Cucurbitacin Q: A selective STAT3 activation inhibitor with potent antitumor activity

Oncogene

Volumn 24, Issue 20, 2005, Pages 3236-3245

  Sun, Jiazhi ^a   Blaskovich, Michelle A ^a   Jove, Richard ^a   Livingston, Sandra K ^a   Coppola, Domenico ^a   Sebti, Saïd M ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Antitumor activity; Apoptosis; Cucurbitacins; JAK2; STAT3

Indexed keywords

CUCURBITACIN A; CUCURBITACIN B; CUCURBITACIN E; CUCURBITACIN GLYCOSIDE; CUCURBITACIN I; CUCURBITACIN Q; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU NICK-END LABELING; INHIBITORY CONCENTRATION 50; JANUS KINASE 2; MICE; MICE, NUDE; MODELS, CHEMICAL; NEOPLASM TRANSPLANTATION; NIH 3T3 CELLS; PHOSPHOTYROSINE; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; STAT3 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRANS-ACTIVATORS; TRITERPENES;

MURINAE; MUS MUSCULUS;

EID: 18844370367     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208470     Document Type: Article

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