JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells

British Journal of Haematology

Volumn 109, Issue 4, 2000, Pages 823-828

  De Vos, John ^a   Jourdan, Michel ^a   Tarte, Karin ^a   Jasmin, Claude ^b   Klein, Bernard ^a,c  

^a INSERM   (France)

^b HÔPITAL PAUL BROUSSE   (France)

^c HÔPITAL SAINT ELOI   (France)

Author keywords

Apoptosis; Inhibitors; Interleukin 6; Multiple myeloma; Protein tyrosine kinase

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN TYROSINE KINASE INHIBITOR; STAT3 PROTEIN; TYRPHOSTIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITOR INTERACTION; ENZYME REGULATION; HUMAN; HUMAN CELL; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANTIGENS, CD; APOPTOSIS; CELL DIVISION; CYTOKINE RECEPTOR GP130; DEPRESSION, CHEMICAL; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-6; JANUS KINASE 2; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MULTIPLE MYELOMA; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; STAT2 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; TYRPHOSTINS;

EID: 0033861096     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02127.x     Document Type: Article

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