The type I IFN system in rheumatoid arthritis

Autoimmunity

Volumn 43, Issue 3, 2010, Pages 220-225

  Conigliaro, Paola ^a,b   Perricone, Carlo ^c   Benson, Robert A ^b   Garside, Paul ^b   Brewer, James M ^b   Perricone, Roberto ^a   Valesini, Guido ^c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Cytokines; IFN I; Inflammation; Plasmacytoid dendritic cells; Rheumatoid arthritis

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; INTERFERON;

ADAPTIVE IMMUNITY; AUTOIMMUNE DISEASE; BONE DESTRUCTION; CARTILAGE DEGENERATION; CELL INFILTRATION; CELLULAR IMMUNITY; CONFERENCE PAPER; DENDRITIC CELL; DRUG MECHANISM; HUMAN; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; MYELOID DENDRITIC CELL; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PLEIOTROPY; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; VIRUS INFECTION;

ANIMALS; ARTHRITIS, RHEUMATOID; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; HUMANS; IMMUNE TOLERANCE; IMMUNITY, INNATE; INTERFERON TYPE I; MICE;

EID: 77951433725     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916930903510914     Document Type: Conference Paper

References (61)

1. McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007;7(6):429-442.
2. Foell D, Wittkowski H, Roth J. Mechanisms of disease: A 'DAMP' view of inflammatory arthritis. Nat Clin Pract Rheumatol 2007;3(7):382-390.
3. Feldmann M. Development of anti-TNF therapy for rheumatoid arthritis. Nat Rev Immunol 2002;2(5):364-371.
4. Goronzy JJ, Weyand CM. T-cell regulation in rheumatoid arthritis. Curr Opin Rheumatol 2004;16(3):212-217.
5. Webb LM, Walmsley MJ, Feldmann M. Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: Requirement for both B7-1 and B7-2. Eur J Immunol 1996;26(10):2320-2328.
6. Kremer JM, Westhovens R, Leon M, Di Giorgio E, Alten R, Steinfeld S, Russell A, Dougados M, Emery P, Nuamah IF, Williams GR, Becker JC, Hagerty DT, Moreland LW. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 2003;349(20):1907-1915.
7. Rönnblom L, Eloranta ML, Alm GV. The type I interferon system in systemic lupus erythematosus. Arthritis Rheum 2006;54(2):408-420.
8. Hardy MP, Owczarek CM, Jermiin LS, Ejdebäck M, Hertzog PJ. Characterization of the type I interferon locus and identification of novel genes. Genomics 2004;84(2): 331-345.
9. Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly PA, Shah K, Ho S, Antonenko S, Liu YJ. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999;284(5421):1835-1837.
10. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004;4:499-511.
11. Baccala R, Hoebe K, Kono DH, Beutler B, Theofilopoulos AN. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat Med 2007;13(5):543-551.
12. Platanias LC. Mechanisms of type-I and type-II-interferonmediated signalling. Nat Rev Immunol 2005;5(5):375-386.
13. Isaacs A, Lindenmann J. Virus interference. I. The interferon. Proc Roy Soc Lond B Biol Sci 1957;147(927):258-267.
14. Fitzgerald-Bocarsly P, Feng D. The role of type I interferon production by dendritic cells in host defense. Biochimie 2007; 89(6-7):843-855.
15. Vremec D, O'Keeffe M, Hochrein H, Fuchsberger M, Caminschi I, Lahoud M, Shortman K. Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells. Blood 2007;109(3):1165-1173. (Pubitemid 46220664)
16. Reise Sousa C. Dendritic cells in a mature age. Nat Rev Immunol 2006;6(6):476-483 (Review).
17. Luft T, Pang KC, Thomas E, Hertzog P, Hart DN, Trapani J, Cebon J. Type I IFNs enhance the terminal differentiation of dendritic cells. J Immunol 1998;161(4):1947-1953.
18. Hibbert L, Pflanz S, De Waal Malefyt R, Kastelein RA. IL-27 and IFN-a signal via Stat1 and Stat3 and induce T-Bet and IL-12Rb2 in naive T cells. J Interferon Cytokine Res 2003;23: 513-522.
19. Kolumam GA, Thomas S, Thompson LJ, Sprent J, Murali-Krishna K. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med 2005;202(5):637-650 [Epub 2005 Aug 29].
20. Theofilopoulos AN, Baccala R, Beutler B, Kono DH. Type I interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol 2005;23:307-336.
21. Rönnblom L, Pascual V. The innate immune system in SLE: Type I interferons and dendritic cells. Lupus 2008;17(5): 394-399.
22. Pettit AR, Thomas R. Dendritic cells: The driving force behind autoimmunity in rheumatoid arthritis? Immunol Cell Biol 1999;77(5):420-427 (Review). (Pubitemid 29476912)
23. Hooks JJ, Moutsopoulos HM, Geis SA, Stahl NI, Decker JL, Notkins AL. Immune interferon in the circulation of patients with autoimmune disease. N Engl J Med 1979;301(1):5-8.
24. Shiozawa S, Chihara K, Shiozawa K, Fujita T, Ikegami H, Koyama S, Kurimoto M. A sensitive radioimmunoassay for alpha-interferon: Circulating alpha-interferon-like substance in the plasma of healthy individuals and rheumatoid arthritis patients. Clin Exp Immunol 1986;66(1):77-87.
25. Hopkins SJ, Meager A. Cytokines in synovial fluid: II. The presence of tumour necrosis factor and interferon. Clin Exp Immunol 1988;73(1):88-92.
26. Fong KY, Boey ML, Koh WH, Feng PH. Cytokine concentrations in the synovial fluid and plasma of rheumatoid arthritis patients: Correlation with bony erosions. Clin Exp Rheumatol 1994;12(1):55-58.
27. Gattorno M, Chicha L, Gregorio A, Ferlito F, Rossi F, Jarrossay D, Lanzavecchia A, Martini A, Manz MG. Distinct expression pattern of IFN-alpha and TNF-alpha in juvenile idiopathic arthritis synovial tissue. Rheumatology (Oxford) 2007;46(4):657-665.
28. Han SW, Lee WK, Kwon KT, Lee BK, Nam EJ, Kim GW. Association of polymorphisms in interferon regulatory factor 5 gene with rheumatoid arthritis: A metaanalysis. J Rheumatol 2009;36(4):693-697.
29. Sigurdsson S, Padyukov L, Kurreeman FA, Liljedahl U, Wiman AC, Alfredsson L, Toes R, Rönnelid J, Klareskog L, Huizinga TW, Alm G, Syvänen AC, Rönnblom L. Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. Arthritis Rheum 2007;56(7):2202-2210.
30. Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, BehrensTW, de Bakker PI, Le JM, Lee HS, Batliwalla F, LiW, Masters SL, Booty MG, Carulli JP, Padyukov L, Alfredsson L, Klareskog L, Chen WV, Amos CI, Criswell LA, Seldin MF, Kastner DL, Gregersen PK. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 2007;357(10):977-986.
31. Frucht DM, Aringer M, Galon J, Danning C, BrownM, Fan S, Centola M, Wu CY, Yamada N, El Gabalawy H, O'Shea JJ. Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation. J Immunol 2000;164(9):4659-4664.
32. Thomas R, Quinn C. Functional differentiation of dendritic cells in rheumatoid arthritis: Role of CD86 in the synovium. J Immunol 1996;156(8):3074-3086.
33. Thomas R, Lipsky PE. Presentation of self peptides by dendritic cells: Possible implications for the pathogenesis of rheumatoid arthritis. Arthritis Rheum 1996;39(2):183-190.
34. Van Krinks CH, Matyszak MK, Gaston JS. Characterization of plasmacytoid dendritic cells in inflammatory arthritis synovial fluid. Rheumatology (Oxford) 2004;43(4):453-460.
35. Palucka AK, Blanck JP, Bennett L, Pascual V, Banchereau J. Cross-regulation of TNF and IFN-alpha in autoimmune diseases. Proc Natl Acad Sci USA 2005;102(9):3372-3377.
36. Lebre MC, Jongbloed SL, Tas SW, Smeets TJ, McInnes IB, Tak PP. Rheumatoid arthritis synovium contains two subsets of CD83-DC-LAMP-dendritic cells with distinct cytokine profiles. Am J Pathol 2008;172(4):940-950.
37. McRae BL, Semnani RT, Hayes MP, van Seventer GA. Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development. J Immunol 1998;160(9):4298-4304.
38. Moseman EA, Liang X, Dawson AJ, Panoskaltsis-Mortari A, Krieg AM, Liu YJ, Blazar BR, Chen W. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J Immunol 2004;173(7):4433-4442.
39. Roelofs MF, Wenink MH, Brentano F, Abdollahi-Roodsaz S, Oppers-Walgreen B, Barrera P, van Riel PL, Joosten LA, Kyburz D, van den Berg WB, Radstake TR. Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4 mediated synovial inflammation in rheumatoid arthritis (RA). Ann Rheum Dis 2009;68(9):1486-1493.
40. Wong T, Majchrzak B, Bogoch E, Keystone EC, Fish EN. Therapeutic implications for interferon-alpha in arthritis: A pilot study. J Rheumatol 2003;30(5):934-940.
41. Niewold TB, Gibofsky A. Concomitant interferon-alpha therapy and tumor necrosis factor alpha inhibition for rheumatoid arthritis and hepatitis C. Arthritis Rheum 2006; 54(7):2335-2337.
42. Passos de Souza E, Evangelista Segundo PT, José FF, Lemaire D, Santiago M. Rheumatoid arthritis induced by alpha-interferon therapy. Clin Rheumatol 2001;20(4): 297-299.
43. Nadir F, Fagiuoli S, Wright HI, Nadir A, Hopp E, Gavaler J, Van Thiel DH. Rheumatoid arthritis: A complication of interferon therapy. J Okla State Med Assoc 1994;87(5): 228-230.
44. Vervoordeldonk MJ, Aalbers CJ, Tak PP. Interferon beta for rheumatoid arthritis: New clothes for an old kid on the block. Ann Rheum Dis 2009;68(2):157-158.
45. Smeets TJ, Dayer JM, Kraan MC, Versendaal J, Chicheportiche R, Breedveld FC, Tak PP. The effects of interferon-beta treatment of synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis. Arthritis Rheum 2000;43(2):270-274.
46. van Holten J, Smeets TJ, Blankert P, Tak PP. Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: Comparison with patients with osteoarthritis and reactive arthritis. Ann Rheum Dis 2005;64(12): 1780-1782.
47. Coclet-Ninin J, Dayer JM, Burger D. Interferon-beta not only inhibits interleukin-1beta and tumor necrosis factor-alpha but stimulates interleukin-1 receptor antagonist production in human peripheral blood mononuclear cells. Eur Cytokine Netw 1997;8(4):345-349.
48. van Holten J, Reedquist K, Sattonet-Roche P, Smeets TJ, Plater-Zyberk C, Vervoordeldonk MJ, Tak PP. Treatment with recombinant interferon-beta reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res Ther 2004;6(3): R239-R249.
49. Triantaphyllopoulos KA, Williams RO, Tailor H, Chernajovsky Y. Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy. Arthritis Rheum 1999;42(1):90-99.
50. Tak PP, Hart BA, Kraan MC, Jonker M, Smeets TJ, Breedveld FC. The effects of interferon beta treatment on arthritis. Rheumatology (Oxford) 1999;38(4):362-369.
51. Bailey-Bucktrout SL, Caulkins SC, Goings G, Fischer JA, Dzionek A, Miller SD. Cutting edge: Central nervous system plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune encephalomyelitis. J Immunol 2008;180(10):6457-6461.
52. Jongbloed SL, Benson RA, Nickdel MB, Garside P, McInnes IB, Brewer JM. Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. J Immunol 2009;182(2):963-968.
53. Maffia P, Brewer JM, Gracie JA, Ianaro A, Leung BP, Mitchell PJ, Smith KM, McInnes IB, Garside P. Inducing experimental arthritis and breaking self-tolerance to jointspecific antigens with trackable, ovalbumin-specific T cells. J Immunol 2004;173(1):151-156.
54. Murphy KM, Heimberger AB, Loh DY. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 1990;250(4988):1720-1723.
55. Smith KM, Pottage L, Thomas ER, Leishman AJ, Doig TN, Xu D, Liew FY, Garside P. Th1 and Th2 CD4+T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo. J Immunol 2000;165(6): 3136-3144.
56. Nickdel MB, Conigliaro P, Valesini G, Hutchison S, Benson R, Bundick RV, Leishman AJ, McInnes IB, Brewer JM, Garside P. Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis. Ann Rheum Dis 2009;68(6):1059-1066.
57. Asselin-Paturel C, Brizard G, Pin JJ, Brière F, Trinchieri G. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J Immunol 2003;171(12):6466-6477.
58. Speziani C, Rivollier A, Gallois A, Coury F, Mazzorana M, Azocar O, Flacher M, Bella C, Tebib J, Jurdic P, Rabourdin-Combe C, Delprat C. Murine dendritic cell transdifferentiation into osteoclasts is differentially regulated by innate and adaptive cytokines. Eur J Immunol 2007;37(3):747-757.
59. Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT. Autoimmunity and bone. Ann N YAcad Sci 2006;1068:275-283.
60. van Duivenvoorde LM, Han WG, Bakker AM, Louis-Plence P, Charbonnier LM, Apparailly F, van der Voort EI, Jorgensen C, HuizingaTW, Toes RE. Immunomodulatory dendritic cells inhibit Th1 responses and arthritis via different mechanisms. J Immunol 2007;179(3):1506-1515.
61. van Duivenvoorde LM, Louis-Plence P, Apparailly F, van der Voort EI, Huizinga TW, Jorgensen C, Toes RE. Antigenspecific immunomodulation of collagen-induced arthritis with tumor necrosis factor-stimulated dendritic cells. Arthritis Rheum 2004;50(10):3354-3364.