메뉴 건너뛰기




Volumn 4, Issue 3, 2009, Pages 201-221

Targeting JAK/STAT signaling pathway in inflammatory diseases

Author keywords

Chronic heart failure; Cytokines; Eye diseases; Inflammation; Irritable bowel disease; Janus kinase; Rheumatoid arthritis; Signal transducers and activators of transcription; Small molecule inhibitors

Indexed keywords

4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; AUROTHIOMALATE; CYT 387; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GLYCOPROTEIN GP 130; INCB 018424; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; JANUS KINASE; JANUS KINASE 3 INHIBITOR; METHOTREXATE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHOTRANSFERASE INHIBITOR; PLACEBO; PROTEIN INHIBITOR OF ACTIVATED STAT; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; PS 020613; PS 078507; REACTIVE OXYGEN METABOLITE; SALAZOSULFAPYRIDINE; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; TG 101348; TOCILIZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; WP 1066;

EID: 77149137827     PISSN: 15743624     EISSN: None     Source Type: Journal    
DOI: 10.2174/157436209789057467     Document Type: Article
Times cited : (68)

References (235)
  • 1
    • 47249110406 scopus 로고    scopus 로고
    • Targeting cytokines, chemokines and adhesion molecules in rheumatoid arthritis
    • Malemud CJ, Reddy SK. Targeting cytokines, chemokines and adhesion molecules in rheumatoid arthritis. Curr Rheum Rev 2008; 4: 219-34.
    • (2008) Curr Rheum Rev , vol.4 , pp. 219-234
    • Malemud, C.J.1    Reddy, S.K.2
  • 2
    • 41649084155 scopus 로고    scopus 로고
    • At the horizon of innovative therapy in rheumatology: new biologic agents
    • Finckh A, Gabay C. At the horizon of innovative therapy in rheumatology: new biologic agents. Curr Opin Rheumatol 2008; 20: 269-75.
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 269-275
    • Finckh, A.1    Gabay, C.2
  • 5
    • 48249107383 scopus 로고    scopus 로고
    • Inflammation in chronic heart failure
    • Parish RC, Evans JD. Inflammation in chronic heart failure. Ann Pharmacother 2008; 42: 1002-16.
    • (2008) Ann Pharmacother , vol.42 , pp. 1002-1016
    • Parish, R.C.1    Evans, J.D.2
  • 7
    • 33846531775 scopus 로고    scopus 로고
    • Cytokines and chemokines in uveitis - Is there a correlation with clinical phenotype?
    • Ooi KG, Galatowicz G, Calder G, Lightman SL. Cytokines and chemokines in uveitis - Is there a correlation with clinical phenotype? Clin Med Res 2006; 4: 294-309.
    • (2006) Clin Med Res , vol.4 , pp. 294-309
    • Ooi, K.G.1    Galatowicz, G.2    Calder, G.3    Lightman, S.L.4
  • 9
    • 34347259525 scopus 로고    scopus 로고
    • IL-28 and IL-29: newcomers to the interferon family
    • Uzé G, Monneron D. IL-28 and IL-29: newcomers to the interferon family. Biochimie 2007; 89: 729-34.
    • (2007) Biochimie , vol.89 , pp. 729-734
    • Uzé, G.1    Monneron, D.2
  • 10
    • 0035500617 scopus 로고    scopus 로고
    • Cross-talk between IL-1 and IL-6 signaling pathways in rheumatoid arthritis synovial fibroblasts
    • Deon D, Ahmed S, Tai K, et al. Cross-talk between IL-1 and IL-6 signaling pathways in rheumatoid arthritis synovial fibroblasts. J Immunol 2001; 167: 5395-403.
    • (2001) J Immunol , vol.167 , pp. 5395-5403
    • Deon, D.1    Ahmed, S.2    Tai, K.3
  • 11
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT signaling pathway: Input and output integration
    • Murray PJ. The JAK-STAT signaling pathway: Input and output integration. J Immunol 2007; 178: 2623-29.
    • (2007) J Immunol , vol.178 , pp. 2623-2629
    • Murray, P.J.1
  • 12
    • 0027485021 scopus 로고
    • Antiinflammatory properties of hepatic acute phase proteins: Preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1β synthesis by human peripheral blood mononuclear cells
    • Tilg HE, Vannier E, Vachino G, Dinarello CA, Mier JW. Antiinflammatory properties of hepatic acute phase proteins: Preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1β synthesis by human peripheral blood mononuclear cells. J Exp Med 1993; 178: 1629-36.
    • (1993) J Exp Med , vol.178 , pp. 1629-1636
    • Tilg, H.E.1    Vannier, E.2    Vachino, G.3    Dinarello, C.A.4    Mier, J.W.5
  • 13
    • 0028031990 scopus 로고
    • Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55
    • Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW. Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood 1994; 83: 113-8.
    • (1994) Blood , vol.83 , pp. 113-118
    • Tilg, H.1    Trehu, E.2    Atkins, M.B.3    Dinarello, C.A.4    Mier, J.W.5
  • 14
    • 0036694589 scopus 로고    scopus 로고
    • IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    • Ishihara K, Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev 2002; 13: 357-68.
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 357-368
    • Ishihara, K.1    Hirano, T.2
  • 15
    • 33645871828 scopus 로고    scopus 로고
    • Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-γ through JAK/STAT pathway by translational regulation
    • Tamai M, Kawakami A, Tanaka F, et al. Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-γ through JAK/STAT pathway by translational regulation. J Lab Clin Med 2006; 147: 182-90.
    • (2006) J Lab Clin Med , vol.147 , pp. 182-190
    • Tamai, M.1    Kawakami, A.2    Tanaka, F.3
  • 16
    • 0036884944 scopus 로고    scopus 로고
    • Rheumatoid arthritis synoviocyte survival is dependent on Stat3
    • Krause A, Scaletta N, Ji JD, Ivashkiv LB. Rheumatoid arthritis synoviocyte survival is dependent on Stat3. J Immunol 2002; 169: 6610-6.
    • (2002) J Immunol , vol.169 , pp. 6610-6616
    • Krause, A.1    Scaletta, N.2    Ji, J.D.3    Ivashkiv, L.B.4
  • 17
    • 7044272247 scopus 로고    scopus 로고
    • Targeting the Jak/STAT pathway for immunosuppression
    • O'Shea JJ. Targeting the Jak/STAT pathway for immunosuppression. Ann Rheum Dis 2004; 63(Suppl 2): ii67-ii71.
    • (2004) Ann Rheum Dis , vol.63 , Issue.SUPPL 2
    • O'Shea, J.J.1
  • 18
    • 38449117957 scopus 로고    scopus 로고
    • Positive and negative role for IL-6, STAT3, and SOCS3 in inflammatory arthritis
    • Kinjyo I, Ohishi M, Shouda T, Kobayashi T, Yoshimura A. Positive and negative role for IL-6, STAT3, and SOCS3 in inflammatory arthritis. Adv Exp Biol Med 2007; 602: 113-24.
    • (2007) Adv Exp Biol Med , vol.602 , pp. 113-124
    • Kinjyo, I.1    Ohishi, M.2    Shouda, T.3    Kobayashi, T.4    Yoshimura, A.5
  • 19
    • 24944520787 scopus 로고    scopus 로고
    • The Jak-STAT pathway in rheumatoid arthritis
    • Walker JG, Smith MD. The Jak-STAT pathway in rheumatoid arthritis. J Rheumatol 2005; 32: 1650-3.
    • (2005) J Rheumatol , vol.32 , pp. 1650-1653
    • Walker, J.G.1    Smith, M.D.2
  • 20
    • 33750347729 scopus 로고    scopus 로고
    • Regulation of Mcl-1 expression in rheumatoid arthritis synovial fibroblasts
    • Liu H, Huang Q, Shi B, Eksarko P, Temkin V, Pope RM. Regulation of Mcl-1 expression in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 2006; 54: 3174-81.
    • (2006) Arthritis Rheum , vol.54 , pp. 3174-3181
    • Liu, H.1    Huang, Q.2    Shi, B.3    Eksarko, P.4    Temkin, V.5    Pope, R.M.6
  • 21
    • 23044506946 scopus 로고    scopus 로고
    • Pathogenesis of psoriatic arthritis
    • Ritchlin CT. Pathogenesis of psoriatic arthritis. Curr Opin Rheumatol 2005; 17: 406-12.
    • (2005) Curr Opin Rheumatol , vol.17 , pp. 406-412
    • Ritchlin, C.T.1
  • 22
    • 0036716702 scopus 로고    scopus 로고
    • Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease
    • Schreiber S, Rosenstiel P, Hampe J, et al. Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease. Gut 2002; 51: 379-85.
    • (2002) Gut , vol.51 , pp. 379-385
    • Schreiber, S.1    Rosenstiel, P.2    Hampe, J.3
  • 23
    • 13744249714 scopus 로고    scopus 로고
    • Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases
    • Mudter J, Weigmann B, Bartsch B, et al. Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases. Am J Gastroenterol 2005; 100: 64-72.
    • (2005) Am J Gastroenterol , vol.100 , pp. 64-72
    • Mudter, J.1    Weigmann, B.2    Bartsch, B.3
  • 24
    • 39649098693 scopus 로고    scopus 로고
    • Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs
    • Malemud CJ, Miller AH. Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs. Expert Opin Ther Targets 2008; 12: 171-83.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 171-183
    • Malemud, C.J.1    Miller, A.H.2
  • 25
    • 21044452305 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation
    • Musso A, Dentelli P, Carlino A, et al. Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation. Inflamm Bowel Dis 2005; 11: 91-8.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 91-98
    • Musso, A.1    Dentelli, P.2    Carlino, A.3
  • 26
    • 27744528319 scopus 로고    scopus 로고
    • JANUS under stress- Role of JAK/STAT signaling pathway in vascular diseases
    • Grote K, Luchtefeld M, Schieffer B. JANUS under stress- Role of JAK/STAT signaling pathway in vascular diseases. Vascul Pharmacol 2005; 43: 357-63.
    • (2005) Vascul Pharmacol , vol.43 , pp. 357-363
    • Grote, K.1    Luchtefeld, M.2    Schieffer, B.3
  • 27
    • 84934437976 scopus 로고    scopus 로고
    • Curcumin and autoimmune disease
    • Bright JJ. Curcumin and autoimmune disease. Adv Exp Biol Med 2007; 595: 425-51.
    • (2007) Adv Exp Biol Med , vol.595 , pp. 425-451
    • Bright, J.J.1
  • 28
    • 32144453842 scopus 로고    scopus 로고
    • JAK/STAT signaling: Regulators and implication in hematological malignancies
    • Valentino L, Pierre J. JAK/STAT signaling: Regulators and implication in hematological malignancies. Biochem Pharmacol 2006; 71: 713-21.
    • (2006) Biochem Pharmacol , vol.71 , pp. 713-721
    • Valentino, L.1    Pierre, J.2
  • 29
  • 30
    • 33745088052 scopus 로고    scopus 로고
    • Small molecular weight inhibitors of stress-activated and mitogen-activated protein kinases
    • Malemud CJ. Small molecular weight inhibitors of stress-activated and mitogen-activated protein kinases. Mini Rev Med Chem 2006; 6: 689-98.
    • (2006) Mini Rev Med Chem , vol.6 , pp. 689-698
    • Malemud, C.J.1
  • 31
    • 34248331345 scopus 로고    scopus 로고
    • Inhibitors of stress-activated/mitogen-activated protein kinase pathways
    • Malemud CJ. Inhibitors of stress-activated/mitogen-activated protein kinase pathways. Curr Opin Pharmacol 2007; 7: 339-43.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 339-343
    • Malemud, C.J.1
  • 32
    • 0031919849 scopus 로고    scopus 로고
    • JAKS and STATs: Biological implications
    • Leonard WJ, O'Shea JJ. JAKS and STATs: Biological implications. Annu Rev Immunol 1998; 16: 293-322.
    • (1998) Annu Rev Immunol , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 33
    • 0034012330 scopus 로고    scopus 로고
    • Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
    • Saharinen P, Takaluoma K, Silvennoinen O. Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol Cell Biol 2000; 20: 3387-95.
    • (2000) Mol Cell Biol , vol.20 , pp. 3387-3395
    • Saharinen, P.1    Takaluoma, K.2    Silvennoinen, O.3
  • 34
    • 0036762867 scopus 로고    scopus 로고
    • Prediction of the structure of human Janus kinase (JAK2) comprising JAK homology domains 1 through 7
    • Giordanetto P, Kroemer RT. Prediction of the structure of human Janus kinase (JAK2) comprising JAK homology domains 1 through 7. Protein Eng 2002; 15: 727-37.
    • (2002) Protein Eng , vol.15 , pp. 727-737
    • Giordanetto, P.1    Kroemer, R.T.2
  • 35
    • 40449121624 scopus 로고    scopus 로고
    • Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation
    • Haan S, Margue C, Engrand A, et al. Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation. J Immunol 2008; 180: 998-1007.
    • (2008) J Immunol , vol.180 , pp. 998-1007
    • Haan, S.1    Margue, C.2    Engrand, A.3
  • 36
    • 0029156416 scopus 로고
    • Cytokines and STATs: how can signals achieve specificity?
    • Ivashkiv LB. Cytokines and STATs: how can signals achieve specificity? Immunity 1995; 3: 1-4.
    • (1995) Immunity , vol.3 , pp. 1-4
    • Ivashkiv, L.B.1
  • 37
    • 0034658024 scopus 로고    scopus 로고
    • Serine phosphorylation of STATs
    • Decker T, Kovarik P. Serine phosphorylation of STATs. Oncogene 2000; 19: 2628-37.
    • (2000) Oncogene , vol.19 , pp. 2628-2637
    • Decker, T.1    Kovarik, P.2
  • 38
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell JR Jr. STATs and gene regulation. Science 1997; 277: 1630-5.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell J.R., Jr.1
  • 39
    • 17644374227 scopus 로고    scopus 로고
    • The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between CREB-binding protein and STAT6
    • Välineva T, Yang J, Palovuori R, Silvennoinen O. The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between CREB-binding protein and STAT6. J Biol Chem 2005; 280: 14989-96.
    • (2005) J Biol Chem , vol.280 , pp. 14989-14996
    • Välineva, T.1    Yang, J.2    Palovuori, R.3    Silvennoinen, O.4
  • 40
    • 39449123058 scopus 로고    scopus 로고
    • Crif1 is a novel transcriptional coactivator of STAT3
    • Kwon M-C, Koo B-K, Moon J-S, et al. Crif1 is a novel transcriptional coactivator of STAT3. EMJO J 2008; 27: 642-53.
    • (2008) EMJO J , vol.27 , pp. 642-653
    • Kwon, M.-C.1    Koo, B.-K.2    Moon, J.-S.3
  • 42
    • 4644261307 scopus 로고    scopus 로고
    • The STAT3 isoforms α and β have unique and specific functions
    • Maritano D, Sugrue ML, Tininini S, et al. The STAT3 isoforms α and β have unique and specific functions. Nat Immunol 2004; 5: 401-9.
    • (2004) Nat Immunol , vol.5 , pp. 401-409
    • Maritano, D.1    Sugrue, M.L.2    Tininini, S.3
  • 43
    • 7044235774 scopus 로고    scopus 로고
    • IFN-γ/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1
    • Jaruga B, Hong F, Kim W-H, Gao B. IFN-γ/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1. Am J Physiol Gastrointest Liver Physiol 2004; 287: G1044-52.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Jaruga, B.1    Hong, F.2    Kim, W.-H.3    Gao, B.4
  • 44
    • 0035877106 scopus 로고    scopus 로고
    • Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion
    • Zhu J, Guo L, Watson CJ, Hu-Li J, Paul WE. Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion. J Immunol 2001; 166: 7276-81.
    • (2001) J Immunol , vol.166 , pp. 7276-7281
    • Zhu, J.1    Guo, L.2    Watson, C.J.3    Hu-Li, J.4    Paul, W.E.5
  • 46
    • 0032996486 scopus 로고    scopus 로고
    • The Jak-STAT pathway: signaling from the receptor to the nucleus
    • Heim MH. The Jak-STAT pathway: signaling from the receptor to the nucleus. J Recept Signal Transduct Res 1999; 19: 75-120.
    • (1999) J Recept Signal Transduct Res , vol.19 , pp. 75-120
    • Heim, M.H.1
  • 47
    • 18244392419 scopus 로고    scopus 로고
    • STAT4. A critical regulator of inflammation in vivo
    • Kaplan MH. STAT4. A critical regulator of inflammation in vivo. Immunol Res 2005; 31: 231-42.
    • (2005) Immunol Res , vol.31 , pp. 231-242
    • Kaplan, M.H.1
  • 48
    • 0035136846 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
    • Epling-Burnette PK, Liu JH, Catlett-Falcone R, et al. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest 2001; 107: 351-62.
    • (2001) J Clin Invest , vol.107 , pp. 351-362
    • Epling-Burnette, P.K.1    Liu, J.H.2    Catlett-Falcone, R.3
  • 49
    • 0035437158 scopus 로고    scopus 로고
    • STAT3 is constitutively activated in Hodgkin cell lines
    • Kube D, Holtick U, Vockerodt M, et al. STAT3 is constitutively activated in Hodgkin cell lines. Blood 2001; 98: 762-70.
    • (2001) Blood , vol.98 , pp. 762-770
    • Kube, D.1    Holtick, U.2    Vockerodt, M.3
  • 50
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: novel molecular targets for cancer drug discovery
    • Turkson J, Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 2000; 19: 6613-26.
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 51
    • 0032805660 scopus 로고    scopus 로고
    • Constitutive activation of STATs upon in vivo human immunodeficiency virus infection
    • Bovolenta C, Camorali L, Lorini AL, et al. Constitutive activation of STATs upon in vivo human immunodeficiency virus infection. Blood 1999; 94: 4202-9.
    • (1999) Blood , vol.94 , pp. 4202-4209
    • Bovolenta, C.1    Camorali, L.2    Lorini, A.L.3
  • 52
    • 33751555600 scopus 로고    scopus 로고
    • General nature of the STAT3-activated anti-inflammatory response
    • El Kasmi KC, Holst J, Coffre M, et al. General nature of the STAT3-activated anti-inflammatory response. J Immunol 2006; 177: 7880-8.
    • (2006) J Immunol , vol.177 , pp. 7880-7888
    • El Kasmi, K.C.1    Holst, J.2    Coffre, M.3
  • 53
    • 0029014206 scopus 로고
    • A novel cytokineinducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
    • Yoshimura A, Ohkubo T, Kiguchi T, et al. A novel cytokineinducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J 1995; 14: 2816-26.
    • (1995) EMBO J , vol.14 , pp. 2816-2826
    • Yoshimura, A.1    Ohkubo, T.2    Kiguchi, T.3
  • 54
    • 0034726958 scopus 로고    scopus 로고
    • The JAK inhibitor, JAK/SOCS-1 selectively inhibits cytokine-induced, but not v-Srcinduced JAK-STAT activation
    • Iwamoto T, Senga T, Naito Y, et al. The JAK inhibitor, JAK/SOCS-1 selectively inhibits cytokine-induced, but not v-Srcinduced JAK-STAT activation. Oncogene 2000; 19: 4795-801.
    • (2000) Oncogene , vol.19 , pp. 4795-4801
    • Iwamoto, T.1    Senga, T.2    Naito, Y.3
  • 55
    • 0034841006 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling
    • Greenhalgh CJ, Hilton DJ. Negative regulation of cytokine signaling. J Leukoc Biol 2001; 70: 348-56.
    • (2001) J Leukoc Biol , vol.70 , pp. 348-356
    • Greenhalgh, C.J.1    Hilton, D.J.2
  • 56
    • 20144367654 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling and immune responses by SOCS proteins
    • Yoshimura A, Nishinakamura H, Matsumura Y, Hanada T. Negative regulation of cytokine signaling and immune responses by SOCS proteins. Arthritis Res Ther 2005; 7: 100-10.
    • (2005) Arthritis Res Ther , vol.7 , pp. 100-110
    • Yoshimura, A.1    Nishinakamura, H.2    Matsumura, Y.3    Hanada, T.4
  • 57
    • 0033544899 scopus 로고    scopus 로고
    • SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
    • Ram PA, Waxman DJ. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J Biol Chem 1999; 274: 35553-61.
    • (1999) J Biol Chem , vol.274 , pp. 35553-35561
    • Ram, P.A.1    Waxman, D.J.2
  • 58
    • 0034801684 scopus 로고    scopus 로고
    • SOCS proteins: Negative regulators of cytokine signaling
    • Krebs DL, Hilton DJ. SOCS proteins: Negative regulators of cytokine signaling. Stem Cells 2001; 19: 378-87.
    • (2001) Stem Cells , vol.19 , pp. 378-387
    • Krebs, D.L.1    Hilton, D.J.2
  • 59
    • 0037317179 scopus 로고    scopus 로고
    • A three-dimensional model of Suppressor of Cytokine Signaling-1 (SOCS-1)
    • Giordanetto F, Kroemer RT. A three-dimensional model of Suppressor of Cytokine Signaling-1 (SOCS-1). Protein Eng 2003; 16: 115-24.
    • (2003) Protein Eng , vol.16 , pp. 115-124
    • Giordanetto, F.1    Kroemer, R.T.2
  • 60
    • 0037162397 scopus 로고    scopus 로고
    • SH2 domains from suppressor of cytokine-signaling-3 and protein phosphatase SHP-2 have similar binding specificities
    • De Souza D, Fabri LJ, Nash A, Hilton DJ, Nicola NA, Baca M. SH2 domains from suppressor of cytokine-signaling-3 and protein phosphatase SHP-2 have similar binding specificities. Biochemistry 2002; 41: 9229-36.
    • (2002) Biochemistry , vol.41 , pp. 9229-9236
    • De Souza, D.1    Fabri, L.J.2    Nash, A.3    Hilton, D.J.4    Nicola, N.A.5    Baca, M.6
  • 61
    • 0033794917 scopus 로고    scopus 로고
    • Roles of SHP-1 tyrosine phosphatase in the negative regulation of cell signaling
    • Zhang J, Somani AK, Siminovitch KA. Roles of SHP-1 tyrosine phosphatase in the negative regulation of cell signaling. Semin Immunol 2000; 12: 361-378.
    • (2000) Semin Immunol , vol.12 , pp. 361-378
    • Zhang, J.1    Somani, A.K.2    Siminovitch, K.A.3
  • 62
    • 0033794973 scopus 로고    scopus 로고
    • The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function
    • Alexander DR. The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function. Semin Immunol 2000; 12: 349-59.
    • (2000) Semin Immunol , vol.12 , pp. 349-359
    • Alexander, D.R.1
  • 63
    • 32644459132 scopus 로고    scopus 로고
    • Regulation of cytokine signaling pathways by PIAS proteins
    • Shuai K. Regulation of cytokine signaling pathways by PIAS proteins. Cell Res 2006; 16: 196-202.
    • (2006) Cell Res , vol.16 , pp. 196-202
    • Shuai, K.1
  • 64
    • 3943099375 scopus 로고    scopus 로고
    • Protein modification by SUMO
    • Johnson ES. Protein modification by SUMO. Annu Rev Biochem 2004; 73: 355-82.
    • (2004) Annu Rev Biochem , vol.73 , pp. 355-382
    • Johnson, E.S.1
  • 65
    • 52949090018 scopus 로고    scopus 로고
    • SOCS regulation of the JAK/STAT signalling pathway
    • Croker BA, Kiu H, Nicholson SE. SOCS regulation of the JAK/STAT signalling pathway. Semin Cell Dev Biol 2008; 19: 414-22.
    • (2008) Semin Cell Dev Biol , vol.19 , pp. 414-422
    • Croker, B.A.1    Kiu, H.2    Nicholson, S.E.3
  • 66
    • 33644888064 scopus 로고    scopus 로고
    • SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation
    • Davey GM, Heath WR, Starr R. SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation. Tissue Antigens 2006; 67: 1-9.
    • (2006) Tissue Antigens , vol.67 , pp. 1-9
    • Davey, G.M.1    Heath, W.R.2    Starr, R.3
  • 67
    • 32044451547 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFN-γ and IL-4 are involved
    • Chinen T, Kobayashi T, Ogata H, et al. Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFN-γ and IL-4 are involved. Gastroenterology 2006; 130: 373-88.
    • (2006) Gastroenterology , vol.130 , pp. 373-388
    • Chinen, T.1    Kobayashi, T.2    Ogata, H.3
  • 68
    • 0035667907 scopus 로고    scopus 로고
    • Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
    • Shouda T, Yoshida T, Hanada T, et al. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J Clin Invest 2001; 108: 1781-88.
    • (2001) J Clin Invest , vol.108 , pp. 1781-1788
    • Shouda, T.1    Yoshida, T.2    Hanada, T.3
  • 69
    • 33847419628 scopus 로고    scopus 로고
    • Activation of the STAT1 signaling pathway in lupus nephritis in MRL/lpr mice
    • Dong J, Wang Q-X, Zhou C-Y, Ma X-F, Zhang Y-C. Activation of the STAT1 signaling pathway in lupus nephritis in MRL/lpr mice. Lupus 2007; 16: 101-9.
    • (2007) Lupus , vol.16 , pp. 101-109
    • Dong, J.1    Wang, Q.-X.2    Zhou, C.-Y.3    Ma, X.-F.4    Zhang, Y.-C.5
  • 70
    • 34848868803 scopus 로고    scopus 로고
    • The expression of SOCS is altered in rheumatoid arthritis
    • Isomäki P, Alanärä T, Isohanni P, et al. The expression of SOCS is altered in rheumatoid arthritis. Rheumatology (Oxford) 2007; 46: 1538-46.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 1538-1546
    • Isomäki, P.1    Alanärä, T.2    Isohanni, P.3
  • 71
    • 0035910753 scopus 로고    scopus 로고
    • CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
    • Suzuki A, Hanada T, Mitsuyama K, et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 2001; 193: 471-81.
    • (2001) J Exp Med , vol.193 , pp. 471-481
    • Suzuki, A.1    Hanada, T.2    Mitsuyama, K.3
  • 72
    • 3042592451 scopus 로고    scopus 로고
    • SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis
    • Yoshida T, Ogata H, Kamio A, et al. SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis. J Exp Med 2004; 199: 1701-7.
    • (2004) J Exp Med , vol.199 , pp. 1701-1707
    • Yoshida, T.1    Ogata, H.2    Kamio, A.3
  • 73
    • 0342313569 scopus 로고    scopus 로고
    • Activation of the IL-4 STAT pathway in rheumatoid synovium
    • Müller-Ladner U, Judex M, Ballhorn W, et al. Activation of the IL-4 STAT pathway in rheumatoid synovium. J Immunol 2000; 164: 3894-901.
    • (2000) J Immunol , vol.164 , pp. 3894-3901
    • Müller-Ladner, U.1    Judex, M.2    Ballhorn, W.3
  • 74
    • 0034867446 scopus 로고    scopus 로고
    • Preferential and persistent activation of the STAT1 pathway in rheumatoid synovial fluid cells
    • Yokota A, Narazaki N, Shima Y, et al. Preferential and persistent activation of the STAT1 pathway in rheumatoid synovial fluid cells. J Rheumatol 2001; 28: 1952-9.
    • (2001) J Rheumatol , vol.28 , pp. 1952-1959
    • Yokota, A.1    Narazaki, N.2    Shima, Y.3
  • 75
    • 1342322752 scopus 로고    scopus 로고
    • Activation of the STAT1 pathway in rheumatoid arthritis
    • Kasperkovitz PV, Verbeet NL, Smeets TJ, et al. Activation of the STAT1 pathway in rheumatoid arthritis. Ann Rheum Dis 2004; 63: 233-9.
    • (2004) Ann Rheum Dis , vol.63 , pp. 233-239
    • Kasperkovitz, P.V.1    Verbeet, N.L.2    Smeets, T.J.3
  • 76
    • 31144460322 scopus 로고    scopus 로고
    • Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis
    • Walker JG, Ahern MJ, Coleman M, et al. Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis. Ann Rheum Dis 2006; 65: 149-56.
    • (2006) Ann Rheum Dis , vol.65 , pp. 149-156
    • Walker, J.G.1    Ahern, M.J.2    Coleman, M.3
  • 77
    • 34547171705 scopus 로고    scopus 로고
    • Characterisation of a dendritic cell subset in synovial tissue which strongly expresses Jak/STAT transcription factors from patients with rheumatoid arthritis
    • Walker JG, Ahern MG, Coleman M, et al. Characterisation of a dendritic cell subset in synovial tissue which strongly expresses Jak/STAT transcription factors from patients with rheumatoid arthritis. Ann Rheum Dis 2007; 66: 992-9.
    • (2007) Ann Rheum Dis , vol.66 , pp. 992-999
    • Walker, J.G.1    Ahern, M.G.2    Coleman, M.3
  • 78
    • 33751300575 scopus 로고    scopus 로고
    • Changes in synovial tissue Jak-STAT expression in rheumatoid arthritis in response to successful DMARD treatment
    • Walker JG, Ahern MJ, Coleman M, et al. Changes in synovial tissue Jak-STAT expression in rheumatoid arthritis in response to successful DMARD treatment. Ann Rheum Dis 2006; 65: 1558-64.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1558-1564
    • Walker, J.G.1    Ahern, M.J.2    Coleman, M.3
  • 79
    • 0035284754 scopus 로고    scopus 로고
    • Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires janus kinase/STAT signaling pathway
    • Li WQ, Dehnade F, Zafarullah M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires janus kinase/STAT signaling pathway. J Immunol 2001; 166: 3491-8.
    • (2001) J Immunol , vol.166 , pp. 3491-3498
    • Li, W.Q.1    Dehnade, F.2    Zafarullah, M.3
  • 80
    • 33847185270 scopus 로고    scopus 로고
    • Signaling pathways implicated in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes
    • El Mabrouk M, Sylvester J, Zafarullah M. Signaling pathways implicated in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes. Biochim Biophys Acta 2007; 1773: 309-20.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 309-320
    • El Mabrouk, M.1    Sylvester, J.2    Zafarullah, M.3
  • 81
    • 0036230531 scopus 로고    scopus 로고
    • Minireview: Neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules
    • Chesnokova V, Melmed S. Minireview: Neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules. Endocrinology 2002; 143: 1571-4.
    • (2002) Endocrinology , vol.143 , pp. 1571-1574
    • Chesnokova, V.1    Melmed, S.2
  • 82
    • 2442646812 scopus 로고    scopus 로고
    • The serum growth hormone to somatostatin ratio is skewed upward in rheumatoid arthritis patients
    • Denko CW, Malemud CJ. The serum growth hormone to somatostatin ratio is skewed upward in rheumatoid arthritis patients. Front Biosci 2004; 9: 1660-4.
    • (2004) Front Biosci , vol.9 , pp. 1660-1664
    • Denko, C.W.1    Malemud, C.J.2
  • 83
    • 33747786726 scopus 로고    scopus 로고
    • Changes in plasma levels of fatderived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis
    • Otero M, Lago R, Gomez R, et al. Changes in plasma levels of fatderived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis 2006; 65: 1198-201.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1198-1201
    • Otero, M.1    Lago, R.2    Gomez, R.3
  • 84
    • 34848847894 scopus 로고    scopus 로고
    • Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities
    • Brentano F, Schorr O, Ospelt C, et al. Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities. Arthritis Rheum 2007; 56: 2829-39.
    • (2007) Arthritis Rheum , vol.56 , pp. 2829-2839
    • Brentano, F.1    Schorr, O.2    Ospelt, C.3
  • 85
    • 33745894354 scopus 로고    scopus 로고
    • Regulation of pre-B cell colony enhancing factor by STAT-3-dependent interleukin-6 trans-signaling Implications in the pathogenesis of rheumatoid arthritis
    • Nowell MA, Richards PJ, Fielding CA, et al. Regulation of pre-B cell colony enhancing factor by STAT-3-dependent interleukin-6 trans-signaling. Implications in the pathogenesis of rheumatoid arthritis. Arthritis Rheum 2006; 54: 2084-95.
    • (2006) Arthritis Rheum , vol.54 , pp. 2084-2095
    • Nowell, M.A.1    Richards, P.J.2    Fielding, C.A.3
  • 86
    • 49449106856 scopus 로고    scopus 로고
    • Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis
    • Nile CR, Read RC, Akil M, Duff GW, Wilson AG. Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis Rheum 2008; 58: 2686-93.
    • (2008) Arthritis Rheum , vol.58 , pp. 2686-2693
    • Nile, C.R.1    Read, R.C.2    Akil, M.3    Duff, G.W.4    Wilson, A.G.5
  • 87
    • 13444256307 scopus 로고    scopus 로고
    • The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models
    • Lubberts E, Koenders MI, van den Berg WB. The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther 2005; 7: 29-37.
    • (2005) Arthritis Res Ther , vol.7 , pp. 29-37
    • Lubberts, E.1    Koenders, M.I.2    van den Berg, W.B.3
  • 88
    • 33646490259 scopus 로고    scopus 로고
    • Interleukin-17 acts independently of TNF-α under arthritic conditions
    • Koenders MI, Lubberts E, van de Loo FAJ, et al. Interleukin-17 acts independently of TNF-α under arthritic conditions. J Immunol 2006; 176: 6262-9.
    • (2006) J Immunol , vol.176 , pp. 6262-6269
    • Koenders, M.I.1    Lubberts, E.2    van de Loo, F.A.J.3
  • 89
    • 33646164439 scopus 로고    scopus 로고
    • Expanding the effector CD4 T-cell repertoire: The Th17 lineage
    • Harrington LE, Mangan PR, Weaver CT. Expanding the effector CD4 T-cell repertoire: The Th17 lineage. Curr Opin Immunol 2006; 18: 349-56.
    • (2006) Curr Opin Immunol , vol.18 , pp. 349-356
    • Harrington, L.E.1    Mangan, P.R.2    Weaver, C.T.3
  • 91
    • 0002966198 scopus 로고    scopus 로고
    • Evidence for the involvement of the JAK/STAT pathway in the signaling mechanism of IL-17
    • Subramaniam SV, Cooper RS, Adunyah SE. Evidence for the involvement of the JAK/STAT pathway in the signaling mechanism of IL-17. Biochem Biophys Res Commun 1999; 262: 14-9.
    • (1999) Biochem Biophys Res Commun , vol.262 , pp. 14-19
    • Subramaniam, S.V.1    Cooper, R.S.2    Adunyah, S.E.3
  • 92
    • 34247593586 scopus 로고    scopus 로고
    • STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
    • Yang XO, Panopoulos AD, Nurieva R, et al. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 2007; 282: 9358-63.
    • (2007) J Biol Chem , vol.282 , pp. 9358-9363
    • Yang, X.O.1    Panopoulos, A.D.2    Nurieva, R.3
  • 93
    • 34547514211 scopus 로고    scopus 로고
    • IL-6 dependent and -independent pa
    • Kimura A, Naka T, Kishimoto T. IL-6 dependent and -independent pathways in the development of interleukin 17-producing T helper cells. Proc Natl Acad Sci USA 2007; 104: 12099-104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12099-12104
    • Kimura, A.1    Naka, T.2    Kishimoto, T.3
  • 94
    • 34447511609 scopus 로고    scopus 로고
    • h with a minimum effect on that of Treg in the steady state
    • h with a minimum effect on that of Treg in the steady state. Int Immunol 2007; 19: 695-702.
    • (2007) Int Immunol , vol.19 , pp. 695-702
    • Nishihara, M.1    Ogura, H.2    Ueda, N.3
  • 95
    • 39549091298 scopus 로고    scopus 로고
    • Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation
    • Chen Z, Laurence A, O'Shea JJ. Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol 2007; 19: 400-8.
    • (2007) Semin Immunol , vol.19 , pp. 400-408
    • Chen, Z.1    Laurence, A.2    O'Shea, J.J.3
  • 96
    • 46949086109 scopus 로고    scopus 로고
    • Mutations in STAT3 and IL12RB1 impair the development of human IL-17 producing T cells
    • de Beaucoudrey L, Puel A, Filipe-Santos O, et al. Mutations in STAT3 and IL12RB1 impair the development of human IL-17 producing T cells. J Exp Med 2008; 205: 1543-50.
    • (2008) J Exp Med , vol.205 , pp. 1543-1550
    • de Beaucoudrey, L.1    Puel, A.2    Filipe-Santos, O.3
  • 98
    • 0034086694 scopus 로고    scopus 로고
    • Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4
    • Chikuma S, Murakami M, Tanaka K, Uede T. Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4. J Cell Biochem 2000; 78: 241-50.
    • (2000) J Cell Biochem , vol.78 , pp. 241-250
    • Chikuma, S.1    Murakami, M.2    Tanaka, K.3    Uede, T.4
  • 99
    • 7244231007 scopus 로고    scopus 로고
    • CTLA-4-Ig activates forkhead transcriptional factors and protects dendritic cells from oxidative stress in nonobese diabetic mice
    • Fallarino F, Bianchi R, Orabona C, et al. CTLA-4-Ig activates forkhead transcriptional factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J Exp Med 2004; 200: 1051-62.
    • (2004) J Exp Med , vol.200 , pp. 1051-1062
    • Fallarino, F.1    Bianchi, R.2    Orabona, C.3
  • 100
    • 21044458270 scopus 로고    scopus 로고
    • Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant
    • Orabona C, Belladonna ML, Vacca C, et al. Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant. J Immunol 2005; 174: 6582-6.
    • (2005) J Immunol , vol.174 , pp. 6582-6586
    • Orabona, C.1    Belladonna, M.L.2    Vacca, C.3
  • 101
  • 103
    • 33744479688 scopus 로고    scopus 로고
    • Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
    • Chen Z, Laurence A, Kanno Y, et al. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci USA 2006; 103: 8137-42.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8137-8142
    • Chen, Z.1    Laurence, A.2    Kanno, Y.3
  • 104
    • 33746190828 scopus 로고    scopus 로고
    • Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo
    • Li Y, Chu N, Rostami A, Zhang GX. Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo. J Immunol 2006; 177: 1679-88.
    • (2006) J Immunol , vol.177 , pp. 1679-1688
    • Li, Y.1    Chu, N.2    Rostami, A.3    Zhang, G.X.4
  • 105
    • 33745834002 scopus 로고    scopus 로고
    • Prostaglandin E2 augments IL-10 signaling and function
    • Cheon H, Rho YH, Choi SJ, et al. Prostaglandin E2 augments IL-10 signaling and function. J Immunol 2006; 177: 1092-100.
    • (2006) J Immunol , vol.177 , pp. 1092-1100
    • Cheon, H.1    Rho, Y.H.2    Choi, S.J.3
  • 106
    • 33751555746 scopus 로고    scopus 로고
    • IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine-signaling-3
    • Qin H, Wilson CA, Roberts KL, Baker BJ, Zhao X, Benveniste EN. IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine-signaling-3. J Immunol 2006; 177: 7761-71.
    • (2006) J Immunol , vol.177 , pp. 7761-7771
    • Qin, H.1    Wilson, C.A.2    Roberts, K.L.3    Baker, B.J.4    Zhao, X.5    Benveniste, E.N.6
  • 107
    • 34547726636 scopus 로고    scopus 로고
    • Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology Identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis
    • Timmer TCG, Baltus B, Vondenhoff M, et al. Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology. Identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis. Arthritis Rheum 2007; 56: 2492-502.
    • (2007) Arthritis Rheum , vol.56 , pp. 2492-2502
    • Timmer, T.C.G.1    Baltus, B.2    Vondenhoff, M.3
  • 109
    • 34548427925 scopus 로고    scopus 로고
    • STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
    • Remmers EF, Plenge RM, Lee AT, et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Eng J Med 2007; 357: 977-86.
    • (2007) N Eng J Med , vol.357 , pp. 977-986
    • Remmers, E.F.1    Plenge, R.M.2    Lee, A.T.3
  • 110
    • 51849120731 scopus 로고    scopus 로고
    • Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases
    • Martínez A, Veradé J, Márquez A, et al. Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. Arthritis Rheum 2008; 58: 2598-602.
    • (2008) Arthritis Rheum , vol.58 , pp. 2598-2602
    • Martínez, A.1    Veradé, J.2    Márquez, A.3
  • 111
    • 47249124862 scopus 로고    scopus 로고
    • Is there a final common pathway for arthritis?
    • Malemud CJ, Schulte ME. Is there a final common pathway for arthritis? Future Rheumatol 2008; 3: 253-68.
    • (2008) Future Rheumatol , vol.3 , pp. 253-268
    • Malemud, C.J.1    Schulte, M.E.2
  • 112
    • 2342605451 scopus 로고    scopus 로고
    • Secretion of oncostatin M by neutrophils in rheumatoid arthritis
    • Cross A, Edwards SW, Bucknall RC, Moots RJ. Secretion of oncostatin M by neutrophils in rheumatoid arthritis. Arthritis Rheum 2004; 50: 1430-6.
    • (2004) Arthritis Rheum , vol.50 , pp. 1430-1436
    • Cross, A.1    Edwards, S.W.2    Bucknall, R.C.3    Moots, R.J.4
  • 113
    • 0032732328 scopus 로고    scopus 로고
    • Involvement of fibroblast growth factor-2 in joint destruction of rheumatoid arthritis patients
    • Manabe N, Oda H, Nakamura K, Kuga Y, Uchida S, Kawaguchi H. Involvement of fibroblast growth factor-2 in joint destruction of rheumatoid arthritis patients. Rheumatology (Oxford) 1999; 38: 714-20.
    • (1999) Rheumatology (Oxford) , vol.38 , pp. 714-720
    • Manabe, N.1    Oda, H.2    Nakamura, K.3    Kuga, Y.4    Uchida, S.5    Kawaguchi, H.6
  • 114
    • 0036786256 scopus 로고    scopus 로고
    • Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on chick chorioallantoic membrane and activates isolated osteoclast resorption in vitro
    • Collin-Osdoby P, Rothe L, Bekker S, Anderson F, Huang Y, Osdoby P. Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on chick chorioallantoic membrane and activates isolated osteoclast resorption in vitro. J Bone Miner Res 2002; 17: 1859-71.
    • (2002) J Bone Miner Res , vol.17 , pp. 1859-1871
    • Collin-Osdoby, P.1    Rothe, L.2    Bekker, S.3    Anderson, F.4    Huang, Y.5    Osdoby, P.6
  • 115
    • 56949093319 scopus 로고    scopus 로고
    • Fibroblast growth factor inhibits interferon-γ-STAT1 and interleukin 6-STAT3 signaling in chondrocytes
    • Krejci P, Prochazkova J, Bryja V, et al. Fibroblast growth factor inhibits interferon-γ-STAT1 and interleukin 6-STAT3 signaling in chondrocytes. Cell Signal 2009; 21: 151-60.
    • (2009) Cell Signal , vol.21 , pp. 151-160
    • Krejci, P.1    Prochazkova, J.2    Bryja, V.3
  • 116
    • 0037105475 scopus 로고    scopus 로고
    • IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms
    • Finnegan A, Grusby MJ, Kaplan CD, et al. IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol 2002; 169: 3345-52.
    • (2002) J Immunol , vol.169 , pp. 3345-3352
    • Finnegan, A.1    Grusby, M.J.2    Kaplan, C.D.3
  • 119
    • 0028069352 scopus 로고
    • Cytokines in intestinal inflammation: pathophysiological and clinical considerations
    • Sartor RB. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 1994; 106: 533-9.
    • (1994) Gastroenterology , vol.106 , pp. 533-539
    • Sartor, R.B.1
  • 120
    • 4143135315 scopus 로고    scopus 로고
    • STAT signaling underlies difference between flagellin-induced and tumor necrosis factor-α-induced epithelial gene expression
    • Yu Y, Zeng H, Vijay-Kumar M, et al. STAT signaling underlies difference between flagellin-induced and tumor necrosis factor-α-induced epithelial gene expression. J Biol Chem 2004; 279: 35210-8.
    • (2004) J Biol Chem , vol.279 , pp. 35210-35218
    • Yu, Y.1    Zeng, H.2    Vijay-Kumar, M.3
  • 121
    • 0028796711 scopus 로고
    • Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6
    • Mitsuyama K, Toyonaga A, Sasaki E, et al. Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6. Gut 1995; 36: 45-9.
    • (1995) Gut , vol.36 , pp. 45-49
    • Mitsuyama, K.1    Toyonaga, A.2    Sasaki, E.3
  • 123
    • 33747774200 scopus 로고    scopus 로고
    • STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice
    • Mitsuyama K, Matsumoto S, Rose-John S, et al. STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Gut 2006; 55: 1263-69.
    • (2006) Gut , vol.55 , pp. 1263-1269
    • Mitsuyama, K.1    Matsumoto, S.2    Rose-John, S.3
  • 124
    • 0038269009 scopus 로고    scopus 로고
    • Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease
    • Lovato P, Brender C, Agnholt J, et al. Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease. J Biol Chem 2003; 278: 16777-81.
    • (2003) J Biol Chem , vol.278 , pp. 16777-16781
    • Lovato, P.1    Brender, C.2    Agnholt, J.3
  • 125
    • 33748994835 scopus 로고    scopus 로고
    • Novel signal transduction pathways Analysis of STAT-3 and Rac-1 signaling in inflammatory bowel disease
    • Atreya R, Atreya I, Neurath MF. Novel signal transduction pathways. Analysis of STAT-3 and Rac-1 signaling in inflammatory bowel disease. Ann NY Acad Sci 2006; 1072: 98-113.
    • (2006) Ann NY Acad Sci , vol.1072 , pp. 98-113
    • Atreya, R.1    Atreya, I.2    Neurath, M.F.3
  • 126
    • 35348951458 scopus 로고    scopus 로고
    • Therapeutic strategies for targeting the IL-6/STAT3 cytokine signaling pathway in inflammatory bowel disease
    • Mitsuyama K, Matsumoto S, Masuda J, et al. Therapeutic strategies for targeting the IL-6/STAT3 cytokine signaling pathway in inflammatory bowel disease. Anticancer Res 2007; 27: 3749-56.
    • (2007) Anticancer Res , vol.27 , pp. 3749-3756
    • Mitsuyama, K.1    Matsumoto, S.2    Masuda, J.3
  • 128
    • 20444453281 scopus 로고    scopus 로고
    • A role of STAT3 in the Rho GTPase-regulated cell migration and proliferation
    • Debidda M, Wang L, Zang H, Poli V, Zheng Y. A role of STAT3 in the Rho GTPase-regulated cell migration and proliferation. J Biol Chem 2005; 280: 17275-85.
    • (2005) J Biol Chem , vol.280 , pp. 17275-17285
    • Debidda, M.1    Wang, L.2    Zang, H.3    Poli, V.4    Zheng, Y.5
  • 129
    • 0030226423 scopus 로고    scopus 로고
    • Basic mechanisms in heart failure: the cytokine hypothesis
    • Seta Y, Shan K, Bozkurt B, Oral H, Mann DL. Basic mechanisms in heart failure: the cytokine hypothesis. J Card Fail 1996; 2: 243-9.
    • (1996) J Card Fail , vol.2 , pp. 243-249
    • Seta, Y.1    Shan, K.2    Bozkurt, B.3    Oral, H.4    Mann, D.L.5
  • 131
    • 1642463859 scopus 로고    scopus 로고
    • Inflammatory mediators in chronic heart failure: an overview
    • Anker SD, von Haehling S. Inflammatory mediators in chronic heart failure: an overview. Heart 2004; 90: 464-70.
    • (2004) Heart , vol.90 , pp. 464-470
    • Anker, S.D.1    von Haehling, S.2
  • 132
    • 0035213726 scopus 로고    scopus 로고
    • Systemic inflammation as a cardiovascular disease risk factor and as a potential target for drug therapy
    • Kaplan RC, Frishman WH. Systemic inflammation as a cardiovascular disease risk factor and as a potential target for drug therapy. Heart Dis 2001; 3: 326-32.
    • (2001) Heart Dis , vol.3 , pp. 326-332
    • Kaplan, R.C.1    Frishman, W.H.2
  • 133
    • 58549103906 scopus 로고    scopus 로고
    • Inflammationsensitive plasma proteins are associated with increased incidence of heart failure: A population-based cohort study
    • Engström G, Hedblad B, Tydén P, Lindgärde F. Inflammationsensitive plasma proteins are associated with increased incidence of heart failure: A population-based cohort study. Atherosclerosis 2009; 202: 617-22.
    • (2009) Atherosclerosis , vol.202 , pp. 617-622
    • Engström, G.1    Hedblad, B.2    Tydén, P.3    Lindgärde, F.4
  • 134
    • 0032053707 scopus 로고    scopus 로고
    • Oxygen radicals and signaling
    • Finkel T. Oxygen radicals and signaling. Curr Opin Cell Biol 1998; 10: 248-53.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 248-253
    • Finkel, T.1
  • 135
    • 0037371354 scopus 로고    scopus 로고
    • Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: Role of metalloproteinase and protein kinase C- delta
    • Frank GD, Mifune M, Inagami T, et al. Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: Role of metalloproteinase and protein kinase C- delta. Mol Cell Biol 2003; 23: 1581-89.
    • (2003) Mol Cell Biol , vol.23 , pp. 1581-1589
    • Frank, G.D.1    Mifune, M.2    Inagami, T.3
  • 136
    • 0034703035 scopus 로고    scopus 로고
    • Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes
    • Sano M, Fukuda K, Kodama H, et al. Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes. J Biol Chem 2000; 275: 29717-23.
    • (2000) J Biol Chem , vol.275 , pp. 29717-29723
    • Sano, M.1    Fukuda, K.2    Kodama, H.3
  • 137
    • 0037215693 scopus 로고    scopus 로고
    • The functional role of the JAK-STAT pathway in post-infarction remodeling
    • El-Adawi H, Deng L, Tramontano A, et al. The functional role of the JAK-STAT pathway in post-infarction remodeling. Cardiovasc Res 2003; 57: 129-38.
    • (2003) Cardiovasc Res , vol.57 , pp. 129-138
    • El-Adawi, H.1    Deng, L.2    Tramontano, A.3
  • 138
    • 14244249930 scopus 로고    scopus 로고
    • Increased expression of IL-6 and LIF in the hypertrophied left ventricle of TGR(mRen2)27 and SHR rats
    • Kurdi M, Randon J, Cerutti C, Bricca G. Increased expression of IL-6 and LIF in the hypertrophied left ventricle of TGR(mRen2)27 and SHR rats. Mol Cell Biochem 2005; 269: 95-101.
    • (2005) Mol Cell Biochem , vol.269 , pp. 95-101
    • Kurdi, M.1    Randon, J.2    Cerutti, C.3    Bricca, G.4
  • 139
    • 0035853414 scopus 로고    scopus 로고
    • Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo
    • Hamanaka I, Saito Y, Yasukawa H, et al. Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo. Circ Res 2001; 88: 727-32.
    • (2001) Circ Res , vol.88 , pp. 727-732
    • Hamanaka, I.1    Saito, Y.2    Yasukawa, H.3
  • 140
    • 0037126009 scopus 로고    scopus 로고
    • Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance
    • Zolk O, Ng LL, O'Brien RJ, Weyand M, Eschenhagen T. Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance. Circulation 2002; 106: 1442-6.
    • (2002) Circulation , vol.106 , pp. 1442-1446
    • Zolk, O.1    Ng, L.L.2    O'Brien, R.J.3    Weyand, M.4    Eschenhagen, T.5
  • 141
    • 0037448803 scopus 로고    scopus 로고
    • Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy
    • Podewski EK, Hilfiker-Kleiner D, Hilfiker A, et al. Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy. Circulation 2003; 107: 798-802.
    • (2003) Circulation , vol.107 , pp. 798-802
    • Podewski, E.K.1    Hilfiker-Kleiner, D.2    Hilfiker, A.3
  • 142
    • 34250315274 scopus 로고    scopus 로고
    • Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis
    • Correction: Basic Res Cardiol 2007; 102: 393-411
    • Fischer P, Hilfiker-Kleiner D. Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis. Basic Res Cardiol 2007; 102: 279-97. Correction: Basic Res Cardiol 2007; 102: 393-411.
    • (2007) Basic Res Cardiol , vol.102 , pp. 279-297
    • Fischer, P.1    Hilfiker-Kleiner, D.2
  • 143
    • 40349100263 scopus 로고    scopus 로고
    • Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects
    • Fischer P, Hilfiker-Kleiner D. Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects. Br J Pharmacol 2008; 153(Suppl 1): S414-27.
    • (2008) Br J Pharmacol , vol.153 , Issue.SUPPL 1
    • Fischer, P.1    Hilfiker-Kleiner, D.2
  • 144
    • 0035188432 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 is a biochemical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways
    • Yasukawa H, Hoshijima M, Gu Y, et al. Suppressor of cytokine signaling-3 is a biochemical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. J Clin Invest 2001; 108: 1459-67.
    • (2001) J Clin Invest , vol.108 , pp. 1459-1467
    • Yasukawa, H.1    Hoshijima, M.2    Gu, Y.3
  • 145
    • 47249142005 scopus 로고    scopus 로고
    • Leptin and mTOR: partners in metabolism and inflammation
    • Maya-Monteiro CM, Bozza PT. Leptin and mTOR: partners in metabolism and inflammation. Cell Cycle 2008; 7: 1713-7.
    • (2008) Cell Cycle , vol.7 , pp. 1713-1717
    • Maya-Monteiro, C.M.1    Bozza, P.T.2
  • 146
    • 0033968596 scopus 로고    scopus 로고
    • Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
    • Yokogami K, Wakisaka S, Avruch J, Reeves SA. Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol 2000; 10: 47-50.
    • (2000) Curr Biol , vol.10 , pp. 47-50
    • Yokogami, K.1    Wakisaka, S.2    Avruch, J.3    Reeves, S.A.4
  • 147
    • 0036375068 scopus 로고    scopus 로고
    • The roles of inflammation, STAT transcription factors, and nerve growth factor in viral reactivation and herpes keratitis
    • Kriesel JD. The roles of inflammation, STAT transcription factors, and nerve growth factor in viral reactivation and herpes keratitis. DNA Cell Biol 2002; 21: 475-81.
    • (2002) DNA Cell Biol , vol.21 , pp. 475-481
    • Kriesel, J.D.1
  • 148
    • 0036400483 scopus 로고    scopus 로고
    • IL-12 plays a significant role in the apoptosis of human T cells in the absence of antigenic stimulation
    • Fan H, Walters CS, Dunston GM, Tackey R. IL-12 plays a significant role in the apoptosis of human T cells in the absence of antigenic stimulation. Cytokine 2002; 19: 126-37.
    • (2002) Cytokine , vol.19 , pp. 126-137
    • Fan, H.1    Walters, C.S.2    Dunston, G.M.3    Tackey, R.4
  • 149
    • 33751211184 scopus 로고    scopus 로고
    • Early pathogenic events associated with Sjögren's syndrome (SjS)-like disease in nod mouse using microarray analysis
    • Killedar SJ, Eckenrode SE, McIndoe RA, et al. Early pathogenic events associated with Sjögren's syndrome (SjS)-like disease in nod mouse using microarray analysis. Lab Invest 2006; 86: 1243-60.
    • (2006) Lab Invest , vol.86 , pp. 1243-1260
    • Killedar, S.J.1    Eckenrode, S.E.2    McIndoe, R.A.3
  • 150
    • 23844507272 scopus 로고    scopus 로고
    • Activated STAT 3 in choroidal neovascular membranes of patients with age-related macular degeneration
    • Fasler-Kan E, Wunderlich K, Hildebrand P, Flammer J, Meyer P. Activated STAT 3 in choroidal neovascular membranes of patients with age-related macular degeneration. Ophthalmologica 2005; 219: 214-21.
    • (2005) Ophthalmologica , vol.219 , pp. 214-221
    • Fasler-Kan, E.1    Wunderlich, K.2    Hildebrand, P.3    Flammer, J.4    Meyer, P.5
  • 151
    • 25144496007 scopus 로고    scopus 로고
    • A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia
    • Dudley AC, Thomas D, Best J, Jenkins A. A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia. Biochem J 2005; 390: 427-36.
    • (2005) Biochem J , vol.390 , pp. 427-436
    • Dudley, A.C.1    Thomas, D.2    Best, J.3    Jenkins, A.4
  • 152
    • 39649101076 scopus 로고    scopus 로고
    • Crystallins of the β/γ-superfamily mimic the effects of lens injury and promote axon regeneration
    • Fischer D, Hauk TG, Müller A, Thanos S. Crystallins of the (/(-superfamily mimic the effects of lens injury and promote axon regeneration. Mol Cell Neurosci 2008; 37: 471-9.
    • (2008) Mol Cell Neurosci , vol.37 , pp. 471-479
    • Fischer, D.1    Hauk, T.G.2    Müller, A.3    Thanos, S.4
  • 153
    • 35448992434 scopus 로고    scopus 로고
    • JAK/STAT pathway mediates retinal ganglion cell survival after acute ocular hypertension but not under normal conditions
    • Huang Y, Cen L-P, Choy KW, et al. JAK/STAT pathway mediates retinal ganglion cell survival after acute ocular hypertension but not under normal conditions. Exp Eye Res 2007; 85: 684-95.
    • (2007) Exp Eye Res , vol.85 , pp. 684-695
    • Huang, Y.1    Cen, L.-P.2    Choy, K.W.3
  • 155
    • 0036095951 scopus 로고    scopus 로고
    • Two NOD Idd-associated intervals contribute to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background
    • Cha S, Nagashima H, Brown VB, Peck AB, Humphreys-Beher MG. Two NOD Idd-associated intervals contribute to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background. Arthritis Rheum 2002; 46: 1390-8.
    • (2002) Arthritis Rheum , vol.46 , pp. 1390-1398
    • Cha, S.1    Nagashima, H.2    Brown, V.B.3    Peck, A.B.4    Humphreys-Beher, M.G.5
  • 156
    • 34547361166 scopus 로고    scopus 로고
    • Age-related maculopathy in light of ischaemia
    • Feigl B. Age-related maculopathy in light of ischaemia. Clin Exp Optom 2007; 90: 263-71.
    • (2007) Clin Exp Optom , vol.90 , pp. 263-271
    • Feigl, B.1
  • 157
    • 33745468352 scopus 로고    scopus 로고
    • The management of glaucoma and intraocular hypertension: current approaches and recent advances
    • Noecker RJ. The management of glaucoma and intraocular hypertension: current approaches and recent advances. Ther Clin Risk Manag 2006; 2: 193-206.
    • (2006) Ther Clin Risk Manag , vol.2 , pp. 193-206
    • Noecker, R.J.1
  • 158
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signaling through the gp130/Jak/STAT pathway
    • Heinrich PC, Behrmann I, Müller-Newen G, Schaper, Graeve L. Interleukin-6-type cytokine signaling through the gp130/Jak/STAT pathway. Biochem J 1998; 334: 297-314.
    • (1998) Biochem J , vol.334 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Müller-Newen, G.3    Schaper, G.L.4
  • 159
    • 0028281794 scopus 로고
    • Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL6beta receptor components
    • Stahl N, Boulton TG, Farruggella T, et al. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL6beta receptor components. Science 1994; 263: 92-5.
    • (1994) Science , vol.263 , pp. 92-95
    • Stahl, N.1    Boulton, T.G.2    Farruggella, T.3
  • 160
    • 0028946158 scopus 로고
    • Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway
    • Heim MH, Kerr IM, Stark GR, Darnell JR Jr. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 1995; 267: 1347-9.
    • (1995) Science , vol.267 , pp. 1347-1349
    • Heim, M.H.1    Kerr, I.M.2    Stark, G.R.3    Darnell J.R., Jr.4
  • 161
    • 0029991793 scopus 로고    scopus 로고
    • Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130 II. Src homology SH2 domains define the specificity of Stat factor activation
    • Hemmann U, Gerhartz C, Hessel B, et al. Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of Stat factor activation. J Biol Chem 1996; 271: 12999-3007.
    • (1996) J Biol Chem , vol.271 , pp. 12999-13007
    • Hemmann, U.1    Gerhartz, C.2    Hessel, B.3
  • 162
    • 0035160256 scopus 로고    scopus 로고
    • Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
    • Jostock T, Müllberg J, Özbek S, et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem 2001; 268: 160-7.
    • (2001) Eur J Biochem , vol.268 , pp. 160-167
    • Jostock, T.1    Müllberg, J.2    Özbek, S.3
  • 163
    • 38449084902 scopus 로고    scopus 로고
    • Humanized antihuman IL-6 antibody, tocilizumab
    • Nishimoto N, Kishimoto K. Humanized antihuman IL-6 antibody, tocilizumab. Handb Exp Pharmacol 2008; 181: 151-60.
    • (2008) Handb Exp Pharmacol , vol.181 , pp. 151-160
    • Nishimoto, N.1    Kishimoto, K.2
  • 164
    • 23644442893 scopus 로고    scopus 로고
    • Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family
    • Mihara M, Kasutani K, Okazaki M, et al. Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family. Int Immunopharmacol 2005; 5: 1731-40.
    • (2005) Int Immunopharmacol , vol.5 , pp. 1731-1740
    • Mihara, M.1    Kasutani, K.2    Okazaki, M.3
  • 165
    • 33847701356 scopus 로고    scopus 로고
    • Characterization of the interleukin (IL)-6 inhibitor IL6-RFP Fused receptor domains act as high affinity cytokine-binding proteins
    • Metz S, Wiesinger M, Vogt M, et al. Characterization of the interleukin (IL)-6 inhibitor IL6-RFP. Fused receptor domains act as high affinity cytokine-binding proteins. J Biol Chem 2007; 282: 1238-48.
    • (2007) J Biol Chem , vol.282 , pp. 1238-1248
    • Metz, S.1    Wiesinger, M.2    Vogt, M.3
  • 166
    • 33645083973 scopus 로고    scopus 로고
    • Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo
    • Chao KC, Chao KF, Chuang CC, Liu SH. Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo. Br J Surg 2006; 93: 332-8.
    • (2006) Br J Surg , vol.93 , pp. 332-338
    • Chao, K.C.1    Chao, K.F.2    Chuang, C.C.3    Liu, S.H.4
  • 167
    • 0037742556 scopus 로고    scopus 로고
    • Interleukin-6 family of cytokines mediates isoproterenol-induced delayed STAT3 activation in mouse heart
    • Yin F, Li P, Zheng M, et al. Interleukin-6 family of cytokines mediates isoproterenol-induced delayed STAT3 activation in mouse heart. J Biol Chem 2003; 278: 21070-5.
    • (2003) J Biol Chem , vol.278 , pp. 21070-21075
    • Yin, F.1    Li, P.2    Zheng, M.3
  • 168
    • 44449165636 scopus 로고    scopus 로고
    • Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors
    • Metz S, Naeth G, Heinrich PC, Müller-Newen G. Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors. J Biol Chem 2008; 283: 5985-95.
    • (2008) J Biol Chem , vol.283 , pp. 5985-5995
    • Metz, S.1    Naeth, G.2    Heinrich, P.C.3    Müller-Newen, G.4
  • 169
    • 0037236826 scopus 로고    scopus 로고
    • IL-28 IL-29 and their class II cytokine receptor IL-28R
    • Sheppard P, Kindsvogel W, Xu W, et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol 2003; 4: 63-8.
    • (2003) Nat Immunol , vol.4 , pp. 63-68
    • Sheppard, P.1    Kindsvogel, W.2    Xu, W.3
  • 170
    • 33947730807 scopus 로고    scopus 로고
    • The newest interleukins: Recent additions to the ever-growing cytokine family
    • Chen Q, Carroll HP, Gadina M. The newest interleukins: Recent additions to the ever-growing cytokine family. Vitam Horm 2006; 74: 207-28.
    • (2006) Vitam Horm , vol.74 , pp. 207-228
    • Chen, Q.1    Carroll, H.P.2    Gadina, M.3
  • 171
    • 42949120754 scopus 로고    scopus 로고
    • Identification of novel direct Stat3 target proteins for control of growth and differentiation
    • Snyder M, Huang XY, Zhang JJ. Identification of novel direct Stat3 target proteins for control of growth and differentiation. J Biol Chem 2008; 283: 3791-8.
    • (2008) J Biol Chem , vol.283 , pp. 3791-3798
    • Snyder, M.1    Huang, X.Y.2    Zhang, J.J.3
  • 172
    • 61449091573 scopus 로고    scopus 로고
    • Identification of the most active interleukin-32 isoform
    • Choi JD, Bae SY, Hong JW, et al. Identification of the most active interleukin-32 isoform. Immunology 2009; 126: 535-42.
    • (2009) Immunology , vol.126 , pp. 535-542
    • Choi, J.D.1    Bae, S.Y.2    Hong, J.W.3
  • 173
    • 0037530607 scopus 로고    scopus 로고
    • TNF-α induces tyrosine phosphorylation and recruitment of the Src homology proteintyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex
    • Bode JG, Schweigart J, Kehrmann J, et al. TNF-α induces tyrosine phosphorylation and recruitment of the Src homology proteintyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex. J Immunol 2003; 171: 257-66.
    • (2003) J Immunol , vol.171 , pp. 257-266
    • Bode, J.G.1    Schweigart, J.2    Kehrmann, J.3
  • 174
    • 0034658111 scopus 로고    scopus 로고
    • Pharmaceutical intervention in the JAK/STAT pathway
    • Seidel HM, Lamb P, Rosen J. Pharmaceutical intervention in the JAK/STAT pathway. Oncogene 2000; 19: 2645-56.
    • (2000) Oncogene , vol.19 , pp. 2645-2656
    • Seidel, H.M.1    Lamb, P.2    Rosen, J.3
  • 176
    • 34347237615 scopus 로고    scopus 로고
    • Novel immunosuppression: Small molecules and biologics
    • Yabu JM, Vincenti F. Novel immunosuppression: Small molecules and biologics. Semin Nephrol 2007; 27: 479-86.
    • (2007) Semin Nephrol , vol.27 , pp. 479-486
    • Yabu, J.M.1    Vincenti, F.2
  • 177
    • 41349094799 scopus 로고    scopus 로고
    • The specificity of JAK3 kinase inhibitors
    • Changelian PS, Moshinsky D, Kuhn CF, et al. The specificity of JAK3 kinase inhibitors. Blood 2008; 111: 2155-7.
    • (2008) Blood , vol.111 , pp. 2155-2157
    • Changelian, P.S.1    Moshinsky, D.2    Kuhn, C.F.3
  • 178
    • 77951942731 scopus 로고    scopus 로고
    • (February 4)
    • http://www.secinfo.com/d11MXs.u2gp4.b.htm (February 4, 2009).
    • (2009)
  • 179
    • 0742318929 scopus 로고    scopus 로고
    • The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models
    • Kudlacz E, Perry B, Sawyer P, et al. The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models. Am J Transplant 2004; 4: 51-7.
    • (2004) Am J Transplant , vol.4 , pp. 51-57
    • Kudlacz, E.1    Perry, B.2    Sawyer, P.3
  • 180
    • 39749164515 scopus 로고    scopus 로고
    • Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
    • Milici AJ, Kudlacz EM, Audoly L, Zwillich S, Changelian P. Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis. Arthritis Res Ther 2008; 10: R14.
    • (2008) Arthritis Res Ther , vol.10
    • Milici, A.J.1    Kudlacz, E.M.2    Audoly, L.3    Zwillich, S.4    Changelian, P.5
  • 181
    • 39149103052 scopus 로고    scopus 로고
    • The JAK-3 inhibitor CP-690550 is a potent antiinflammatory agent in a murine model of pulmonary eosinophilia
    • Kudlacz E, Conklyn M, Andresen C, Whitney-Pickett C, Changelian P. The JAK-3 inhibitor, CP-690550 is a potent antiinflammatory agent in a murine model of pulmonary eosinophilia. Eur J Pharmacol 2008; 582: 154-61.
    • (2008) Eur J Pharmacol , vol.582 , pp. 154-161
    • Kudlacz, E.1    Conklyn, M.2    Andresen, C.3    Whitney-Pickett, C.4    Changelian, P.5
  • 182
    • 0028925778 scopus 로고
    • Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain
    • Cao X, Shores EW, Hu-Li J, et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 1995; 2: 223-38.
    • (1995) Immunity , vol.2 , pp. 223-238
    • Cao, X.1    Shores, E.W.2    Hu-Li, J.3
  • 183
    • 77951970470 scopus 로고    scopus 로고
    • http://www.asx.com.au/asxpdf/20080731/pdf/31bg1crwqz4w8t.pdf.
  • 184
    • 77951967612 scopus 로고    scopus 로고
    • Preclinical characterization of INCB02850 JAK1/JAK2 selective clinical candidate
    • [Abstract]
    • Fridman J, Scherle P, Collins R, et al. Preclinical characterization of INCB02850, JAK1/JAK2 selective clinical candidate. Arthritis Rheum 2008; 58(Suppl): S296-S297 [Abstract].
    • (2008) Arthritis Rheum , vol.58 , Issue.SUPPL
    • Fridman, J.1    Scherle, P.2    Collins, R.3
  • 185
    • 41249099841 scopus 로고    scopus 로고
    • Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera
    • Wernig G, Kharas MG, Okabe R, et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell 2008; 13: 311-20.
    • (2008) Cancer Cell , vol.13 , pp. 311-320
    • Wernig, G.1    Kharas, M.G.2    Okabe, R.3
  • 186
    • 41249098776 scopus 로고    scopus 로고
    • Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors
    • Geron I, Abrahamsson AE, Barroga CF, et al. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell 2008; 13: 321-30.
    • (2008) Cancer Cell , vol.13 , pp. 321-330
    • Geron, I.1    Abrahamsson, A.E.2    Barroga, C.F.3
  • 188
    • 0030687560 scopus 로고    scopus 로고
    • Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor
    • Dinan L, Whiting P, Girault J-P, et al. Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor. Biochem J 1997; 327: 643-50.
    • (1997) Biochem J , vol.327 , pp. 643-650
    • Dinan, L.1    Whiting, P.2    Girault, J.-P.3
  • 189
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 2003; 63: 1270-9.
    • (2003) Cancer Res , vol.63 , pp. 1270-1279
    • Blaskovich, M.A.1    Sun, J.2    Cantor, A.3    Turkson, J.4    Jove, R.5    Sebti, S.M.6
  • 190
    • 18844370367 scopus 로고    scopus 로고
    • Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
    • Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D, Sebti SM. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene 2005; 24: 3236-45.
    • (2005) Oncogene , vol.24 , pp. 3236-3245
    • Sun, J.1    Blaskovich, M.A.2    Jove, R.3    Livingston, S.K.4    Coppola, D.5    Sebti, S.M.6
  • 191
    • 42149111675 scopus 로고    scopus 로고
    • Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using Type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma
    • Fujita M, Zhu X, Sasaki K, et al. Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using Type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma. J Immunol 2008; 180: 2089-98.
    • (2008) J Immunol , vol.180 , pp. 2089-2098
    • Fujita, M.1    Zhu, X.2    Sasaki, K.3
  • 192
    • 35448979864 scopus 로고    scopus 로고
    • A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients
    • Hussain SF, Kong L-Y, Jordan J, et al. A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res 2007; 67: 9630-6.
    • (2007) Cancer Res , vol.67 , pp. 9630-9636
    • Hussain, S.F.1    Kong, L.-Y.2    Jordan, J.3
  • 193
    • 34247154498 scopus 로고    scopus 로고
    • A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo
    • Iwamaru A, Szymanski S, Iwado E, et al. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene 2007; 26: 2435-44.
    • (2007) Oncogene , vol.26 , pp. 2435-2444
    • Iwamaru, A.1    Szymanski, S.2    Iwado, E.3
  • 194
    • 12344328541 scopus 로고    scopus 로고
    • Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity
    • Turkson J, Zhang S, Palmer J, et al. Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. Mol Cancer Ther 2004; 3: 1533-42.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1533-1542
    • Turkson, J.1    Zhang, S.2    Palmer, J.3
  • 195
    • 25444444988 scopus 로고    scopus 로고
    • Activation of dendritic cells via inhibition of Jak2/STAT3 signaling
    • Nefedova Y, Cheng P, Gilkes D, et al. Activation of dendritic cells via inhibition of Jak2/STAT3 signaling. J Immunol 2005; 175: 4338-46.
    • (2005) J Immunol , vol.175 , pp. 4338-4346
    • Nefedova, Y.1    Cheng, P.2    Gilkes, D.3
  • 196
    • 4644249098 scopus 로고    scopus 로고
    • IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation
    • Park SJ, Nakagawa T, Kitamura H, et al. IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immunol 2004; 173: 3844-54.
    • (2004) J Immunol , vol.173 , pp. 3844-3854
    • Park, S.J.1    Nakagawa, T.2    Kitamura, H.3
  • 197
    • 0025160266 scopus 로고
    • Tyrphostins-potential antiproliferative agents and novel molecular tools
    • Levitski A. Tyrphostins-potential antiproliferative agents and novel molecular tools. Biochem Pharmacol 1990; 40: 913-8.
    • (1990) Biochem Pharmacol , vol.40 , pp. 913-918
    • Levitski, A.1
  • 198
    • 2042503119 scopus 로고    scopus 로고
    • Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated T cells
    • Kirken RA, Erwin RA, Taub D, et al. Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated T cells. J Leukoc Biol 1999; 65: 891-99.
    • (1999) J Leukoc Biol , vol.65 , pp. 891-899
    • Kirken, R.A.1    Erwin, R.A.2    Taub, D.3
  • 199
    • 13344295097 scopus 로고    scopus 로고
    • Inhibition of acute lymphoblastic leukaemia by a Jak-2 inihibitor
    • Meydan N, Grunberger T, Dadi H, et al. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inihibitor. Nature 1996; 379: 645-8.
    • (1996) Nature , vol.379 , pp. 645-648
    • Meydan, N.1    Grunberger, T.2    Dadi, H.3
  • 200
    • 85047698100 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells
    • Burke WM, Jin X, Lin H-J, et al. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene 2001; 20: 7925-34.
    • (2001) Oncogene , vol.20 , pp. 7925-7934
    • Burke, W.M.1    Jin, X.2    Lin, H.-J.3
  • 201
    • 0033861096 scopus 로고    scopus 로고
    • JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogenactivated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells
    • De Vos M, Jourdan M, Tarte K, Jasmin C, Klein B. JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogenactivated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells. Br J Haematol 2000; 109: 823-28.
    • (2000) Br J Haematol , vol.109 , pp. 823-828
    • De Vos, M.1    Jourdan, M.2    Tarte, K.3    Jasmin, C.4    Klein, B.5
  • 202
    • 0030945058 scopus 로고    scopus 로고
    • Granulocyte colonystimulating factor receptor at various differentiation stages of normal and leukemic hematopoietic cells
    • Shinjo K, Takeshita A, Ohnishi K, Ohno R. Granulocyte colonystimulating factor receptor at various differentiation stages of normal and leukemic hematopoietic cells. Leuk Lymphoma 1997; 25: 37-46.
    • (1997) Leuk Lymphoma , vol.25 , pp. 37-46
    • Shinjo, K.1    Takeshita, A.2    Ohnishi, K.3    Ohno, R.4
  • 203
    • 0032504007 scopus 로고    scopus 로고
    • A small, nonpeptidyl mimic of granulocyte-colony-stimulating factor
    • Tian S-S, Lamb P, King AG, et al. A small, nonpeptidyl mimic of granulocyte-colony-stimulating factor. Science 1998; 281: 257-9.
    • (1998) Science , vol.281 , pp. 257-259
    • Tian, S.-S.1    Lamb, P.2    King, A.G.3
  • 204
    • 0037646490 scopus 로고    scopus 로고
    • Selective binding and oligomerization of the murine granulocyte colony-stimulating factor receptor by low molecular weight non peptidyl ligand
    • Doyle ML, Tian SS, Miller SG, et al. Selective binding and oligomerization of the murine granulocyte colony-stimulating factor receptor by low molecular weight non peptidyl ligand. J Biol Chem 2003; 278: 9426-34.
    • (2003) J Biol Chem , vol.278 , pp. 9426-9434
    • Doyle, M.L.1    Tian, S.S.2    Miller, S.G.3
  • 205
    • 19744365702 scopus 로고    scopus 로고
    • A small moleculekinase interaction map for clinical kinase inhibitors
    • Fabian MA, Biggs WH III, Treiber DK, et al. A small moleculekinase interaction map for clinical kinase inhibitors. Nat Biotechnol 2005; 23: 329-36.
    • (2005) Nat Biotechnol , vol.23 , pp. 329-336
    • Fabian, M.A.1    Biggs W.H. III2    Treiber, D.K.3
  • 206
    • 36549040859 scopus 로고    scopus 로고
    • The selectivity of protein kinase inhibitors: a further update
    • Bain J, Plater L, Elliott M, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 2007; 408: 297-315.
    • (2007) Biochem J , vol.408 , pp. 297-315
    • Bain, J.1    Plater, L.2    Elliott, M.3
  • 207
    • 63449124343 scopus 로고    scopus 로고
    • The selectivity of inhibitors of protein kinase CK2, an update
    • Pagano MA, Bain J, Kazimierczuk Z, et al. The selectivity of inhibitors of protein kinase CK2, an update. Biochem J 2008; 415: 353-65.
    • (2008) Biochem J , vol.415 , pp. 353-365
    • Pagano, M.A.1    Bain, J.2    Kazimierczuk, Z.3
  • 208
    • 0034284027 scopus 로고    scopus 로고
    • Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies
    • Reuter CWM, Morgan MA, Bergmann L. Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies. Blood 2000; 96: 1655-69.
    • (2000) Blood , vol.96 , pp. 1655-1669
    • Reuter, C.W.M.1    Morgan, M.A.2    Bergmann, L.3
  • 209
    • 24744467401 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1α and antiangiogenic activity of farnesyltransferase inhibitor SCH663336 in human aerodigestive tract cancer
    • Han J-Y, Oh SH, Morgillo F, et al. Hypoxia-inducible factor 1( and antiangiogenic activity of farnesyltransferase inhibitor SCH663336 in human aerodigestive tract cancer. J Natl Cancer Inst 2005; 97: 1272-86.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1272-1286
    • Han, J.-Y.1    Oh, S.H.2    Morgillo, F.3
  • 210
    • 36549089617 scopus 로고    scopus 로고
    • SCH663336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 in lung cancer and interacts with a small molecule inhibitor of epidermal growth factor receptor/ human epidermal growth factor receptor 2
    • Dowlati A, Kluge A, Nethery D, Halmos B, Kern JA. SCH663336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 in lung cancer and interacts with a small molecule inhibitor of epidermal growth factor receptor/ human epidermal growth factor receptor 2. Anticancer Drugs 2008; 19: 9-16.
    • (2008) Anticancer Drugs , vol.19 , pp. 9-16
    • Dowlati, A.1    Kluge, A.2    Nethery, D.3    Halmos, B.4    Kern, J.A.5
  • 211
    • 33750056679 scopus 로고    scopus 로고
    • Growth hormone VEGF and FGF: Involvement in rheumatoid arthritis
    • Malemud CJ. Growth hormone, VEGF and FGF: Involvement in rheumatoid arthritis. Clin Chim Acta 2007; 375: 10-9.
    • (2007) Clin Chim Acta , vol.375 , pp. 10-19
    • Malemud, C.J.1
  • 212
    • 35748979444 scopus 로고    scopus 로고
    • Interleukin-6 in the pathogenesis of rheumatoid arthritis
    • Park JY, Pillinger MH. Interleukin-6 in the pathogenesis of rheumatoid arthritis. Bull NY Hosp Joint Dis 2007; 65(Suppl 1): S4-10.
    • (2007) Bull NY Hosp Joint Dis , vol.65 , Issue.SUPPL 1
    • Park, J.Y.1    Pillinger, M.H.2
  • 213
    • 51349134454 scopus 로고    scopus 로고
    • Actemra poised to launch IL-6 inhibitors
    • Erratum: Nat Biotech 2008; 26: 1383
    • Melton L, Coombs A. Actemra poised to launch IL-6 inhibitors. Nat Biotech 2008; 26: 957-9. Erratum: Nat Biotech 2008; 26: 1383.
    • (2008) Nat Biotech , vol.26 , pp. 957-959
    • Melton, L.1    Coombs, A.2
  • 214
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to tumour necrosis factor biologicals: results for a 24-week multicentre randomized placebo controlled trial
    • Emery P, Keystone E, Tony H-P, et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to tumour necrosis factor biologicals: results for a 24-week multicentre randomized placebo controlled trial. Ann Rheum Dis 2008; 57: 1516-23.
    • (2008) Ann Rheum Dis , vol.57 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.-P.3
  • 215
    • 77951948581 scopus 로고    scopus 로고
    • (February 4)
    • http://clinicaltrials.gov/ct2/show/NCT00603512 (February 4, 2009).
    • (2009)
  • 216
    • 77951942979 scopus 로고    scopus 로고
    • (February 4)
    • http://clinicaltrial.gov/ct2/show/NCT00615199 (February 4, 2009).
    • (2009)
  • 217
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study
    • Genovese MC, McKay JD, Nasonov EL, et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs. The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum 2008; 58: 2968-80.
    • (2008) Arthritis Rheum , vol.58 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3
  • 218
    • 33749363027 scopus 로고    scopus 로고
    • CHARISMA Study Group. Double-blind randomized controlled clinical trial of the interleukin-6 receptor, antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
    • Maini RN, Taylor PC, Szechinski J, et al. CHARISMA Study Group. Double-blind randomized controlled clinical trial of the interleukin-6 receptor, antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 2006; 54: 2817-29.
    • (2006) Arthritis Rheum , vol.54 , pp. 2817-2829
    • Maini, R.N.1    Taylor, P.C.2    Szechinski, J.3
  • 219
    • 40749114497 scopus 로고    scopus 로고
    • OPTION Investigators. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study). A double-blind, placebo-controlled randomised trial
    • Smolen JS, Beaulieu A, Rubbert-Roth A, et al. OPTION Investigators. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study). A double-blind, placebo-controlled randomised trial. Lancet 2008; 371: 987-97.
    • (2008) Lancet , vol.371 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3
  • 220
    • 62549116770 scopus 로고    scopus 로고
    • Safety of tocilizumab in patients with rheumatoid arthritis: Pooled analysis of five phase 3 clinical trials
    • [Abstract]
    • Smolen JS, Beaulieu AD, Dikranian A, et al. Safety of tocilizumab in patients with rheumatoid arthritis: Pooled analysis of five phase 3 clinical trials. Arthritis Rheum 2008; 58 (Suppl): S784 [Abstract].
    • (2008) Arthritis Rheum , vol.58 , Issue.SUPPL
    • Smolen, J.S.1    Beaulieu, A.D.2    Dikranian, A.3
  • 221
    • 33845970885 scopus 로고    scopus 로고
    • Arthritis clinical trials revealed
    • Hampton T. Arthritis clinical trials revealed. JAMA 2007; 297: 28-9.
    • (2007) JAMA , vol.297 , pp. 28-29
    • Hampton, T.1
  • 222
    • 77951940766 scopus 로고    scopus 로고
    • (February 4)
    • http://clinicaltrial.gov/ct2/show/NCT00678210 (February 4, 2009).
    • (2009)
  • 223
    • 62849101304 scopus 로고    scopus 로고
    • Coadministration of an oral JAK inhibitor CP690 550 and methotrexate is well tolerated in patients with rheumatoid arthritis
    • [Abstract]
    • Wilkinson B, Chow V, LaBadie R, Zwillich Sh, Cohen S. Coadministration of an oral JAK inhibitor CP690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis. Arthritis Rheum 2008; 58(Suppl): S297 [Abstract].
    • (2008) Arthritis Rheum , vol.58 , Issue.SUPPL
    • Wilkinson, B.1    Chow, V.2    LaBadie, R.3    Zwillich, Sh.4    Cohen, S.5
  • 224
    • 77951945155 scopus 로고    scopus 로고
    • (February 4)
    • http://www.incyte.com (February 4, 2009).
    • (2009)
  • 225
    • 62849108810 scopus 로고    scopus 로고
    • A randomized placebocontrolled study of INCB018424, a selective janus kinase 1&2 (JAK1&2) inhibitor in rheumatoid arthritis (RA)
    • [Abstract]
    • Williams W, Scherle P, Shi P, et al. A randomized placebocontrolled study of INCB018424, a selective janus kinase 1&2 (JAK1&2) inhibitor in rheumatoid arthritis (RA). Arthritis Rheum 2008; 58 (Suppl): S431 [Abstract].
    • (2008) Arthritis Rheum , vol.58 , Issue.SUPPL
    • Williams, W.1    Scherle, P.2    Shi, P.3
  • 226
    • 17044444647 scopus 로고    scopus 로고
    • STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction
    • Takeshita T, Arita T, Higuchi M, et al. STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. Immunity 1997; 6: 449-57.
    • (1997) Immunity , vol.6 , pp. 449-457
    • Takeshita, T.1    Arita, T.2    Higuchi, M.3
  • 228
    • 39149109887 scopus 로고    scopus 로고
    • The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
    • Liu X, Wang L, Zhao K, et al. The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature 2008; 451: 846-50.
    • (2008) Nature , vol.451 , pp. 846-850
    • Liu, X.1    Wang, L.2    Zhao, K.3
  • 229
    • 2542501657 scopus 로고    scopus 로고
    • Ubiquitin ligases and the immune response
    • Liu Y-C. Ubiquitin ligases and the immune response. Annu Rev Immunol 2004; 22: 81-127.
    • (2004) Annu Rev Immunol , vol.22 , pp. 81-127
    • Liu, Y.-C.1
  • 230
    • 0032194952 scopus 로고    scopus 로고
    • p48/STAT-1α-containing complexes play a predominant role in induction of IFN-γ-inducible protein 10 kDa (IP-10) by IFN-α alone or in synergy with TNF-α
    • Majumder S, Zhou LZ-H, Chaturvedi P, Babcock G, Aras S, Ransohoff RM. p48/STAT-1α-containing complexes play a predominant role in induction of IFN-γ-inducible protein, 10 kDa (IP-10) by IFN- gamma; alone or in synergy with TNF-α. J Immunol 1998; 161: 4736-44.
    • (1998) J Immunol , vol.161 , pp. 4736-4744
    • Majumder, S.1    Zhou, L.-H.2    Chaturvedi, P.3    Babcock, G.4    Aras, S.5    Ransohoff, R.M.6
  • 231
    • 51049109691 scopus 로고    scopus 로고
    • The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells
    • Zemskova M, Sahakian E, Bashkirova S, Lilly M. The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells. J Biol Chem 2008; 283: 20635-44.
    • (2008) J Biol Chem , vol.283 , pp. 20635-20644
    • Zemskova, M.1    Sahakian, E.2    Bashkirova, S.3    Lilly, M.4
  • 232
    • 0036840415 scopus 로고    scopus 로고
    • The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4 5-bisphosphate in plasma membranes
    • Lim J, Yusoff P, Wong ESM, et al. The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4, 5-bisphosphate in plasma membranes. Mol Cell Biol 2002; 22: 7953-66.
    • (2002) Mol Cell Biol , vol.22 , pp. 7953-7966
    • Lim, J.1    Yusoff, P.2    Wong, E.S.M.3
  • 233
    • 33845987501 scopus 로고    scopus 로고
    • The VASP-Spred-Sprouty domain puzzle
    • Bundschu K, Walter U, Schuh K. The VASP-Spred-Sprouty domain puzzle. J Biol Chem 2006; 281: 36477-81.
    • (2006) J Biol Chem , vol.281 , pp. 36477-36481
    • Bundschu, K.1    Walter, U.2    Schuh, K.3
  • 234
    • 34548751238 scopus 로고    scopus 로고
    • Getting a first clue about SPRED functions
    • Bundschu K, Walter U, Schuh K. Getting a first clue about SPRED functions. Bioessays 2007; 29: 897-907.
    • (2007) Bioessays , vol.29 , pp. 897-907
    • Bundschu, K.1    Walter, U.2    Schuh, K.3
  • 235
    • 61649119398 scopus 로고    scopus 로고
    • Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocyes
    • Yammani RR, Long D, Loeser RF. Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocyes. Arthritis Rheum 2009; 60: 792-800.
    • (2009) Arthritis Rheum , vol.60 , pp. 792-800
    • Yammani, R.R.1    Long, D.2    Loeser, R.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.