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Volumn 29, Issue 1, 2010, Pages

Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; INTERLEUKIN 6; MESSENGER RNA; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT3 PROTEIN; VASCULOTROPIN RECEPTOR; ALPHA CYANO (3,4 DIHYDROXY) N BENZYLCINNAMIDE; ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE; ANTINEOPLASTIC AGENT; TYRPHOSTIN; VASCULOTROPIN A;

EID: 77952315859     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-29-51     Document Type: Article
Times cited : (89)

References (34)
  • 2
    • 0346220407 scopus 로고    scopus 로고
    • The challenge of pancreatic cancer
    • Postier RG: The challenge of pancreatic cancer. Am J Surg 2003, 186:579-582.
    • (2003) Am J Surg , vol.186 , pp. 579-582
    • Postier, R.G.1
  • 4
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptional control and their impact on cellular function
    • Bromberg J, Darnell JE Jr: The role of STATs in transcriptional control and their impact on cellular function. Oncogene 2000, 19:2468-2473.
    • (2000) Oncogene , vol.19 , pp. 2468-2473
    • Bromberg, J.1    Darnell, J.E.2
  • 5
    • 33947417336 scopus 로고    scopus 로고
    • Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: Clinical implications
    • Huang S: Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications. Clin Cancer Res 2007, 13:1362-1366.
    • (2007) Clin Cancer Res , vol.13 , pp. 1362-1366
    • Huang, S.1
  • 6
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    • Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, et al.: Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002, 21:2000-2008.
    • (2002) Oncogene , vol.21 , pp. 2000-2008
    • Niu, G.1    Wright, K.L.2    Huang, M.3    Song, L.4    Haura, E.5    Turkson, J.6
  • 7
    • 2442685645 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis
    • Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, et al.: Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 2004, 23: 3550-3560.
    • (2004) Oncogene , vol.23 , pp. 3550-3560
    • Xie, T.X.1    Wei, D.2    Liu, M.3    Gao, A.C.4    Ali-Osman, F.5    Sawaya, R.6
  • 8
    • 0042825695 scopus 로고    scopus 로고
    • Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer
    • Scholz A, Heinze S, Detjen KM, Peters M, Welzel M, Hauff P, et al.: Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. Gastroenterology 2003, 125:891-905.
    • (2003) Gastroenterology , vol.125 , pp. 891-905
    • Scholz, A.1    Heinze, S.2    Detjen, K.M.3    Peters, M.4    Welzel, M.5    Hauff, P.6
  • 9
    • 14544278383 scopus 로고    scopus 로고
    • Activation of STAT3 signaling in human stomach adenocarcinoma drug-resistant cell line and its relationship with expression of vascular endothelial growth factor
    • Yu LF, Cheng Y, Qiao MM, Zhang YP, Wu YL: Activation of STAT3 signaling in human stomach adenocarcinoma drug-resistant cell line and its relationship with expression of vascular endothelial growth factor. World J Gastroenterol 2005, 11:875-879.
    • (2005) World J Gastroenterol , vol.11 , pp. 875-879
    • Yu, L.F.1    Cheng, Y.2    Qiao, M.M.3    Zhang, Y.P.4    Wu, Y.L.5
  • 10
    • 3943103442 scopus 로고    scopus 로고
    • RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells
    • Lee SO, Lou W, Qureshi KM, Mehraein-Ghomi F, Trump DL, Gao AC: RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. Prostate 2004, 60:303-309.
    • (2004) Prostate , vol.60 , pp. 303-309
    • Lee, S.O.1    Lou, W.2    Qureshi, K.M.3    Mehraein-Ghomi, F.4    Trump, D.L.5    Gao, A.C.6
  • 11
    • 0037434666 scopus 로고    scopus 로고
    • Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells
    • Zhang F, Li C, Halfter H, Liu J: Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells. Oncogene 2003, 22:894-905.
    • (2003) Oncogene , vol.22 , pp. 894-905
    • Zhang, F.1    Li, C.2    Halfter, H.3    Liu, J.4
  • 12
    • 33645506849 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor
    • Alvarez JV, Greulich H, Sellers WR, Meyerson M, Frank DA: Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer Res 2006, 66:3162-3168.
    • (2006) Cancer Res , vol.66 , pp. 3162-3168
    • Alvarez, J.V.1    Greulich, H.2    Sellers, W.R.3    Meyerson, M.4    Frank, D.A.5
  • 13
    • 0035852765 scopus 로고    scopus 로고
    • Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1
    • Shen Y, Devgan G, Darnell JE Jr, Bromberg JF: Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc Natl Acad Sci USA 2001, 98:1543-1548.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1543-1548
    • Shen, Y.1    Devgan, G.2    Darnell, J.E.3    Bromberg, J.F.4
  • 14
    • 85047699293 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
    • Zamo A, Chiarle R, Piva R, Howes J, Fan Y, Chilosi M, et al.: Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene 2002, 21:1038-1047.
    • (2002) Oncogene , vol.21 , pp. 1038-1047
    • Zamo, A.1    Chiarle, R.2    Piva, R.3    Howes, J.4    Fan, Y.5    Chilosi, M.6
  • 15
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM: Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 2003, 63: 1270-1279.
    • (2003) Cancer Res , vol.63 , pp. 1270-1279
    • Blaskovich, M.A.1    Sun, J.2    Cantor, A.3    Turkson, J.4    Jove, R.5    Sebti, S.M.6
  • 16
    • 0037112367 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 in human prostate tumors and cell lines: Direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells
    • Mora LB, Buettner R, Seigne J, Diaz J, Ahmad N, Garcia R, et al.: Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res 2002, 62:6659-6666.
    • (2002) Cancer Res , vol.62 , pp. 6659-6666
    • Mora, L.B.1    Buettner, R.2    Seigne, J.3    Diaz, J.4    Ahmad, N.5    Garcia, R.6
  • 17
    • 13344295097 scopus 로고    scopus 로고
    • Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
    • Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, et al.: Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 1996, 379:645-648.
    • (1996) Nature , vol.379 , pp. 645-648
    • Meydan, N.1    Grunberger, T.2    Dadi, H.3    Shahar, M.4    Arpaia, E.5    Lapidot, Z.6
  • 18
    • 40149094813 scopus 로고    scopus 로고
    • Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells
    • Xiong H, Zhang ZG, Tian XQ, Sun DF, Liang QC, Zhang YJ, et al.: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. Neoplasia 2008, 10:287-297.
    • (2008) Neoplasia , vol.10 , pp. 287-297
    • Xiong, H.1    Zhang, Z.G.2    Tian, X.Q.3    Sun, D.F.4    Liang, Q.C.5    Zhang, Y.J.6
  • 19
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
    • Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR: Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev 2007, 21:1396-1408.
    • (2007) Genes Dev , vol.21 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 20
    • 38849182684 scopus 로고    scopus 로고
    • REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells
    • Sekikawa A, Fukui H, Fujii S, Ichikawa K, Tomita S, Imura J, et al.: REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. Carcinogenesis 2008, 29:76-83.
    • (2008) Carcinogenesis , vol.29 , pp. 76-83
    • Sekikawa, A.1    Fukui, H.2    Fujii, S.3    Ichikawa, K.4    Tomita, S.5    Imura, J.6
  • 21
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • Hodge DR, Hurt EM, Farrar WL: The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 2005, 41:2502-2512.
    • (2005) Eur J Cancer , vol.41 , pp. 2502-2512
    • Hodge, D.R.1    Hurt, E.M.2    Farrar, W.L.3
  • 23
    • 34249902824 scopus 로고    scopus 로고
    • RNA interferencemediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells
    • Qiu Z, Huang C, Sun J, Qiu W, Zhang J, Li H, et al.: RNA interferencemediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells. Cancer Sci 2007, 98:1099-1106.
    • (2007) Cancer Sci , vol.98 , pp. 1099-1106
    • Qiu, Z.1    Huang, C.2    Sun, J.3    Qiu, W.4    Zhang, J.5    Li, H.6
  • 24
    • 33750292431 scopus 로고    scopus 로고
    • Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro
    • Huang C, Cao J, Huang KJ, Zhang F, Jiang T, Zhu L, et al.: Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro. Cancer Sci 2006, 97:1417-1423.
    • (2006) Cancer Sci , vol.97 , pp. 1417-1423
    • Huang, C.1    Cao, J.2    Huang, K.J.3    Zhang, F.4    Jiang, T.5    Zhu, L.6
  • 25
    • 21344435775 scopus 로고    scopus 로고
    • Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer
    • Haura EB, Turkson J, Jove R: Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol 2005, 2: 315-324.
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 315-324
    • Haura, E.B.1    Turkson, J.2    Jove, R.3
  • 26
    • 0142122338 scopus 로고    scopus 로고
    • Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer
    • Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, et al.: Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer. Cancer Lett 2003, 201:107-116.
    • (2003) Cancer Lett , vol.201 , pp. 107-116
    • Toyonaga, T.1    Nakano, K.2    Nagano, M.3    Zhao, G.4    Yamaguchi, K.5    Kuroki, S.6
  • 27
    • 33749046082 scopus 로고    scopus 로고
    • Activation of STAT3 in thymic epithelial tumours correlates with tumour type and clinical behaviour
    • Chang KC, Wu MH, Jones D, Chen FF, Tseng YL: Activation of STAT3 in thymic epithelial tumours correlates with tumour type and clinical behaviour. J Pathol 2006, 210:224-233.
    • (2006) J Pathol , vol.210 , pp. 224-233
    • Chang, K.C.1    Wu, M.H.2    Jones, D.3    Chen, F.F.4    Tseng, Y.L.5
  • 28
    • 23444452377 scopus 로고    scopus 로고
    • Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors
    • Kusaba T, Nakayama T, Yamazumi K, Yakata Y, Yoshizaki A, Nagayasu T, et al.: Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. J Clin Pathol 2005, 58: 833-838.
    • (2005) J Clin Pathol , vol.58 , pp. 833-838
    • Kusaba, T.1    Nakayama, T.2    Yamazumi, K.3    Yakata, Y.4    Yoshizaki, A.5    Nagayasu, T.6
  • 29
    • 21044447810 scopus 로고    scopus 로고
    • Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma
    • Suiqing C, Min Z, Lirong C: Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma. J Dermatol 2005, 32:354-360.
    • (2005) J Dermatol , vol.32 , pp. 354-360
    • Suiqing, C.1    Min, Z.2    Lirong, C.3
  • 30
    • 0033119833 scopus 로고    scopus 로고
    • Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
    • Grunstein J, Roberts WG, Mathieu-Costello O, Hanahan D, Johnson RS: Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function. Cancer Res 1999, 59:1592-1598.
    • (1999) Cancer Res , vol.59 , pp. 1592-1598
    • Grunstein, J.1    Roberts, W.G.2    Mathieu-Costello, O.3    Hanahan, D.4    Johnson, R.S.5
  • 31
    • 0037461934 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
    • Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, et al.: Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 2003, 22:319-329.
    • (2003) Oncogene , vol.22 , pp. 319-329
    • Wei, D.1    Le, X.2    Zheng, L.3    Wang, L.4    Frey, J.A.5    Gao, A.C.6
  • 32
    • 0036267895 scopus 로고    scopus 로고
    • Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas
    • Matsuyama Y, Takao S, Aikou T: Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas. J Surg Oncol 2002, 80:105-110.
    • (2002) J Surg Oncol , vol.80 , pp. 105-110
    • Matsuyama, Y.1    Takao, S.2    Aikou, T.3
  • 33
    • 21444444445 scopus 로고    scopus 로고
    • Involvement of matrix metalloproteinase-7 in invasion-metastasis through induction of cell dissociation in pancreatic cancer
    • Tan X, Egami H, Ishikawa S, Sugita H, Kamohara H, Nakagawa M, et al.: Involvement of matrix metalloproteinase-7 in invasion-metastasis through induction of cell dissociation in pancreatic cancer. Int J Oncol 2005, 26:1283-1289.
    • (2005) Int J Oncol , vol.26 , pp. 1283-1289
    • Tan, X.1    Egami, H.2    Ishikawa, S.3    Sugita, H.4    Kamohara, H.5    Nakagawa, M.6


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