;69 Suppl 1:i77-i82.
    • (2010) Ann Rheum Dis , vol.69 , Issue.SUPPL. 1
    • Hammaker, D.1    Firestein, G.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.