Key regulatory molecules of cartilage destruction in rheumatoid arthritis: An in vitro study

Arthritis Research and Therapy

Volumn 10, Issue 1, 2008, Pages

  Andreas, Kristin ^a   Lübke, Carsten ^a   Häupl, Thomas ^a   Dehne, Tilo ^a   Morawietz, Lars ^a   Ringe, Jochen ^a   Kaps, Christian ^b   Sittinger, Michael ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b TRANSTISSUE TECHNOLOGIES GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2A RECEPTOR; ALGINIC ACID; ANTIBODY; CARTILAGE OLIGOMERIC MATRIX PROTEIN; CHEMOKINE RECEPTOR CXCR4; CXCL1 CHEMOKINE; CYCLOOXYGENASE 2; CYTOKINE; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE ELASTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN SERINE THREONINE KINASE; PROTEOCHONDROITIN SULFATE; SPERMINE SYNTHASE; STROMELYSIN 2; TOLL LIKE RECEPTOR 2; VIRUS T ANTIGEN;

ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL CULTURE; CELL IMMORTALIZATION; CELL STIMULATION; COMPUTER PROGRAM; CONTROLLED STUDY; DNA MICROARRAY; FIBROBLAST; GENE EXPRESSION PROFILING; GENETIC SELECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MARKER GENE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SIMIAN VIRUS 40; SUPERNATANT; UNINDEXED SEQUENCE; ARTICULAR CARTILAGE; COMPUTER SYSTEM; METABOLISM; PATHOLOGY; PROTEOMICS; REPRODUCIBILITY; SYNOVIUM;

ARTHRITIS, RHEUMATOID; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; COMPUTER SYSTEMS; FIBROBLASTS; GENE EXPRESSION PROFILING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEOMICS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNOVIAL MEMBRANE;

EID: 39049144388     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2358     Document Type: Article

References (60)

1. Müller-Ladner U Pap T Gay RE Neidhart M Gay S Mechanisms of disease: The molecular and cellular basis of joint destruction in rheumatoid arthritis Nat Clin Pract Rheumatol 2005, 1:102-110. 10.1038/ ncprheum0047 16932639
2. Kinne RW Brauer R Stuhlmüller B Palombo-Kinne E Burmester GR Macrophages in rheumatoid arthritis Arthritis Res 2000, 2:189-202. 130001 11094428 10.1186/ar86
3. Huber LC Distler O Tarner I Gay RE Gay S Pap T Synovial fibroblasts: Key players in rheumatoid arthritis Rheumatology (Oxford) 2006, 45:669-675. 10.1093/rheumatology/kel065 16567358
4. Firestein GS Zvaifler NJ How important are T cells in chronic rheumatoid synovitis?: II. T cell-independent mechanisms from beginning to end Arthritis Rheum 2002, 46:298-308. 10.1002/art.502 11840432
5. Kasama T Miwa Y Isozaki T Odai T Adachi M Kunkel SL Neutrophil-derived cytokines: Potential therapeutic targets in inflammation Curr Drug Targets Inflamm Allergy 2005, 4:273-279. 10.2174/1568010054022114 16101533
6. Martinez-Gamboa L Brezinschek HP Burmester GR Dorner T Immunopathologic role of B lymphocytes in rheumatoid arthritis: Rationale of B cell-directed therapy Autoimmun Rev 2006, 5:437-442. 10.1016/ j.autrev.2006.02.004 16920569
7. Devauchelle V Marion S Cagnard N Mistou S Falgarone G Breban M Letourneur F Pitaval A Alibert O Lucchesi C Anract P Hamadouche M Ayral X Dougados M Gidrol X Fournier C Chiocchia G DNA microarray allows molecular profiling of rheumatoid arthritis and identification of pathophysiological targets Genes Immun 2004, 5:597-608. 10.1038/ sj.gene.6364132 15496955
8. Justen HP Grunewald E Totzke G Gouni-Berthold I Sachinidis A Wessinghage D Vetter H Schulze-Osthoff K Ko Y Differential gene expression in synovium of rheumatoid arthritis and osteoarthritis Mol Cell Biol Res Commun 2000, 3:165-172. 10.1006/mcbr.2000.0211 10860865
9. Ruschpler P Lorenz P Eichler W Koczan D Hanel C Scholz R Melzer C Thiesen HJ Stiehl P High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis Arthritis Res Ther 2003, 5:R241-R252. 193722 12932287 10.1186/ar783
10. Karouzakis E Neidhart M Gay RE Gay S Molecular and cellular basis of rheumatoid joint destruction Immunol Lett 2006, 106:8-13. 10.1016/ j.imlet.2006.04.011 16824621
11. Goldring SR Pathogenesis of bone and cartilage destruction in rheumatoid arthritis Rheumatology (Oxford) 2003, 42(Suppl 2):iI11-ii16. 12817090
12. Holmdahl R Lorentzen JC Lu S Olofsson P Wester L Holmberg J Pettersson U Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis Immunol Rev 2001, 184:184-202. 10.1034/ j.1600-065x.2001.1840117.x 12086312
13. Keffer J Probert L Cazlaris H Georgopoulos S Kaslaris E Kioussis D Kollias G Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis Embo J 1991, 10:4025-4031. 453150 1721867
14. O'Sullivan FX Fassbender HG Gay S Koopman WJ Etiopathogenesis of the rheumatoid arthritis-like disease in MRL/l mice. I. The histomorphologic basis of joint destruction Arthritis Rheum 1985, 28:529-536. 10.1002/ art.1780280511 4004962
15. Holmdahl R Andersson ME Goldschmidt TJ Jansson L Karlsson M Malmstrom V Mo J Collagen induced arthritis as an experimental model for rheumatoid arthritis. Immunogenetics, pathogenesis and autoimmunity Apmis 1989, 97:575-584. 2665798
16. Geiler T Kriegsmann J Keyszer GM Gay RE Gay S A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice Arthritis Rheum 1994, 37:1664-1671. 10.1002/art.1780371116 7526870
17. Russell WMS Burch RL The Principles of Humane Experimental Technique Springfield, Illinois: Charles C Thomas 1959:238.
18. Häuselmann HJ Fernandes RJ Mok SS Schmid TM Block JA Aydelotte MB Kuettner KE Thonar EJ Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads J Cell Sci 1994, 107:17-27. 8175906
19. Lemare F Steimberg N Le Griel C Demignot S Adolphe M Dedifferentiated chondrocytes cultured in alginate beads: Restoration of the differentiated phenotype and of the metabolic responses to interleukin-1β J Cell Physiol 1998, 176:303-313. 10.1002/ (SICI)1097-4652(199808)176:2<303::AID-JCP8>3.0.CO;2-S 9648917
20. Darling EM Athanasiou KA Rapid phenotypic changes in passaged articular chondrocyte subpopulations J Orthop Res 2005, 23:425-432. 10.1016/ j.orthres.2004.08.008 15734258
21. Chia SH Homicz MR Schumacher BL Thonar EJ Masuda K Sah RL Watson D Characterization of human nasal septal chondrocytes cultured in alginate J Am Coll Surg 2005, 200:691-704. 10.1016/j.jamcollsurg.2005.01.006 15848359
22. Haas C Aicher WK Dinkel A Peter HH Eibel H Characterization of SV40T antigen immortalized human synovial fibroblasts: Maintained expression patterns of EGR-1, HLA-DR and some surface receptors Rheumatol Int 1997, 16:241-247. 10.1007/BF01375656 9106935
23. Häupl T Yahyawi M Lübke C Ringe J Rohrlach T Burmester GR Sittinger M Kaps C Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs J Biomol Screen 2007, 12:328-340. 10.1177/1087057107299261 17379860
24. Parak WJ Dannohl S George M Schuler MK Schaumburger J Gaub HE Muller O Aicher WK Metabolic activation stimulates acid production in synovial fibroblasts J Rheumatol 2000, 27:2312-2322. 11036823
25. Kaps C Bramlage C Smolian H Haisch A Ungethüm U Burmester GR Sittinger M Gross G Häupl T Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction Arthritis Rheum 2002, 46:149-162. 10.1002/ 1529-0131(200201)46:1<149::AID-ART10058>3.0.CO;2-W 11817587
26. Aicher WK Dinkel A Grimbacher B Haas C Seydlitz-Kurzbach EV Peter HH Eibel H Serum response elements activate and cAMP responsive elements inhibit expression of transcription factor Egr-1 in synovial fibroblasts of rheumatoid arthritis patients Int Immunol 1999, 11:47-61. 10.1093/ intimm/11.1.47 10050673
27. Peng X Wood CL Blalock EM Chen KC Landfield PW Stromberg AJ Statistical implications of pooling RNA samples for microarray experiments BMC Bioinformatics 2003, 4:26. 166151 12823867 10.1186/1471-2105-4-26
28. Mary-Huard T Daudin JJ Baccini M Biggeri A Bar-Hen A Biases induced by pooling samples in microarray experiments Bioinformatics (Oxford, England) 2007, 23:i313-i318. 10.1093/bioinformatics/btm182 17646312
29. Irizarry RA Bolstad BM Collin F Cope LM Hobbs B Speed TP Summaries of Affymetrix GeneChip probe level data Nucleic Acids Res 2003, 31:e15. 150247 12582260 10.1093/nar/gng015
30. Sturn A Quackenbush J Trajanoski Z Genesis: Cluster analysis of microarray data Bioinformatics (Oxford, England) 2002, 18:207-208. 10.1093/bioinformatics/18.1.207 11836235
31. Gabay C Interleukin-6 and chronic inflammation Arthritis Res Ther 2006, 8(Suppl 2):S3. 10.1186/ar1917 16899107
32. Georganas C Liu H Perlman H Hoffmann A Thimmapaya B Pope RM Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: The dominant role for NF-κB but not C/EBP β or c-Jun J Immunol 2000, 165:7199-7206. 11120852
33. Legendre F Dudhia J Pujol JP Bogdanowicz P JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression J Biol Chem 2003, 278:2903-2912. 10.1074/jbc.M110773200 12419823
34. Yuan GH Masuko-Hongo K Sakata M Tsuruha J Onuma H Nakamura H Aoki H Kato T Nishioka K The role of C-C chemokines and their receptors in osteoarthritis Arthritis Rheum 2001, 44:1056-1070. 10.1002/ 1529-0131(200105)44:5<1056::AID-ANR186>3.0.CO;2-U 11352237
35. Asamitsu K Sakurada S Mashiba K Nakagawa K Torikai K Onozaki K Okamoto T Alteration of the cellular response to interleukin-1β by SV40 large T antigen in rheumatoid synovial fibroblasts Arch Virol 1999, 144:317-327. 10.1007/s007050050506 10470256
36. 2 receptors and activity is potentiated by an adenosine deaminase inhibitor and a phosphodiesterase inhibitor Osteoarthritis Cartilage 2002, 10:34-43. 10.1053/joca.2001.0479 11795981
37. Taskiran D Stefanovic-Racic M Georgescu H Evans C Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1 Biochem Biophys Res Commun 1994, 200:142-148. 10.1006/bbrc.1994.1426 7513156
38. Cao M Westerhausen-Larson A Niyibizi C Kavalkovich K Georgescu HI Rizzo CF Hebda PA Stefanovic-Racic M Evans CH Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target Biochem J 1997, 324:305-310. 1218431 9164871
39. Lotz M The role of nitric oxide in articular cartilage damage Rheum Dis Clin North Am 1999, 25:269-282. 10.1016/S0889-857X(05)70067-3 10356417
40. Clancy RM Abramson SB Kohne C Rediske J Nitric oxide attenuates cellular hexose monophosphate shunt response to oxidants in articular chondrocytes and acts to promote oxidant injury J Cell Physiol 1997, 172:183-191. 10.1002/ (SICI)1097-4652(199708)172:2<183::AID-JCP5>3.0.CO;2-K 9258339
41. van't Hof RJ Hocking L Wright PK Ralston SH Nitric oxide is a mediator of apoptosis in the rheumatoid joint Rheumatology (Oxford) 2000, 39:1004-1008. 10.1093/rheumatology/39.9.1004 10986306
42. Mastbergen SC Lafeber FP Bijlsma JW Selective COX-2 inhibition prevents proinflammatory cytokine-induced cartilage damage Rheumatology (Oxford) 2002, 41:801-808. 10.1093/rheumatology/41.7.801 12096231
43. Gosset M Berenbaum F Levy A Pigenet A Thirion S Saffar JL Jacques C Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene Arthritis Res Ther 2006, 8:R135. 1779392 16872525 10.1186/ar2024
44. Kojima F Naraba H Miyamoto S Beppu M Aoki H Kawai S Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis Arthritis Res Ther 2004, 6:R355. R365 464891 15225371 10.1186/ar1195
45. Pahl HL Activators and target genes of Rel/NF-κB transcription factors Oncogene 1999, 18:6853-6866. 10.1038/sj.onc.1203239 10602461
46. Vincenti MP Brinckerhoff CE Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: Integration of complex signaling pathways for the recruitment of gene-specific transcription factors Arthritis Res 2002, 4:157-164. 128926 12010565 10.1186/ar401
47. D'Acquisto F May MJ Ghosh S Inhibition of nuclear factor κB (NF-κB): An emerging theme in anti-inflammatory therapies Mol Interv 2002, 2:22-35. 10.1124/mi.2.1.22 14993359
48. Thome M Hofmann K Burns K Martinon F Bodmer JL Mattmann C Tschopp J Identification of CARDIAK, a RIP-like kinase that associates with caspase-1 Curr Biol 1998, 8:885-888. 10.1016/S0960-9822(07)00352-1 9705938
49. McCarthy JV Ni J Dixit VM RIP2 is a novel NF-κB-activating and cell death-inducing kinase J Biol Chem 1998, 273:16968-16975. 10.1074/ jbc.273.27.16968 9642260
50. Mazzetti I Magagnoli G Paoletti S Uguccioni M Olivotto E Vitellozzi R Cattini L Facchini A Borzi RM A role for chemokines in the induction of chondrocyte phenotype modulation Arthritis Rheum 2004, 50:112-122. 10.1002/art.11474 14730607
51. Borzi RM Mazzetti I Cattini L Uguccioni M Baggiolini M Facchini A Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines Arthritis Rheum 2000, 43:1734-1741. 10.1002/ 1529-0131(200008)43:8<1734::AID-ANR9>3.0.CO;2-B 10943863
52. Lotz M Cytokines in cartilage injury and repair Clin Orthop Relat Res 2001, 391(Suppl):S108-S115. 10.1097/00003086-200110001-00011 11603695
53. Borzi RM Mazzetti I Magagnoli G Paoletti S Uguccioni M Gatti R Orlandini G Cattini L Facchini A Growth-related oncogene α induction of apoptosis in osteoarthritis chondrocytes Arthritis Rheum 2002, 46:3201-3211. 10.1002/art.10650 12483724
54. Lotz M Terkeltaub R Villiger PM Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes J Immunol 1992, 148:466-473. 1729366
55. Schutyser E Struyf S Van Damme J The CC chemokine CCL20 and its receptor CCR6 Cytokine Growth Factor Rev 2003, 14:409-426. 10.1016/ S1359-6101(03)00049-2 12948524
56. Kanbe K Takemura T Takeuchi K Chen Q Takagishi K Inoue K Synovectomy reduces stromal-cell-derived factor-1 (SDF-1) which is involved in the destruction of cartilage in osteoarthritis and rheumatoid arthritis J Bone Joint Surg Br 2004, 86:296-300. 10.1302/0301-620X.86B2.14474 15046450
57. Barksby HE Milner JM Patterson AM Peake NJ Hui W Robson T Lakey R Middleton J Cawston TE Richards CD Rowan AD Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: Implications for cartilage degradation in arthritis Arthritis Rheum 2006, 54:3244-3253. 10.1002/art.22167 17009259
58. Wang X Liang J Koike T Sun H Ichikawa T Kitajima S Morimoto M Shikama H Watanabe T Sasaguri Y Fan J Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits Am J Pathol 2004, 165:1375-1383. 1618618 15466401
59. Jones SW Brockbank SM Mobbs ML Le Good NJ Soma-Haddrick S Heuze AJ Langham CJ Timms D Newham P Needham MR The orphan G-protein coupled receptor RDC1: Evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover Osteoarthritis Cartilage 2006, 14:597-608. 10.1016/j.joca.2006.01.007 16647866
60. Hausser HJ Decking R Brenner RE Testican-1, an inhibitor of pro-MMP-2 activation, is expressed in cartilage Osteoarthritis Cartilage 2004, 12:870-877. 10.1016/j.joca.2004.07.008 15501402