메뉴 건너뛰기




Volumn 2009, Issue , 2009, Pages

The discovery of novel experimental therapies for inflammatory arthritis

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2 ACETYL 4 (1,2,3,4 TETRAHYDROXYBUTYL)IMIDAZOLE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 (4 BROMO 2 CHLOROANILINO) 4 FLUORO 1 METHYL 1H BENZIMIDAZOLE 6 CARBOHYDROXAMIC ACID 2 HYDROXYETHYL ESTER; ANTIRHEUMATIC AGENT; ARRY 162; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; FOSTAMATINIB; FR 180204; GLPG 0259; INDOLE 5 CARBOXAMIDE; INTERLEUKIN 7 RECEPTOR ALPHA; LX 2931; METHOTREXATE; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; PLACEBO; POLYUBIQUITIN; PROTEASOME; PROTEIN KINASE SYK; R 406; R 788; SD 282; SPHINGOSINE 1 PHOSPHATE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG; AUTACOID; DRUG DERIVATIVE; INTERLEUKIN 7 RECEPTOR; LYSOPHOSPHOLIPID; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

EID: 77953643594     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2009/698769     Document Type: Review
Times cited : (13)

References (145)
  • 2
    • 67650073255 scopus 로고    scopus 로고
    • Methotrexate in combination with sulfasalazine is more effective in rheumatoid arthritis patients who failed sulfasalazine than in patients naivetobothdrugs
    • L. G. Schipper, J. Fransen, P. Barrera, and P. L. C. M. van Riel, "Methotrexate in combination with sulfasalazine is more effective in rheumatoid arthritis patients who failed sulfasalazine than in patients naivetobothdrugs," Rheumatology, vol. 48, no. 7, pp. 828-833, 2009.
    • (2009) Rheumatology , vol.48 , Issue.7 , pp. 828-833
    • Schipper, L.G.1    Fransen, J.2    Barrera, P.3    Van Riel, P.L.C.M.4
  • 3
    • 45149113632 scopus 로고    scopus 로고
    • Aggressive combination therapy with intra-articular glucocorticoid injections and conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis: Second- year clinical and radiographic results from the CIMESTRA study
    • M. L. Hetland, K. Stengaard-Pedersen, P. Junker, et al., "Aggressive combination therapy with intra-articular glucocorticoid injections and conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis: second- year clinical and radiographic results from the CIMESTRA study," Annals of the Rheumatic Diseases,vol. 67, no.6,pp. 815-822,2008.
    • (2008) Annals of the Rheumatic Diseases , vol.67 , Issue.6 , pp. 815-822
    • Hetland, M.L.1    Stengaard-Pedersen, K.2    Junker, P.3
  • 4
    • 67449136094 scopus 로고    scopus 로고
    • Comparative overview of safety of the biologics in rheumatoid arthritis
    • M. Khraishi, "Comparative overview of safety of the biologics in rheumatoid arthritis," Journal of Rheumatology, vol. 36, supplement 82, pp. 25-32, 2009.
    • (2009) Journal of Rheumatology , vol.36 , Issue.SUPPL. 82 , pp. 25-32
    • Khraishi, M.1
  • 5
    • 67649961801 scopus 로고    scopus 로고
    • Biologic therapy for rheumatoid arthritis: Clinical efficacy and predictors of response
    • L. J. Gibbons and K. L. Hyrich, "Biologic therapy for rheumatoid arthritis: clinical efficacy and predictors of response," BioDrugs, vol. 23, no. 2, pp. 111-124, 2009.
    • (2009) BioDrugs , vol.23 , Issue.2 , pp. 111-124
    • Gibbons, L.J.1    Hyrich, K.L.2
  • 6
    • 62849119976 scopus 로고    scopus 로고
    • Certolizumab pegol-what role does this new TNF inhibitor have in the treatment of RA?
    • D. E. Furst, "Certolizumab pegol-what role does this new TNF inhibitor have in the treatment of RA?" Nature Clinical Practice Rheumatology, vol. 5, no. 3, pp. 134-135, 2009.
    • (2009) Nature Clinical Practice Rheumatology , vol.5 , Issue.3 , pp. 134-135
    • Furst, D.E.1
  • 7
    • 67649873326 scopus 로고    scopus 로고
    • Golimumab: In the treatment of rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis
    • V. Oldfield and G. L. Plosker, "Golimumab: in the treatment of rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis," BioDrugs, vol. 23, no. 2, pp. 125-135, 2009.
    • (2009) BioDrugs , vol.23 , Issue.2 , pp. 125-135
    • Oldfield, V.1    Plosker, G.L.2
  • 9
    • 70350531479 scopus 로고    scopus 로고
    • Prospective new biological therapies for rheumatoid arthritis
    • L. Senolt, J. Vencovsky, K. Pavelka, C. Ospelt, and S. Gay, "Prospective new biological therapies for rheumatoid arthritis," Autoimmunity Reviews, vol. 9, no. 2, pp. 102-107, 2009.
    • (2009) Autoimmunity Reviews , vol.9 , Issue.2 , pp. 102-107
    • Senolt, L.1    Vencovsky, J.2    Pavelka, K.3    Ospelt, C.4    Gay, S.5
  • 10
    • 58849156486 scopus 로고    scopus 로고
    • Canakinumab,a fully-human mAb against IL-1// for the potential treatment of inflammatory disorders
    • L. D. Churchand, M.F.McDermott,"Canakinumab,a fully-human mAb against IL-1// for the potential treatment of inflammatory disorders," Current Opinion in Molecular Therapeutics, vol. 11, no. 1, pp. 81-89, 2009.
    • (2009) Current Opinion in Molecular Therapeutics , vol.11 , Issue.1 , pp. 81-89
    • Churchand, L.D.1    McDermott, M.F.2
  • 11
    • 67650175475 scopus 로고    scopus 로고
    • Costimula- tion blockade in rheumatic diseases: Where we are?
    • V. Goëb, M. H. Buch, E. M. Vital, and P. Emery, "Costimula- tion blockade in rheumatic diseases: where we are?" Current Opinion in Rheumatology, vol. 21, no. 3, pp. 244-250, 2009.
    • (2009) Current Opinion in Rheumatology , vol.21 , Issue.3 , pp. 244-250
    • Goëb, V.1    Buch, M.H.2    Vital, E.M.3    Emery, P.4
  • 12
    • 61349096538 scopus 로고    scopus 로고
    • Modulation of T-cell co-stimulation in rheumatoid arthritis: Clinical experience with abatacept
    • B. Laganà, M. Vinciguerra, and R. D'Amelio, "Modulation of T-cell co-stimulation in rheumatoid arthritis: clinical experience with abatacept," Clinical Drug Investigation, vol. 29, no. 3, pp. 185-202, 2009.
    • (2009) Clinical Drug Investigation , vol.29 , Issue.3 , pp. 185-202
    • Laganà, B.1    Vinciguerra, M.2    D'Amelio, R.3
  • 13
    • 53849085112 scopus 로고    scopus 로고
    • Abatacept: A T-cell co-stimulation modulator for the treatment ofrheumatoid arthritis
    • A. J. K. Ostör, "Abatacept: a T-cell co-stimulation modulator for the treatment ofrheumatoid arthritis," Clinical Rheumatology, vol. 27, no. 11, pp. 1343-1353, 2008.
    • (2008) Clinical Rheumatology , vol.27 , Issue.11 , pp. 1343-1353
    • Ostör, A.J.K.1
  • 14
    • 33845592936 scopus 로고    scopus 로고
    • Rituximab: Novel B-cell depletion therapy for the treatment of rheumatoid arthritis
    • S. Dass, E. M. Vital, and P. Emery, "Rituximab: novel B-cell depletion therapy for the treatment of rheumatoid arthritis," Expert Opinion on Pharmacotherapy, vol. 7, no. 18, pp. 2559-2570, 2006.
    • (2006) Expert Opinion on Pharmacotherapy , vol.7 , Issue.18 , pp. 2559-2570
    • Dass, S.1    Vital, E.M.2    Emery, P.3
  • 15
    • 73349104126 scopus 로고    scopus 로고
    • Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: Depletion of memory B cells correlates with clinical response
    • article R131
    • M. Nakou, G. Katsikas, P. Sidiropoulos, et al., "Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response," Arthritis Research & Therapy, vol. 11, no. 4, article R131,2009.
    • (2009) Arthritis Research & Therapy , vol.11 , Issue.4
    • Nakou, M.1    Katsikas, G.2    Sidiropoulos, P.3
  • 17
    • 41649084155 scopus 로고    scopus 로고
    • At the horizon of innovative therapy in rheumatology: New biologic agents
    • A. Finckh and C. Gabay, "At the horizon of innovative therapy in rheumatology: new biologic agents," Current Opinion in Rheumatology, vol. 20, no. 3, pp. 269-275, 2008.
    • (2008) Current Opinion in Rheumatology , vol.20 , Issue.3 , pp. 269-275
    • Finckh, A.1    Gabay, C.2
  • 18
    • 69549124775 scopus 로고    scopus 로고
    • Targeting interleukin-6 in pediatric rheumatic diseases
    • F. De Benedetti, "Targeting interleukin-6 in pediatric rheumatic diseases," Current Opinion in Rheumatology, vol. 21, no. 5, pp. 533-537, 2009.
    • (2009) Current Opinion in Rheumatology , vol.21 , Issue.5 , pp. 533-537
    • De Benedetti, F.1
  • 19
    • 9144271026 scopus 로고    scopus 로고
    • Acquired resistance of human T cells to sulfasalazine: Stability of the resistant phenotype and sensitivity to non- related DMARDs
    • J. van der Heijden, M. C. de Jong, B. A. Dijkmans, et al., "Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non- related DMARDs," Annals ofthe Rheumatic Diseases, vol. 63, no. 2, pp. 131-137, 2004.
    • (2004) Annals Ofthe Rheumatic Diseases , vol.63 , Issue.2 , pp. 131-137
    • Heijden Der J.Van1    De Jong, M.C.2    Dijkmans, B.A.3
  • 20
    • 30844470446 scopus 로고    scopus 로고
    • Real-world utilization of DMARDs and biologics in rheumatoid arthritis: The RADIUS (Rheumatoid Arthritis Disease-Modifying Anti-Rheumatic Drug Intervention and Utilization Study) study
    • A. Gibofsky, W. R. Palmer, J. A. Goldman, et al., "Real-world utilization of DMARDs and biologics in rheumatoid arthritis: the RADIUS (Rheumatoid Arthritis Disease-Modifying Anti-Rheumatic Drug Intervention and Utilization Study) study," Current Medical Research and Opinion, vol. 22, no. 1, pp. 169-183, 2006.
    • (2006) Current Medical Research and Opinion , vol.22 , Issue.1 , pp. 169-183
    • Gibofsky, A.1    Palmer, W.R.2    Goldman, J.A.3
  • 21
    • 34548757514 scopus 로고    scopus 로고
    • The efficacy of anti-TNF in rheumatoid arthritis, a comparison between randomised controlled trials and clinical practice
    • W. Kievit, J. Fransen, A.J.M. Oerlemans, et al., "The efficacy of anti-TNF in rheumatoid arthritis, a comparison between randomised controlled trials and clinical practice," Annals of the Rheumatic Diseases, vol. 66, no. 11, pp. 1473-1478, 2007.
    • (2007) Annals of the Rheumatic Diseases , vol.66 , Issue.11 , pp. 1473-1478
    • Kievit, W.1    Fransen, J.2    Oerlemans, A.J.M.3
  • 22
    • 43749095432 scopus 로고    scopus 로고
    • Tumor necrosis factor antagonist responsiveness in a United States rheumatoid arthritis cohort
    • J. D. Greenberg, M. Kishimoto, V. Strand, et al., "Tumor necrosis factor antagonist responsiveness in a United States rheumatoid arthritis cohort," American Journal ofMedicine, vol. 121, no. 6, pp. 532-538, 2008.
    • (2008) American Journal of Medicine , vol.121 , Issue.6 , pp. 532-538
    • Greenberg, J.D.1    Kishimoto, M.2    Strand, V.3
  • 23
    • 58349113392 scopus 로고    scopus 로고
    • Risk of serious infections during rituximab, abatacept and anakinra treatments for rheumatoid arthritis: Meta-analyses ofrandomised placebo-controlled trials
    • C. Salliot, M. Dougados, L. Gossec, "Risk of serious infections during rituximab, abatacept and anakinra treatments for rheumatoid arthritis: Meta-analyses ofrandomised placebo-controlled trials", Annals ofthe Rheumatic Diseases, Vol. 68, no. 1, pp. 25-32, 2009.
    • (2009) Annals Ofthe Rheumatic Diseases , vol.68 , Issue.1 , pp. 25-32
    • Salliot, C.1    Dougados, M.2    Gossec, L.3
  • 24
    • 67549117204 scopus 로고    scopus 로고
    • The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: Meta and exposure-adjusted pooled analyses of serious adverse events
    • J. P. Leombruno, T. R. Einarson, and E. C. Keystone, "The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events," Annals of the Rheumatic Diseases, vol. 68, no. 7, pp. 1136-1145, 2009.
    • (2009) Annals of the Rheumatic Diseases , vol.68 , Issue.7 , pp. 1136-1145
    • Leombruno, J.P.1    Einarson, T.R.2    Keystone, E.C.3
  • 25
    • 77953823409 scopus 로고    scopus 로고
    • Defining novel targets for intervention in rheumatoid arthritis: An overview
    • C. J. Malemud, "Defining novel targets for intervention in rheumatoid arthritis: an overview," Current Rheumatology Reviews, vol. 4, no. 4, pp. 214-218, 2008.
    • (2008) Current Rheumatology Reviews , vol.4 , Issue.4 , pp. 214-218
    • Malemud, C.J.1
  • 26
    • 77149137827 scopus 로고    scopus 로고
    • Targeting JAK/STAT signaling pathway in inflammatory diseases
    • C. J. Malemud and E. Pearlman, "Targeting JAK/STAT signaling pathway in inflammatory diseases," Current Signal Transduction Therapy, vol. 4, no. 4, pp. 201-221, 2009.
    • (2009) Current Signal Transduction Therapy , vol.4 , Issue.4 , pp. 201-221
    • Malemud, C.J.1    Pearlman, E.2
  • 27
    • 34248331345 scopus 로고    scopus 로고
    • Inhibitors of stress-activated protein/ mitogen-activated protein kinase pathways
    • C. J. Malemud, "Inhibitors of stress-activated protein/ mitogen-activated protein kinase pathways," Current Opinion in Pharmacology, vol. 7, no. 3, pp. 339-343, 2007.
    • (2007) Current Opinion in Pharmacology , vol.7 , Issue.3 , pp. 339-343
    • Malemud, C.J.1
  • 28
    • 70350133698 scopus 로고    scopus 로고
    • Successful structure-based design of recent p38 MAP kinase inhibitors
    • S. C. Karcher and S. A. Laufer, "Successful structure-based design of recent p38 MAP kinase inhibitors," Current Topics in Medicinal Chemistry, vol. 9, no. 7, pp. 655-676, 2009.
    • (2009) Current Topics in Medicinal Chemistry , vol.9 , Issue.7 , pp. 655-676
    • Karcher, S.C.1    Laufer, S.A.2
  • 29
    • 67650116365 scopus 로고    scopus 로고
    • Clinical value of blocking IL- 6receptor
    • T. Mima and N. Nishimoto, "Clinical value of blocking IL- 6receptor,"Current Opinion in Rheumatology, vol. 21, no. 3, pp. 224-230, 2009.
    • (2009) Current Opinion in Rheumatology , vol.21 , Issue.3 , pp. 224-230
    • Mima, T.1    Nishimoto, N.2
  • 30
    • 77953473493 scopus 로고    scopus 로고
    • Recent advances in neutralizing the IL-6 pathway in arthritis
    • C. J. Malemud, "Recent advances in neutralizing the IL-6 pathway in arthritis," Open Access Rheumatology: Research & Reviews, vol. 1, no. 1, pp. 1-18, 2009.
    • (2009) Open Access Rheumatology: Research & Reviews , vol.1 , Issue.1 , pp. 1-18
    • Malemud, C.J.1
  • 32
    • 38149117052 scopus 로고    scopus 로고
    • Sphingosine kinase signalling in immune cells: Potential as novel therapeutic targets
    • A. J. Melendez, "Sphingosine kinase signalling in immune cells: potential as novel therapeutic targets," Biochimica et Biophysica Acta, vol. 1784, no. 1, pp. 66-75, 2008.
    • (2008) Biochimica et Biophysica Acta , vol.1784 , Issue.1 , pp. 66-75
    • Melendez, A.J.1
  • 33
    • 68349093905 scopus 로고    scopus 로고
    • Regulation of macrophage function by sphingosine-1-phosphate
    • A. Weigert, N. Weis, and B. Brune, "Regulation of macrophage function by sphingosine-1-phosphate," Immunobiology, vol. 214, no. 9-10, pp. 748-760, 2009.
    • (2009) Immunobiology , vol.214 , Issue.9-10 , pp. 748-760
    • Weigert, A.1    Weis, N.2    Brune, B.3
  • 38
    • 47249124862 scopus 로고    scopus 로고
    • Is there a final common pathway for arthritis?
    • C. J. Malemud and M. E. Schulte, "Is there a final common pathway for arthritis?" Future Rheumatology,vol. 3, no. 3, pp. 253-268, 2008.
    • (2008) Future Rheumatology , vol.3 , Issue.3 , pp. 253-268
    • Malemud, C.J.1    Schulte, M.E.2
  • 39
    • 20944435137 scopus 로고    scopus 로고
    • Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis
    • Y. Kariya, A. Kihara, M. Ikeda, et al., "Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis," Genes to Cells, vol. 10, no. 6, pp. 605-615, 2005.
    • (2005) Genes to Cells , vol.10 , Issue.6 , pp. 605-615
    • Kariya, Y.1    Kihara, A.2    Ikeda, M.3
  • 40
    • 67649980370 scopus 로고    scopus 로고
    • Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders
    • J. T. Bagdanoff, M. S. Donoviel, A. Nouraldeen, et al., "Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders," Journal ofMedicinal Chemistry, vol. 52, no. 13, pp. 3941-3953, 2009.
    • (2009) Journal OfMedicinal Chemistry , vol.52 , Issue.13 , pp. 3941-3953
    • Bagdanoff, J.T.1    Donoviel, M.S.2    Nouraldeen, A.3
  • 41
    • 58149306392 scopus 로고    scopus 로고
    • Sphingolipid metabolizing enzymes as novel therapeutics
    • A. Billich and T. Baumruker, "Sphingolipid metabolizing enzymes as novel therapeutics," Subcellular Biochemistry, vol. 49, pp. 487-522, 2008.
    • (2008) Subcellular Biochemistry , vol.49 , pp. 487-522
    • Billich, A.1    Baumruker, T.2
  • 42
    • 77953818742 scopus 로고    scopus 로고
    • http://www.mskreport.com/articles.cfm?articleID=3416.
  • 43
    • 0041703016 scopus 로고    scopus 로고
    • The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF- α
    • B. J. Pettus, J. Bielawski, A. M. Porcelli, et al., "The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF- α," FASEB Journal, vol. 17, no. 11, pp. 1411-1421,2003.
    • (2003) FASEB Journal , vol.17 , Issue.11 , pp. 1411-1421
    • Pettus, B.J.1    Bielawski, J.2    Porcelli, A.M.3
  • 44
    • 33847055467 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses
    • D. Mechtcheriakova, A. Wlachos, J. Sobanov, et al., "Sph- ingosine 1-phosphate phosphatase 2 is induced during inflammatory responses," Cellular Signalling, vol. 19, no. 4, pp. 748-760, 2007.
    • (2007) Cellular Signalling , vol.19 , Issue.4 , pp. 748-760
    • Mechtcheriakova, D.1    Wlachos, A.2    Sobanov, J.3
  • 45
    • 0031757825 scopus 로고    scopus 로고
    • Role of interleukin-7 in T-cell development from hematopoietic stem cells
    • K. Akashi, M. Kondo, and I. L. Weissman, "Role of interleukin-7 in T-cell development from hematopoietic stem cells," Immunological Reviews, vol. 165, pp. 13-28, 1998.
    • (1998) Immunological Reviews , vol.165 , pp. 13-28
    • Akashi, K.1    Kondo, M.2    Weissman, I.L.3
  • 46
    • 67651096055 scopus 로고    scopus 로고
    • Regulation of T cell- dendritic cell interactions by IL-7 governs T-cell activation and homeostasis
    • M. Saini, C. Pearson, and B. Seddon, "Regulation of T cell- dendritic cell interactions by IL-7 governs T-cell activation and homeostasis," Blood, vol.113, no.23, pp. 5793-5800, 2009.
    • (2009) Blood , vol.113 , Issue.23 , pp. 5793-5800
    • Saini, M.1    Pearson, C.2    Seddon, B.3
  • 47
    • 65449185003 scopus 로고    scopus 로고
    • Novel function for interleukin-7 in dendritic cell development
    • T. K. Vogt, A. Link, J. Perrin, D. Finke, and S. A. Luther, "Novel function for interleukin-7 in dendritic cell development," Blood, vol.113, no.17, pp. 3961-3968, 2009.
    • (2009) Blood , vol.113 , Issue.17 , pp. 3961-3968
    • Vogt, T.K.1    Link, A.2    Perrin, J.3    Finke, D.4    Luther, S.A.5
  • 48
    • 70149094177 scopus 로고    scopus 로고
    • + lymphoid tissue inducer cells
    • S. Schmutz, N. Bosco, S. Chappaz, et al., "Cutting edge: IL- 7 regulates the peripheral pool of adult ROR γ+ lymphoid tissue inducer cells," Journal of Immunology, vol.183, no.4, pp. 2217-2221,2009.
    • (2009) Journal of Immunology , vol.183 , Issue.4 , pp. 2217-2221
    • Schmutz, S.1    Bosco, N.2    Chappaz, S.3
  • 49
    • 33751207432 scopus 로고    scopus 로고
    • Cell-surface IL-7 receptor expression facilitates the purification of FOXP3+ regulatory T cells
    • A. H. Banham, "Cell-surface IL-7 receptor expression facilitates the purification of FOXP3+ regulatory T cells," Trends in Immunology, vol.27, no.12, pp. 541-544, 2006.
    • (2006) Trends in Immunology , vol.27 , Issue.12 , pp. 541-544
    • Banham, A.H.1
  • 50
    • 0032911491 scopus 로고    scopus 로고
    • Biological and clinical implications of interleukin-7 and lymphopoiesis
    • P. M. Appasamy, "Biological and clinical implications of interleukin-7 and lymphopoiesis," Cytokines, Cellular and Molecular Therapy, vol.5, no.1, pp. 25-39, 1999.
    • (1999) Cytokines, Cellular and Molecular Therapy , vol.5 , Issue.1 , pp. 25-39
    • Appasamy, P.M.1
  • 51
    • 47249110406 scopus 로고    scopus 로고
    • Targeting cytokines, chemokines and adhesion molecules in rheumatoid arthritis
    • C. J. Malemud and S. K. Reddy, "Targeting cytokines, chemokines and adhesion molecules in rheumatoid arthritis," Current RheumatologyReviews, vol.4, no.4, pp. 219-234, 2008.
    • (2008) Current RheumatologyReviews , vol.4 , Issue.4 , pp. 219-234
    • Malemud, C.J.1    Reddy, S.K.2
  • 52
    • 0031587826 scopus 로고    scopus 로고
    • Bcl-2 rescues T lymphopoiesis in interleukin- 7 receptor-deficient mice
    • K. Akashi, M. Kondo, U. von Freeden-Jeffry, R. Murray, and I. L. Weissman, "Bcl-2 rescues T lymphopoiesis in interleukin- 7 receptor-deficient mice," Cell, vol.89, no.7, pp. 1033-1041, 1997.
    • (1997) Cell , vol.89 , Issue.7 , pp. 1033-1041
    • Akashi, K.1    Kondo, M.2    Von Freeden-Jeffry, U.3    Murray, R.4    Weissman, I.L.5
  • 53
    • 0036849781 scopus 로고    scopus 로고
    • Bax deficiency partially corrects interleukin-7 receptor α deficiency
    • A. R. Khaled, W. Q. Li, J. Huang, et al., "Bax deficiency partially corrects interleukin-7 receptor α deficiency," Immunity, vol.17, no.5, pp. 561-573, 2002.
    • (2002) Immunity , vol.17 , Issue.5 , pp. 561-573
    • Khaled, A.R.1    Li, W.Q.2    Huang, J.3
  • 54
    • 10744221710 scopus 로고    scopus 로고
    • Complementary signaling through flt3 and interleukin-7 receptor α is indispensable for fetal and adult B cell genesis
    • E. Sitnicka, C. Brakebusch, I.-L. Martensson, et al., "Complementary signaling through flt3 and interleukin-7 receptor α is indispensable for fetal and adult B cell genesis," Journal of Experimental Medicine, vol.198, no.10, pp. 1495-1506,2003.
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.10 , pp. 1495-1506
    • Sitnicka, E.1    Brakebusch, C.2    Martensson, I.-L.3
  • 55
    • 44849125718 scopus 로고    scopus 로고
    • Interleukin-7 in rheumatoid arthritis
    • S. M. Churchman and F. Ponchel, "Interleukin-7 in rheumatoid arthritis," Rheumatology, vol.47, no.6, pp. 753-759, 2008.
    • (2008) Rheumatology , vol.47 , Issue.6 , pp. 753-759
    • Churchman, S.M.1    Ponchel, F.2
  • 56
    • 33745042388 scopus 로고    scopus 로고
    • Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells
    • S.-I. Sawa, D. Kamimura, G.-H. Jin, et al., "Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells," Journal of Experimental Medicine, vol.203, no.6, pp. 1459-1470, 2006.
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.6 , pp. 1459-1470
    • Sawa, S.-I.1    Kamimura, D.2    Jin, G.-H.3
  • 57
    • 55349112529 scopus 로고    scopus 로고
    • IL-7 and IL-15: Biology and roles in T-cell immunity in health and disease
    • H.-R. Kim, K.-A. Hwang, S.-H. Park, and I. Kang, "IL-7 and IL-15: biology and roles in T-cell immunity in health and disease," Critical Reviews in Immunology, vol.28, no.4, pp. 325-339, 2008.
    • (2008) Critical Reviews in Immunology , vol.28 , Issue.4 , pp. 325-339
    • Kim, H.-R.1    Hwang, K.-A.2    Park, S.-H.3    Kang, I.4
  • 59
    • 34248181158 scopus 로고    scopus 로고
    • Persistence of interleukin 7 activity and levels on tumour necrosis factor α blockade in patients with rheumatoid arthritis
    • J. A. G. van Roon, S. A. Y. Hartgring, M. W.-V. Wijk, et al., "Persistence of interleukin 7 activity and levels on tumour necrosis factor α blockade in patients with rheumatoid arthritis," Annals of the Rheumatic Diseases, vol.66, no.5, pp. 664-669, 2007.
    • (2007) Annals of the Rheumatic Diseases , vol.66 , Issue.5 , pp. 664-669
    • Van Roon, J.A.G.1    Hartgring, S.A.Y.2    Wijk, M.W.-V.3
  • 60
    • 69449099657 scopus 로고    scopus 로고
    • Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis
    • S. A. Y. Hartgring, J.A.G. Van Roon, M.W.V. Wijk, et al., "Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis," Arthritis and Rheumatism, vol.60, no.9, pp. 2595-2605, 2009.
    • (2009) Arthritis and Rheumatism , vol.60 , Issue.9 , pp. 2595-2605
    • Hartgring, S.A.Y.1    Van Roon, J.A.G.2    Wijk, M.W.V.3
  • 61
    • 68349139357 scopus 로고    scopus 로고
    • Increased numbers of IL-7 receptor molecules on CD4+CD25-CD107a+ T-cells in patients with autoimmune diseases affecting the central nervous system
    • N. K. Vudattu, S. Kuhlmann-Berenzon, M. Khademi, V. Seyfert, T. Olsson, and M. J. Maeurer, "Increased numbers of IL-7 receptor molecules on CD4+CD25-CD107a+ T-cells in patients with autoimmune diseases affecting the central nervous system," PLoS ONE, vol.4, no.8, article e6534, 2009.
    • (2009) PLoS ONE , vol.4 , Issue.8
    • Vudattu, N.K.1    Kuhlmann-Berenzon, S.2    Khademi, M.3    Seyfert, V.4    Olsson, T.5    Maeurer, M.J.6
  • 62
    • 77953470983 scopus 로고    scopus 로고
    • Role of nonreceptor tyrosine and threonine kinase inhibitors
    • J. García-Foncillas, Ed.
    • C. J. Malemud, "Role of nonreceptor tyrosine and threonine kinase inhibitors," in Molecular Biology of Cancer: Toward New Therapies, J. García-Foncillas, Ed., pp. 537-555, Prous Science, Barcelona, Spain, 2009.
    • (2009) Molecular Biology of Cancer: Toward New Therapies , pp. 537-555
    • Malemud, C.J.1
  • 64
    • 0037126634 scopus 로고    scopus 로고
    • The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation
    • N. Rao, A. K. Ghosh, S. Ota, et al., "The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation," EMBO Journal, vol.20, no.24, pp. 7085-7095, 2002.
    • (2002) EMBO Journal , vol.20 , Issue.24 , pp. 7085-7095
    • Rao, N.1    Ghosh, A.K.2    Ota, S.3
  • 65
    • 58149475823 scopus 로고    scopus 로고
    • Tyrosine kinases as targets in rheumatoid arthritis
    • A. G. Tristano, "Tyrosine kinases as targets in rheumatoid arthritis," International Immunopharmacology, vol.9, no.1, pp. 1-9, 2009.
    • (2009) International Immunopharmacology , vol.9 , Issue.1 , pp. 1-9
    • Tristano, A.G.1
  • 66
    • 44449118619 scopus 로고    scopus 로고
    • Spleen tyrosine kinase: A novel target for therapeutic intervention of rheumatoid arthritis
    • M. Bajpai, P. Chopra, S. G. Dastidar, and A. Ray, "Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis," Expert Opinion on Investigational Drugs, vol.17, no.5, pp. 641-659, 2008.
    • (2008) Expert Opinion on Investigational Drugs , vol.17 , Issue.5 , pp. 641-659
    • Bajpai, M.1    Chopra, P.2    Dastidar, S.G.3    Ray, A.4
  • 67
    • 63449105305 scopus 로고    scopus 로고
    • PLCγ2 is essential for formation and maintenance of memory B cells
    • M. Hikida, S. Casola, N. Takahashi, et al., "PLCγ2 is essential for formation and maintenance of memory B cells," Journal of Experimental Medicine, vol.206, no.3, pp. 681-689, 2009.
    • (2009) Journal of Experimental Medicine , vol.206 , Issue.3 , pp. 681-689
    • Hikida, M.1    Casola, S.2    Takahashi, N.3
  • 68
    • 34547849752 scopus 로고    scopus 로고
    • Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor
    • P. R. Pine, B. Chang, N. Schoettler, et al., "Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor," Clinical Immunology, vol.124, no.3, pp. 244-257, 2007.
    • (2007) Clinical Immunology , vol.124 , Issue.3 , pp. 244-257
    • Pine, P.R.1    Chang, B.2    Schoettler, N.3
  • 69
    • 62249125407 scopus 로고    scopus 로고
    • Fostamatinib, a Syk inhibitor prodrug for the treatment of inflammatory diseases
    • M. Bajpai, "Fostamatinib, a Syk inhibitor prodrug for the treatment of inflammatory diseases," IDrugs,vol.12, no.3, pp. 174-185,2009.
    • (2009) IDrugs , vol.12 , Issue.3 , pp. 174-185
    • Bajpai, M.1
  • 70
    • 55849114400 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with a Syk kinase inhibitor: A twelve-week, randomized, placebo-controlled trial
    • M. E. Weinblatt, A. Kavanaugh, R. Burgos-Vargas, et al., "Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial," Arthritis and Rheumatism, vol.58, no.11, pp. 3309-3318, 2008.
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.11 , pp. 3309-3318
    • Weinblatt, M.E.1    Kavanaugh, A.2    Burgos-Vargas, R.3
  • 71
    • 5444228751 scopus 로고    scopus 로고
    • Protein kinases in chondrocyte signaling and osteoarthritis
    • C. J. Malemud, "Protein kinases in chondrocyte signaling and osteoarthritis," Clinical Orthopaedics and Related Research, no.427, supplement, pp. S145-S151, 2004.
    • (2004) Clinical Orthopaedics and Related Research, No. , Issue.427
    • Malemud, C.J.1
  • 72
    • 20444418706 scopus 로고    scopus 로고
    • MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression
    • G. L. Johnson, H. G. Dohlman, and L. M. Graves, "MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression," Current Opinion in Chemical Biology, vol.9, no.3, pp. 325-331,2005.
    • (2005) Current Opinion in Chemical Biology , vol.9 , Issue.3 , pp. 325-331
    • Johnson, G.L.1    Dohlman, H.G.2    Graves, L.M.3
  • 73
    • 47249089733 scopus 로고    scopus 로고
    • MAP kinases
    • J. Buckwalter, M. Lotz, and J.- F. Stoltz, Eds.
    • C. J. Malemud, "MAP kinases," in OA, Inflammation and Degradation: A Continuum, J. Buckwalter, M. Lotz, and J.- F. Stoltz, Eds., vol.70 of Biomedical and Health Research, pp. 99-117, IOS Press, Amsterdam, The Netherlands, 2007.
    • (2007) OA, Inflammation and Degradation: A Continuum , vol.70 , pp. 99-117
    • Malemud, C.J.1
  • 74
    • 34548559114 scopus 로고    scopus 로고
    • Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma
    • I. Breitkreutz, M. S. Raab, S. Vallet, et al., "Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma," British Journal of Haematology, vol.139, no.1, pp. 55-63, 2007.
    • (2007) British Journal of Haematology , vol.139 , Issue.1 , pp. 55-63
    • Breitkreutz, I.1    Raab, M.S.2    Vallet, S.3
  • 75
    • 0346525140 scopus 로고    scopus 로고
    • U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells
    • H. Hotokezaka, E. Sakai, K. Kanaoka, et al., "U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells," The Journal of Biological Chemistry, vol.277, no.49, pp. 47366-47372, 2002.
    • (2002) The Journal of Biological Chemistry , vol.277 , Issue.49 , pp. 47366-47372
    • Hotokezaka, H.1    Sakai, E.2    Kanaoka, K.3
  • 76
    • 60649086256 scopus 로고    scopus 로고
    • Garden of therapeutic delights: New targets in rheumatic diseases
    • J. M. Waldburger and G. S. Firestein, "Garden of therapeutic delights: new targets in rheumatic diseases," Arthritis Research and Therapy, vol.11, no.1, article 206, 2009.
    • (2009) Arthritis Research and Therapy , vol.11 , Issue.1
    • Waldburger, J.M.1    Firestein, G.S.2
  • 77
    • 58049129497 scopus 로고    scopus 로고
    • AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways
    • H. B. Kwak, H.M.Sun, H. Ha, J.H.Lee, H.N.Kim, and Z. H. Lee, "AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways," Molecules and Cells, vol.26, no.5, pp. 436-442, 2008.
    • (2008) Molecules and Cells , vol.26 , Issue.5 , pp. 436-442
    • Kwak, H.B.1    Sun, H.M.2    Ha, H.3    Lee, J.H.4    Kim, H.N.5    Lee, Z.H.6
  • 78
    • 3242781731 scopus 로고    scopus 로고
    • Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
    • L. C. Hof bauer and M. Schoppet, "Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases," Journal of the American Medical Association, vol.292, no.4, pp. 490-495, 2004.
    • (2004) Journal of the American Medical Association , vol.292 , Issue.4 , pp. 490-495
    • Hof Bauer, L.C.1    Schoppet, M.2
  • 79
    • 42049110350 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor κb ligand and osteoprotegerin regulation of bone remodeling in health and disease
    • A.E. Kearns,S.Khosla,andP.J.Kostenuik,"Receptor activator of nuclear factor κB ligand and osteoprotegerin regulation of bone remodeling in health and disease," Endocrine Reviews, vol.29, no.2, pp. 155-192, 2008.
    • (2008) Endocrine Reviews , vol.29 , Issue.2 , pp. 155-192
  • 80
    • 44649089666 scopus 로고    scopus 로고
    • Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors
    • J. A. McCubrey, M. Milella, A. Tafuri, et al., "Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors," Current Opinion in Investigational Drugs,vol. 9,no.6,pp. 614-630, 2008.
    • (2008) Current Opinion in Investigational Drugs , vol.9 , Issue.6 , pp. 614-630
    • McCubrey, J.A.1    Milella, M.2    Tafuri, A.3
  • 81
    • 33748063941 scopus 로고    scopus 로고
    • Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance
    • J. A. McCubrey, L. S. Steelman, S. L. Abrams, et al., "Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance," Advances in Enzyme Regulation, vol.46, no.1, pp. 249-279, 2006.
    • (2006) Advances in Enzyme Regulation , vol.46 , Issue.1 , pp. 249-279
    • McCubrey, J.A.1    Steelman, L.S.2    Abrams, S.L.3
  • 82
    • 35348923750 scopus 로고    scopus 로고
    • Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: Potential proinflammatory mechanisms
    • M. J. Thiel, C. J. Schaefer, M. E. Lesch, et al., "Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms," Arthritis and Rheumatism, vol.56, no.10, pp. 3347-3357, 2007.
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.10 , pp. 3347-3357
    • Thiel, M.J.1    Schaefer, C.J.2    Lesch, M.E.3
  • 83
    • 51549098356 scopus 로고    scopus 로고
    • ERK inhibitors as a potential new therapy for rheumatoid arthritis
    • M. Ohori, "ERK inhibitors as a potential new therapy for rheumatoid arthritis," Drug News and Perspectives, vol.21, no.5, pp. 245-250, 2008.
    • (2008) Drug News and Perspectives , vol.21 , Issue.5 , pp. 245-250
    • Ohori, M.1
  • 84
    • 77953815376 scopus 로고    scopus 로고
    • http://www.pharmalive.com/News/Index.cfm?articleid=649388.
  • 85
    • 69449094454 scopus 로고    scopus 로고
    • Induction of apoptosis in the synovium of mice with autoantibody- mediated arthritis by the intraarticular injection of double- stranded microRNA-15a
    • Y. Nagata, T. Nakasa, Y. Mochizuki, et al., "Induction of apoptosis in the synovium of mice with autoantibody- mediated arthritis by the intraarticular injection of double- stranded microRNA-15a," Arthritis and Rheumatism, vol.60, no.9, pp. 2677-2683, 2009.
    • (2009) Arthritis and Rheumatism , vol.60 , Issue.9 , pp. 2677-2683
    • Nagata, Y.1    Nakasa, T.2    Mochizuki, Y.3
  • 86
    • 70350489381 scopus 로고    scopus 로고
    • Intra- articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis
    • article R16
    • Q. Yao, D. W. Seol, Z. Mi, and P. D. Robbins, "Intra- articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis," Arthritis Research & Therapy, vol.8, no.1, article R16, 2006.
    • (2006) Arthritis Research & Therapy , vol.8 , Issue.1
    • Yao, Q.1    Seol, D.W.2    Mi, Z.3    Robbins, P.D.4
  • 87
  • 89
    • 42549091024 scopus 로고    scopus 로고
    • DoesMK5 reconcile classical and atypical MAP kinases?
    • M.Perander, S.M.Keyse, and O.-M.Seternes,"DoesMK5 reconcile classical and atypical MAP kinases?" Frontiers in Bioscience, vol.13, no.12, pp. 4617-4624, 2008.
    • (2008) Frontiers in Bioscience , vol.13 , Issue.12 , pp. 4617-4624
    • Perander, M.1    Keyse, S.M.2    Seternes, O.-M.3
  • 90
    • 33845918999 scopus 로고    scopus 로고
    • Regulation of MAPK-activated protein kinase 5 activity and subcellularlocalization by the atypical MAPK ERK4/MAPK4
    • E. Åberg, M. Perander, B. Johansen, et al., "Regulation of MAPK-activated protein kinase 5 activity and subcellularlocalization by the atypical MAPK ERK4/MAPK4," The Journal of Biological Chemistry, vol.281, no.46, pp. 35499-35510,2006.
    • (2006) The Journal of Biological Chemistry , vol.281 , Issue.46 , pp. 35499-35510
    • Åberg, E.1    Perander, M.2    Johansen, B.3
  • 91
    • 52049108016 scopus 로고    scopus 로고
    • Specificity of signaling from MAPKs to MAP- KAPKs: Kinases' tango nuevo
    • M. Gaestel, "Specificity of signaling from MAPKs to MAP- KAPKs: kinases' tango nuevo," Frontiers in Bioscience, vol.13, pp. 6050-6059, 2008.
    • (2008) Frontiers in Bioscience , vol.13 , pp. 6050-6059
    • Gaestel, M.1
  • 92
    • 60549113678 scopus 로고    scopus 로고
    • PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5
    • S. Kostenko, M. Johannessen, and U. Moens, "PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5," Cellular Signalling, vol.21, no.5, pp. 712-718, 2009.
    • (2009) Cellular Signalling , vol.21 , Issue.5 , pp. 712-718
    • Kostenko, S.1    Johannessen, M.2    Moens, U.3
  • 93
    • 63849154800 scopus 로고    scopus 로고
    • Dysregu- lation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation
    • K. L. Wood, H. L. Twigg III, and A. I. Doseff,"Dysregu- lation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation," Frontiers in Bioscience, vol.14, pp. 3771-3781,2009.
    • (2009) Frontiers in Bioscience , vol.14 , pp. 3771-3781
    • Wood, K.L.1    Twigg Iii, H.L.2    Doseff, A.I.3
  • 94
    • 33646882893 scopus 로고    scopus 로고
    • Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis
    • M. F. Roelof s, W. C. Boelens, L. A. B. Joosten, et al., "Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis," Journal of Immunology, vol.176, no.11, pp. 7021-7027, 2006.
    • (2006) Journal of Immunology , vol.176 , Issue.11 , pp. 7021-7027
    • Roelof, S.M.F.1    Boelens, W.C.2    Joosten, L.A.B.3
  • 96
    • 7044230065 scopus 로고    scopus 로고
    • Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts
    • M. Yoshida, M. Niwa, A. Ishisaki, et al., "Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts," Prostaglandins Leukotrienes and Essential Fatty Acids, vol.71, no.6, pp. 351-362, 2004.
    • (2004) Prostaglandins Leukotrienes and Essential Fatty Acids , vol.71 , Issue.6 , pp. 351-362
    • Yoshida, M.1    Niwa, M.2    Ishisaki, A.3
  • 97
    • 33745248460 scopus 로고    scopus 로고
    • A selective p38α mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis
    • S. Medicherla, J. Y. Ma, R. Mangadu, et al., "A selective p38α mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis," Journal of Pharmacology and Experimental Therapeutics, vol.318, no.1, pp. 132-141, 2006.
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.318 , Issue.1 , pp. 132-141
    • Medicherla, S.1    Ma, J.Y.2    Mangadu, R.3
  • 98
    • 70349895664 scopus 로고    scopus 로고
    • The tran- scriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5
    • N. Gerits, A. Shiryaev, S. Kostenko, et al., "The tran- scriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5," Cellular and Molecular Biology Letters, vol.14, no.4, pp. 548-574, 2009.
    • (2009) Cellular and Molecular Biology Letters , vol.14 , Issue.4 , pp. 548-574
    • Gerits, N.1    Shiryaev, A.2    Kostenko, S.3
  • 99
    • 33846282393 scopus 로고    scopus 로고
    • PRAK Is essential for ras- induced senescence and tumor suppression
    • P. Sun, N. Yoshizuka, L. New, et al., "PRAK Is essential for ras- induced senescence and tumor suppression," Cell, vol.128, no.2, pp. 295-308, 2007.
    • (2007) Cell , vol.128 , Issue.2 , pp. 295-308
    • Sun, P.1    Yoshizuka, N.2    New, L.3
  • 100
    • 33746121228 scopus 로고    scopus 로고
    • 2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts: Role in suppression of c/EBP/NF-κB-mediated MEKK1-induced MMP-1 expression
    • 2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts: role in suppression of c/EBP/NF-κB-mediated MEKK1-induced MMP-1 expression," The Journal of Biological Chemistry, vol.281, no.29, pp. 19849-19860, 2006.
    • (2006) The Journal of Biological Chemistry , vol.281 , Issue.29 , pp. 19849-19860
    • Faour, W.H.1    He, Q.2    Mancini, A.3    Jovanovic, D.4    Antoniou, J.5    Di Battista, J.A.6
  • 102
    • 77953835941 scopus 로고    scopus 로고
    • http://nmcc-vikas.gov.in/AhmedabadPharma/Galapagoshtml.
  • 104
    • 38549095711 scopus 로고    scopus 로고
    • Micro- management of the immune system by microRNAs
    • H. F. Lodish, B. Zhou, G. Liu, and C.-Z. Chen, "Micro- management of the immune system by microRNAs," Nature Reviews Immunology, vol.8, no.2, pp. 120-130, 2008.
    • (2008) Nature Reviews Immunology , vol.8 , Issue.2 , pp. 120-130
    • Lodish, H.F.1    Zhou, B.2    Liu, G.3    Chen, C.-Z.4
  • 105
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, of ten flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • B. P. Lewis, C. B. Burge, and D. P. Bartel, "Conserved seed pairing, of ten flanked by adenosines, indicates that thousands of human genes are microRNA targets," Cell, vol.120, no.1,pp. 15-20, 2005.
    • (2005) Cell , vol.120 , Issue.1 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 106
    • 67650360177 scopus 로고    scopus 로고
    • Epige- netic control in rheumatoid arthritis synovial fibroblasts
    • E. Karouzakis, R. E. Gay, S. Gay, and M. Neidhart, "Epige- netic control in rheumatoid arthritis synovial fibroblasts," Nature Reviews Rheumatology, vol.5, no.5, pp. 266-272, 2009.
    • (2009) Nature Reviews Rheumatology , vol.5 , Issue.5 , pp. 266-272
    • Karouzakis, E.1    Gay, R.E.2    Gay, S.3    Neidhart, M.4
  • 109
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • D. P. Bartel, "MicroRNAs: genomics, biogenesis, mechanism, and function," Cell, vol.116, no.2, pp. 281-297, 2004.
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 110
    • 43949136123 scopus 로고    scopus 로고
    • Expression of microRNA-146 in rheumatoid arthritis synovial tissue
    • T. Nakasa, S. Miyaki, A. Okubo, et al., "Expression of microRNA-146 in rheumatoid arthritis synovial tissue," Arthritis and Rheumatism, vol.58, no.5, pp. 1284-1292, 2008.
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.5 , pp. 1284-1292
    • Nakasa, T.1    Miyaki, S.2    Okubo, A.3
  • 111
    • 42449156220 scopus 로고    scopus 로고
    • Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
    • J. Stanczyk, D. M. L. Pedrioli, F. Brentano, et al., "Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis," Arthritis and Rheumatism, vol.58, no.4, pp. 1001-1009, 2008.
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.4 , pp. 1001-1009
    • Stanczyk, J.1    Pedrioli, D.M.L.2    Brentano, F.3
  • 112
    • 52249094653 scopus 로고    scopus 로고
    • Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    • article R101
    • K. M. Pauley, M. Satoh, A. L. Chan, M. R. Bubb, W. H. Reeves, and E. K. L. Chan, "Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients," Arthritis Research and Therapy, vol.10, no.4, article R101, 2008.
    • (2008) Arthritis Research and Therapy , vol.10 , Issue.4
    • Pauley, K.M.1    Satoh, M.2    Chan, A.L.3    Bubb, M.R.4    Reeves, W.H.5    Chan, E.K.L.6
  • 113
    • 70350132390 scopus 로고    scopus 로고
    • Small molecule inhibitors of phosphoinositide 3-kinase (PI3K) δ and γ
    • M. K. Ameriks and J. D. Venable, "Small molecule inhibitors of phosphoinositide 3-kinase (PI3K) δ and γ," Current Topics in Medicinal Chemistry, vol.9, no.8, pp. 738-753, 2009.
    • (2009) Current Topics in Medicinal Chemistry , vol.9 , Issue.8 , pp. 738-753
    • Ameriks, M.K.1    Venable, J.D.2
  • 114
    • 33847239467 scopus 로고    scopus 로고
    • PI3Kδ and PI3Kγ: Partners in crime in inflammation in rheumatoid arthritis and beyond?
    • C. Rommel, M. Camps, and H. Ji, "PI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?" Nature Reviews Immunology,vol.7,no.3,pp. 191-201,2007.
    • (2007) Nature Reviews Immunology , vol.7 , Issue.3 , pp. 191-201
    • Rommel, C.1    Camps, M.2    Ji, H.3
  • 115
    • 73349137325 scopus 로고    scopus 로고
    • Downregulation of heat shock protein 70 protects rheumatoid arthritis fibroblast-like synoviocytes from nitric oxide-induced apoptosis
    • article R130
    • E. H. Kang, D. J. Kim, E. Y. Lee, Y. J. Lee, E. B. Lee, and Y. W. Song, "Downregulation of heat shock protein 70 protects rheumatoid arthritis fibroblast-like synoviocytes from nitric oxide-induced apoptosis," Arthritis Research & Therapy, vol.11, no.4, article R130, 2009.
    • (2009) Arthritis Research & Therapy , vol.11 , Issue.4
    • Kang, E.H.1    Kim, D.J.2    Lee, E.Y.3    Lee, Y.J.4    Lee, E.B.5    Song, Y.W.6
  • 116
    • 70349466536 scopus 로고    scopus 로고
    • Aberrant integrin activation induces p38 MAPK phosphorylation resulting in suppressed Fas-mediated apoptosis in T cells: Implications for rheumatoid arthritis
    • Y. Lin, C.-C. Su, J.-Y. Huang, et al., "Aberrant integrin activation induces p38 MAPK phosphorylation resulting in suppressed Fas-mediated apoptosis in T cells: implications for rheumatoid arthritis," Molecular Immunology, vol.46, no.16, pp. 3328-3335,2009.
    • (2009) Molecular Immunology , vol.46 , Issue.16 , pp. 3328-3335
    • Lin, Y.1    Su, C.-C.2    Huang, J.-Y.3
  • 118
    • 61849124795 scopus 로고    scopus 로고
    • Bcl-3, a multifaceted modulator of NF-κB-mediated gene transcription
    • S. Palmer and Y. H. Chen, "Bcl-3, a multifaceted modulator of NF-κB-mediated gene transcription," Immunologic Research, vol.42, no.1-3, pp. 210-218, 2008.
    • (2008) Immunologic Research , vol.42 , Issue.1 , pp. 210-218
    • Palmer, S.1    Chen, Y.H.2
  • 119
    • 69449088802 scopus 로고    scopus 로고
    • Outside-to-inside signaling through transmem- brane tumor necrosis factor reverses pathologic interleukin- 1/3 production and deficient apoptosis of rheumatoid arthritis monocytes
    • U. Meusch, M. Rossol, C. Baerwald, S. Hauschildt, and U. Wagner, "Outside-to-inside signaling through transmem- brane tumor necrosis factor reverses pathologic interleukin- 1/3 production and deficient apoptosis of rheumatoid arthritis monocytes," Arthritis and Rheumatism,vol.60,no.9,pp. 2612-2621,2009.
    • (2009) Arthritis and Rheumatism , vol.60 , Issue.9 , pp. 2612-2621
    • Meusch, U.1    Rossol, M.2    Baerwald, C.3    Hauschildt, S.4    Wagner, U.5
  • 120
    • 77649260574 scopus 로고    scopus 로고
    • Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): Causes and consequences for immune function, cell survival and therapeutic intervention
    • In press.
    • D. C. Phillips, H. I. Dias, G. D. Kitas, and H. R. Griffiths, "Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival and therapeutic intervention," Antioxid Redox Signal. In press.
    • Antioxid Redox Signal
    • Phillips, D.C.1    Dias, H.I.2    Kitas, G.D.3    Griffiths, H.R.4
  • 121
    • 68149139457 scopus 로고    scopus 로고
    • BH3-only proteins in rheumatoid arthritis: Potential targets for therapeutic intervention
    • J. Hutcheson and H. Perlman, "BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention," Oncogene, vol.27, supplement 1, pp. S168-S175, 2008.
    • (2008) Oncogene , vol.27
    • Hutcheson, J.1    Perlman, H.2
  • 123
    • 18144416502 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phos- phatidylinositol 3-kinase/Akt
    • J. Morel, R. Audo, M. Hahne, and B. Combe, "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phos- phatidylinositol 3-kinase/Akt," The Journal of Biological Chemistry, vol.280, no.16, pp. 15709-15718, 2005.
    • (2005) The Journal of Biological Chemistry , vol.280 , Issue.16 , pp. 15709-15718
    • Morel, J.1    Audo, R.2    Hahne, M.3    Combe, B.4
  • 124
    • 33745700485 scopus 로고    scopus 로고
    • Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis
    • A. Jüngel, V. Baresova, C. Ospelt, et al., "Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis," Annals of the Rheumatic Diseases, vol.65, no.7, pp. 910-912, 2006.
    • (2006) Annals of the Rheumatic Diseases , vol.65 , Issue.7 , pp. 910-912
    • Jüngel, A.1    Baresova, V.2    Ospelt, C.3
  • 125
    • 33645871828 scopus 로고    scopus 로고
    • Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-y through JAK/STAT pathway by translational regulation
    • M. Tamai, A. Kawakami, F. Tanaka, et al., "Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-y through JAK/STAT pathway by translational regulation," Journal of Laboratory and Clinical Medicine, vol.147, no.4, pp. 182-190,2006.
    • (2006) Journal of Laboratory and Clinical Medicine , vol.147 , Issue.4 , pp. 182-190
    • Tamai, M.1    Kawakami, A.2    Tanaka, F.3
  • 126
    • 34347220864 scopus 로고    scopus 로고
    • Interferon-γ is produced by another player of innate immune responses: The interferon-producing killer dendritic cell (IKDC)
    • M. Bonmort, E. Ullrich, G. Mignot, B. Jacobs, N. Chaput, and L. Zitvogel, "Interferon-γ is produced by another player of innate immune responses: the interferon-producing killer dendritic cell (IKDC)," Biochimie, vol.89, no.6-7, pp. 872-877, 2007.
    • (2007) Biochimie , vol.89 , Issue.6-7 , pp. 872-877
    • Bonmort, M.1    Ullrich, E.2    Mignot, G.3    Jacobs, B.4    Chaput, N.5    Zitvogel, L.6
  • 127
    • 69849094949 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors cooperate with IFN-γ to restore caspase-8 expression and overcome TRAIL resistance in cancers withsilencing of caspase-8
    • S. Häcker, A. Dittrich, A. Mohr, et al., "Histone deacetylase inhibitors cooperate with IFN-γ to restore caspase-8 expression and overcome TRAIL resistance in cancers withsilencing of caspase-8," Oncogene, vol.28, no.35, pp. 3097-3110, 2009.
    • (2009) Oncogene , vol.28 , Issue.35 , pp. 3097-3110
    • Häcker, S.1    Dittrich, A.2    Mohr, A.3
  • 128
    • 69049110871 scopus 로고    scopus 로고
    • The pleiotropic effect of TRAIL on tumor-like synovial fibroblasts from rheumatoid arthritis patients is mediated by caspases
    • R. Audo, B. Combe, B. Coulet, J. Morel, and M. Hahne, "The pleiotropic effect of TRAIL on tumor-like synovial fibroblasts from rheumatoid arthritis patients is mediated by caspases," Cell Death and Differentiation, vol.16, no.9, pp. 1227-1237, 2009.
    • (2009) Cell Death and Differentiation , vol.16 , Issue.9 , pp. 1227-1237
    • Audo, R.1    Combe, B.2    Coulet, B.3    Morel, J.4    Hahne, M.5
  • 129
    • 62849096248 scopus 로고    scopus 로고
    • Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis is cell cycle-dependent
    • article R16
    • N. Pundt, M. A. Peters, C. Wunrau, et al., "Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis is cell cycle-dependent," Arthritis Research and Therapy, vol.11, no.1, article R16, 2009.
    • (2009) Arthritis Research and Therapy , vol.11 , Issue.1
    • Pundt, N.1    Peters, M.A.2    Wunrau, C.3
  • 130
    • 34347237670 scopus 로고    scopus 로고
    • Concurrent gene therapy strategies effectively destroy synoviocytes of patients with rheumatoid arthritis
    • E. Terzioglu, A. Bisgin, A. D. Sanlioglu, et al., "Concurrent gene therapy strategies effectively destroy synoviocytes of patients with rheumatoid arthritis," Rheumatology, vol.46, no.5, pp. 783-789, 2007.
    • (2007) Rheumatology , vol.46 , Issue.5 , pp. 783-789
    • Terzioglu, E.1    Bisgin, A.2    Sanlioglu, A.D.3
  • 131
    • 27144503348 scopus 로고    scopus 로고
    • Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity
    • X. Liu, P. Yue, F. R. Khuri, and S.-Y. Sun, "Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity," Cancer Research, vol.65, no.20, pp. 9169-9175, 2005.
    • (2005) Cancer Research , vol.65 , Issue.20 , pp. 9169-9175
    • Liu, X.1    Yue, P.2    Khuri, F.R.3    Sun, S.-Y.4
  • 132
    • 34848836010 scopus 로고    scopus 로고
    • Gene therapy for arthritis: Defining novel gene targets
    • C. J. Malemud, "Gene therapy for arthritis: defining novel gene targets," Gene Therapy and Molecular Biology, vol.11, no.1, pp. 27-36, 2007.
    • (2007) Gene Therapy and Molecular Biology , vol.11 , Issue.1 , pp. 27-36
    • Malemud, C.J.1
  • 133
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: A suitable antineoplastic target
    • J. Adams, "The proteasome: a suitable antineoplastic target," Nature Reviews Cancer, vol.4, no.5, pp. 349-360, 2004.
    • (2004) Nature Reviews Cancer , vol.4 , Issue.5 , pp. 349-360
    • Adams, J.1
  • 134
    • 0028234770 scopus 로고
    • Distinct 19S and 20S subcomplexes of the 26S proteasome and their distribution in the nucleus and cytoplasm
    • J. M. Peters, W. W. Franke, and J. A. Kleinschmidt, "Distinct 19S and 20S subcomplexes of the 26S proteasome and their distribution in the nucleus and cytoplasm," The Journal of Biological Chemistry, vol.269, no.10, pp. 7709-7718, 1994.
    • (1994) The Journal of Biological Chemistry , vol.269 , Issue.10 , pp. 7709-7718
    • Peters, J.M.1    Franke, W.W.2    Kleinschmidt, J.A.3
  • 135
    • 34250011799 scopus 로고    scopus 로고
    • The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases
    • J. Wang and M. A. Maldonado, "The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases," Cellular & Molecular Immunology,vol.3,no.4,pp. 255-261,2006.
    • (2006) Cellular & Molecular Immunology , vol.3 , Issue.4 , pp. 255-261
    • Wang, J.1    Maldonado, M.A.2
  • 136
  • 137
    • 50249092779 scopus 로고    scopus 로고
    • Development of proteasome inhibitors in oncology and autoimmune diseases
    • M. K. Bennett and C. J. Kirk, "Development of proteasome inhibitors in oncology and autoimmune diseases," Current Opinion in Drug Discovery and Development, vol.11, no.5, pp. 616-625, 2008.
    • (2008) Current Opinion in Drug Discovery and Development , vol.11 , Issue.5 , pp. 616-625
    • Bennett, M.K.1    Kirk, C.J.2
  • 139
    • 43949095463 scopus 로고    scopus 로고
    • Proteasome inhibition as a novel therapy in treating rheumatoid arthritis
    • J. Brun, "Proteasome inhibition as a novel therapy in treating rheumatoid arthritis," Medical Hypotheses,vol.71,no.1,pp. 65-72, 2008.
    • (2008) Medical Hypotheses , vol.71 , Issue.1 , pp. 65-72
    • Brun, J.1
  • 140
    • 68949154568 scopus 로고    scopus 로고
    • FoxM1 is a general target for proteasome inhibitors
    • article e6593
    • U. G. Bhat, M. Halasi, and A. L. Gartel, "FoxM1 is a general target for proteasome inhibitors," PLoS ONE, vol.4, no.8, article e6593, 2009.
    • (2009) PLoS ONE , vol.4 , Issue.8
    • Bhat, U.G.1    Halasi, M.2    Gartel, A.L.3
  • 141
    • 70350509121 scopus 로고    scopus 로고
    • Proteasome inhibition activates the mitochondrial pathway of apoptosis inhumanCD4+Tcells
    • C. Berges, H. Haberstock, D. Fuchs, et al., "Proteasome inhibition activates the mitochondrial pathway of apoptosis inhumanCD4+Tcells,"Journal of Cellular Biochemistry, vol.108, no.4, pp. 935-946, 2009.
    • (2009) Journal of Cellular Biochemistry , vol.108 , Issue.4 , pp. 935-946
    • Berges, C.1    Haberstock, H.2    Fuchs, D.3
  • 142
    • 63049137443 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib inhibits the release of NF-κB-inducible cytokines and induces apoptosis of activated T cells from rheumatoid arthritis patients
    • J. W. van der Heijden, R. Oerlemans, W. F. Lems, R. J. Scheper, B. A. C. Dijkmans, and G. Jansen, "The proteasome inhibitor bortezomib inhibits the release of NF-κB-inducible cytokines and induces apoptosis of activated T cells from rheumatoid arthritis patients," Clinical and Experimental Rheumatology, vol.27, no.1, pp. 92-98, 2009.
    • (2009) Clinical and Experimental Rheumatology , vol.27 , Issue.1 , pp. 92-98
    • Heijden Der Van, J.W.1    Oerlemans, R.2    Lems, W.F.3    Scheper, R.J.4    Dijkmans, B.A.C.5    Jansen, G.6
  • 143
    • 54049112718 scopus 로고    scopus 로고
    • Targeting NF-κB: A promising molecular therapy in inflammatory arthritis
    • J. A. Roman-Blas and S. A. Jimenez, "Targeting NF-kappa;B: a promising molecular therapy in inflammatory arthritis," International Reviews of Immunology, vol.27, no.5, pp. 351-374, 2008.
    • (2008) International Reviews of Immunology , vol.27 , Issue.5 , pp. 351-374
    • Roman-Blas, J.A.1    Jimenez, S.A.2
  • 144
    • 70350521808 scopus 로고    scopus 로고
    • A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner
    • L. Rifas and M. N. Weitzmann, "A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner," Arthritis and Rheumatism, vol.60, no.11, pp. 3324-3335, 2009.
    • (2009) Arthritis and Rheumatism , vol.60 , Issue.11 , pp. 3324-3335
    • Rifas, L.1    Weitzmann, M.N.2
  • 145
    • 54849420079 scopus 로고    scopus 로고
    • Proteasome inhibitors induce osteoclast survival by activating the Akt pathway
    • H. B. Kwak, M. S. Lee, H. S. Kim, et al., "Proteasome inhibitors induce osteoclast survival by activating the Akt pathway," Biochemical and Biophysical Research Communications, vol.377, no.1, pp. 1-6, 2008.
    • (2008) Biochemical and Biophysical Research Communications , vol.377 , Issue.1 , pp. 1-6
    • Kwak, H.B.1    Lee, M.S.2    Kim, H.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.