A completely foreign receptor can mediate an interferon-γ-like response

EMBO Journal

Volumn 20, Issue 19, 2001, Pages 5431-5442

  Strobl, Birgit ^a   Arulampalam, Velmurugesan ^a   Is'Harc, Hayaatun ^a   Newman, Sally J ^a   Schlaak, Jörg F ^a   Watling, Diane ^a   Costa Pereira, Ana P ^a   Schaper, Fred ^b   Behrmann, Iris ^b   Sheehan, Kathleen C F ^c   Schreiber, Robert D ^c   Horn, Friedemann ^d   Heinrich, Peter C ^b   Kerr, Ian M ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Institute for Clinical Immunology   (Germany)

Author keywords

Cytokine; Interferon; Modular signalling; Receptor cross phosphorylation

Indexed keywords

CYTOKINE; ERYTHROPOIETIN RECEPTOR; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GLYCOPROTEIN GP 130; INTERLEUKIN 6 RECEPTOR; PROTEIN SUBUNIT; STAT1 PROTEIN;

ARTICLE; CHIMERA; COMPLEX FORMATION; CONTROLLED STUDY; FIBROSARCOMA; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION;

DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INTERFERON TYPE II; NUCLEAR PROTEINS; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, ERYTHROPOIETIN; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERFERON; RECEPTORS, INTERLEUKIN-6; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 17944381636     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.19.5431     Document Type: Article

References (50)

1. Analysis of gene expression using high density and IFN-γ-specific low-density cDNA arrays
2. Analysis and purification of human lymphoblastoid (Namalwa) interferon using a monoclonal antibody
3. Ligand-induced assembly and activation of the γ interferon receptor in intact cells
4. The IFNγ receptor: A paradigm for cytokine receptor signaling
5. Kinase-negative mutants of JAK1 can sustain interferon-γ-inducible gene expression but not an antiviral state
6. IL3
7. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
8. Structural analysis of the human interferon γ receptor: A small segment of the intracellular domain is specifically required for class I major histocompatibility complex antigen induction and antiviral activity
9. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
10. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, set of genes
11. Identification of a functionally important sequence in the C terminus of the interferon-γ receptor
12. Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130
13. p53 is associated with cellular microtubules and is transported to the nucleus by dynein
14. Biologic consequences of Stat1-independent IFN signaling
15. p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons
16. Ligand-induced IFNγ receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)
17. A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6
18. Interleukin-6-type cytokine signaling through the gp130/Jak/STAT pathway
19. Jaks and Stats in signaling by the cytokine receptor superfamily
20. The β chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor
21. Identification of an interferon-γ receptor α chain sequence required for JAK-1 binding
22. Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
23. Interaction between the components of the interferon γ receptor complex
24. Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-γ uses a different signaling pathway
25. STAT1 from the cell membrane to the DNA
26. Design of conditionally active STATs: Insights into STAT activation and gene regulatory function
27. Arginine methylation of STAT1 modulates IFNα/β-induced transcription
28. The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
29. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
30. Dimerisation of the interferon Type I receptor IFNaR2-2 is sufficient for induction of interferon effector genes but not for full antiviral activity
31. Use of a selectable marker regulated by α interferon to obtain mutations in the signaling pathway
32. Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells
33. Regulation of c-myc expression by IFN-γ through STAT1-dependent and independent pathways
34. Stat1-independent regulation of gene expression in response to IFN-γ
35. The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction
36. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
37. Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1
38. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
39. How cells respond to interferons
40. Cross talk between interferon-γ and -α/β signaling components in caveolar membrane domains
41. A weak signal for strong responses - Interferon α/β revisited
42. The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130
43. Translocation and reversible localisation of signaling proteins: A dynamic future for signal transduction
44. The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon α-dependent transcriptional activation but not serine phosphorylation of STAT proteins
45. Activation of the Rac1/p38 MAP kinase pathway by Type I IFNs regulates transcriptional activation via serine phosphorylation of Histone H3
46. Protein kinase Cα controls erythropoietin receptor signaling
47. Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-γ signal transduction pathway
48. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation
49. Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone
50. Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer