메뉴 건너뛰기




Volumn 27, Issue 8, 2009, Pages 1760-1771

Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog

Author keywords

Cell signaling; Embryonic stem cells; Self renewal; Signal transducer and activator of transcription; Small interfering RNA

Indexed keywords

STAT3 PROTEIN; TRANSCRIPTION FACTOR NANOG;

EID: 69249107379     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.110     Document Type: Article
Times cited : (156)

References (40)
  • 1
    • 11144314914 scopus 로고    scopus 로고
    • The molecular basis of pluripotency in mouse embryonic stem cells
    • Chambers I. The molecular basis of pluripotency in mouse embryonic stem cells. Cloning Stem Cells 2004;6:386-391.
    • (2004) Cloning Stem Cells , vol.6 , pp. 386-391
    • Chambers, I.1
  • 2
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    • Ying QL, Nichols J, Chambers I et al. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003;115:281-292.
    • (2003) Cell , vol.115 , pp. 281-292
    • Ying, Q.L.1    Nichols, J.2    Chambers, I.3
  • 3
    • 0030875352 scopus 로고    scopus 로고
    • Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells
    • Boeuf H, Hauss C, Graeve FD et al. Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells. J Cell Biol 1997;138:1207-1217.
    • (1997) J Cell Biol , vol.138 , pp. 1207-1217
    • Boeuf, H.1    Hauss, C.2    Graeve, F.D.3
  • 4
    • 9144239955 scopus 로고    scopus 로고
    • Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signalling
    • Paling NR, Wheadon H, Bone HK et al. Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signalling. J Biol Chem 2004;279:48063-48070.
    • (2004) J Biol Chem , vol.279 , pp. 48063-48070
    • Paling, N.R.1    Wheadon, H.2    Bone, H.K.3
  • 5
    • 3843055775 scopus 로고    scopus 로고
    • The Src family of tyrosine kinases is important for embryonic stem cell self-renewal
    • Annerén C, Cowan CA, Melton DA. The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. J Biol Chem 2004;279:31590-31598.
    • (2004) J Biol Chem , vol.279 , pp. 31590-31598
    • Annerén, C.1    Cowan, C.A.2    Melton, D.A.3
  • 6
    • 0033152966 scopus 로고    scopus 로고
    • Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells
    • Burdon T, Stracey C, Chambers I et al. Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol 1999;210:30-43.
    • (1999) Dev Biol , vol.210 , pp. 30-43
    • Burdon, T.1    Stracey, C.2    Chambers, I.3
  • 7
    • 0032127977 scopus 로고    scopus 로고
    • Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
    • Niwa H, Burdon T, Chambers I et al. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev 1998;12:2048-2060.
    • (1998) Genes Dev , vol.12 , pp. 2048-2060
    • Niwa, H.1    Burdon, T.2    Chambers, I.3
  • 8
    • 0033517123 scopus 로고    scopus 로고
    • STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
    • Matsuda T, Nakamura T, Nakao K et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J 1999;18:4261-4269.
    • (1999) EMBO J , vol.18 , pp. 4261-4269
    • Matsuda, T.1    Nakamura, T.2    Nakao, K.3
  • 9
    • 16844364151 scopus 로고    scopus 로고
    • LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
    • Cartwright P, McLean C, Sheppard A et al. LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development 2005;132:885-896.
    • (2005) Development , vol.132 , pp. 885-896
    • Cartwright, P.1    McLean, C.2    Sheppard, A.3
  • 10
    • 37349062460 scopus 로고    scopus 로고
    • Self-renewal of murine embryonic stem (ES) cells is supported by the serine/threonine kinases Pim-1 and Pim-3
    • Aksoy I, Sakabedoyan C, Bourillot PY et al. Self-renewal of murine embryonic stem (ES) cells is supported by the serine/threonine kinases Pim-1 and Pim-3. Stem Cells 2007;25:2996-3004.
    • (2007) Stem Cells , vol.25 , pp. 2996-3004
    • Aksoy, I.1    Sakabedoyan, C.2    Bourillot, P.Y.3
  • 11
    • 44349149344 scopus 로고    scopus 로고
    • STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells
    • Ura H, Usuda M, Kinoshita K et al. STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells. J Biol Chem 2008;283:9713-9723.
    • (2008) J Biol Chem , vol.283 , pp. 9713-9723
    • Ura, H.1    Usuda, M.2    Kinoshita, K.3
  • 12
    • 0034724677 scopus 로고    scopus 로고
    • SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
    • Schmitz J, Weissenbach M, Haan S et al. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J Biol Chem 2000;275:12848-12856.
    • (2000) J Biol Chem , vol.275 , pp. 12848-12856
    • Schmitz, J.1    Weissenbach, M.2    Haan, S.3
  • 13
    • 44649183963 scopus 로고    scopus 로고
    • Stem cell-specific expression of Dax1 is conferred by STAT3 and Oct3/4 in embryonic stem cells
    • Sun C, Nakatake Y, Ura H et al. Stem cell-specific expression of Dax1 is conferred by STAT3 and Oct3/4 in embryonic stem cells. Biochem Biophys Res Commun 2008;372:91-96.
    • (2008) Biochem Biophys Res Commun , vol.372 , pp. 91-96
    • Sun, C.1    Nakatake, Y.2    Ura, H.3
  • 14
    • 28444480969 scopus 로고    scopus 로고
    • Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells
    • Sekkaï D, Gruel G, Herry M et al. Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells. Stem Cells 2005;23:1634-1642.
    • (2005) Stem Cells , vol.23 , pp. 1634-1642
    • Sekkaï, D.1    Gruel, G.2    Herry, M.3
  • 15
    • 33846207147 scopus 로고    scopus 로고
    • Identification of Jmjd1a as a STAT3 Downstream Gene in mES Cells
    • Ko SY, Kang HY, Lee HS et al. Identification of Jmjd1a as a STAT3 Downstream Gene in mES Cells. Cell Struct Funct 2006;31:53-62.
    • (2006) Cell Struct Funct , vol.31 , pp. 53-62
    • Ko, S.Y.1    Kang, H.Y.2    Lee, H.S.3
  • 16
    • 0038143611 scopus 로고    scopus 로고
    • Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    • Chambers I, Colby D, Robertson M et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113:643-655.
    • (2003) Cell , vol.113 , pp. 643-655
    • Chambers, I.1    Colby, D.2    Robertson, M.3
  • 17
    • 0037806031 scopus 로고    scopus 로고
    • The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
    • Mitsui K, Tokuzawa Y, Itoh H et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003;113:631-642.
    • (2003) Cell , vol.113 , pp. 631-642
    • Mitsui, K.1    Tokuzawa, Y.2    Itoh, H.3
  • 18
    • 0032582513 scopus 로고    scopus 로고
    • Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    • Nichols J, Zevnik B, Anastassiadis K et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998;95:379-391.
    • (1998) Cell , vol.95 , pp. 379-391
    • Nichols, J.1    Zevnik, B.2    Anastassiadis, K.3
  • 19
    • 0037227099 scopus 로고    scopus 로고
    • Multipotent cell lineages in early mouse development depend on SOX2 function
    • Avilion AA, Nicolis SK, Pevny LH et al. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 2003;17:126-140.
    • (2003) Genes Dev , vol.17 , pp. 126-140
    • Avilion, A.A.1    Nicolis, S.K.2    Pevny, L.H.3
  • 20
    • 27644483064 scopus 로고    scopus 로고
    • Regulatory networks in embryo-derived pluripotent stem cells
    • Boiani M, Scholer HR. Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol 2005;6:872-884.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 872-884
    • Boiani, M.1    Scholer, H.R.2
  • 21
    • 37549002155 scopus 로고    scopus 로고
    • Nanog safeguards pluripotency and mediates germline development
    • Chambers I, Silva J, Colby D et al. Nanog safeguards pluripotency and mediates germline development. Nature 2007;450:1230-1234.
    • (2007) Nature , vol.450 , pp. 1230-1234
    • Chambers, I.1    Silva, J.2    Colby, D.3
  • 22
    • 39149130361 scopus 로고    scopus 로고
    • Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
    • Jaenisch R, Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 2008;132:567-582.
    • (2008) Cell , vol.132 , pp. 567-582
    • Jaenisch, R.1    Young, R.2
  • 23
    • 33645381936 scopus 로고    scopus 로고
    • The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
    • Loh YH, Wu Q, Chew JL et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 2006;38:431-440.
    • (2006) Nat Genet , vol.38 , pp. 431-440
    • Loh, Y.H.1    Wu, Q.2    Chew, J.L.3
  • 24
    • 25144525014 scopus 로고    scopus 로고
    • Core transcriptional regulatory circuitry in human embryonic stem cells
    • Boyer LA, Lee TI, Cole MF et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005;122:947-956.
    • (2005) Cell , vol.122 , pp. 947-956
    • Boyer, L.A.1    Lee, T.I.2    Cole, M.F.3
  • 25
    • 34247264419 scopus 로고    scopus 로고
    • Zic3 is required for maintenance of pluripotency in embryonic stem cells
    • Lim LS, Loh YH, Zhang W et al. Zic3 is required for maintenance of pluripotency in embryonic stem cells. Mol Biol Cell 2007;18:1348-1358.
    • (2007) Mol Biol Cell , vol.18 , pp. 1348-1358
    • Lim, L.S.1    Loh, Y.H.2    Zhang, W.3
  • 26
    • 41149174852 scopus 로고    scopus 로고
    • Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells
    • Cole MF, Johnstone SE, Newman JJ et al. Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev 2008;22:746-755.
    • (2008) Genes Dev , vol.22 , pp. 746-755
    • Cole, M.F.1    Johnstone, S.E.2    Newman, J.J.3
  • 27
    • 44649117905 scopus 로고    scopus 로고
    • Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
    • Chen X, Xu H, Yuan P et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008;133:1106-1117.
    • (2008) Cell , vol.133 , pp. 1106-1117
    • Chen, X.1    Xu, H.2    Yuan, P.3
  • 28
    • 0035956864 scopus 로고    scopus 로고
    • An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives
    • Vallier L, Mancip J, Markossian S et al. An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives. Proc Natl Acad Sci U S A 2001;98:2467-2472.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2467-2472
    • Vallier, L.1    Mancip, J.2    Markossian, S.3
  • 29
    • 48649107569 scopus 로고    scopus 로고
    • Derivation and cloning of a novel rhesus ES cell line stably expressing tau-GFP
    • Wianny F, Bernat A, Marcy G et al. Derivation and cloning of a novel rhesus ES cell line stably expressing tau-GFP. Stem Cells 2008;26:1444-1453.
    • (2008) Stem Cells , vol.26 , pp. 1444-1453
    • Wianny, F.1    Bernat, A.2    Marcy, G.3
  • 30
    • 0036903270 scopus 로고    scopus 로고
    • Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation
    • Aubert J, Dunstan H, Chambers I et al. Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol 2002;20:1240-1245.
    • (2002) Nat Biotechnol , vol.20 , pp. 1240-1245
    • Aubert, J.1    Dunstan, H.2    Chambers, I.3
  • 31
    • 0142121516 scopus 로고    scopus 로고
    • Exploration, normalization, and summaries of high density oligonucleotide array probe level data
    • Irizarry RA, Hobbs B, Collin F et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003;4:249-264.
    • (2003) Biostatistics , vol.4 , pp. 249-264
    • Irizarry, R.A.1    Hobbs, B.2    Collin, F.3
  • 32
    • 0032441150 scopus 로고    scopus 로고
    • Cluster analysis and display of genome-wide expression patterns
    • Eisen MB, Spellman PT, Brown PO et al. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 1998;95:14863-14868.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 14863-14868
    • Eisen, M.B.1    Spellman, P.T.2    Brown, P.O.3
  • 33
    • 11244281579 scopus 로고    scopus 로고
    • Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4
    • Li Y, McClintick J, Zhong L et al. Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood 2005;105:635-637.
    • (2005) Blood , vol.105 , pp. 635-637
    • Li, Y.1    McClintick, J.2    Zhong, L.3
  • 34
    • 52649115940 scopus 로고    scopus 로고
    • Klf5 is involved in self-renewal of mouse embryonic stem cells
    • Parisi S, Passaro F, Aloia L et al. Klf5 is involved in self-renewal of mouse embryonic stem cells. J Cell Sci 2008;121:2629-2634.
    • (2008) J Cell Sci , vol.121 , pp. 2629-2634
    • Parisi, S.1    Passaro, F.2    Aloia, L.3
  • 35
    • 40249093059 scopus 로고    scopus 로고
    • A core Klf circuitry regulates sel-frenewal of embryonic stem cells
    • Jiang J, Chan YS, Loh YH et al. A core Klf circuitry regulates sel-frenewal of embryonic stem cells. Nat Cell Biol 2008;10:353-360.
    • (2008) Nat Cell Biol , vol.10 , pp. 353-360
    • Jiang, J.1    Chan, Y.S.2    Loh, Y.H.3
  • 36
    • 54949147295 scopus 로고    scopus 로고
    • Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem
    • Ema M, Mori D, Niwa H et al. Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell 2008;3:555-567.
    • (2008) Cell , vol.3 , pp. 555-567
    • Ema, M.1    Mori, D.2    Niwa, H.3
  • 37
    • 0033151832 scopus 로고    scopus 로고
    • Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway
    • Park J, Leong ML, Buse P et al. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 1999;18:3024-3033.
    • (1999) EMBO J , vol.18 , pp. 3024-3033
    • Park, J.1    Leong, M.L.2    Buse, P.3
  • 38
    • 0033560707 scopus 로고    scopus 로고
    • Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
    • Kobayashi T, Cohen P. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J 1999;339(pt 2):319-328.
    • (1999) Biochem J , vol.339 , Issue.PART 2 , pp. 319-328
    • Kobayashi, T.1    Cohen, P.2
  • 39
    • 44349170450 scopus 로고    scopus 로고
    • The ground state of embryonic stem cell self-renewal
    • Ying QL, Wray J, Nichols J et al. The ground state of embryonic stem cell self-renewal. Nature 2008;453:519-523.
    • (2008) Nature , vol.453 , pp. 519-523
    • Ying, Q.L.1    Wray, J.2    Nichols, J.3
  • 40
    • 33747747661 scopus 로고    scopus 로고
    • Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells
    • Wu Q, Chen X, Zhang J et al. Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem 2006;281:24090-24094.
    • (2006) J Biol Chem , vol.281 , pp. 24090-24094
    • Wu, Q.1    Chen, X.2    Zhang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.