JAK/STAT-dependent gene regulation by cytokines

Drug News and Perspectives

Volumn 18, Issue 4, 2005, Pages 243-249

  Hebenstreit, Daniel ^a   Horejs Hoeck, J ^a   Duschl, A ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 11; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 9; JANUS KINASE; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; LIPOPOLYSACCHARIDE; PROTEIN; PROTEIN SH2; PROTEIN TYK2; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; SUMO PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; UNCLASSIFIED DRUG; UNINDEXED DRUG;

DNA BINDING; GENE CONTROL; HUMAN; IMMUNE SYSTEM; NONHUMAN; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; MILK PROTEINS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 23244449296     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2005.18.4.908658     Document Type: Review

References (77)

1. Krolewski, J.J., Lee, R., Eddy, R., Shows, T.B. and Dalla-Favera, R. Identification and chromosomal mapping of new human tyrosine kinase genes. Oncogene 1990, 5: 277-82.
2. Firmbach-Kraft, I., Byers, M., Shows, T., Dalla-Favera, R. and Krolewski, J.J. tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. Oncogene 1990, 5: 1329-36.
3. Velazquez, L., Fellous, M., Stark, G.R. and Pellegrini, S. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 1992, 70: 313-22.
4. Yamaoka, K., Saharinen, P., Pesu, M., Holt, V.E., III, Silvennoinen, O. and O'Shea, J.J. The Janus kinases (Jaks). Genome Biol 2004, 5: 253.
5. Fu, X.Y., Schindler, C., Improta, T., Aebersold, R. and Darnell, J.E., Jr. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci USA 1992, 89: 7840-3.
6. Schindler, C., Fu, X.Y., Improta, T., Aebersold, R. and Darnell, J.E., Jr. Proteins of transcription factor ISGF-3: One gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc Natl Acad Sci USA 1992, 89: 7836-9.
7. Schindler, C., Shuai, K., Prezioso, V.R. and Darnell, J.E., Jr. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 1992, 257: 809-13.
8. Agaisse, H. and Perrimon, N. The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev 2004, 198: 72-82.
9. Kisseleva, T., Bhattacharya, S., Braunstein, J. and Schindler, C. W. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 2002, 285: 1-24.
10. Zhou, Y.J., Chen, M., Cusack, N.A. et al. Unexpected effects of FERM domain mutations on catalytic activity of Jak3: Structural implication for Janus kinases. Mol Cell 2001, 8: 959-69.
11. Paulson, M., Pisharody, S., Pan, L., Guadagno, S., Mui, A.L. and Levy, D.E. Stat protein transactivation domains recruit p300/CBP through widely divergent sequences. J Biol Chem 1999, 274: 25343-9.
12. Pfitzner, E., Jahne, R., Wissler, M., Stoecklin, E. and Groner, B. p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response. Mol Endocrinol 1998, 12: 1582-93.
13. Shankaranarayanan, P., Chaitidis, P., Kuhn, H. and Nigam, S. Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. J Biol Chem 2001, 276: 42753-60.
14. Sawyer, T.K. Src homology-2 domains: Structure, mechanisms, and drug discovery. Biopolymers 1998, 47: 243-61.
15. Chen, X., Vinkemeier, U., Zhao, Y., Jeruzalmi, D., Darnell, J.E., Jr. and Kuriyan, J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 1998, 93: 827-39.
16. Becker, S., Groner, B. and Muller, C.W. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 1998, 394: 145-51.
17. Yang, E., Henriksen, M.A., Schaefer, O., Zakharova, N. and Darnell, J.E., Jr. Dissociation time from DNA determines transcriptional function in a STAT1 linker mutant. J Biol Chem 2002, 277: 13455-62.
18. Begitt, A., Meyer, T., van Rossum, M. and Vinkemeier, U. Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain. Proc Natl Acad Sci USA 2000, 97: 10418-23.
19. Shimoda, K., Kato, K., Aoki, K. et al. Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity 2000, 13: 561-71.
20. Karaghiosoff, M., Neubauer, H., Lassnig, C. et al. Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity 2000, 13: 549-60.
21. Karaghiosoff, M., Steinborn, R., Kovarik, P. et al. Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat Immunol 2003, 4: 471-7.
22. Stoiber, D., Kovacic, B., Schuster, C. et al. TYK2 is a key regulator of the surveillance of B lymphoid tumors. J Clin Invest 2004, 114: 1650-8.
23. Rodig, S.J., Meraz, M.A., White, J.M. et al. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 1998, 93: 373-83.
24. Neubauer, H., Cumano, A., Muller, M., Wu, H., Huffstadt, U. and Pfeffer, K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 1998, 93: 397-409.
25. Parganas, E., Wang, D., Stravopodis, D. et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 1998, 93: 385-95.
26. O'Shea, J.J., Pesu, M., Borie, D.C. and Changelian, P.S. A new modality for immunosuppression: Targeting the JAK/ STAT pathway. Nat Rev Drug Discov 2004, 3: 555-64.
27. Nosaka, T., van Deursen, J.M., Tripp, R.A. et al. Defective lymphoid development in mice lacking Jak3. Science 1995, 270: 800-2.
28. Park, S.Y., Saijo, K., Takahashi, T. et al. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 1995, 3: 771-82.
29. Thomis, D.C., Gurniak, C.B., Tivol, E., Sharpe, A.H. and Berg, L.J. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 1995, 270: 794-7.
30. Durbin, J.E., Hackenmiller, R., Simon, M.C. and Levy, D.E. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996, 84: 443-50.
31. Meraz, M.A., White, J.M., Sheehan, K.C. et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996, 84: 431-42.
32. Kaplan, D.H., Shankaran, V., Dighe, A.S. et al. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci USA 1998, 95: 7556-61.
33. Lucas, S., Ghilardi, N., Li, J. and de Sauvage, F.J. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc Natl Acad Sci USA 2003, 100: 15047-52.
34. Park, C., Li, S., Cha, E. and Schindler, C. Immune response in Stat2 knockout mice. Immunity 2000, 13: 795-804.
35. Takeda, K., Noguchi, K., Shi, W. et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci USA 1997, 94: 3801-4.
36. Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T. and Akira, S. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice. J Immunol 1998, 161: 4652-60.
37. Akira, S., Nishio, Y., Inoue, M. et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 1994, 77: 63-71.
38. Alonzi, T., Maritano, D., Gorgoni, B., Rizzuto, G., Libert, C. and Poli, V. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver. Mol Cell Biol 2001, 21: 1621-32.
39. Takeda, K., Clausen, B.E., Kaisho, T. et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999, 10: 39-49.
40. Sano, S., Itami, S., Takeda, K. et al. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. Embo J 1999, 18: 4657-68.
41. Turkson, J. STAT proteins as novel targets for cancer drug discovery. Expert Opin Ther Targets 2004, 8: 409-22.
42. Kaplan, M.H., Sun, Y.L., Hoey, T. and Grusby, M.J. impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996, 382: 174-7.
43. Thierfelder, W.E., van Deursen, J.M., Yamamoto, K. et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996, 382: 171-4.
44. Watford, W.T., Hissong, B.D., Bream, J.H., Kanno, Y., Muul, L. and O'Shea, J.J. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev 2004, 202: 139-56.
45. Liu, X., Robinson, G.W., Wagner, K.U., Garrett, L., Wynshaw-Boris, A. and Hennighausen, L. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev 1997, 11: 179-86.
46. Udy, G.B., Towers, R.P., Snell, R.G. et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci USA 1997, 94: 7239-44.
47. Teglund, S., McKay, C., Schuetz, E. et al. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 1998, 93: 841-50.
48. Moriggl, R., Topham, D.J., Teglund, S. et al. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 1999, 10: 249-59.
49. Zhu, J., Cote-Sierra, J., Guo, L. and Paul, W.E. Stat5 activation plays a critical role in Th2 differentiation. Immunity 2003, 19: 739-48.
50. Shimoda, K., van Deursen, J., Sangster, M.Y. et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996, 380: 630-3.
51. Takeda, K., Tanaka, T., Shi, W. et al. Essential role of Stat6 in IL-4 signalling. Nature 1996, 380: 627-30.
52. Shuai, K. and Liu, B. Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol 2003, 3: 900-11.
53. Chen, W., Daines, M.O. and Khurana Hershey, G.K. Turning off signal transducer and activator of transcription (STAT): The negative regulation of STAT signaling. J Allergy Clin Immunol 2004, 114: 476-89; quiz 90.
54. Schmidt, D. and Muller, S. PIAS/SUMO: New partners in transcriptional regulation. Cell Mol Life Sci 2003, 60: 2561-74.
55. Malakhova, O.A., Yan, M., Malakhov, M.P. et al. Protein ISGylation modulates the JAK-STAT signaling pathway. Genes Dev 2003, 17: 455-60.
56. Malakhov, M.P., Kim, K.I., Malakhova, O.A., Jacobs, B.S., Borden, E.G. and Zhang, D.E. High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction. J Biol Chem 2003, 278: 16608-13.
57. Mowen, K.A., Tang, J., Zhu, W. et al. Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell 2001, 104: 731-41.
58. Chen, W., Daines, M.O. and Hershey, G.K. Methylation of STAT6 modulates STAT6 phosphorylation, nuclear translocation, and DNA-binding activity. J Immunol 2004, 172: 6744-50.
59. Ilangumaran, S., Ramanathan, S. and Rottapel, R. Regulation of the immune system by SOCS family adaptor proteins. Semin Immunol 2004, 16: 351-65.
60. Elliott, J. and Johnston, J.A. SOCS: Role in inflammation, allergy and homeostasis. Trends Immunol 2004, 25: 434-40.
61. Alexander, W.S. and Hilton, D.J. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol 2004, 22: 503-29.
62. Hebenstreit, D., Luft, P., Schmiedlechner, A. et al. IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site. J Immunol 2003, 171: 5901-7.
63. Andrews, R.P., Ericksen, M.B., Cunningham, C.M., Daines, M.O. and Hershey, G.K. Analysis of the life cycle of stat6. Continuous cycling of STAT6 is required for IL-4 signaling. J Biol Chem 2002, 277: 36563-9.
64. Swameye, I., Muller, T.G., Timmer, J., Sandra, O. and Klingmuller, U. Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by data-based modeling. Proc Natl Acad Sci USA 2003, 100: 1028-33.
65. Pranada, A.L., Metz, S., Herrmann, A., Heinrich, P.C. and Muller-Newen, G. Real time analysis of STAT3 nucleocytoplasmic shuttling. J Biol Chem 2004, 279: 15114-23.
66. Marg, A., Shan, Y., Meyer, T., Meissner, T., Brandenburg, M. and Vinkemeier, U. Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1. J Cell Biol 2004, 165: 823-33.
67. Meyer, T., Marg, A., Lemke, P., Wiesner, B. and Vinkemeier, U. DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1. Genes Dev 2003, 17: 1992-2005.
68. McBride, K.M., McDonald, C. and Reich, N.C. Nuclear export signal located within the DNA-binding domain of the STAT1 transcription factor. Embo J 2000, 19: 6196-206.
69. Mowen, K. and David, M. Regulation of STAT1 nuclear export by Jak1. Mol Cell Biol 2000, 20: 7273-81.
70. Melen, K., Kinnunen, L. and Julkunen, I. Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs. J Biol Chem 2001, 276: 16447-55.
71. Bhattacharya, S. and Schindler, C. Regulation of Stat3 nuclear export. J Clin Invest 2003, 111: 553-9.
72. Kessler, D.S., Levy, D.E. and Darnell, J.E., Jr. Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes. Proc Natl Acad Sci USA 1988, 85: 8521-5.
73. Ehret, G.B., Reichenbach, P., Schindler, U. et al. DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J Biol Chem 2001, 276: 6675-88.
74. Chen, Z., Lund, R., Aittokallio, T., Kosonen, M., Nevalainen, O. and Lahesmaa, R. Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. J Immunol 2003, 171: 3627-35.
75. Lund, R., Aittokallio, T., Nevalainen, O. and Lahesmaa, R. Identification of novel genes regulated by IL-12, IL-4, or TGF-beta during the early polarization of CD4+ lymphocytes. J Immunol 2003, 171: 5328-36.
76. Der, S.D., Zhou, A., Williams, B.R. and Silverman, R.H. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci USA 1998, 95: 15623-8.
77. Luo, C. and Laaja, P. Inhibitors of JAKs/STATs and the kinases: A possible new cluster of drugs. Drug Discov Today 2004, 9: 268-75.